Wwp1 (WW domain containing E3 ubiquitin protein ligase 1) - Rat Genome Database

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Gene: Wwp1 (WW domain containing E3 ubiquitin protein ligase 1) Rattus norvegicus
Analyze
Symbol: Wwp1
Name: WW domain containing E3 ubiquitin protein ligase 1
RGD ID: 1311734
Description: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in negative regulation of DNA-templated transcription; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein polyubiquitination. Predicted to be active in cytoplasm. Orthologous to human WWP1 (WW domain containing E3 ubiquitin protein ligase 1); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; endocytosis pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC297930; NEDD4-like E3 ubiquitin-protein ligase WWP1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2533,092,379 - 33,185,887 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl533,098,494 - 33,186,046 (-)Ensembl
Rnor_6.0533,608,489 - 33,696,487 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl533,609,136 - 33,664,435 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0538,260,478 - 38,350,828 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4534,238,505 - 34,325,951 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1534,238,684 - 34,326,130 (-)NCBI
Celera532,188,567 - 32,274,141 (-)NCBICelera
Cytogenetic Map5q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The Nedd4-like family of E3 ubiquitin ligases and cancer. Chen C and Matesic LE, Cancer Metastasis Rev. 2007 Dec;26(3-4):587-604.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11375995   PMID:12477932   PMID:14556380   PMID:16728642   PMID:19047365   PMID:19561640   PMID:23146885   PMID:23533145   PMID:33198785  


Genomics

Comparative Map Data
Wwp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2533,092,379 - 33,185,887 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl533,098,494 - 33,186,046 (-)Ensembl
Rnor_6.0533,608,489 - 33,696,487 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl533,609,136 - 33,664,435 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0538,260,478 - 38,350,828 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4534,238,505 - 34,325,951 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1534,238,684 - 34,326,130 (-)NCBI
Celera532,188,567 - 32,274,141 (-)NCBICelera
Cytogenetic Map5q13NCBI
WWP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38886,342,547 - 86,468,503 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl886,342,547 - 86,478,420 (+)EnsemblGRCh38hg38GRCh38
GRCh37887,354,776 - 87,480,732 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36887,424,110 - 87,549,297 (+)NCBINCBI36hg18NCBI36
Build 34887,424,109 - 87,549,292NCBI
Celera883,549,943 - 83,675,018 (+)NCBI
Cytogenetic Map8q21.3NCBI
HuRef882,564,176 - 82,689,578 (+)NCBIHuRef
CHM1_1887,396,265 - 87,521,678 (+)NCBICHM1_1
T2T-CHM13v2.0887,462,833 - 87,588,744 (+)NCBI
Wwp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39419,608,296 - 19,709,004 (-)NCBIGRCm39mm39
GRCm39 Ensembl419,608,303 - 19,708,993 (-)Ensembl
GRCm38419,608,296 - 19,709,004 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl419,608,303 - 19,708,993 (-)EnsemblGRCm38mm10GRCm38
MGSCv37419,536,820 - 19,636,140 (-)NCBIGRCm37mm9NCBIm37
MGSCv36419,536,820 - 19,636,140 (-)NCBImm8
Celera419,371,659 - 19,470,678 (-)NCBICelera
Cytogenetic Map4A3NCBI
Wwp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554174,000,966 - 4,061,908 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554174,011,302 - 4,064,584 (+)NCBIChiLan1.0ChiLan1.0
WWP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1885,009,945 - 85,134,671 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl885,009,951 - 85,134,671 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0883,039,632 - 83,165,010 (+)NCBIMhudiblu_PPA_v0panPan3
WWP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12932,523,719 - 32,620,507 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2932,533,619 - 32,625,787 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2932,723,880 - 32,846,291 (+)NCBI
ROS_Cfam_1.02932,658,784 - 32,781,246 (+)NCBI
ROS_Cfam_1.0 Ensembl2932,658,688 - 32,775,049 (+)Ensembl
UMICH_Zoey_3.12932,702,621 - 32,825,078 (+)NCBI
UNSW_CanFamBas_1.02932,727,090 - 32,849,648 (+)NCBI
UU_Cfam_GSD_1.02933,147,532 - 33,269,942 (+)NCBI
Wwp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530346,744,643 - 46,827,533 (-)NCBI
SpeTri2.0NW_004936544965,189 - 1,048,530 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WWP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl450,388,464 - 50,503,253 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1450,370,072 - 50,509,314 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2455,285,901 - 55,426,098 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WWP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1881,529,520 - 81,651,478 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603959,298,882 - 59,421,031 (-)NCBIVero_WHO_p1.0
Wwp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247445,329,535 - 5,435,819 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
BQ200491  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2533,159,442 - 33,159,602 (+)MAPPERmRatBN7.2
Rnor_6.0533,670,065 - 33,670,224NCBIRnor6.0
Rnor_5.0538,324,629 - 38,324,788UniSTSRnor5.0
RGSC_v3.4534,299,486 - 34,299,645UniSTSRGSC3.4
Celera532,247,748 - 32,247,907UniSTS
RH 3.4 Map5165.42UniSTS
Cytogenetic Map5q13UniSTS
RH132168  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2533,098,041 - 33,098,259 (+)MAPPERmRatBN7.2
Rnor_6.0533,608,684 - 33,608,901NCBIRnor6.0
Rnor_5.0538,263,088 - 38,263,305UniSTSRnor5.0
RGSC_v3.4534,238,056 - 34,238,273UniSTSRGSC3.4
Celera532,188,118 - 32,188,335UniSTS
RH 3.4 Map5164.12UniSTS
Cytogenetic Map5q13UniSTS
RH142934  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2533,132,598 - 33,132,821 (+)MAPPERmRatBN7.2
Rnor_6.0533,643,238 - 33,643,460NCBIRnor6.0
Rnor_5.0538,297,642 - 38,297,864UniSTSRnor5.0
RGSC_v3.4534,272,611 - 34,272,833UniSTSRGSC3.4
Celera532,220,901 - 32,221,123UniSTS
RH 3.4 Map5165.12UniSTS
Cytogenetic Map5q13UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat
1549901Neudeg2Neurodegradation QTL 240nervous system integrity trait (VT:0010566)mononuclear cell count (CMO:0002119)52483871044045280Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:37
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000009047
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 54 41 15 41 8 11 74 35 41 11 8
Low 1 3 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009047   ⟹   ENSRNOP00000009047
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl533,098,494 - 33,186,046 (-)Ensembl
Rnor_6.0 Ensembl533,609,136 - 33,664,435 (-)Ensembl
RefSeq Acc Id: NM_001024757   ⟹   NP_001019928
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2533,098,491 - 33,185,843 (-)NCBI
Rnor_6.0533,609,133 - 33,696,487 (-)NCBI
Rnor_5.0538,260,478 - 38,350,828 (-)NCBI
RGSC_v3.4534,238,505 - 34,325,951 (-)RGD
Celera532,188,567 - 32,274,141 (-)RGD
Sequence:
RefSeq Acc Id: XM_006237930   ⟹   XP_006237992
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2533,092,379 - 33,185,887 (-)NCBI
Rnor_6.0533,608,489 - 33,696,428 (-)NCBI
Rnor_5.0538,260,478 - 38,350,828 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006237931   ⟹   XP_006237993
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2533,098,491 - 33,160,081 (-)NCBI
Rnor_6.0533,609,133 - 33,671,140 (-)NCBI
Rnor_5.0538,260,478 - 38,350,828 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008763591   ⟹   XP_008761813
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2533,098,491 - 33,139,000 (-)NCBI
Rnor_6.0533,609,133 - 33,649,773 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001019928 (Get FASTA)   NCBI Sequence Viewer  
  XP_006237992 (Get FASTA)   NCBI Sequence Viewer  
  XP_006237993 (Get FASTA)   NCBI Sequence Viewer  
  XP_008761813 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH97386 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001019928   ⟸   NM_001024757
- UniProtKB: Q4V8H7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237992   ⟸   XM_006237930
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006237993   ⟸   XM_006237931
- Peptide Label: isoform X2
- UniProtKB: Q4V8H7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761813   ⟸   XM_008763591
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000009047   ⟸   ENSRNOT00000009047

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4V8H7-F1-model_v2 AlphaFold Q4V8H7 1-918 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
5 33609452 33609453 A C snv WN/N (MCW)
5 33624300 33624301 T C snv WKY/N (MCW), MR/N (MCW), M520/N (MCW), BN/SsN (MCW)
5 33624331 33624332 C G snv WN/N (MCW), WKY/N (MCW), M520/N (MCW), ACI/N (MCW)
5 33627885 33627886 A G snv F344/NRrrc (MCW), Buf/N (MCW), BN/SsN (MCW), ACI/N (MCW), M520/N (MCW), WN/N (MCW), WKY/N (MCW), MR/N (MCW)


Assembly: RGSC_v3.4
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
5 34238824 34238825 A C snv SHRSP/Gcrc (MDC), WN/N (KNAW)
5 34253633 34253634 T A snv SS/JrHsdMcwi (MCW)
5 34253646 34253647 T A snv SS/JrHsdMcwi (MCW)
5 34253649 34253650 T A snv SS/JrHsdMcwi (MCW)
5 34253672 34253673 T C snv M520/N (KNAW), MR/N (KNAW), WKY/N (KNAW), LCR/1Mco (UMich), LE/Stm (KNAW), BN/NHsdMcwi (KNAW), BN/SsN (KNAW), SHRSP/Gcrc (MDC), SS/JrHsdMcwi (MCW), FHL/EurMcwi (MCW)
5 34253703 34253704 C G snv ACI/N (KNAW), FHL/EurMcwi (MCW), SS/JrHsdMcwi (MCW), SHRSP/Gcrc (MDC), LCR/1Mco (UMich), WN/N (KNAW), WKY/N (KNAW), M520/N (KNAW), BN/NHsdMcwi (KNAW)
5 34253929 34253930 T G snv FHL/EurMcwi (MCW)
5 34253937 34253938 G T snv FHL/EurMcwi (MCW)
5 34253949 34253950 C T snv FHL/EurMcwi (MCW)
5 34253955 34253956 T C snv FHL/EurMcwi (MCW)
5 34257257 34257258 A G snv FHL/EurMcwi (MCW), WN/N (KNAW), WKY/N (KNAW), MR/N (KNAW), M520/N (KNAW), LE/Stm (KNAW), F344/NRrrc (KNAW), BUF/N (KNAW), BN/NHsdMcwi (KNAW), SS/JrHsdMcwi (MCW), ACI/N (KNAW), BN/SsN (KNAW)
5 34279477 34279478 T C snv WN/N (KNAW)
5 34288486 34288487 C T snv SHRSP/Gcrc (MDC)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311734 AgrOrtholog
BioCyc Gene G2FUF-41838 BioCyc
Ensembl Genes ENSRNOG00000006328 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000009047 ENTREZGENE
  ENSRNOP00000009047.6 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009047 ENTREZGENE
  ENSRNOT00000009047.6 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.150 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7446512 IMAGE-MGC_LOAD
InterPro C2_Ca-dep UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  E3_ub_ligase_SMURF1 UniProtKB/TrEMBL
  HECT UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/TrEMBL
  WW_Rsp5_WWP UniProtKB/TrEMBL
KEGG Report rno:297930 UniProtKB/TrEMBL
MGC_CLONE MGC:114426 IMAGE-MGC_LOAD
NCBI Gene 297930 ENTREZGENE
Pfam HECT UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
  PF00397 UniProtKB/TrEMBL
PhenoGen Wwp1 PhenoGen
PIRSF E3_ub_ligase_SMURF1 UniProtKB/TrEMBL
PROSITE HECT UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
SMART HECTc UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
  SM00456 UniProtKB/TrEMBL
Superfamily-SCOP HECT UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
  WW_Rsp5_WWP UniProtKB/TrEMBL
UniProt F7FIK1_RAT UniProtKB/TrEMBL
  Q4V8H7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Wwp1  WW domain containing E3 ubiquitin protein ligase 1  Wwp1_predicted  WW domain containing E3 ubiquitin protein ligase 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Wwp1_predicted  WW domain containing E3 ubiquitin protein ligase 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED