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ONTOLOGY REPORT - ANNOTATIONS

Term:lytic vacuole organization
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Accession:GO:0080171 term browser browse the term
Definition:A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole.
Synonyms:exact_synonym: lytic vacuole organisation
 narrow_synonym: lytic vacuolar assembly
 related_synonym: lytic vacuole biogenesis;   lytic vacuole organization and biogenesis


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lysosomal lumen acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp6ap2 ATPase H+ transporting accessory protein 2 involved_in ISO
IEA
ISS		 (PMID:32276428)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:32276428 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:10,183,983...10,210,948
Ensembl chr  X:10,183,068...10,210,918 		JBrowse link
G Ccdc115 coiled-coil domain containing 115 involved_in ISO (PMID:28296633) RGD PMID:28296633 NCBI chr 9:36,650,384...36,654,348
Ensembl chr 9:36,649,271...36,653,946 		JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in ISO
IBA		 (PMID:11722572)
GO_REF:0000033		 RGD
GO_Central		 PMID:11722572 GO_REF:0000033 NCBI chr 1:181,156,071...181,169,458
Ensembl chr 1:181,156,073...181,167,434 		JBrowse link
G Cln5 CLN5, intracellular trafficking protein involved_in ISO (PMID:11722572) RGD PMID:11722572 NCBI chr15:79,893,573...79,903,438
Ensembl chr15:79,893,548...79,903,438 		JBrowse link
G Cln6 CLN6, transmembrane ER protein involved_in ISO (PMID:11722572) RGD PMID:11722572 NCBI chr 8:63,303,356...63,318,360
Ensembl chr 8:63,303,029...63,318,360 		JBrowse link
G Creg1 cellular repressor of E1A-stimulated genes 1 acts_upstream_of_or_within ISO (PMID:33966596) RGD PMID:33966596 NCBI chr13:78,019,814...78,032,310
Ensembl chr13:78,019,843...78,032,308 		JBrowse link
G Grn granulin precursor involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:28073925)		 UniProt
Ensembl
RGD		 PMID:28073925 GO_REF:0000024 GO_REF:0000107 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:37390818)		 Ensembl
UniProt
RGD		 PMID:37390818 GO_REF:0000024 GO_REF:0000107 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:37390818)		 Ensembl
UniProt
RGD		 PMID:37390818 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522 		JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 involved_in ISO
ISS		 (PMID:11722572)
PMID:8895569		 RGD PMID:11722572 PMID:8895569 RGD:8553248 NCBI chr 5:135,121,164...135,142,048
Ensembl chr 5:135,121,163...135,142,048 		JBrowse link
G Snapin SNAP-associated protein acts_upstream_of_or_within ISO MGI:3608768 (PMID:20920792) RGD PMID:20920792 NCBI chr 2:175,971,575...175,974,164
Ensembl chr 2:175,971,257...175,974,231 		JBrowse link
G Tmem106b transmembrane protein 106B acts_upstream_of_or_within ISO MGI:5319917 (PMID:28728022) RGD PMID:28728022 NCBI chr 4:41,328,125...41,347,315
Ensembl chr 4:41,327,994...41,345,619 		JBrowse link
G Tmem199 transmembrane protein 199 involved_in ISO
IEA
ISS		 (PMID:28296633)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:28296633 GO_REF:0000024 GO_REF:0000107 NCBI chr10:63,402,493...63,407,065
Ensembl chr10:63,402,494...63,407,108 		JBrowse link
G Tmem9 transmembrane protein 9 involved_in ISO (PMID:30374053) RGD PMID:30374053 NCBI chr13:47,458,486...47,475,832
Ensembl chr13:47,458,498...47,475,832 		JBrowse link
lysosomal lumen pH elevation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in ISO (PMID:10924275) RGD PMID:10924275 NCBI chr 1:181,156,071...181,169,458
Ensembl chr 1:181,156,073...181,167,434 		JBrowse link
G Oca2 OCA2 melanosomal transmembrane protein involved_in ISO (PMID:25513726), (PMID:32966160) RGD PMID:25513726 PMID:32966160 NCBI chr 1:107,116,278...107,446,093
Ensembl chr 1:107,116,278...107,446,074 		JBrowse link
G Slc45a2 solute carrier family 45, member 2 involved_in ISO (PMID:32966160)
(MGI:7338895|PMID:35469906)		 RGD PMID:32966160 PMID:35469906 MGI:7338895 NCBI chr 2:59,963,599...59,996,408
Ensembl chr 2:59,963,706...59,996,317 		JBrowse link
G Tmem175 transmembrane protein 175 involved_in ISS
ISO		 GO_REF:0000024
(PMID:35333573), (PMID:35750034), (PMID:37390818)		 UniProt
RGD		 PMID:35333573 PMID:35750034 PMID:37390818 GO_REF:0000024 NCBI chr14:1,073,410...1,089,764
Ensembl chr14:1,073,523...1,089,819 		JBrowse link
lysosomal membrane organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arf1 ADP-ribosylation factor 1 IDA RGD PMID:9538255 RGD:9684948 NCBI chr10:43,997,983...44,014,461
Ensembl chr10:43,997,986...44,014,434 		JBrowse link
G Atp10b ATPase phospholipid transporting 10B involved_in ISO (PMID:32172343) RGD PMID:32172343 NCBI chr10:27,495,207...27,751,313
Ensembl chr10:27,408,747...27,749,637 		JBrowse link
lysosome organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 involved_in ISO (PMID:15163665) RGD PMID:15163665 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Acp2 acid phosphatase 2, lysosomal involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:2180084|MGI:3574793 (PMID:15604265), (PMID:9228031)		 GO_Central
RGD		 PMID:9228031 PMID:15604265 GO_REF:0000033 NCBI chr 3:77,175,022...77,185,180
Ensembl chr 3:77,175,895...77,185,680 		JBrowse link
G Acp3 acid phosphatase 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:104,905,570...104,956,146
Ensembl chr 8:104,905,586...104,954,236 		JBrowse link
G Acp4 acid phosphatase 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:94,736,376...94,751,871
Ensembl chr 1:94,735,514...94,744,623 		JBrowse link
G Aktip AKT interacting protein involved_in ISO
IEA
ISS		 (PMID:18799622)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:18799622 GO_REF:0000024 GO_REF:0000107 NCBI chr19:15,866,811...15,877,123
Ensembl chr19:15,866,928...15,886,663 		JBrowse link
G Ap3b1 adaptor related protein complex 3 subunit beta 1 acts_upstream_of_or_within ISO (PMID:30786955), (PMID:9931340) RGD PMID:9931340 PMID:30786955 NCBI chr 2:25,600,069...25,800,937
Ensembl chr 2:25,600,040...25,800,935 		JBrowse link
G Ap5z1 adaptor related protein complex 5 subunit zeta 1 acts_upstream_of_or_within ISO (PMID:37871017) RGD PMID:37871017 NCBI chr12:12,093,834...12,109,043
Ensembl chr12:12,093,834...12,108,511 		JBrowse link
G Arsg arylsulfatase G acts_upstream_of_or_within ISO (PMID:26975023) RGD PMID:26975023 NCBI chr10:94,412,261...94,551,224
Ensembl chr10:94,447,399...94,542,941 		JBrowse link
G Becn1 beclin 1 acts_upstream_of_or_within ISO MGI:2683696 (PMID:18497889) RGD PMID:18497889 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Chmp5 charged multivesicular body protein 5 acts_upstream_of_or_within ISO MGI:3626293 (PMID:16567502) RGD PMID:16567502 NCBI chr 5:56,081,385...56,098,529
Ensembl chr 5:56,081,343...56,098,529 		JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:1933976|MGI:2388887|MGI:3623134 (PMID:10191119), (PMID:10440905), (PMID:10527801), (PMID:15588329)		 GO_Central
RGD		 PMID:10191119 PMID:10440905 PMID:10527801 PMID:15588329 GO_REF:0000033 NCBI chr 1:181,156,071...181,169,458
Ensembl chr 1:181,156,073...181,167,434 		JBrowse link
G Cln5 CLN5, intracellular trafficking protein involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:3521802 (PMID:15459177)		 GO_Central
RGD		 PMID:15459177 GO_REF:0000033 NCBI chr15:79,893,573...79,903,438
Ensembl chr15:79,893,548...79,903,438 		JBrowse link
G Cln6 CLN6, transmembrane ER protein involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:2159328 (PMID:26681805), (PMID:9600738)		 GO_Central
RGD		 PMID:9600738 PMID:26681805 GO_REF:0000033 NCBI chr 8:63,303,356...63,318,360
Ensembl chr 8:63,303,029...63,318,360 		JBrowse link
G Cln8 CLN8, transmembrane ER and ERGIC protein acts_upstream_of_or_within ISO MGI:1856959 (PMID:10087069), (PMID:7613514), (PMID:8144516), (PMID:8160780) RGD PMID:7613514 PMID:8144516 PMID:8160780 PMID:10087069 NCBI chr16:74,749,662...74,759,553
Ensembl chr16:74,749,662...74,759,774 		JBrowse link
G Clvs1 clavesin 1 involved_in IMP
IBA		 PMID:19651769
GO_REF:0000033		 GO_Central PMID:19651769 GO_REF:0000033, RGD:8553526 NCBI chr 5:22,408,384...22,604,281
Ensembl chr 5:22,408,384...22,604,270 		JBrowse link
G Clvs2 clavesin 2 involved_in IMP
IBA		 PMID:19651769
GO_REF:0000033		 GO_Central PMID:19651769 GO_REF:0000033, RGD:8553526 NCBI chr 1:23,735,660...23,842,685
Ensembl chr 1:23,735,272...23,842,692 		JBrowse link
G Creg1 cellular repressor of E1A-stimulated genes 1 acts_upstream_of_or_within ISO (PMID:33966596) RGD PMID:33966596 NCBI chr13:78,019,814...78,032,310
Ensembl chr13:78,019,843...78,032,308 		JBrowse link
G Fhip1b FHF complex subunit HOOK interacting protein 1B involved_in ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000107
(PMID:18799622)		 UniProt
GO_Central
Ensembl
RGD		 PMID:18799622 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:159,718,679...159,748,449
Ensembl chr 1:159,726,004...159,748,408 		JBrowse link
G Gaa alpha glucosidase involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000107
MGI:2148550|MGI:2179961 (PMID:10547605), (PMID:11328962), (PMID:12115977), (PMID:15169761), (PMID:9384603), (PMID:9668092)
GO_REF:0000033
(PMID:7717400)		 Ensembl
RGD
GO_Central		 PMID:7717400 PMID:9384603 PMID:9668092 PMID:10547605 PMID:11328962 More... GO_REF:0000033 GO_REF:0000107 NCBI chr10:104,529,673...104,546,836
Ensembl chr10:104,529,747...104,546,836 		JBrowse link
G Gba1 glucosylceramidase beta 1 involved_in ISO (PMID:27378698)
(MGI:5817293|PMID:27378698)		 RGD PMID:27378698 MGI:5817293 NCBI chr 2:174,609,437...174,615,457
Ensembl chr 2:174,609,403...174,618,263 		JBrowse link
G Gnptab N-acetylglucosamine-1-phosphate transferase subunits alpha and beta involved_in ISO (PMID:21719679) RGD PMID:21719679 NCBI chr 7:22,800,502...22,866,336
Ensembl chr 7:22,800,485...22,866,933 		JBrowse link
G Grn granulin precursor involved_in ISO
ISS		 (MGI:6274951|PMID:27789271)
GO_REF:0000024		 RGD
UniProt		 PMID:27789271 GO_REF:0000024 MGI:6274951 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Hexa hexosaminidase subunit alpha acts_upstream_of_or_within ISO MGI:1857181|MGI:2429698|MGI:3581540|MGI:96074 (PMID:10591619), (PMID:14972652), (PMID:7937929), (PMID:8747922), (PMID:8896570), (PMID:9103204), (PMID:9184660), (PMID:9302266), (PMID:9645704) RGD PMID:7937929 PMID:8747922 PMID:8896570 PMID:9103204 PMID:9184660 More... NCBI chr 8:59,936,526...59,961,654
Ensembl chr 8:59,936,660...59,962,013 		JBrowse link
G Hexb hexosaminidase subunit beta involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2429701|MGI:96073 (PMID:8789434), (PMID:8896570), (PMID:9184660), (PMID:9645704)		 Ensembl
RGD		 PMID:8789434 PMID:8896570 PMID:9184660 PMID:9645704 GO_REF:0000107 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223 		JBrowse link
G Hook1 hook microtubule-tethering protein 1 involved_in ISO (PMID:18799622) RGD PMID:18799622 NCBI chr 5:110,824,501...110,887,791
Ensembl chr 5:110,824,501...110,887,787 		JBrowse link
G Hook2 hook microtubule-tethering protein 2 involved_in ISO (PMID:18799622) RGD PMID:18799622 NCBI chr19:23,151,869...23,170,139
Ensembl chr19:23,151,870...23,164,181 		JBrowse link
G Hook3 hook microtubule-tethering protein 3 involved_in ISO (PMID:18799622) RGD PMID:18799622 NCBI chr16:65,954,293...66,058,812
Ensembl chr16:65,954,350...66,061,338 		JBrowse link
G Hps1 HPS1, biogenesis of lysosomal organelles complex 3 subunit 1 acts_upstream_of_or_within ISO (PMID:30786955) RGD PMID:30786955 NCBI chr 1:241,551,180...241,577,292
Ensembl chr 1:241,551,175...241,577,268 		JBrowse link
G Hps4 HPS4, biogenesis of lysosomal organelles complex 3 subunit 2 involved_in ISO (PMID:12663659) RGD PMID:12663659 NCBI chr12:44,264,037...44,294,791
Ensembl chr12:44,264,037...44,294,632 		JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 acts_upstream_of_or_within ISO MGI:3799948 (PMID:29180785) RGD PMID:29180785 NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927 		JBrowse link
G Idua alpha-L-iduronidase acts_upstream_of_or_within ISO MGI:2176236|MGI:4415188 (PMID:19751987), (PMID:9097952) RGD PMID:9097952 PMID:19751987 NCBI chr14:1,031,588...1,059,494
Ensembl chr14:1,032,171...1,046,522 		JBrowse link
G Lamtor1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000002
(MGI:4887551|PMID:19177150)		 UniProt
InterPro
RGD		 PMID:19177150 GO_REF:0000002 GO_REF:0000024 MGI:4887551 NCBI chr 1:156,272,116...156,277,687
Ensembl chr 1:156,272,064...156,291,179 		JBrowse link
G Lamtor1l1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 like 1 involved_in ISS
IEA		 GO_REF:0000024
GO_REF:0000002		 UniProt
InterPro		 GO_REF:0000002 GO_REF:0000024 NCBI chr  X:34,637,460...34,638,509
Ensembl chr  X:34,637,459...34,638,516 		JBrowse link
G Lipa lipase A, lysosomal acid type involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2451080 (PMID:25807535), (PMID:29374543)		 Ensembl
RGD		 PMID:25807535 PMID:29374543 GO_REF:0000107 NCBI chr 1:232,024,351...232,057,735
Ensembl chr 1:232,024,356...232,057,633 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 involved_in ISO (PMID:25416817) RGD PMID:25416817 NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703 		JBrowse link
G Lyset lysosomal enzyme trafficking factor involved_in ISS
ISO		 GO_REF:0000024
(PMID:36096887)		 UniProt
RGD		 PMID:36096887 GO_REF:0000024 NCBI chr 6:121,884,577...121,886,319
Ensembl chr 6:121,884,643...121,886,275 		JBrowse link
G Lyst lysosomal trafficking regulator acts_upstream_of_or_within ISO MGI:1855968|MGI:1855969 (PMID:1113502), (PMID:4031470), (PMID:4697831), (PMID:6170520), (PMID:9368050) RGD PMID:1113502 PMID:4031470 PMID:4697831 PMID:6170520 PMID:9368050 NCBI chr17:86,241,384...86,443,501
Ensembl chr17:86,241,384...86,443,480 		JBrowse link
G Mbtps1 membrane-bound transcription factor peptidase, site 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:21719679)		 UniProt
Ensembl
RGD		 PMID:21719679 GO_REF:0000024 GO_REF:0000107 NCBI chr19:47,561,598...47,612,769
Ensembl chr19:47,561,598...47,612,791 		JBrowse link
G Mfsd8 major facilitator superfamily domain containing 8 acts_upstream_of_or_within ISO MGI:4456699 (PMID:24423645), (PMID:26681805), (PMID:35025759) RGD PMID:24423645 PMID:26681805 PMID:35025759 NCBI chr 2:123,822,042...123,847,808
Ensembl chr 2:123,816,614...123,857,971 		JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in ISO
IEA
ISS		 (PMID:22692423)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:22692423 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myo7a myosin VIIA involved_in ISO (PMID:16001398) RGD PMID:16001398 NCBI chr 1:152,342,611...152,414,171
Ensembl chr 1:152,344,448...152,414,157 		JBrowse link
G Naglu N-acetyl-alpha-glucosaminidase acts_upstream_of_or_within ISO MGI:1934018 (PMID:17712420), (PMID:19632871), (PMID:25524704), (PMID:26607664) RGD PMID:17712420 PMID:19632871 PMID:25524704 PMID:26607664 NCBI chr10:86,001,545...86,009,049
Ensembl chr10:86,001,566...86,008,972 		JBrowse link
G Pi4kb phosphatidylinositol 4-kinase beta involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:25365221)		 Ensembl
RGD		 PMID:25365221 GO_REF:0000107 NCBI chr 2:182,540,377...182,572,684
Ensembl chr 2:182,540,567...182,588,488 		JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 acts_upstream_of_or_within ISO MGI:2176390|MGI:3527191 (PMID:16368712), (PMID:16542649) RGD PMID:16368712 PMID:16542649 NCBI chr 5:135,121,164...135,142,048
Ensembl chr 5:135,121,163...135,142,048 		JBrowse link
G Snapin SNAP-associated protein involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:3608768 (PMID:20920792)		 GO_Central
RGD		 PMID:20920792 GO_REF:0000033 NCBI chr 2:175,971,575...175,974,164
Ensembl chr 2:175,971,257...175,974,231 		JBrowse link
G Spg11 SPG11 vesicle trafficking associated, spatacsin acts_upstream_of_or_within ISO (PMID:25365221)
MGI:4377985|MGI:6451766 (PMID:26284655), (PMID:28237315), (PMID:31637311), (PMID:37871017)		 RGD PMID:25365221 PMID:26284655 PMID:28237315 PMID:31637311 PMID:37871017 NCBI chr 3:109,007,658...109,072,904
Ensembl chr 3:109,008,135...109,072,911 		JBrowse link
G Tfe3 transcription factor binding to IGHM enhancer 3 involved_in ISO (PMID:24448649) RGD PMID:24448649 NCBI chr  X:14,729,547...14,742,830
Ensembl chr  X:14,729,550...14,742,571 		JBrowse link
G Tfeb transcription factor EB involved_in
acts_upstream_of_or_within		 ISO (PMID:22692423), (PMID:23434374), (PMID:32612235), (PMID:32753672), (PMID:35662396)
(PMID:31637311)		 RGD PMID:22692423 PMID:23434374 PMID:31637311 PMID:32612235 PMID:32753672 More... NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714 		JBrowse link
G Tmem106b transmembrane protein 106B involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:25066864)		 GO_Central
RGD		 PMID:25066864 GO_REF:0000033 NCBI chr 4:41,328,125...41,347,315
Ensembl chr 4:41,327,994...41,345,619 		JBrowse link
G Tpcn2 two pore segment channel 2 involved_in ISO UniProtKB:Q8NHX9 (PMID:25416817) RGD PMID:25416817 NCBI chr 1:200,416,538...200,446,252
Ensembl chr 1:200,416,540...200,446,236 		JBrowse link
G Tpp1 tripeptidyl peptidase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3521972 (PMID:15483130)		 Ensembl
RGD		 PMID:15483130 GO_REF:0000107 NCBI chr 1:160,097,984...160,104,108
Ensembl chr 1:160,096,833...160,104,129 		JBrowse link
G Vps18 VPS18 core subunit of CORVET and HOPS complexes involved_in ISO
IBA		 (PMID:18799622)
GO_REF:0000033		 RGD
GO_Central		 PMID:18799622 GO_REF:0000033 NCBI chr 3:106,279,444...106,290,298
Ensembl chr 3:106,279,425...106,291,964 		JBrowse link
G Vps35 VPS35 retromer complex component involved_in ISO (MGI:5694519|PMID:26203154) RGD PMID:26203154 MGI:5694519 NCBI chr19:21,765,771...21,801,620
Ensembl chr19:21,765,749...21,801,618 		JBrowse link
G Washc5 WASH complex subunit 5 acts_upstream_of_or_within ISO MGI:6246601 (PMID:30061306) RGD PMID:30061306 NCBI chr 7:90,884,192...90,936,096
Ensembl chr 7:90,884,197...90,936,103 		JBrowse link
G Zfyve26 zinc finger FYVE-type containing 26 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:25365221)
(PMID:37871017)
GO_REF:0000107		 RGD
Ensembl		 PMID:25365221 PMID:37871017 GO_REF:0000107 NCBI chr 6:98,031,874...98,095,538
Ensembl chr 6:98,032,520...98,095,480 		JBrowse link
G Zkscan3 zinc finger with KRAB and SCAN domains 3 involved_in ISO (PMID:23434374) RGD PMID:23434374 NCBI chr17:43,217,168...43,232,828
Ensembl chr17:43,217,222...43,232,827 		JBrowse link
multivesicular body-lysosome fusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chmp3 charged multivesicular body protein 3 involved_in ISO (PMID:16554368) RGD PMID:16554368 NCBI chr 4:103,576,453...103,622,566
Ensembl chr 4:103,576,515...103,623,959 		JBrowse link
negative regulation of lysosome organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1 IMP RGD PMID:25561470 RGD:11561937 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Flcn folliculin involved_in ISO (PMID:37079666) RGD PMID:37079666 NCBI chr10:44,588,621...44,607,808
Ensembl chr10:44,588,624...44,607,769 		JBrowse link
G Fnip1 folliculin interacting protein 1 involved_in ISO (PMID:37079666) RGD PMID:37079666 NCBI chr10:38,567,728...38,650,824
Ensembl chr10:38,567,729...38,650,824 		JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in ISO
ISS
IEA		 (PMID:24448649), (PMID:32612235)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:24448649 PMID:32612235 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
phagolysosome assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Coro1a coronin 1A involved_in ISO (PMID:12132654) RGD PMID:12132654 NCBI chr 1:181,295,561...181,300,566
Ensembl chr 1:181,295,562...181,300,534 		JBrowse link
G Myo7a myosin VIIA acts_upstream_of_or_within ISO MGI:2155422 (PMID:12743369) RGD PMID:12743369 NCBI chr 1:152,342,611...152,414,171
Ensembl chr 1:152,344,448...152,414,157 		JBrowse link
G P2rx7 purinergic receptor P2X 7 acts_upstream_of_or_within ISO MGI:3606250 (PMID:11544318) RGD PMID:11544318 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619 		JBrowse link
G Srpx sushi-repeat-containing protein, X-linked involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:3706175 (PMID:19368996)		 GO_Central
RGD		 PMID:19368996 GO_REF:0000033 NCBI chr  X:12,676,984...12,751,296
Ensembl chr  X:12,566,645...12,747,882 		JBrowse link
phagolysosome assembly involved in apoptotic cell clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab14 RAB14, member RAS oncogene family involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:18,501,953...18,523,253
Ensembl chr 3:18,501,963...18,523,172 		JBrowse link
phagosome-lysosome docking term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in ISO (MGI:5698740|PMID:26450516) RGD PMID:26450516 MGI:5698740 NCBI chr 1:181,156,071...181,169,458
Ensembl chr 1:181,156,073...181,167,434 		JBrowse link
phagosome-lysosome fusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arl8b ADP-ribosylation factor like GTPase 8B involved_in ISS
ISO		 GO_REF:0000024
(PMID:21802320)		 UniProt
RGD		 PMID:21802320 GO_REF:0000024 NCBI chr 4:141,748,634...141,792,605
Ensembl chr 4:141,748,587...141,792,596 		JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in ISO (MGI:5698740|PMID:26450516) RGD PMID:26450516 MGI:5698740 NCBI chr 1:181,156,071...181,169,458
Ensembl chr 1:181,156,073...181,167,434 		JBrowse link
G Pikfyve phosphoinositide kinase, FYVE-type zinc finger containing involved_in ISO
IBA		 (PMID:28779020)
GO_REF:0000033
(MGI:6103777|PMID:28779020)		 RGD
GO_Central		 PMID:28779020 GO_REF:0000033 MGI:6103777 NCBI chr 9:66,563,747...66,657,873
Ensembl chr 9:66,563,727...66,657,868 		JBrowse link
G Pla2g5 phospholipase A2, group V involved_in ISS
ISO		 GO_REF:0000024
(MGI:3841317|PMID:19342668)		 UniProt
RGD		 PMID:19342668 GO_REF:0000024 MGI:3841317 NCBI chr 5:151,041,339...151,109,433
Ensembl chr 5:151,041,340...151,062,658 		JBrowse link
G Rab20 RAB20, member RAS oncogene family involved_in ISO (PMID:21255211) RGD PMID:21255211 NCBI chr16:78,019,337...78,043,529
Ensembl chr16:78,019,337...78,043,529 		JBrowse link
G Rab34 RAB34, member RAS oncogene family involved_in ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000107
(MGI:5467668|PMID:23197834)
(PMID:21255211)		 UniProt
GO_Central
Ensembl
RGD		 PMID:21255211 PMID:23197834 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 MGI:5467668 NCBI chr10:63,083,319...63,087,538
Ensembl chr10:63,083,338...63,087,538 		JBrowse link
G Rab39a RAB39A, member RAS oncogene family involved_in ISO
IBA		 (PMID:21255211)
GO_REF:0000033		 RGD
GO_Central		 PMID:21255211 GO_REF:0000033 NCBI chr 8:54,088,246...54,105,867
Ensembl chr 8:54,088,129...54,106,483 		JBrowse link
G Rab7a RAB7A, member RAS oncogene family involved_in ISO
IBA
ISS		 (PMID:21255211)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:21255211 GO_REF:0000024 GO_REF:0000033 NCBI chr 4:120,461,966...120,510,756
Ensembl chr 4:120,461,963...120,506,889 		JBrowse link
G Rab7b Rab7b, member RAS oncogene family involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:43,121,168...43,147,581
Ensembl chr13:43,121,226...43,147,581 		JBrowse link
G Syt7 synaptotagmin 7 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3690533|PMID:16982801)		 UniProt
RGD		 PMID:16982801 GO_REF:0000024 MGI:3690533 NCBI chr 1:207,031,359...207,093,787
Ensembl chr 1:207,031,592...207,089,026 		JBrowse link
G Tmem175 transmembrane protein 175 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5693670|PMID:26317472)		 UniProt
RGD		 PMID:26317472 GO_REF:0000024 MGI:5693670 NCBI chr14:1,073,410...1,089,764
Ensembl chr14:1,073,523...1,089,819 		JBrowse link
phagosome-lysosome fusion involved in apoptotic cell clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Spg11 SPG11 vesicle trafficking associated, spatacsin acts_upstream_of_or_within ISO MGI:4377985 (PMID:26284655) RGD PMID:26284655 NCBI chr 3:109,007,658...109,072,904
Ensembl chr 3:109,008,135...109,072,911 		JBrowse link
positive regulation of lysosomal membrane permeability term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hspa8 heat shock protein family A (Hsp70) member 8 IMP RGD PMID:9038169 RGD:10059368 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Laptm5 lysosomal protein transmembrane 5 involved_in ISO (PMID:19787053) RGD PMID:19787053 NCBI chr 5:143,087,759...143,109,807
Ensembl chr 5:143,087,759...143,109,807 		JBrowse link
positive regulation of lysosome organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grn granulin precursor involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:28073925)
GO_REF:0000107
(MGI:5905514|PMID:28073925)		 UniProt
RGD
Ensembl		 PMID:28073925 GO_REF:0000024 GO_REF:0000107 MGI:5905514 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Irgm immunity-related GTPase M involved_in ISO (PMID:32753672) RGD PMID:32753672 NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578 		JBrowse link
G Mcoln1 mucolipin TRP cation channel 1 involved_in ISO (PMID:25720963) RGD PMID:25720963 NCBI chr12:1,560,341...1,574,252
Ensembl chr12:1,560,359...1,574,252 		JBrowse link
G Ppp3cb protein phosphatase 3 catalytic subunit beta involved_in ISO (PMID:25720963), (PMID:32753672) RGD PMID:25720963 PMID:32753672 NCBI chr15:3,759,950...3,804,976
Ensembl chr15:3,760,030...3,804,981 		JBrowse link
regulation of lysosomal lumen pH term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC681325 hypothetical protein LOC681325 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:74,312,698...74,316,311
Ensembl chr  X:74,312,661...74,316,635 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 involved_in ISO (PMID:22012985) RGD PMID:22012985 NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703 		JBrowse link
G Spns1 SPNS lysolipid transporter 1, lysophospholipid involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:36161949)		 Ensembl
RGD		 PMID:36161949 GO_REF:0000107 NCBI chr 1:180,942,088...180,949,415
Ensembl chr 1:180,942,088...180,949,370 		JBrowse link
G Tasl TLR adaptor interacting with endolysosomal SLC15A4 involved_in ISO
IBA		 (PMID:31001245)
GO_REF:0000033		 RGD
GO_Central		 PMID:31001245 GO_REF:0000033 NCBI chr  X:50,403,962...50,423,141
Ensembl chr  X:50,361,248...50,423,269 		JBrowse link
G Tmem165 transmembrane protein 165 involved_in ISO
ISS		 (PMID:23569283)
GO_REF:0000024		 RGD
UniProt		 PMID:23569283 GO_REF:0000024 NCBI chr14:31,993,489...32,018,717
Ensembl chr14:31,993,493...32,018,717 		JBrowse link
G Tmem175 transmembrane protein 175 involved_in ISS
ISO		 GO_REF:0000024
(PMID:35750034)
(MGI:5693670|PMID:26317472)		 UniProt
RGD		 PMID:26317472 PMID:35750034 GO_REF:0000024 MGI:5693670 NCBI chr14:1,073,410...1,089,764
Ensembl chr14:1,073,523...1,089,819 		JBrowse link
G Vps33a VPS33A core subunit of CORVET and HOPS complexes involved_in ISO
IEA
ISS		 (PMID:28013294)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:28013294 GO_REF:0000024 GO_REF:0000107 NCBI chr12:33,024,596...33,051,399
Ensembl chr12:33,024,650...33,051,393 		JBrowse link
regulation of lysosomal membrane permeability term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Laptm4b lysosomal protein transmembrane 4 beta involved_in ISO
IEA
ISS		 (PMID:26280656)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:26280656 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:65,434,525...65,477,386
Ensembl chr 7:65,434,394...65,477,383 		JBrowse link
regulation of lysosome organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grn granulin precursor acts_upstream_of_or_within ISO MGI:3762618 (PMID:28728022) RGD PMID:28728022 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Laptm4b lysosomal protein transmembrane 4 beta involved_in ISO
IEA
ISS		 (PMID:26280656)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:26280656 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:65,434,525...65,477,386
Ensembl chr 7:65,434,394...65,477,383 		JBrowse link
G Tmem106b transmembrane protein 106B acts_upstream_of_or_within ISO MGI:5319917 (PMID:28728022) RGD PMID:28728022 NCBI chr 4:41,328,125...41,347,315
Ensembl chr 4:41,327,994...41,345,619 		JBrowse link
G Trex1 three prime repair exonuclease 1 acts_upstream_of_or_within ISO MGI:3052754 (PMID:23160154) RGD PMID:23160154 NCBI chr 8:109,706,613...109,707,913
Ensembl chr 8:109,706,613...109,708,796 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19870
    cellular process 18312
      cellular component organization or biogenesis 6999
        cellular component organization 6747
          organelle organization 3721
            vacuole organization 228
              lytic vacuole organization 95
                lysosome organization + 95
paths to the root