Ap3b1 (adaptor related protein complex 3 subunit beta 1) - Rat Genome Database

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Gene: Ap3b1 (adaptor related protein complex 3 subunit beta 1) Rattus norvegicus
Analyze
Symbol: Ap3b1
Name: adaptor related protein complex 3 subunit beta 1
RGD ID: 1310256
Description: Predicted to enable GTP-dependent protein binding activity and protein phosphatase binding activity. Predicted to be involved in anterograde synaptic vesicle transport and synaptic vesicle budding from endosome. Predicted to act upstream of or within with a negative effect on mRNA transcription by RNA polymerase II and regulation of catalytic activity. Predicted to act upstream of or within several processes, including establishment of protein localization to organelle; hemopoiesis; and vesicle organization. Predicted to be located in several cellular components, including axon cytoplasm; clathrin-coated vesicle membrane; and mitochondrion. Predicted to be part of AP-3 adaptor complex and clathrin adaptor complex. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome; Hermansky-Pudlak syndrome 2; interstitial lung disease; neutropenia; and pulmonary fibrosis. Orthologous to human AP3B1 (adaptor related protein complex 3 subunit beta 1); INTERACTS WITH 2,4-dinitrotoluene; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adaptor-related protein complex 3, beta 1 subunit; AP-3 complex subunit beta-1; LOC309969
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2225,600,069 - 25,800,937 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl225,600,040 - 25,800,935 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx232,628,825 - 32,828,969 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0230,729,080 - 30,929,207 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0225,553,041 - 25,753,147 (+)NCBIRnor_WKY
Rnor_6.0224,022,815 - 24,227,522 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl224,024,791 - 24,226,224 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0243,195,152 - 43,397,102 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4224,670,078 - 24,872,770 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1224,557,732 - 24,793,137 (+)NCBI
Celera221,672,156 - 21,872,572 (+)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The Hermansky-Pudlak syndrome 1 (HPS1) and HPS2 genes independently contribute to the production and function of platelet dense granules, melanosomes, and lysosomes. Feng L, etal., Blood. 2002 Mar 1;99(5):1651-8.
2. Genomic structure of the mouse Ap3b1 gene in normal and pearl mice. Feng L, etal., Genomics. 2000 Nov 1;69(3):370-9.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Interstitial lung disease and pulmonary fibrosis in Hermansky-Pudlak syndrome type 2, an adaptor protein-3 complex disease. Gochuico BR, etal., Mol Med. 2012 Feb 10;18:56-64. doi: 10.2119/molmed.2011.00198.
6. Disorders of vesicles of lysosomal lineage: the Hermansky-Pudlak syndromes. Huizing M and Gahl WA, Curr Mol Med. 2002 Aug;2(5):451-67.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:6696991   PMID:9188501   PMID:9931340   PMID:11058094   PMID:11452004   PMID:11588176   PMID:12777251   PMID:14557411   PMID:17622474   PMID:17897319   PMID:19841138   PMID:19946888  
PMID:20847273   PMID:21998198   PMID:22511774   PMID:23146885   PMID:23748140  


Genomics

Comparative Map Data
Ap3b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2225,600,069 - 25,800,937 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl225,600,040 - 25,800,935 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx232,628,825 - 32,828,969 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0230,729,080 - 30,929,207 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0225,553,041 - 25,753,147 (+)NCBIRnor_WKY
Rnor_6.0224,022,815 - 24,227,522 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl224,024,791 - 24,226,224 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0243,195,152 - 43,397,102 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4224,670,078 - 24,872,770 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1224,557,732 - 24,793,137 (+)NCBI
Celera221,672,156 - 21,872,572 (+)NCBICelera
Cytogenetic Map2q12NCBI
AP3B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38578,000,522 - 78,294,698 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl578,000,522 - 78,294,762 (-)EnsemblGRCh38hg38GRCh38
GRCh37577,296,346 - 77,590,522 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36577,333,906 - 77,626,284 (-)NCBINCBI36Build 36hg18NCBI36
Build 34577,333,906 - 77,626,284NCBI
Celera573,192,009 - 73,483,332 (-)NCBICelera
Cytogenetic Map5q14.1NCBI
HuRef572,504,871 - 72,797,261 (-)NCBIHuRef
CHM1_1576,732,015 - 77,024,021 (-)NCBICHM1_1
T2T-CHM13v2.0578,482,312 - 78,776,325 (-)NCBIT2T-CHM13v2.0
Ap3b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391394,492,332 - 94,702,838 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1394,495,468 - 94,702,825 (+)EnsemblGRCm39 Ensembl
GRCm381394,358,960 - 94,566,316 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1394,358,960 - 94,566,317 (+)EnsemblGRCm38mm10GRCm38
MGSCv371395,128,915 - 95,336,271 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361395,459,730 - 95,667,014 (+)NCBIMGSCv36mm8
Celera1397,976,815 - 98,179,412 (+)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1349.22NCBI
Ap3b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542522,792,616 - 23,051,737 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542522,792,616 - 23,051,509 (+)NCBIChiLan1.0ChiLan1.0
AP3B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1537,502,986 - 37,835,904 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl537,503,162 - 37,840,205 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0537,015,518 - 37,305,769 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
AP3B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1328,481,974 - 28,748,095 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl328,481,038 - 28,751,258 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha329,722,995 - 29,988,777 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0328,405,848 - 28,672,345 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl328,405,824 - 28,675,022 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1328,341,769 - 28,607,713 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0328,320,012 - 28,585,750 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0328,647,884 - 28,914,348 (+)NCBIUU_Cfam_GSD_1.0
Ap3b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213184,654,420 - 184,894,394 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365495,965,143 - 6,204,379 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365495,964,240 - 6,205,245 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AP3B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl286,873,290 - 87,142,768 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1286,875,922 - 87,142,722 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2288,534,908 - 88,719,584 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AP3B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1472,225,658 - 72,524,971 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl472,225,599 - 72,524,933 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604921,065,319 - 21,365,237 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ap3b1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248692,459,947 - 2,741,328 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248692,459,370 - 2,741,529 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ap3b1
1233 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:328
Count of miRNA genes:187
Interacting mature miRNAs:211
Transcripts:ENSRNOT00000066302
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat

Markers in Region
C78395  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2225,800,384 - 25,800,535 (+)MAPPERmRatBN7.2
Rnor_6.0224,224,962 - 24,225,112NCBIRnor6.0
Rnor_5.0243,394,542 - 43,394,692UniSTSRnor5.0
RGSC_v3.4224,872,218 - 24,872,368UniSTSRGSC3.4
Celera221,872,020 - 21,872,170UniSTS
Cytogenetic Map2q12UniSTS
RH141388  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2225,599,102 - 25,599,299 (+)MAPPERmRatBN7.2
Rnor_6.0224,023,868 - 24,024,064NCBIRnor6.0
Rnor_5.0243,194,268 - 43,194,464UniSTSRnor5.0
RGSC_v3.4224,669,112 - 24,669,308UniSTSRGSC3.4
Celera221,671,190 - 21,671,386UniSTS
Cytogenetic Map2q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 2 3 74 35 41 11 2
Low 6 8 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000066302   ⟹   ENSRNOP00000060116
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl225,600,040 - 25,800,935 (+)Ensembl
Rnor_6.0 Ensembl224,024,834 - 24,225,514 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000089599   ⟹   ENSRNOP00000069838
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl224,024,791 - 24,226,224 (+)Ensembl
RefSeq Acc Id: NM_001107646   ⟹   NP_001101116
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2225,600,069 - 25,800,937 (+)NCBI
Rnor_6.0224,024,834 - 24,225,514 (+)NCBI
Rnor_5.0243,195,152 - 43,397,102 (+)NCBI
RGSC_v3.4224,670,078 - 24,872,770 (+)RGD
Celera221,672,156 - 21,872,572 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001101116 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM10075 (Get FASTA)   NCBI Sequence Viewer  
  EDM10076 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001101116   ⟸   NM_001107646
- UniProtKB: D3ZIF5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069838   ⟸   ENSRNOT00000089599
RefSeq Acc Id: ENSRNOP00000060116   ⟸   ENSRNOT00000066302
Protein Domains
AP3B1_C   B2-adapt-app_C

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JWD6-F1-model_v2 AlphaFold A0A0G2JWD6 1-1096 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691081
Promoter ID:EPDNEW_R1597
Type:initiation region
Name:Ap3b1_1
Description:adaptor-related protein complex 3, beta 1 subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0224,024,789 - 24,024,849EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310256 AgrOrtholog
BioCyc Gene G2FUF-54830 BioCyc
Ensembl Genes ENSRNOG00000010624 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000060116.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066302.2 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
InterPro AP3_beta UniProtKB/TrEMBL
  AP3B1_Ser UniProtKB/TrEMBL
  AP3B_C UniProtKB/TrEMBL
  AP_beta UniProtKB/TrEMBL
  ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  B-adaptin_app_sub_C UniProtKB/TrEMBL
  Clathrin/coatomer_adapt-like_N UniProtKB/TrEMBL
KEGG Report rno:309969 UniProtKB/TrEMBL
NCBI Gene 309969 ENTREZGENE
PANTHER PTHR11134 UniProtKB/TrEMBL
Pfam Adaptin_N UniProtKB/TrEMBL
  AP3B1_C UniProtKB/TrEMBL
  SEEEED UniProtKB/TrEMBL
PhenoGen Ap3b1 PhenoGen
PIRSF AP3_complex_beta UniProtKB/TrEMBL
SMART AP3B1_C UniProtKB/TrEMBL
  B2-adapt-app_C UniProtKB/TrEMBL
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
UniProt D3ZIF5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-03 Ap3b1  adaptor related protein complex 3 subunit beta 1  Ap3b1  adaptor-related protein complex 3, beta 1 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ap3b1  adaptor-related protein complex 3, beta 1 subunit   Ap3b1_predicted  adaptor-related protein complex 3, beta 1 subunit (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ap3b1_predicted  adaptor-related protein complex 3, beta 1 subunit (predicted)      Symbol and Name status set to approved 70820 APPROVED