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ONTOLOGY REPORT - ANNOTATIONS

Term:lysosome organization
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Accession:GO:0007040 term browser browse the term
Definition:A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases.
Synonyms:exact_synonym: lysosome organisation
 related_synonym: lysosome organization and biogenesis
 never_in_taxon: NCBITaxon:4751 ! Fungi


show annotations for term's descendants           Sort by:
lysosome organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 involved_in ISO (PMID:15163665) RGD PMID:15163665 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Acp2 acid phosphatase 2, lysosomal involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:2180084|MGI:3574793 (PMID:15604265), (PMID:9228031)		 GO_Central
RGD		 PMID:9228031 PMID:15604265 GO_REF:0000033 NCBI chr 3:77,175,022...77,185,180
Ensembl chr 3:77,175,895...77,185,680 		JBrowse link
G Acp3 acid phosphatase 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:104,905,570...104,956,146
Ensembl chr 8:104,905,586...104,954,236 		JBrowse link
G Acp4 acid phosphatase 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:94,736,376...94,751,871
Ensembl chr 1:94,735,514...94,744,623 		JBrowse link
G Aktip AKT interacting protein involved_in ISO
IEA
ISS		 (PMID:18799622)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:18799622 GO_REF:0000024 GO_REF:0000107 NCBI chr19:15,866,811...15,877,123
Ensembl chr19:15,866,928...15,886,663 		JBrowse link
G Ap3b1 adaptor related protein complex 3 subunit beta 1 acts_upstream_of_or_within ISO (PMID:30786955), (PMID:9931340) RGD PMID:9931340 PMID:30786955 NCBI chr 2:25,600,069...25,800,937
Ensembl chr 2:25,600,040...25,800,935 		JBrowse link
G Ap5z1 adaptor related protein complex 5 subunit zeta 1 acts_upstream_of_or_within ISO (PMID:37871017) RGD PMID:37871017 NCBI chr12:12,093,834...12,109,043
Ensembl chr12:12,093,834...12,108,511 		JBrowse link
G Arsg arylsulfatase G acts_upstream_of_or_within ISO (PMID:26975023) RGD PMID:26975023 NCBI chr10:94,412,261...94,551,224
Ensembl chr10:94,447,399...94,542,941 		JBrowse link
G Becn1 beclin 1 acts_upstream_of_or_within ISO MGI:2683696 (PMID:18497889) RGD PMID:18497889 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Chmp5 charged multivesicular body protein 5 acts_upstream_of_or_within ISO MGI:3626293 (PMID:16567502) RGD PMID:16567502 NCBI chr 5:56,081,385...56,098,529
Ensembl chr 5:56,081,343...56,098,529 		JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:1933976|MGI:2388887|MGI:3623134 (PMID:10191119), (PMID:10440905), (PMID:10527801), (PMID:15588329)		 GO_Central
RGD		 PMID:10191119 PMID:10440905 PMID:10527801 PMID:15588329 GO_REF:0000033 NCBI chr 1:181,156,071...181,169,458
Ensembl chr 1:181,156,073...181,167,434 		JBrowse link
G Cln5 CLN5, intracellular trafficking protein involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:3521802 (PMID:15459177)		 GO_Central
RGD		 PMID:15459177 GO_REF:0000033 NCBI chr15:79,893,573...79,903,438
Ensembl chr15:79,893,548...79,903,438 		JBrowse link
G Cln6 CLN6, transmembrane ER protein involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:2159328 (PMID:26681805), (PMID:9600738)		 GO_Central
RGD		 PMID:9600738 PMID:26681805 GO_REF:0000033 NCBI chr 8:63,303,356...63,318,360
Ensembl chr 8:63,303,029...63,318,360 		JBrowse link
G Cln8 CLN8, transmembrane ER and ERGIC protein acts_upstream_of_or_within ISO MGI:1856959 (PMID:10087069), (PMID:7613514), (PMID:8144516), (PMID:8160780) RGD PMID:7613514 PMID:8144516 PMID:8160780 PMID:10087069 NCBI chr16:74,749,662...74,759,553
Ensembl chr16:74,749,662...74,759,774 		JBrowse link
G Clvs1 clavesin 1 involved_in IMP
IBA		 PMID:19651769
GO_REF:0000033		 GO_Central PMID:19651769 GO_REF:0000033, RGD:8553526 NCBI chr 5:22,408,384...22,604,281
Ensembl chr 5:22,408,384...22,604,270 		JBrowse link
G Clvs2 clavesin 2 involved_in IMP
IBA		 PMID:19651769
GO_REF:0000033		 GO_Central PMID:19651769 GO_REF:0000033, RGD:8553526 NCBI chr 1:23,735,660...23,842,685
Ensembl chr 1:23,735,272...23,842,692 		JBrowse link
G Creg1 cellular repressor of E1A-stimulated genes 1 acts_upstream_of_or_within ISO (PMID:33966596) RGD PMID:33966596 NCBI chr13:78,019,814...78,032,310
Ensembl chr13:78,019,843...78,032,308 		JBrowse link
G Fhip1b FHF complex subunit HOOK interacting protein 1B involved_in ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000107
(PMID:18799622)		 UniProt
GO_Central
Ensembl
RGD		 PMID:18799622 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:159,718,679...159,748,449
Ensembl chr 1:159,726,004...159,748,408 		JBrowse link
G Gaa alpha glucosidase involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000107
MGI:2148550|MGI:2179961 (PMID:10547605), (PMID:11328962), (PMID:12115977), (PMID:15169761), (PMID:9384603), (PMID:9668092)
GO_REF:0000033
(PMID:7717400)		 Ensembl
RGD
GO_Central		 PMID:7717400 PMID:9384603 PMID:9668092 PMID:10547605 PMID:11328962 More... GO_REF:0000033 GO_REF:0000107 NCBI chr10:104,529,673...104,546,836
Ensembl chr10:104,529,747...104,546,836 		JBrowse link
G Gba1 glucosylceramidase beta 1 involved_in ISO (PMID:27378698)
(MGI:5817293|PMID:27378698)		 RGD PMID:27378698 MGI:5817293 NCBI chr 2:174,609,437...174,615,457
Ensembl chr 2:174,609,403...174,618,263 		JBrowse link
G Gnptab N-acetylglucosamine-1-phosphate transferase subunits alpha and beta involved_in ISO (PMID:21719679) RGD PMID:21719679 NCBI chr 7:22,800,502...22,866,336
Ensembl chr 7:22,800,485...22,866,933 		JBrowse link
G Grn granulin precursor involved_in ISO
ISS		 (MGI:6274951|PMID:27789271)
GO_REF:0000024		 RGD
UniProt		 PMID:27789271 GO_REF:0000024 MGI:6274951 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Hexa hexosaminidase subunit alpha acts_upstream_of_or_within ISO MGI:1857181|MGI:2429698|MGI:3581540|MGI:96074 (PMID:10591619), (PMID:14972652), (PMID:7937929), (PMID:8747922), (PMID:8896570), (PMID:9103204), (PMID:9184660), (PMID:9302266), (PMID:9645704) RGD PMID:7937929 PMID:8747922 PMID:8896570 PMID:9103204 PMID:9184660 More... NCBI chr 8:59,936,526...59,961,654
Ensembl chr 8:59,936,660...59,962,013 		JBrowse link
G Hexb hexosaminidase subunit beta involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2429701|MGI:96073 (PMID:8789434), (PMID:8896570), (PMID:9184660), (PMID:9645704)		 Ensembl
RGD		 PMID:8789434 PMID:8896570 PMID:9184660 PMID:9645704 GO_REF:0000107 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223 		JBrowse link
G Hook1 hook microtubule-tethering protein 1 involved_in ISO (PMID:18799622) RGD PMID:18799622 NCBI chr 5:110,824,501...110,887,791
Ensembl chr 5:110,824,501...110,887,787 		JBrowse link
G Hook2 hook microtubule-tethering protein 2 involved_in ISO (PMID:18799622) RGD PMID:18799622 NCBI chr19:23,151,869...23,170,139
Ensembl chr19:23,151,870...23,164,181 		JBrowse link
G Hook3 hook microtubule-tethering protein 3 involved_in ISO (PMID:18799622) RGD PMID:18799622 NCBI chr16:65,954,293...66,058,812
Ensembl chr16:65,954,350...66,061,338 		JBrowse link
G Hps1 HPS1, biogenesis of lysosomal organelles complex 3 subunit 1 acts_upstream_of_or_within ISO (PMID:30786955) RGD PMID:30786955 NCBI chr 1:241,551,180...241,577,292
Ensembl chr 1:241,551,175...241,577,268 		JBrowse link
G Hps4 HPS4, biogenesis of lysosomal organelles complex 3 subunit 2 involved_in ISO (PMID:12663659) RGD PMID:12663659 NCBI chr12:44,264,037...44,294,791
Ensembl chr12:44,264,037...44,294,632 		JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 acts_upstream_of_or_within ISO MGI:3799948 (PMID:29180785) RGD PMID:29180785 NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927 		JBrowse link
G Idua alpha-L-iduronidase acts_upstream_of_or_within ISO MGI:2176236|MGI:4415188 (PMID:19751987), (PMID:9097952) RGD PMID:9097952 PMID:19751987 NCBI chr14:1,031,588...1,059,494
Ensembl chr14:1,032,171...1,046,522 		JBrowse link
G Lamtor1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000002
(MGI:4887551|PMID:19177150)		 UniProt
InterPro
RGD		 PMID:19177150 GO_REF:0000002 GO_REF:0000024 MGI:4887551 NCBI chr 1:156,272,116...156,277,687
Ensembl chr 1:156,272,064...156,291,179 		JBrowse link
G Lamtor1l1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 like 1 involved_in ISS
IEA		 GO_REF:0000024
GO_REF:0000002		 UniProt
InterPro		 GO_REF:0000002 GO_REF:0000024 NCBI chr  X:34,637,460...34,638,509
Ensembl chr  X:34,637,459...34,638,516 		JBrowse link
G Lipa lipase A, lysosomal acid type involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2451080 (PMID:25807535), (PMID:29374543)		 Ensembl
RGD		 PMID:25807535 PMID:29374543 GO_REF:0000107 NCBI chr 1:232,024,351...232,057,735
Ensembl chr 1:232,024,356...232,057,633 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 involved_in ISO (PMID:25416817) RGD PMID:25416817 NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703 		JBrowse link
G Lyset lysosomal enzyme trafficking factor involved_in ISS
ISO		 GO_REF:0000024
(PMID:36096887)		 UniProt
RGD		 PMID:36096887 GO_REF:0000024 NCBI chr 6:121,884,577...121,886,319
Ensembl chr 6:121,884,643...121,886,275 		JBrowse link
G Lyst lysosomal trafficking regulator acts_upstream_of_or_within ISO MGI:1855968|MGI:1855969 (PMID:1113502), (PMID:4031470), (PMID:4697831), (PMID:6170520), (PMID:9368050) RGD PMID:1113502 PMID:4031470 PMID:4697831 PMID:6170520 PMID:9368050 NCBI chr17:86,241,384...86,443,501
Ensembl chr17:86,241,384...86,443,480 		JBrowse link
G Mbtps1 membrane-bound transcription factor peptidase, site 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:21719679)		 UniProt
Ensembl
RGD		 PMID:21719679 GO_REF:0000024 GO_REF:0000107 NCBI chr19:47,561,598...47,612,769
Ensembl chr19:47,561,598...47,612,791 		JBrowse link
G Mfsd8 major facilitator superfamily domain containing 8 acts_upstream_of_or_within ISO MGI:4456699 (PMID:24423645), (PMID:26681805), (PMID:35025759) RGD PMID:24423645 PMID:26681805 PMID:35025759 NCBI chr 2:123,822,042...123,847,808
Ensembl chr 2:123,816,614...123,857,971 		JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in ISO
IEA
ISS		 (PMID:22692423)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:22692423 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myo7a myosin VIIA involved_in ISO (PMID:16001398) RGD PMID:16001398 NCBI chr 1:152,342,611...152,414,171
Ensembl chr 1:152,344,448...152,414,157 		JBrowse link
G Naglu N-acetyl-alpha-glucosaminidase acts_upstream_of_or_within ISO MGI:1934018 (PMID:17712420), (PMID:19632871), (PMID:25524704), (PMID:26607664) RGD PMID:17712420 PMID:19632871 PMID:25524704 PMID:26607664 NCBI chr10:86,001,545...86,009,049
Ensembl chr10:86,001,566...86,008,972 		JBrowse link
G Pi4kb phosphatidylinositol 4-kinase beta involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:25365221)		 Ensembl
RGD		 PMID:25365221 GO_REF:0000107 NCBI chr 2:182,540,377...182,572,684
Ensembl chr 2:182,540,567...182,588,488 		JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 acts_upstream_of_or_within ISO MGI:2176390|MGI:3527191 (PMID:16368712), (PMID:16542649) RGD PMID:16368712 PMID:16542649 NCBI chr 5:135,121,164...135,142,048
Ensembl chr 5:135,121,163...135,142,048 		JBrowse link
G Snapin SNAP-associated protein involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:3608768 (PMID:20920792)		 GO_Central
RGD		 PMID:20920792 GO_REF:0000033 NCBI chr 2:175,971,575...175,974,164
Ensembl chr 2:175,971,257...175,974,231 		JBrowse link
G Spg11 SPG11 vesicle trafficking associated, spatacsin acts_upstream_of_or_within ISO (PMID:25365221)
MGI:4377985|MGI:6451766 (PMID:26284655), (PMID:28237315), (PMID:31637311), (PMID:37871017)		 RGD PMID:25365221 PMID:26284655 PMID:28237315 PMID:31637311 PMID:37871017 NCBI chr 3:109,007,658...109,072,904
Ensembl chr 3:109,008,135...109,072,911 		JBrowse link
G Tfe3 transcription factor binding to IGHM enhancer 3 involved_in ISO (PMID:24448649) RGD PMID:24448649 NCBI chr  X:14,729,547...14,742,830
Ensembl chr  X:14,729,550...14,742,571 		JBrowse link
G Tfeb transcription factor EB involved_in
acts_upstream_of_or_within		 ISO (PMID:22692423), (PMID:23434374), (PMID:32612235), (PMID:32753672), (PMID:35662396)
(PMID:31637311)		 RGD PMID:22692423 PMID:23434374 PMID:31637311 PMID:32612235 PMID:32753672 More... NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714 		JBrowse link
G Tmem106b transmembrane protein 106B involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:25066864)		 GO_Central
RGD		 PMID:25066864 GO_REF:0000033 NCBI chr 4:41,328,125...41,347,315
Ensembl chr 4:41,327,994...41,345,619 		JBrowse link
G Tpcn2 two pore segment channel 2 involved_in ISO UniProtKB:Q8NHX9 (PMID:25416817) RGD PMID:25416817 NCBI chr 1:200,416,538...200,446,252
Ensembl chr 1:200,416,540...200,446,236 		JBrowse link
G Tpp1 tripeptidyl peptidase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3521972 (PMID:15483130)		 Ensembl
RGD		 PMID:15483130 GO_REF:0000107 NCBI chr 1:160,097,984...160,104,108
Ensembl chr 1:160,096,833...160,104,129 		JBrowse link
G Vps18 VPS18 core subunit of CORVET and HOPS complexes involved_in ISO
IBA		 (PMID:18799622)
GO_REF:0000033		 RGD
GO_Central		 PMID:18799622 GO_REF:0000033 NCBI chr 3:106,279,444...106,290,298
Ensembl chr 3:106,279,425...106,291,964 		JBrowse link
G Vps35 VPS35 retromer complex component involved_in ISO (MGI:5694519|PMID:26203154) RGD PMID:26203154 MGI:5694519 NCBI chr19:21,765,771...21,801,620
Ensembl chr19:21,765,749...21,801,618 		JBrowse link
G Washc5 WASH complex subunit 5 acts_upstream_of_or_within ISO MGI:6246601 (PMID:30061306) RGD PMID:30061306 NCBI chr 7:90,884,192...90,936,096
Ensembl chr 7:90,884,197...90,936,103 		JBrowse link
G Zfyve26 zinc finger FYVE-type containing 26 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:25365221)
GO_REF:0000107
(PMID:37871017)		 RGD
Ensembl		 PMID:25365221 PMID:37871017 GO_REF:0000107 NCBI chr 6:98,031,874...98,095,538
Ensembl chr 6:98,032,520...98,095,480 		JBrowse link
G Zkscan3 zinc finger with KRAB and SCAN domains 3 involved_in ISO (PMID:23434374) RGD PMID:23434374 NCBI chr17:43,217,168...43,232,828
Ensembl chr17:43,217,222...43,232,827 		JBrowse link
lysosomal lumen acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp6ap2 ATPase H+ transporting accessory protein 2 involved_in ISO
IEA
ISS		 (PMID:32276428)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:32276428 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:10,183,983...10,210,948
Ensembl chr  X:10,183,068...10,210,918 		JBrowse link
G Ccdc115 coiled-coil domain containing 115 involved_in ISO (PMID:28296633) RGD PMID:28296633 NCBI chr 9:36,650,384...36,654,348
Ensembl chr 9:36,649,271...36,653,946 		JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in ISO
IBA		 (PMID:11722572)
GO_REF:0000033		 RGD
GO_Central		 PMID:11722572 GO_REF:0000033 NCBI chr 1:181,156,071...181,169,458
Ensembl chr 1:181,156,073...181,167,434 		JBrowse link
G Cln5 CLN5, intracellular trafficking protein involved_in ISO (PMID:11722572) RGD PMID:11722572 NCBI chr15:79,893,573...79,903,438
Ensembl chr15:79,893,548...79,903,438 		JBrowse link
G Cln6 CLN6, transmembrane ER protein involved_in ISO (PMID:11722572) RGD PMID:11722572 NCBI chr 8:63,303,356...63,318,360
Ensembl chr 8:63,303,029...63,318,360 		JBrowse link
G Creg1 cellular repressor of E1A-stimulated genes 1 acts_upstream_of_or_within ISO (PMID:33966596) RGD PMID:33966596 NCBI chr13:78,019,814...78,032,310
Ensembl chr13:78,019,843...78,032,308 		JBrowse link
G Grn granulin precursor involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:28073925)		 UniProt
Ensembl
RGD		 PMID:28073925 GO_REF:0000024 GO_REF:0000107 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:37390818)		 Ensembl
UniProt
RGD		 PMID:37390818 GO_REF:0000024 GO_REF:0000107 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:37390818)		 Ensembl
UniProt
RGD		 PMID:37390818 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522 		JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 involved_in ISO
ISS		 (PMID:11722572)
PMID:8895569		 RGD PMID:11722572 PMID:8895569 RGD:8553248 NCBI chr 5:135,121,164...135,142,048
Ensembl chr 5:135,121,163...135,142,048 		JBrowse link
G Snapin SNAP-associated protein acts_upstream_of_or_within ISO MGI:3608768 (PMID:20920792) RGD PMID:20920792 NCBI chr 2:175,971,575...175,974,164
Ensembl chr 2:175,971,257...175,974,231 		JBrowse link
G Tmem106b transmembrane protein 106B acts_upstream_of_or_within ISO MGI:5319917 (PMID:28728022) RGD PMID:28728022 NCBI chr 4:41,328,125...41,347,315
Ensembl chr 4:41,327,994...41,345,619 		JBrowse link
G Tmem199 transmembrane protein 199 involved_in ISO
IEA
ISS		 (PMID:28296633)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:28296633 GO_REF:0000024 GO_REF:0000107 NCBI chr10:63,402,493...63,407,065
Ensembl chr10:63,402,494...63,407,108 		JBrowse link
G Tmem9 transmembrane protein 9 involved_in ISO (PMID:30374053) RGD PMID:30374053 NCBI chr13:47,458,486...47,475,832
Ensembl chr13:47,458,498...47,475,832 		JBrowse link
lysosomal lumen pH elevation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in ISO (PMID:10924275) RGD PMID:10924275 NCBI chr 1:181,156,071...181,169,458
Ensembl chr 1:181,156,073...181,167,434 		JBrowse link
G Oca2 OCA2 melanosomal transmembrane protein involved_in ISO (PMID:25513726), (PMID:32966160) RGD PMID:25513726 PMID:32966160 NCBI chr 1:107,116,278...107,446,093
Ensembl chr 1:107,116,278...107,446,074 		JBrowse link
G Slc45a2 solute carrier family 45, member 2 involved_in ISO (PMID:32966160)
(MGI:7338895|PMID:35469906)		 RGD PMID:32966160 PMID:35469906 MGI:7338895 NCBI chr 2:59,963,599...59,996,408
Ensembl chr 2:59,963,706...59,996,317 		JBrowse link
G Tmem175 transmembrane protein 175 involved_in ISS
ISO		 GO_REF:0000024
(PMID:35333573), (PMID:35750034), (PMID:37390818)		 UniProt
RGD		 PMID:35333573 PMID:35750034 PMID:37390818 GO_REF:0000024 NCBI chr14:1,073,410...1,089,764
Ensembl chr14:1,073,523...1,089,819 		JBrowse link
lysosomal membrane organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arf1 ADP-ribosylation factor 1 IDA RGD PMID:9538255 RGD:9684948 NCBI chr10:43,997,983...44,014,461
Ensembl chr10:43,997,986...44,014,434 		JBrowse link
G Atp10b ATPase phospholipid transporting 10B involved_in ISO (PMID:32172343) RGD PMID:32172343 NCBI chr10:27,495,207...27,751,313
Ensembl chr10:27,408,747...27,749,637 		JBrowse link
multivesicular body-lysosome fusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chmp3 charged multivesicular body protein 3 involved_in ISO (PMID:16554368) RGD PMID:16554368 NCBI chr 4:103,576,453...103,622,566
Ensembl chr 4:103,576,515...103,623,959 		JBrowse link
negative regulation of lysosome organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1 IMP RGD PMID:25561470 RGD:11561937 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Flcn folliculin involved_in ISO (PMID:37079666) RGD PMID:37079666 NCBI chr10:44,588,621...44,607,808
Ensembl chr10:44,588,624...44,607,769 		JBrowse link
G Fnip1 folliculin interacting protein 1 involved_in ISO (PMID:37079666) RGD PMID:37079666 NCBI chr10:38,567,728...38,650,824
Ensembl chr10:38,567,729...38,650,824 		JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in ISO
ISS
IEA		 (PMID:24448649), (PMID:32612235)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:24448649 PMID:32612235 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
phagolysosome assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Coro1a coronin 1A involved_in ISO (PMID:12132654) RGD PMID:12132654 NCBI chr 1:181,295,561...181,300,566
Ensembl chr 1:181,295,562...181,300,534 		JBrowse link
G Myo7a myosin VIIA acts_upstream_of_or_within ISO MGI:2155422 (PMID:12743369) RGD PMID:12743369 NCBI chr 1:152,342,611...152,414,171
Ensembl chr 1:152,344,448...152,414,157 		JBrowse link
G P2rx7 purinergic receptor P2X 7 acts_upstream_of_or_within ISO MGI:3606250 (PMID:11544318) RGD PMID:11544318 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619 		JBrowse link
G Srpx sushi-repeat-containing protein, X-linked involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:3706175 (PMID:19368996)		 GO_Central
RGD		 PMID:19368996 GO_REF:0000033 NCBI chr  X:12,676,984...12,751,296
Ensembl chr  X:12,566,645...12,747,882 		JBrowse link
phagolysosome assembly involved in apoptotic cell clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab14 RAB14, member RAS oncogene family involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:18,501,953...18,523,253
Ensembl chr 3:18,501,963...18,523,172 		JBrowse link
phagosome-lysosome docking term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in ISO (MGI:5698740|PMID:26450516) RGD PMID:26450516 MGI:5698740 NCBI chr 1:181,156,071...181,169,458
Ensembl chr 1:181,156,073...181,167,434 		JBrowse link
phagosome-lysosome fusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arl8b ADP-ribosylation factor like GTPase 8B involved_in ISS
ISO		 GO_REF:0000024
(PMID:21802320)		 UniProt
RGD		 PMID:21802320 GO_REF:0000024 NCBI chr 4:141,748,634...141,792,605
Ensembl chr 4:141,748,587...141,792,596 		JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in ISO (MGI:5698740|PMID:26450516) RGD PMID:26450516 MGI:5698740 NCBI chr 1:181,156,071...181,169,458
Ensembl chr 1:181,156,073...181,167,434 		JBrowse link
G Pikfyve phosphoinositide kinase, FYVE-type zinc finger containing involved_in ISO
IBA		 (PMID:28779020)
GO_REF:0000033
(MGI:6103777|PMID:28779020)		 RGD
GO_Central		 PMID:28779020 GO_REF:0000033 MGI:6103777 NCBI chr 9:66,563,747...66,657,873
Ensembl chr 9:66,563,727...66,657,868 		JBrowse link
G Pla2g5 phospholipase A2, group V involved_in ISS
ISO		 GO_REF:0000024
(MGI:3841317|PMID:19342668)		 UniProt
RGD		 PMID:19342668 GO_REF:0000024 MGI:3841317 NCBI chr 5:151,041,339...151,109,433
Ensembl chr 5:151,041,340...151,062,658 		JBrowse link
G Rab20 RAB20, member RAS oncogene family involved_in ISO (PMID:21255211) RGD PMID:21255211 NCBI chr16:78,019,337...78,043,529
Ensembl chr16:78,019,337...78,043,529 		JBrowse link
G Rab34 RAB34, member RAS oncogene family involved_in ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000107
(MGI:5467668|PMID:23197834)
(PMID:21255211)		 UniProt
GO_Central
Ensembl
RGD		 PMID:21255211 PMID:23197834 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 MGI:5467668 NCBI chr10:63,083,319...63,087,538
Ensembl chr10:63,083,338...63,087,538 		JBrowse link
G Rab39a RAB39A, member RAS oncogene family involved_in ISO
IBA		 (PMID:21255211)
GO_REF:0000033		 RGD
GO_Central		 PMID:21255211 GO_REF:0000033 NCBI chr 8:54,088,246...54,105,867
Ensembl chr 8:54,088,129...54,106,483 		JBrowse link
G Rab7a RAB7A, member RAS oncogene family involved_in ISO
IBA
ISS		 (PMID:21255211)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:21255211 GO_REF:0000024 GO_REF:0000033 NCBI chr 4:120,461,966...120,510,756
Ensembl chr 4:120,461,963...120,506,889 		JBrowse link
G Rab7b Rab7b, member RAS oncogene family involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:43,121,168...43,147,581
Ensembl chr13:43,121,226...43,147,581 		JBrowse link
G Syt7 synaptotagmin 7 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3690533|PMID:16982801)		 UniProt
RGD		 PMID:16982801 GO_REF:0000024 MGI:3690533 NCBI chr 1:207,031,359...207,093,787
Ensembl chr 1:207,031,592...207,089,026 		JBrowse link
G Tmem175 transmembrane protein 175 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5693670|PMID:26317472)		 UniProt
RGD		 PMID:26317472 GO_REF:0000024 MGI:5693670 NCBI chr14:1,073,410...1,089,764
Ensembl chr14:1,073,523...1,089,819 		JBrowse link
phagosome-lysosome fusion involved in apoptotic cell clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Spg11 SPG11 vesicle trafficking associated, spatacsin acts_upstream_of_or_within ISO MGI:4377985 (PMID:26284655) RGD PMID:26284655 NCBI chr 3:109,007,658...109,072,904
Ensembl chr 3:109,008,135...109,072,911 		JBrowse link
positive regulation of lysosomal membrane permeability term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hspa8 heat shock protein family A (Hsp70) member 8 IMP RGD PMID:9038169 RGD:10059368 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Laptm5 lysosomal protein transmembrane 5 involved_in ISO (PMID:19787053) RGD PMID:19787053 NCBI chr 5:143,087,759...143,109,807
Ensembl chr 5:143,087,759...143,109,807 		JBrowse link
positive regulation of lysosome organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grn granulin precursor involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:28073925)
GO_REF:0000107
(MGI:5905514|PMID:28073925)		 UniProt
RGD
Ensembl		 PMID:28073925 GO_REF:0000024 GO_REF:0000107 MGI:5905514 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Irgm immunity-related GTPase M involved_in ISO (PMID:32753672) RGD PMID:32753672 NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578 		JBrowse link
G Mcoln1 mucolipin TRP cation channel 1 involved_in ISO (PMID:25720963) RGD PMID:25720963 NCBI chr12:1,560,341...1,574,252
Ensembl chr12:1,560,359...1,574,252 		JBrowse link
G Ppp3cb protein phosphatase 3 catalytic subunit beta involved_in ISO (PMID:25720963), (PMID:32753672) RGD PMID:25720963 PMID:32753672 NCBI chr15:3,759,950...3,804,976
Ensembl chr15:3,760,030...3,804,981 		JBrowse link
regulation of lysosomal lumen pH term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC681325 hypothetical protein LOC681325 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:74,312,698...74,316,311
Ensembl chr  X:74,312,661...74,316,635 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 involved_in ISO (PMID:22012985) RGD PMID:22012985 NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703 		JBrowse link
G Spns1 SPNS lysolipid transporter 1, lysophospholipid involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:36161949)		 Ensembl
RGD		 PMID:36161949 GO_REF:0000107 NCBI chr 1:180,942,088...180,949,415
Ensembl chr 1:180,942,088...180,949,370 		JBrowse link
G Tasl TLR adaptor interacting with endolysosomal SLC15A4 involved_in ISO
IBA		 (PMID:31001245)
GO_REF:0000033		 RGD
GO_Central		 PMID:31001245 GO_REF:0000033 NCBI chr  X:50,403,962...50,423,141
Ensembl chr  X:50,361,248...50,423,269 		JBrowse link
G Tmem165 transmembrane protein 165 involved_in ISO
ISS		 (PMID:23569283)
GO_REF:0000024		 RGD
UniProt		 PMID:23569283 GO_REF:0000024 NCBI chr14:31,993,489...32,018,717
Ensembl chr14:31,993,493...32,018,717 		JBrowse link
G Tmem175 transmembrane protein 175 involved_in ISS
ISO		 GO_REF:0000024
(PMID:35750034)
(MGI:5693670|PMID:26317472)		 UniProt
RGD		 PMID:26317472 PMID:35750034 GO_REF:0000024 MGI:5693670 NCBI chr14:1,073,410...1,089,764
Ensembl chr14:1,073,523...1,089,819 		JBrowse link
G Vps33a VPS33A core subunit of CORVET and HOPS complexes involved_in ISO
IEA
ISS		 (PMID:28013294)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:28013294 GO_REF:0000024 GO_REF:0000107 NCBI chr12:33,024,596...33,051,399
Ensembl chr12:33,024,650...33,051,393 		JBrowse link
regulation of lysosomal membrane permeability term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Laptm4b lysosomal protein transmembrane 4 beta involved_in ISO
IEA
ISS		 (PMID:26280656)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:26280656 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:65,434,525...65,477,386
Ensembl chr 7:65,434,394...65,477,383 		JBrowse link
regulation of lysosome organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grn granulin precursor acts_upstream_of_or_within ISO MGI:3762618 (PMID:28728022) RGD PMID:28728022 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Laptm4b lysosomal protein transmembrane 4 beta involved_in ISO
IEA
ISS		 (PMID:26280656)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:26280656 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:65,434,525...65,477,386
Ensembl chr 7:65,434,394...65,477,383 		JBrowse link
G Tmem106b transmembrane protein 106B acts_upstream_of_or_within ISO MGI:5319917 (PMID:28728022) RGD PMID:28728022 NCBI chr 4:41,328,125...41,347,315
Ensembl chr 4:41,327,994...41,345,619 		JBrowse link
G Trex1 three prime repair exonuclease 1 acts_upstream_of_or_within ISO MGI:3052754 (PMID:23160154) RGD PMID:23160154 NCBI chr 8:109,706,613...109,707,913
Ensembl chr 8:109,706,613...109,708,796 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20115
    cellular process 18524
      cellular component organization or biogenesis 7070
        cellular component organization 6819
          organelle organization 3726
            vacuole organization 228
              lytic vacuole organization 95
                lysosome organization 95
                  lysosomal membrane organization + 6
                  negative regulation of lysosome organization 4
                  phagolysosome assembly + 17
                  positive regulation of lysosome organization 4
                  regulation of lysosomal lumen pH + 23
                  regulation of lysosome organization + 11
paths to the root