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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:29073
Term: L-ascorbic acid
Definition: The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.
Chemical ID: MESH:D001205
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2multiple interactionsEXP 6480464CTD[alpha-Tocopherol co-treated with Ascorbic Acid] inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 mRNA]; Ascorbic Acid inhibits the reaction [Humic Substances results in decreased expression of BCL2 protein]; Ascorbic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of BCL2 protein]; Ascorbic Acid inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein]; Ascorbic Acid promotes the reaction [lead acetate results in increased expression of BCL2 protein]PMID:17959157 PMID:18683188 PMID:18758938 PMID:21262251 PMID:29297235
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDAscorbic Acid results in decreased expression of BCL2 mRNAPMID:21919647
Bcl2increases abundanceISOBCL2 (Homo sapiens)6480464CTDBCL2 protein results in increased abundance of Ascorbic AcidPMID:15449323
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTDAscorbic Acid inhibits the reaction [glycidamide results in decreased expression of BCL2 mRNA]PMID:32632975
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[arsenic trioxide co-treated with Ascorbic Acid co-treated with Disulfiram] results in decreased expression of BCL2 protein; [Ascorbic Acid co-treated with Quartz] results in increased expression of BCL2 mRNA; Ascorbic Acid inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]; Ascorbic Acid inhibits the reaction [Silicon Dioxide results in decreased expression of BCL2 mRNA]; Ascorbic Acid inhibits the reaction [Silicon Dioxide results in decreased expression of BCL2 protein]PMID:17166419 PMID:22245848 PMID:24126434 PMID:27381660
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