Mbtps1 (membrane-bound transcription factor peptidase, site 1) - Rat Genome Database

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Gene: Mbtps1 (membrane-bound transcription factor peptidase, site 1) Rattus norvegicus
Analyze
Symbol: Mbtps1
Name: membrane-bound transcription factor peptidase, site 1
RGD ID: 70935
Description: Exhibits serine-type endopeptidase activity. Predicted to be involved in several processes, including lysosome organization; protein import into nucleus; and proteolysis. Localizes to Golgi apparatus. Orthologous to human MBTPS1 (membrane bound transcription factor peptidase, site 1); PARTICIPATES IN sterol regulatory element-binding protein signaling pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH ammonium chloride; bisphenol A; dibutyl phthalate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: endopeptidase S1P; membrane-bound transcription factor protease, site 1; membrane-bound transcription factor site-1 protease; S1p; S1P endopeptidase; site-1 protease; Ski-1; subtilisin/kexin isozyme 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21947,561,598 - 47,612,769 (-)NCBI
Rnor_6.0 Ensembl1952,146,808 - 52,206,310 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01952,146,507 - 52,206,310 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01962,894,989 - 62,954,792 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41949,751,424 - 49,802,700 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11949,756,304 - 49,807,581 (-)NCBI
Celera1946,820,963 - 46,871,847 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:11069896   PMID:11163209   PMID:11717426   PMID:15938716   PMID:17643267   PMID:21719679   PMID:30046013  


Genomics

Comparative Map Data
Mbtps1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21947,561,598 - 47,612,769 (-)NCBI
Rnor_6.0 Ensembl1952,146,808 - 52,206,310 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01952,146,507 - 52,206,310 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01962,894,989 - 62,954,792 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41949,751,424 - 49,802,700 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11949,756,304 - 49,807,581 (-)NCBI
Celera1946,820,963 - 46,871,847 (-)NCBICelera
Cytogenetic Map19q12NCBI
MBTPS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1684,053,761 - 84,116,942 (-)EnsemblGRCh38hg38GRCh38
GRCh381684,053,763 - 84,116,942 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371684,087,368 - 84,150,547 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361682,644,869 - 82,708,018 (-)NCBINCBI36hg18NCBI36
Build 341682,644,871 - 82,708,018NCBI
Celera1668,389,268 - 68,452,435 (-)NCBI
Cytogenetic Map16q23.3-q24.1NCBI
HuRef1669,841,352 - 69,904,502 (-)NCBIHuRef
CHM1_11685,498,379 - 85,561,933 (-)NCBICHM1_1
Mbtps1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398120,234,890 - 120,285,603 (-)NCBIGRCm39mm39
GRCm39 Ensembl8120,234,895 - 120,285,474 (-)Ensembl
GRCm388119,508,151 - 119,558,864 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8119,508,156 - 119,558,735 (-)EnsemblGRCm38mm10GRCm38
MGSCv378122,032,051 - 122,082,661 (-)NCBIGRCm37mm9NCBIm37
MGSCv368122,394,132 - 122,444,704 (-)NCBImm8
Celera8123,725,569 - 123,776,209 (-)NCBICelera
Cytogenetic Map8E1NCBI
Mbtps1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955564176,230 - 228,587 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955564176,230 - 226,555 (+)NCBIChiLan1.0ChiLan1.0
MBTPS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11684,063,508 - 84,126,000 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1684,063,508 - 84,126,000 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01664,719,971 - 64,783,119 (-)NCBIMhudiblu_PPA_v0panPan3
MBTPS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1568,228,176 - 68,281,175 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl568,228,238 - 68,280,515 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha568,242,379 - 68,295,248 (+)NCBI
ROS_Cfam_1.0568,526,299 - 68,579,190 (+)NCBI
UMICH_Zoey_3.1568,474,058 - 68,526,939 (+)NCBI
UNSW_CanFamBas_1.0568,310,640 - 68,363,509 (+)NCBI
UU_Cfam_GSD_1.0568,726,354 - 68,779,243 (+)NCBI
Mbtps1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934927,942,920 - 27,998,011 (+)NCBI
SpeTri2.0NW_0049366413,696,506 - 3,751,558 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MBTPS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl64,503,573 - 4,558,609 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.164,503,530 - 4,558,601 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.265,085,217 - 5,140,266 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MBTPS1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1569,464,064 - 69,527,588 (-)NCBI
ChlSab1.1 Ensembl569,463,920 - 69,527,541 (-)Ensembl
Mbtps1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247463,466,723 - 3,521,830 (+)NCBI

Position Markers
RH127834  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21947,561,709 - 47,561,912 (+)MAPPER
Rnor_6.01952,146,617 - 52,146,819NCBIRnor6.0
Rnor_5.01962,895,099 - 62,895,301UniSTSRnor5.0
RGSC_v3.41949,751,233 - 49,751,435UniSTSRGSC3.4
Celera1946,820,772 - 46,820,974UniSTS
RH 3.4 Map19653.0UniSTS
Cytogenetic Map19q12UniSTS
RH129347  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21947,561,672 - 47,561,857 (+)MAPPER
Rnor_6.01952,146,580 - 52,146,764NCBIRnor6.0
Rnor_5.01962,895,062 - 62,895,246UniSTSRnor5.0
RGSC_v3.41949,751,196 - 49,751,380UniSTSRGSC3.4
Celera1946,820,735 - 46,820,919UniSTS
RH 3.4 Map19652.8UniSTS
Cytogenetic Map19q12UniSTS
UniSTS:225106  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21947,601,467 - 47,601,642 (+)MAPPER
Rnor_6.01952,195,075 - 52,195,249NCBIRnor6.0
Rnor_6.01952,186,247 - 52,186,421NCBIRnor6.0
Rnor_5.01962,934,729 - 62,934,903UniSTSRnor5.0
Rnor_5.01962,943,557 - 62,943,731UniSTSRnor5.0
RGSC_v3.41949,791,465 - 49,791,639UniSTSRGSC3.4
Celera1946,860,612 - 46,860,786UniSTS
Cytogenetic Map19q12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19243296362275575Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19650676160220581Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191702800352538299Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191899398262275575Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191917749562275575Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)192140778762275575Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192481825762275575Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)193299439262275575Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193791679960220451Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193791679960220451Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194883071260220581Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:214
Count of miRNA genes:151
Interacting mature miRNAs:173
Transcripts:ENSRNOT00000020838
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 40 11 8
Low 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000020838   ⟹   ENSRNOP00000020838
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1952,147,127 - 52,186,260 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000087886   ⟹   ENSRNOP00000071317
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1952,146,808 - 52,206,310 (-)Ensembl
RefSeq Acc Id: NM_053569   ⟹   NP_446021
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21947,561,901 - 47,612,703 (-)NCBI
Rnor_6.01952,146,808 - 52,206,310 (-)NCBI
Rnor_5.01962,894,989 - 62,954,792 (-)NCBI
RGSC_v3.41949,751,424 - 49,802,700 (-)RGD
Celera1946,820,963 - 46,871,847 (-)RGD
Sequence:
RefSeq Acc Id: XM_006255723   ⟹   XP_006255785
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01952,146,507 - 52,187,408 (-)NCBI
Rnor_5.01962,894,989 - 62,954,792 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008772651   ⟹   XP_008770873
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21947,569,334 - 47,612,769 (-)NCBI
Rnor_6.01952,154,222 - 52,187,411 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601395   ⟹   XP_017456884
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01952,146,507 - 52,187,409 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039098048   ⟹   XP_038953976
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21947,561,598 - 47,612,769 (-)NCBI
RefSeq Acc Id: XM_039098049   ⟹   XP_038953977
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21947,561,598 - 47,612,766 (-)NCBI
RefSeq Acc Id: XM_039098050   ⟹   XP_038953978
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21947,571,697 - 47,612,768 (-)NCBI
RefSeq Acc Id: XM_039098051   ⟹   XP_038953979
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21947,561,598 - 47,581,939 (-)NCBI
RefSeq Acc Id: XR_005496693
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21947,562,279 - 47,612,768 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_446021   ⟸   NM_053569
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: XP_006255785   ⟸   XM_006255723
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008770873   ⟸   XM_008772651
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017456884   ⟸   XM_017601395
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000071317   ⟸   ENSRNOT00000087886
RefSeq Acc Id: ENSRNOP00000020838   ⟸   ENSRNOT00000020838
RefSeq Acc Id: XP_038953976   ⟸   XM_039098048
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038953977   ⟸   XM_039098049
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038953979   ⟸   XM_039098051
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038953978   ⟸   XM_039098050
- Peptide Label: isoform X4
Protein Domains
Peptidase S8

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701181
Promoter ID:EPDNEW_R11703
Type:initiation region
Name:Mbtps1_1
Description:membrane-bound transcription factor peptidase, site 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01952,206,316 - 52,206,376EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70935 AgrOrtholog
Ensembl Genes ENSRNOG00000015173 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000020838 UniProtKB/Swiss-Prot
  ENSRNOP00000071317 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020838 UniProtKB/Swiss-Prot
  ENSRNOT00000087886 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.200 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5623811 IMAGE-MGC_LOAD
InterPro Peptidase_S8/S53_dom UniProtKB/Swiss-Prot
  Peptidase_S8/S53_dom_sf UniProtKB/Swiss-Prot
  Peptidase_S8_His-AS UniProtKB/Swiss-Prot
  Peptidase_S8_Ser-AS UniProtKB/Swiss-Prot
  Peptidase_S8_subtilisin-rel UniProtKB/Swiss-Prot
  Site-1_peptidase_cat_dom UniProtKB/Swiss-Prot
KEGG Report rno:89842 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72356 IMAGE-MGC_LOAD
NCBI Gene 89842 ENTREZGENE
Pfam Peptidase_S8 UniProtKB/Swiss-Prot
PhenoGen Mbtps1 PhenoGen
PRINTS SUBTILISIN UniProtKB/Swiss-Prot
PROSITE SUBTILASE UniProtKB/Swiss-Prot
  SUBTILASE_HIS UniProtKB/Swiss-Prot
  SUBTILASE_SER UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52743 UniProtKB/Swiss-Prot
UniProt MBTP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary G3V7Z2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Mbtps1  membrane-bound transcription factor peptidase, site 1    membrane-bound transcription factor protease, site 1  Name updated 1299863 APPROVED
2002-07-09 Mbtps1  membrane-bound transcription factor protease, site 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization appears in the Golgi apparatus and within small punctate structures reminiscent of endosomes 70790