Tpp1 (tripeptidyl peptidase 1) - Rat Genome Database

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Gene: Tpp1 (tripeptidyl peptidase 1) Rattus norvegicus
Analyze
Symbol: Tpp1
Name: tripeptidyl peptidase 1
RGD ID: 621296
Description: Enables endopeptidase activity; peptide binding activity; and tripeptidyl-peptidase activity. Involved in protein catabolic process. Predicted to be located in several cellular components, including lysosome; membrane raft; and recycling endosome. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 7 and neuronal ceroid lipofuscinosis 2. Orthologous to human TPP1 (tripeptidyl peptidase 1); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ceroid-lipofuscinosis, neuronal 2; Cln2; TPP-1; TPP-I; tripeptidyl aminopeptidase; tripeptidyl peptidase I; tripeptidyl-peptidase 1; tripeptidyl-peptidase I
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81169,509,816 - 169,515,939 (-)NCBIGRCr8
mRatBN7.21160,097,984 - 160,104,108 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1160,096,833 - 160,104,129 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1168,120,535 - 168,126,656 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01175,306,532 - 175,312,653 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01168,208,290 - 168,214,411 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01170,588,036 - 170,594,159 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1170,588,035 - 170,594,168 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01177,592,725 - 177,600,011 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41163,490,394 - 163,496,517 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11163,585,870 - 163,591,994 (-)NCBI
Celera1158,029,903 - 158,035,938 (-)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-bromohexadecanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-tert-Octylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
alpha,alpha-trehalose  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
dorsomorphin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenamidone  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
gentamycin  (EXP,ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
methyl methanesulfonate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosomorpholine  (EXP)
nickel atom  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-tert-Amylphenol  (EXP)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
pirimiphos-methyl  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
Propiverine  (EXP)
quercetin  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
Yessotoxin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
Golgi apparatus  (IEA,ISO,ISS)
lysosome  (IEA,ISO,ISS)
melanosome  (IEA)
membrane raft  (IEA,ISO,ISS)
recycling endosome  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Characterization of endopeptidase activity of tripeptidyl peptidase-I/CLN2 protein which is deficient in classical late infantile neuronal ceroid lipofuscinosis. Ezaki J, etal., Biochem Biophys Res Commun. 2000 Feb 24;268(3):904-8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice. Gupta P, etal., Proc Natl Acad Sci U S A 2001 Nov 20;98(24):13566-71.
4. Genetical studies of low plasma alkaline phosphatase (ALP) activity in the IS strain of rats. Maekawa R, etal., Jikken Dobutsu 1982 Jan;31(1):13-9.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Association of mutations in a lysosomal protein with classical late-infantile neuronal ceroid lipofuscinosis. Sleat DE, etal., Science 1997 Sep 19;277(5333):1802-5.
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
14. A model of tripeptidyl-peptidase I (CLN2), a ubiquitous and highly conserved member of the sedolisin family of serine-carboxyl peptidases. Wlodawer A, etal., BMC Struct Biol. 2003 Nov 11;3:8.
Additional References at PubMed
PMID:8215436   PMID:9659384   PMID:9989590   PMID:10617131   PMID:10965052   PMID:11054422   PMID:12134079   PMID:14651853   PMID:15158442   PMID:15317752   PMID:15483130   PMID:17237713  
PMID:18317235   PMID:19056867   PMID:19941651   PMID:20404094   PMID:21492153   PMID:23376485   PMID:23533145   PMID:24841565   PMID:25636608   PMID:27263093   PMID:31533043   PMID:35805162  


Genomics

Comparative Map Data
Tpp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81169,509,816 - 169,515,939 (-)NCBIGRCr8
mRatBN7.21160,097,984 - 160,104,108 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1160,096,833 - 160,104,129 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1168,120,535 - 168,126,656 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01175,306,532 - 175,312,653 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01168,208,290 - 168,214,411 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01170,588,036 - 170,594,159 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1170,588,035 - 170,594,168 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01177,592,725 - 177,600,011 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41163,490,394 - 163,496,517 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11163,585,870 - 163,591,994 (-)NCBI
Celera1158,029,903 - 158,035,938 (-)NCBICelera
Cytogenetic Map1q32NCBI
TPP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38116,612,768 - 6,619,422 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl116,612,768 - 6,619,448 (-)EnsemblGRCh38hg38GRCh38
GRCh37116,633,999 - 6,640,653 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36116,590,573 - 6,597,268 (-)NCBINCBI36Build 36hg18NCBI36
Celera116,753,063 - 6,759,757 (-)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef116,292,929 - 6,299,623 (-)NCBIHuRef
CHM1_1116,632,898 - 6,639,593 (-)NCBICHM1_1
T2T-CHM13v2.0116,671,236 - 6,677,889 (-)NCBIT2T-CHM13v2.0
Tpp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397105,394,018 - 105,401,489 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7105,394,018 - 105,401,442 (-)EnsemblGRCm39 Ensembl
GRCm387105,744,811 - 105,752,282 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7105,744,811 - 105,752,235 (-)EnsemblGRCm38mm10GRCm38
MGSCv377112,893,361 - 112,900,721 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367105,618,668 - 105,626,028 (-)NCBIMGSCv36mm8
Celera7106,016,147 - 106,023,505 (-)NCBICelera
Cytogenetic Map7E3NCBI
cM Map755.97NCBI
Tpp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541422,324,856 - 22,330,912 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541422,324,847 - 22,330,912 (-)NCBIChiLan1.0ChiLan1.0
TPP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v299,049,953 - 9,056,684 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1119,013,770 - 9,020,494 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0116,744,815 - 6,751,556 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1116,427,516 - 6,434,222 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl116,427,522 - 6,434,222 (-)Ensemblpanpan1.1panPan2
TPP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12129,921,764 - 29,926,974 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2129,921,764 - 29,926,986 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2129,623,623 - 29,628,832 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02130,747,948 - 30,753,157 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2130,746,092 - 30,753,273 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12130,068,707 - 30,073,915 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02130,234,365 - 30,239,567 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02130,429,691 - 30,434,901 (-)NCBIUU_Cfam_GSD_1.0
Tpp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494755,998,722 - 56,005,618 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936842669,863 - 676,720 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936842669,869 - 676,706 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl93,135,642 - 3,143,404 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.193,135,580 - 3,143,408 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.293,792,812 - 3,800,637 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TPP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1158,205,999 - 58,211,743 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl158,206,072 - 58,210,945 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038156,031,787 - 156,038,501 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tpp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248178,104,939 - 8,111,035 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248178,104,934 - 8,111,049 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tpp1
14 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:497
Count of miRNA genes:237
Interacting mature miRNAs:281
Transcripts:ENSRNOT00000026280
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1123556856242907031Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1117917486196963478Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1136745990163747690Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144267916172949660Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144267916174133260Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1582204Livw1Liver weight QTL 13.60.0003liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)1155422851172949803Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
8693608Alc24Alcohol consumption QTL 242.30.74drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1150452391168228760Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1123556856196963478Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1156677124176484451Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat

Markers in Region
D1Bda72  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81169,513,425 - 169,513,977 (+)Marker Load Pipeline
mRatBN7.21160,101,593 - 160,102,145 (+)MAPPERmRatBN7.2
Rnor_6.01170,591,646 - 170,592,197NCBIRnor6.0
Rnor_5.01177,597,498 - 177,598,049UniSTSRnor5.0
RGSC_v3.41163,494,004 - 163,494,555UniSTSRGSC3.4
Celera1158,033,425 - 158,033,976UniSTS
Cytogenetic Map1q33UniSTS
AW107731  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21160,098,383 - 160,098,574 (+)MAPPERmRatBN7.2
Rnor_6.01170,588,436 - 170,588,626NCBIRnor6.0
Rnor_5.01177,594,288 - 177,594,478UniSTSRnor5.0
RGSC_v3.41163,490,794 - 163,490,984UniSTSRGSC3.4
Celera1158,030,215 - 158,030,405UniSTS
Cytogenetic Map1q33UniSTS
UniSTS:496054  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81169,513,687 - 169,513,968 (+)Marker Load Pipeline
mRatBN7.21160,101,855 - 160,102,136 (+)MAPPERmRatBN7.2
Rnor_6.01170,591,908 - 170,592,188NCBIRnor6.0
Rnor_5.01177,597,760 - 177,598,040UniSTSRnor5.0
RGSC_v3.41163,494,266 - 163,494,546UniSTSRGSC3.4
Celera1158,033,687 - 158,033,967UniSTS
Cytogenetic Map1q33UniSTS
PCDH16_1801  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21160,104,936 - 160,105,822 (+)MAPPERmRatBN7.2
Rnor_6.01170,594,988 - 170,595,873NCBIRnor6.0
Rnor_5.01177,600,840 - 177,601,725UniSTSRnor5.0
RGSC_v3.41163,497,346 - 163,498,231UniSTSRGSC3.4
Celera1158,036,769 - 158,037,654UniSTS
Cytogenetic Map1q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000026280   ⟹   ENSRNOP00000026280
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1160,096,833 - 160,104,081 (-)Ensembl
Rnor_6.0 Ensembl1170,588,035 - 170,594,168 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105058   ⟹   ENSRNOP00000092024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1160,096,833 - 160,104,129 (-)Ensembl
RefSeq Acc Id: NM_031357   ⟹   NP_112647
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81169,509,816 - 169,515,939 (-)NCBI
mRatBN7.21160,097,984 - 160,104,108 (-)NCBI
Rnor_6.01170,588,036 - 170,594,159 (-)NCBI
Rnor_5.01177,592,725 - 177,600,011 (-)NCBI
RGSC_v3.41163,490,394 - 163,496,517 (-)RGD
Celera1158,029,903 - 158,035,938 (-)NCBI
Sequence:
RefSeq Acc Id: NP_112647   ⟸   NM_031357
- Peptide Label: precursor
- UniProtKB: Q9EQV6 (UniProtKB/Swiss-Prot),   Q642E6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026280   ⟸   ENSRNOT00000026280
Ensembl Acc Id: ENSRNOP00000092024   ⟸   ENSRNOT00000105058
Protein Domains
Peptidase S53   Peptidase S53 activation

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9EQV6-F1-model_v2 AlphaFold Q9EQV6 1-563 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690293
Promoter ID:EPDNEW_R818
Type:multiple initiation site
Name:Tpp1_1
Description:tripeptidyl peptidase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01170,594,183 - 170,594,243EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621296 AgrOrtholog
BioCyc Gene G2FUF-58007 BioCyc
Ensembl Genes ENSRNOG00000019212 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000026280 ENTREZGENE
Gene3D-CATH 3.40.50.200 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7107183 IMAGE-MGC_LOAD
InterPro Peptidase_S8/S53_dom UniProtKB/Swiss-Prot
  Peptidase_S8/S53_dom_sf UniProtKB/Swiss-Prot
  S53_propep UniProtKB/Swiss-Prot
  Sedolisin_dom UniProtKB/Swiss-Prot
  Tripeptidyl-peptidase_I UniProtKB/Swiss-Prot
KEGG Report rno:83534 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93364 IMAGE-MGC_LOAD
NCBI Gene 83534 ENTREZGENE
PANTHER PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2 UniProtKB/Swiss-Prot
  TRIPEPTIDYL-PEPTIDASE 1 UniProtKB/Swiss-Prot
Pfam Peptidase_S8 UniProtKB/Swiss-Prot
  Pro-kuma_activ UniProtKB/Swiss-Prot
PhenoGen Tpp1 PhenoGen
PROSITE SEDOLISIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019212 RatGTEx
SMART Pro-kuma_activ UniProtKB/Swiss-Prot
Superfamily-SCOP Protease propeptides/inhibitors UniProtKB/Swiss-Prot
  SSF52743 UniProtKB/Swiss-Prot
UniProt A0A8I6GJE9_RAT UniProtKB/TrEMBL
  A6I7N0_RAT UniProtKB/TrEMBL
  A6I7N2_RAT UniProtKB/TrEMBL
  A6I7N3_RAT UniProtKB/TrEMBL
  A6I7N4_RAT UniProtKB/TrEMBL
  A6I7N5_RAT UniProtKB/TrEMBL
  F7F942_RAT UniProtKB/TrEMBL
  Q642E6 ENTREZGENE, UniProtKB/TrEMBL
  Q9EQV6 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Tpp1  tripeptidyl peptidase 1  Tpp1  tripeptidyl peptidase I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Tpp1  tripeptidyl peptidase I  Cln2  ceroid-lipofuscinosis, neuronal 2  Symbol and Name updated 1299863 APPROVED
2005-01-20 Cln2  ceroid-lipofuscinosis, neuronal 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Cln2        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease mutation of the human homolog causes the lysosomal storage disease classic late infantile neuronal ceroid lipofuscinosis (CLN2) 1302340