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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:16118
Term: berberine
Definition: A botanical anti-fungal agent that has formula C20H18NO4.
Chemical ID: MESH:D001599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2increases expressionEXP 6480464CTDBerberine results in increased expression of BCL2 proteinPMID:25600690
Bcl2multiple interactionsEXP 6480464CTDBerberine inhibits the reaction [Chlorpyrifos results in decreased expression of BCL2 mRNA]; Berberine inhibits the reaction [Mercuric Chloride results in decreased expression of BCL2 protein]; Berberine inhibits the reaction [Thioacetamide results in increased expression of BCL2 mRNA]PMID:24751971 PMID:25600690 PMID:30138605 PMID:35439518
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDBerberine results in decreased expression of BCL2 mRNA; Berberine results in decreased expression of BCL2 proteinPMID:16505103 PMID:20656010
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTDBerberine results in increased expression of BCL2 proteinPMID:23954465
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[Berberine co-treated with Cisplatin] results in decreased expression of BCL2 protein; [Berberine co-treated with Niacinamide] results in decreased expression of BCL2 protein; Berberine inhibits the reaction [Glucose results in decreased expression of BCL2 protein]PMID:23954465 PMID:26712469 PMID:36070022
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