GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bcl2 | increases expression | ISO | Bcl2 (Mus musculus) | 127285675 | RGD | N-nitrosodiethylamine increases expression of Bcl2 mRNA in liver | | Bcl2 | increases expression | EXP | | 6480464 | CTD | Diethylnitrosamine results in increased expression of BCL2 mRNA; Diethylnitrosamine results in increased expression of BCL2 protein | PMID:15682466 PMID:19073162 PMID:19931519 PMID:22393308 PMID:30423403 PMID:31129132 PMID:35437842 | Bcl2 | multiple interactions | EXP | | 6480464 | CTD | [2-aminofluorene co-treated with Diethylnitrosamine] results in increased expression of BCL2 protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2 protein; [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of BCL2 mRNA; [Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of BCL2 mRNA; [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of BCL2 mRNA; Fluorouracil inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 mRNA]; Fluorouracil inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 protein]; fumagillin inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 mRNA]; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2 protein]; morin inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 protein]; neferine inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 mRNA]; neferine inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 protein]; Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of BCL2 mRNA]; Plant Oils inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 mRNA]; Plant Oils inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 protein]; Resveratrol inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 protein]; Silymarin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of BCL2 mRNA]; Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of BCL2 mRNA]; thymoquinone inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of BCL2 mRNA]; thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 mRNA]; zerumbone inhibits the reaction [[2-aminofluorene co-treated with Diethylnitrosamine] results in increased expression of BCL2 protein]; zolmitriptan inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 mRNA]; zolmitriptan inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 protein] | PMID:11915028 PMID:15682466 PMID:19073162 PMID:19931519 PMID:20452335 PMID:21295105 PMID:22393308 PMID:23830814 PMID:29923357 PMID:30423403 PMID:31129132 PMID:35437842 | Bcl2 | decreases response to substance | ISO | Bcl2 (Mus musculus) | 6480464 | CTD | BCL2 protein results in decreased susceptibility to Diethylnitrosamine | PMID:12000706 | Bcl2 | increases expression | ISO | Bcl2 (Mus musculus) | 6480464 | CTD | Diethylnitrosamine results in increased expression of BCL2 mRNA; Diethylnitrosamine results in increased expression of BCL2 protein | PMID:24535843 PMID:34726822 | Bcl2 | increases expression | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | Diethylnitrosamine results in increased expression of BCL2 protein | PMID:21776270 | Bcl2 | multiple interactions | ISO | Bcl2 (Mus musculus) | 6480464 | CTD | BCL2 protein inhibits the reaction [TGFA protein results in increased susceptibility to Diethylnitrosamine]; maculosin inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 protein]; Quercetin inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 protein] | PMID:12000706 PMID:34726822 | | ||||||||||||||||||||||
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