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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:transforming growth factor-beta Smad dependent signaling pathway
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Accession:PW:0000490 term browser browse the term
Definition:Transforming growth factor-beta (TGF-beta) signaling is one of the best characterized modules of the Tgf-b superfamily pathways. Binding to the type II receptor leads to activation of the type I receptor and subsequent activation of the Smad pathway. Nuclear translocation of Smad(s) and interaction with transcription factors leads to activation or repression of many genes.
Synonyms:related_synonym: TGF- beta signaling pathway - SMAD dependent;   TGF-beta Smad dependent signaling pathway
 alt_id: PID:200227;   Reactome:R-HSA-170834
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transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin IMP RGD PMID:12809600 RGD:2298922 NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:156,569,860...156,619,868 		JBrowse link
G Arrb2 arrestin, beta 2 ISO PID PID:200227 NCBI chr10:55,645,539...55,653,485
Ensembl chr10:55,645,357...55,653,487 		JBrowse link
G Atf3 activating transcription factor 3 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750 		JBrowse link
G Axin1 axin 1 ISO PID PID:200227 NCBI chr10:15,667,894...15,720,092
Ensembl chr10:15,667,958...15,720,092 		JBrowse link
G Bambi BMP and activin membrane-bound inhibitor ISO PID PID:200227 NCBI chr17:58,816,438...58,821,003
Ensembl chr17:58,816,442...58,821,247 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha ISO PID PID:200227 NCBI chr18:56,648,779...56,711,505
Ensembl chr18:56,649,025...56,711,504 		JBrowse link
G Cav1 caveolin 1 ISO PID PID:200227 NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:46,600,738...46,639,740 		JBrowse link
G Ccn2 cellular communication network factor 2 ISO PID PID:200227 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 IMP RGD PMID:16891311 RGD:1625706 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339 		JBrowse link
G Crebbp CREB binding lysine acetyltransferase ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,822,620...11,968,266 		JBrowse link
G Ctnnb1 catenin beta 1 ISO PID PID:200227 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Dact2 dishevelled-binding antagonist of beta-catenin 2 ISO PID PID:200227 NCBI chr 1:63,854,182...63,864,153
Ensembl chr 1:63,854,182...63,864,255 		JBrowse link
G Daxx death-domain associated protein ISO PID PID:200227 NCBI chr20:4,971,973...4,978,062
Ensembl chr20:4,971,941...4,977,720 		JBrowse link
G Dcn decorin ISO RGD PMID:12809600 RGD:2298922 NCBI chr 7:34,167,973...34,208,004
Ensembl chr 7:34,163,011...34,218,926 		JBrowse link
G Dynlrb1 dynein light chain roadblock-type 1 ISO PID PID:200227 NCBI chr 3:164,197,892...164,224,409
Ensembl chr 3:164,202,953...164,224,409 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A ISO PID PID:200227 NCBI chr 2:144,911,247...144,944,705
Ensembl chr 2:144,911,153...144,945,201 		JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A ISO PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr 3:160,500,748...160,520,492
Ensembl chr 3:160,500,726...160,524,233 		JBrowse link
G Foxh1 forkhead box H1 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr 7:110,268,608...110,272,105
Ensembl chr 7:110,268,612...110,270,692 		JBrowse link
G Foxo1 forkhead box O1 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419 		JBrowse link
G Foxo3 forkhead box O3 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845 		JBrowse link
G Foxo4 forkhead box O4 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr  X:70,425,218...70,432,120
Ensembl chr  X:70,425,563...70,432,120 		JBrowse link
G Grb2 growth factor receptor bound protein 2 ISO PID PID:200227 NCBI chr10:101,380,354...101,448,138
Ensembl chr10:101,380,356...101,448,138 		JBrowse link
G Itch itchy E3 ubiquitin protein ligase ISO PID PID:200227 NCBI chr 3:164,102,490...164,193,932
Ensembl chr 3:164,105,812...164,193,932 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 ISO PID PID:200227 NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:51,154,352...51,212,012 		JBrowse link
G Nedd4l NEDD4 like E3 ubiquitin protein ligase ISO PID PID:200227 NCBI chr18:60,663,918...60,996,824
Ensembl chr18:60,663,970...60,996,824 		JBrowse link
G Ocln occludin ISO PID PID:200227 NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411 		JBrowse link
G Pard6a par-6 family cell polarity regulator alpha ISO PID PID:200227 NCBI chr19:50,499,420...50,502,301
Ensembl chr19:50,499,442...50,502,674 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 ISO PID PID:200227 NCBI chr10:13,610,000...13,687,226
Ensembl chr10:13,610,063...13,679,181 		JBrowse link
G Pml PML nuclear body scaffold ISO PID PID:200227 NCBI chr 8:67,523,164...67,557,801
Ensembl chr 8:67,523,164...67,576,083 		JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha ISO PID PID:200227 NCBI chr 1:210,914,576...210,918,193
Ensembl chr 1:210,914,567...210,918,193 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A ISO PID PID:200227 NCBI chr 1:105,136,521...105,139,596
Ensembl chr 1:105,136,525...105,139,774 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha ISO PID PID:200227 NCBI chr10:36,856,534...36,878,789 JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta ISO PID PID:200227 NCBI chr16:65,261,178...65,282,658
Ensembl chr16:65,261,181...65,282,634 		JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha ISO PID PID:200227 NCBI chr15:45,380,142...45,439,428
Ensembl chr15:45,379,683...45,439,405 		JBrowse link
G Rhoa ras homolog family member A ISO PID PID:200227 NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302 		JBrowse link
G Rnf111 ring finger protein 111 ISO PID PID:200227 NCBI chr 8:79,984,831...80,061,022
Ensembl chr 8:79,984,837...80,060,984 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 ISO PID PID:200227 NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238 		JBrowse link
G Runx1 RUNX family transcription factor 1 IMP RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr11:45,325,778...45,560,300
Ensembl chr11:45,329,044...45,564,925 		JBrowse link
G Runx2 RUNX family transcription factor 2 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027 		JBrowse link
G Runx3 RUNX family transcription factor 3 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr 5:152,644,270...152,702,835
Ensembl chr 5:152,644,270...152,702,835 		JBrowse link
G Shc1 SHC adaptor protein 1 ISO PID PID:200227 NCBI chr 2:177,135,649...177,147,257
Ensembl chr 2:177,135,659...177,147,914 		JBrowse link
G Skil SKI-like proto-oncogene ISO PID PID:200227 NCBI chr 2:114,175,534...114,203,663
Ensembl chr 2:114,175,534...114,201,974 		JBrowse link
G Smad2 SMAD family member 2 IDA
ISO
IMP 		PID
RGD		 PMID:16959941 PMID:12809600 PMID:18684975 PID:200227, RGD:1599906, RGD:2298922, RGD:2302517 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388 		JBrowse link
G Smad3 SMAD family member 3 ISO
IDA
IMP 		PID
RGD		 PMID:12809600 PMID:12702545 PMID:16891311 PID:200227, RGD:2298922, RGD:1299323, RGD:1625706 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324 		JBrowse link
G Smad4 SMAD family member 4 IDA
ISO 		PID
RGD		 PMID:16959941 PMID:12809600 PID:200227, RGD:1599906, RGD:2298922 NCBI chr18:69,518,988...69,549,684
Ensembl chr18:69,518,988...69,549,684 		JBrowse link
G Smad7 SMAD family member 7 ISO PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr18:71,263,508...71,291,849
Ensembl chr18:71,263,508...71,291,849 		JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 ISO PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr12:14,748,717...14,840,273
Ensembl chr12:14,749,043...14,840,273 		JBrowse link
G Smurf2 SMAD specific E3 ubiquitin protein ligase 2 ISO PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr10:92,261,516...92,362,185
Ensembl chr10:92,261,525...92,362,552 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO PID PID:200227 NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:20,286,117...20,363,350 		JBrowse link
G Sptbn1 spectrin, beta, non-erythrocytic 1 ISO PID PID:200227 NCBI chr14:108,042,629...108,217,884
Ensembl chr14:108,042,629...108,217,836 		JBrowse link
G Strap serine/threonine kinase receptor associated protein ISO PID PID:200227 NCBI chr 4:172,377,325...172,391,573
Ensembl chr 4:172,377,305...172,392,436 		JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 ISO PID PID:200227 NCBI chr 7:113,556,157...113,587,351
Ensembl chr 7:113,555,819...113,587,351 		JBrowse link
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 ISO PID PID:200227 NCBI chr 1:4,195,400...4,245,485
Ensembl chr 1:4,195,400...4,245,485 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO PID
RGD		 PMID:15109563 PID:200227, RGD:2298921 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 ISO PID
RGD		 PMID:15109563 PID:200227, RGD:2298921 NCBI chr13:100,691,540...100,793,227
Ensembl chr13:100,692,953...100,792,856 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 ISO PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr 6:111,435,170...111,457,646
Ensembl chr 6:111,435,170...111,456,946 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 ISO
IMP 		RGD PMID:12809600 PMID:18684975 RGD:2298922, RGD:2302517 NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:66,449,293...66,527,260 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 ISO
IMP 		PID
RGD		 PMID:15109563 PMID:14729511 PMID:18684975 PID:200227, RGD:2298921, RGD:1579921, RGD:2302517 NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:124,674,986...124,761,469 		JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 ISO PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr14:2,634,294...2,810,269
Ensembl chr14:2,634,188...2,810,271 		JBrowse link
G Tgfbrap1 transforming growth factor, beta receptor associated protein 1 ISO PID PID:200227 NCBI chr 9:52,813,087...52,863,441
Ensembl chr 9:52,813,087...52,863,441 		JBrowse link
G Wwp1 WW domain containing E3 ubiquitin protein ligase 1 ISO PID PID:200227 NCBI chr 5:37,889,280...37,982,743
Ensembl chr 5:37,895,398...37,982,959 		JBrowse link
G Xiap X-linked inhibitor of apoptosis ISO PID PID:200227 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:125,737,971...125,803,978 		JBrowse link
G Yap1 Yes1 associated transcriptional regulator ISO PID PID:200227 NCBI chr 8:13,380,551...13,451,640
Ensembl chr 8:13,380,551...13,451,437 		JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon ISO PID PID:200227 NCBI chr10:61,082,934...61,120,618
Ensembl chr10:61,106,716...61,114,291 		JBrowse link
G Zfyve16 zinc finger FYVE-type containing 16 ISO PID PID:200227 NCBI chr 2:25,448,264...25,495,180
Ensembl chr 2:25,448,829...25,483,295 		JBrowse link
G Zfyve9 zinc finger FYVE-type containing 9 ISO PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr 5:128,599,379...128,758,394
Ensembl chr 5:128,599,379...128,758,394 		JBrowse link
altered transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smad2 SMAD family member 2 ISO RGD PMID:17613544 PMID:18662538 RGD:2306282, RGD:2308865 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388 		JBrowse link
G Smad3 SMAD family member 3 ISO RGD PMID:17613544 PMID:18772397 RGD:2306282, RGD:5490966 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324 		JBrowse link
G Smad4 SMAD family member 4 ISO RGD PMID:17613544 PMID:18662538 PMID:18772397 PMID:19506583 RGD:2306282, RGD:2308865, RGD:5490966, RGD:5490965 NCBI chr18:69,518,988...69,549,684
Ensembl chr18:69,518,988...69,549,684 		JBrowse link
G Smad7 SMAD family member 7 ISO RGD PMID:18662538 RGD:2308865 NCBI chr18:71,263,508...71,291,849
Ensembl chr18:71,263,508...71,291,849 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO RGD PMID:18313409 PMID:17613544 RGD:2299005, RGD:2306282 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 ISO RGD PMID:18313409 PMID:17613544 RGD:2299005, RGD:2306282 NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:66,449,293...66,527,260 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 ISO RGD PMID:18313409 PMID:17613544 PMID:18662538 PMID:18772397 PMID:19506583 RGD:2299005, RGD:2306282, RGD:2308865, RGD:5490966, RGD:5490965 NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:124,674,986...124,761,469 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      signaling pathway pertinent to development 536
        transforming growth factor-beta Smad dependent signaling pathway 66
          altered transforming growth factor-beta Smad dependent signaling pathway 7
Path 2
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      growth factor signaling pathway 523
        transforming growth factor-beta superfamily mediated signaling pathway 150
          transforming growth factor-beta signaling pathway 68
            transforming growth factor-beta Smad dependent signaling pathway 66
              altered transforming growth factor-beta Smad dependent signaling pathway 7
paths to the root