GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bcl2 | increases expression | EXP | | 6480464 | CTD | Copper results in increased expression of BCL2 protein | PMID:30556269 | Bcl2 | multiple interactions | EXP | | 6480464 | CTD | [Copper co-treated with pyrrolidine dithiocarbamic acid] results in decreased expression of BCL2 mRNA; [Copper co-treated with pyrrolidine dithiocarbamic acid] results in decreased expression of BCL2 protein; [Copper Sulfate results in increased abundance of Copper] which results in decreased expression of BCL2 mRNA; [Copper Sulfate results in increased abundance of Copper] which results in increased expression of BCL2 protein; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased expression of BCL2 mRNA]; Deferoxamine inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased expression of BCL2 mRNA]; Rutin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BCL2 protein] | PMID:22085843 PMID:32881150 PMID:34577062 | Bcl2 | decreases expression | ISO | Bcl2 (Mus musculus) | 6480464 | CTD | Copper analog results in decreased expression of BCL2 protein; Copper results in decreased expression of BCL2 protein | PMID:22000994 PMID:34676557 | Bcl2 | decreases expression | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | Copper results in decreased expression of BCL2 mRNA; Copper results in decreased expression of BCL2 protein | PMID:16391388 PMID:16962711 | Bcl2 | multiple interactions | ISO | Bcl2 (Mus musculus) | 6480464 | CTD | [Copper Sulfate results in increased abundance of Copper] which results in decreased expression of BCL2 mRNA; [Copper Sulfate results in increased abundance of Copper] which results in decreased expression of BCL2 protein | PMID:31491480 | Bcl2 | multiple interactions | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | [Chelating Agents binds to Copper] which results in decreased expression of BCL2 protein; [Copper co-treated with Disulfiram] results in decreased expression of BCL2 protein | PMID:23033007 PMID:30911355 | |
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