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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:30052
Term: copper(0)
Definition: An elemental copper that has formula Cu.
Chemical ID: MESH:D003300
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2increases expressionEXP 6480464CTDCopper results in increased expression of BCL2 proteinPMID:30556269
Bcl2multiple interactionsEXP 6480464CTD[Copper co-treated with pyrrolidine dithiocarbamic acid] results in decreased expression of BCL2 mRNA; [Copper co-treated with pyrrolidine dithiocarbamic acid] results in decreased expression of BCL2 protein; [Copper Sulfate results in increased abundance of Copper] which results in decreased expression of BCL2 mRNA; [Copper Sulfate results in increased abundance of Copper] which results in increased expression of BCL2 protein; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased expression of BCL2 mRNA]; Deferoxamine inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased expression of BCL2 mRNA]; Rutin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BCL2 protein]PMID:22085843 PMID:32881150 PMID:34577062
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDCopper analog results in decreased expression of BCL2 protein; Copper results in decreased expression of BCL2 proteinPMID:22000994 PMID:34676557
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDCopper results in decreased expression of BCL2 mRNA; Copper results in decreased expression of BCL2 proteinPMID:16391388 PMID:16962711
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTD[Copper Sulfate results in increased abundance of Copper] which results in decreased expression of BCL2 mRNA; [Copper Sulfate results in increased abundance of Copper] which results in decreased expression of BCL2 proteinPMID:31491480
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[Chelating Agents binds to Copper] which results in decreased expression of BCL2 protein; [Copper co-treated with Disulfiram] results in decreased expression of BCL2 proteinPMID:23033007 PMID:30911355
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