Mbtps1 (membrane-bound transcription factor peptidase, site 1) - Rat Genome Database

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Gene: Mbtps1 (membrane-bound transcription factor peptidase, site 1) Rattus norvegicus
Analyze
Symbol: Mbtps1
Name: membrane-bound transcription factor peptidase, site 1
RGD ID: 70935
Description: Enables serine-type endopeptidase activity. Predicted to be involved in lysosome organization; proteolysis; and regulation of vesicle-mediated transport. Predicted to act upstream of or within lipid metabolic process and protein import into nucleus. Located in Golgi apparatus. Human ortholog(s) of this gene implicated in spondyloepiphyseal dysplasia Kondo-Fu type. Orthologous to human MBTPS1 (membrane bound transcription factor peptidase, site 1); PARTICIPATES IN sterol regulatory element-binding protein signaling pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: endopeptidase S1P; membrane-bound transcription factor protease, site 1; membrane-bound transcription factor site-1 protease; S1p; S1P endopeptidase; site-1 protease; Ski-1; subtilisin/kexin isozyme 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21947,561,598 - 47,612,769 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1947,561,598 - 47,612,791 (-)Ensembl
Rnor_6.01952,146,507 - 52,206,310 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1952,146,808 - 52,206,310 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01962,894,989 - 62,954,792 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41949,751,424 - 49,802,700 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11949,756,304 - 49,807,581 (-)NCBI
Celera1946,820,963 - 46,871,847 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:11069896   PMID:11163209   PMID:11717426   PMID:15938716   PMID:17643267   PMID:21719679   PMID:30046013   PMID:33738762  


Genomics

Comparative Map Data
Mbtps1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21947,561,598 - 47,612,769 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1947,561,598 - 47,612,791 (-)Ensembl
Rnor_6.01952,146,507 - 52,206,310 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1952,146,808 - 52,206,310 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01962,894,989 - 62,954,792 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41949,751,424 - 49,802,700 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11949,756,304 - 49,807,581 (-)NCBI
Celera1946,820,963 - 46,871,847 (-)NCBICelera
Cytogenetic Map19q12NCBI
MBTPS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381684,053,763 - 84,116,942 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1684,053,761 - 84,116,942 (-)EnsemblGRCh38hg38GRCh38
GRCh371684,087,368 - 84,150,547 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361682,644,869 - 82,708,018 (-)NCBINCBI36hg18NCBI36
Build 341682,644,871 - 82,708,018NCBI
Celera1668,389,268 - 68,452,435 (-)NCBI
Cytogenetic Map16q23.3-q24.1NCBI
HuRef1669,841,352 - 69,904,502 (-)NCBIHuRef
CHM1_11685,498,381 - 85,561,902 (-)NCBICHM1_1
T2T-CHM13v2.01690,119,889 - 90,183,036 (-)NCBI
Mbtps1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398120,234,890 - 120,285,603 (-)NCBIGRCm39mm39
GRCm39 Ensembl8120,234,895 - 120,285,474 (-)Ensembl
GRCm388119,508,151 - 119,558,864 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8119,508,156 - 119,558,735 (-)EnsemblGRCm38mm10GRCm38
MGSCv378122,032,051 - 122,082,661 (-)NCBIGRCm37mm9NCBIm37
MGSCv368122,394,132 - 122,444,704 (-)NCBImm8
Celera8123,725,569 - 123,776,209 (-)NCBICelera
Cytogenetic Map8E1NCBI
Mbtps1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955564176,230 - 228,587 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955564176,230 - 226,555 (+)NCBIChiLan1.0ChiLan1.0
MBTPS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11684,063,508 - 84,126,000 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1684,063,508 - 84,126,000 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01664,719,971 - 64,783,119 (-)NCBIMhudiblu_PPA_v0panPan3
MBTPS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1568,228,176 - 68,281,175 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl568,228,238 - 68,280,515 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha568,242,379 - 68,295,248 (+)NCBI
ROS_Cfam_1.0568,526,299 - 68,579,190 (+)NCBI
ROS_Cfam_1.0 Ensembl568,526,329 - 68,579,190 (+)Ensembl
UMICH_Zoey_3.1568,474,058 - 68,526,939 (+)NCBI
UNSW_CanFamBas_1.0568,310,640 - 68,363,509 (+)NCBI
UU_Cfam_GSD_1.0568,726,354 - 68,779,243 (+)NCBI
Mbtps1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934927,942,920 - 27,998,011 (+)NCBI
SpeTri2.0NW_0049366413,696,506 - 3,751,558 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MBTPS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl64,503,573 - 4,558,609 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.164,503,530 - 4,558,601 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.265,085,217 - 5,140,266 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MBTPS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1569,464,064 - 69,527,588 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl569,463,920 - 69,527,541 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660476,231,679 - 6,295,208 (+)NCBIVero_WHO_p1.0
Mbtps1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247463,455,995 - 3,523,262 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247463,466,723 - 3,521,830 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH127834  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21947,561,709 - 47,561,912 (+)MAPPERmRatBN7.2
Rnor_6.01952,146,617 - 52,146,819NCBIRnor6.0
Rnor_5.01962,895,099 - 62,895,301UniSTSRnor5.0
RGSC_v3.41949,751,233 - 49,751,435UniSTSRGSC3.4
Celera1946,820,772 - 46,820,974UniSTS
RH 3.4 Map19653.0UniSTS
Cytogenetic Map19q12UniSTS
RH129347  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21947,561,672 - 47,561,857 (+)MAPPERmRatBN7.2
Rnor_6.01952,146,580 - 52,146,764NCBIRnor6.0
Rnor_5.01962,895,062 - 62,895,246UniSTSRnor5.0
RGSC_v3.41949,751,196 - 49,751,380UniSTSRGSC3.4
Celera1946,820,735 - 46,820,919UniSTS
RH 3.4 Map19652.8UniSTS
Cytogenetic Map19q12UniSTS
UniSTS:225106  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21947,601,467 - 47,601,642 (+)MAPPERmRatBN7.2
Rnor_6.01952,195,075 - 52,195,249NCBIRnor6.0
Rnor_6.01952,186,247 - 52,186,421NCBIRnor6.0
Rnor_5.01962,934,729 - 62,934,903UniSTSRnor5.0
Rnor_5.01962,943,557 - 62,943,731UniSTSRnor5.0
RGSC_v3.41949,791,465 - 49,791,639UniSTSRGSC3.4
Celera1946,860,612 - 46,860,786UniSTS
Cytogenetic Map19q12UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:214
Count of miRNA genes:151
Interacting mature miRNAs:173
Transcripts:ENSRNOT00000020838
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 40 11 8
Low 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000020838   ⟹   ENSRNOP00000020838
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1947,561,601 - 47,612,791 (-)Ensembl
Rnor_6.0 Ensembl1952,147,127 - 52,186,260 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000087886   ⟹   ENSRNOP00000071317
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1947,561,598 - 47,612,723 (-)Ensembl
Rnor_6.0 Ensembl1952,146,808 - 52,206,310 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108847   ⟹   ENSRNOP00000077523
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1947,561,606 - 47,612,703 (-)Ensembl
RefSeq Acc Id: NM_053569   ⟹   NP_446021
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21947,561,901 - 47,612,703 (-)NCBI
Rnor_6.01952,146,808 - 52,206,310 (-)NCBI
Rnor_5.01962,894,989 - 62,954,792 (-)NCBI
RGSC_v3.41949,751,424 - 49,802,700 (-)RGD
Celera1946,820,963 - 46,871,847 (-)RGD
Sequence:
RefSeq Acc Id: XM_008772651   ⟹   XP_008770873
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21947,569,334 - 47,612,769 (-)NCBI
Rnor_6.01952,154,222 - 52,187,411 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039098048   ⟹   XP_038953976
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21947,561,598 - 47,612,769 (-)NCBI
RefSeq Acc Id: XM_039098049   ⟹   XP_038953977
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21947,561,598 - 47,612,766 (-)NCBI
RefSeq Acc Id: XM_039098050   ⟹   XP_038953978
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21947,571,697 - 47,612,768 (-)NCBI
RefSeq Acc Id: XM_039098051   ⟹   XP_038953979
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21947,561,598 - 47,581,939 (-)NCBI
RefSeq Acc Id: XR_005496693
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21947,562,279 - 47,612,768 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_446021   ⟸   NM_053569
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: XP_008770873   ⟸   XM_008772651
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000071317   ⟸   ENSRNOT00000087886
RefSeq Acc Id: ENSRNOP00000020838   ⟸   ENSRNOT00000020838
RefSeq Acc Id: XP_038953976   ⟸   XM_039098048
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038953977   ⟸   XM_039098049
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038953979   ⟸   XM_039098051
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038953978   ⟸   XM_039098050
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000077523   ⟸   ENSRNOT00000108847
Protein Domains
Peptidase S8

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WTZ3-F1-model_v2 AlphaFold Q9WTZ3 1-1052 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701181
Promoter ID:EPDNEW_R11703
Type:initiation region
Name:Mbtps1_1
Description:membrane-bound transcription factor peptidase, site 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01952,206,316 - 52,206,376EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70935 AgrOrtholog
BioCyc Gene G2FUF-5515 BioCyc
Ensembl Genes ENSRNOG00000015173 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000020838 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000071317 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020838 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000087886 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.200 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5623811 IMAGE-MGC_LOAD
InterPro Peptidase_S8/S53_dom UniProtKB/Swiss-Prot
  Peptidase_S8/S53_dom_sf UniProtKB/Swiss-Prot
  Peptidase_S8_His-AS UniProtKB/Swiss-Prot
  Peptidase_S8_Ser-AS UniProtKB/Swiss-Prot
  Peptidase_S8_subtilisin-rel UniProtKB/Swiss-Prot
  Site-1_peptidase_cat_dom UniProtKB/Swiss-Prot
KEGG Report rno:89842 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72356 IMAGE-MGC_LOAD
NCBI Gene 89842 ENTREZGENE
Pfam Peptidase_S8 UniProtKB/Swiss-Prot
PhenoGen Mbtps1 PhenoGen
PRINTS SUBTILISIN UniProtKB/Swiss-Prot
PROSITE SUBTILASE UniProtKB/Swiss-Prot
  SUBTILASE_HIS UniProtKB/Swiss-Prot
  SUBTILASE_SER UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52743 UniProtKB/Swiss-Prot
UniProt MBTP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary G3V7Z2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Mbtps1  membrane-bound transcription factor peptidase, site 1    membrane-bound transcription factor protease, site 1  Name updated 1299863 APPROVED
2002-07-09 Mbtps1  membrane-bound transcription factor protease, site 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization appears in the Golgi apparatus and within small punctate structures reminiscent of endosomes 70790