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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2multiple interactionsEXP 6480464CTD[[pirinixic acid results in increased expression of UCP2 protein] which results in decreased expression of BCL2 protein] which results in increased susceptibility to Potassium Cyanide; [[pirinixic acid results in increased expression of UCP2 protein] which results in increased abundance of Hydrogen Peroxide] which results in decreased expression of BCL2 protein; [pirinixic acid results in increased expression of UCP2 protein] which results in increased degradation of BCL2 protein; lactacystin inhibits the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased degradation of BCL2 protein]; Potassium Cyanide promotes the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased degradation of BCL2 protein]PMID:19361538
Bcl2increases expressionISOBcl2 (Mus musculus)6480464CTDpirinixic acid results in increased expression of BCL2 proteinPMID:10426811
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