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ONTOLOGY REPORT - ANNOTATIONS


Term:lung alveolus development
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Accession:GO:0048286 term browser browse the term
Definition:The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways.
Synonyms:exact_synonym: alveolarization;   alveologenesis



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lung alveolus development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca12 ATP binding cassette subfamily A member 12 NOT|acts_upstream_of_or_within ISO MGI:3528440 (MGI:3829841|PMID:18957418)
MGI:3809668 (MGI:3807143|PMID:18632686)
RGD PMID:18632686 PMID:18957418 MGI:3807143 MGI:3829841 NCBI chr 9:72,822,661...72,995,748
Ensembl chr 9:72,823,350...72,996,049
JBrowse link
G Ace angiotensin I converting enzyme IMP RGD PMID:22587910 RGD:6893470 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ada adenosine deaminase acts_upstream_of_or_within ISO MGI:1857117|MGI:2683027 (MGI:1861066|PMID:10899903) RGD PMID:10899903 MGI:1861066 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
JBrowse link
G Atp7a ATPase copper transporting alpha acts_upstream_of_or_within ISO MGI:1856097 (MGI:54141|PMID:937819) RGD PMID:937819 MGI:54141 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354
JBrowse link
G Atxn1 ataxin 1 acts_upstream_of_or_within ISO MGI:1918972|MGI:3694797 (MGI:5298126|PMID:22014525) RGD PMID:22014525 MGI:5298126 NCBI chr17:18,737,491...19,142,360
Ensembl chr17:18,737,533...19,142,360
JBrowse link
G Atxn1l ataxin 1-like acts_upstream_of_or_within ISO MGI:104783|MGI:1918972|MGI:5301616 (MGI:5298126|PMID:22014525) RGD PMID:22014525 MGI:5298126
G Bmp4 bone morphogenetic protein 4 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:8674409)
GO_REF:0000107
RGD
Ensembl
PMID:8674409 GO_REF:0000107 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 involved_in ISO (MGI:3799581|PMID:18552156) RGD PMID:18552156 MGI:3799581 NCBI chr 9:61,192,718...61,307,280
Ensembl chr 9:61,190,566...61,301,809
JBrowse link
G Cic capicua transcriptional repressor acts_upstream_of_or_within ISO MGI:104783|MGI:3694797|MGI:4125985 (MGI:5298126|PMID:22014525) RGD PMID:22014525 MGI:5298126 NCBI chr 1:80,853,920...80,880,537
Ensembl chr 1:80,853,920...80,880,532
JBrowse link
G Dbn1 drebrin 1 IEP RGD PMID:15928322 RGD:10398812 NCBI chr17:9,150,608...9,164,982
Ensembl chr17:9,150,659...9,164,984
JBrowse link
G Edn2 endothelin 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:5519239 (MGI:5514104|PMID:23676500)
Ensembl
RGD
PMID:23676500 GO_REF:0000107 MGI:5514104 NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:133,751,217...133,756,814
JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:4366137|PMID:19710174)
UniProt
RGD
PMID:19710174 GO_REF:0000024 MGI:4366137 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282
JBrowse link
G Fgf10 fibroblast growth factor 10 acts_upstream_of_or_within ISO MGI:3629660|MGI:95523 (MGI:3688953|PMID:16989802), (MGI:3716020|PMID:17560563) RGD PMID:16989802 PMID:17560563 MGI:3688953 MGI:3716020 NCBI chr 2:50,801,897...50,875,428
Ensembl chr 2:50,800,992...50,876,866
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 acts_upstream_of_or_within ISO MGI:1099809|MGI:3629660 (MGI:3688953|PMID:16989802) RGD PMID:16989802 MGI:3688953 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
JBrowse link
G Flt4 Fms related receptor tyrosine kinase 4 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1856694 (MGI:5582954|PMID:24733830)
Ensembl
RGD
PMID:24733830 GO_REF:0000107 MGI:5582954 NCBI chr10:33,913,725...33,954,770
Ensembl chr10:33,913,608...33,954,770
JBrowse link
G Foxf1 forkhead box F1 acts_upstream_of_or_within ISO MGI:1929432 (MGI:2135612|PMID:11493558) RGD PMID:11493558 MGI:2135612 NCBI chr19:49,153,729...49,157,741
Ensembl chr19:49,153,699...49,157,738
JBrowse link
G Foxp2 forkhead box P2 acts_upstream_of_or_within ISO MGI:3584266 (MGI:3710027|PMID:17428829) RGD PMID:17428829 MGI:3710027 NCBI chr 4:43,133,827...43,712,442
Ensembl chr 4:43,133,912...43,711,683
JBrowse link
G Fzd1 frizzled class receptor 1 IEP RGD PMID:17911382 RGD:2304247 NCBI chr 4:29,310,303...29,314,701 JBrowse link
G Gh1 growth hormone 1 IMP RGD PMID:18985281 RGD:2315627 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
JBrowse link
G Hopx HOP homeobox acts_upstream_of_or_within ISO MGI:2389244 (MGI:3709528|PMID:16510470) RGD PMID:16510470 MGI:3709528 NCBI chr14:31,055,912...31,082,909
Ensembl chr14:31,075,148...31,082,909
JBrowse link
G Hoxa5 homeo box A5 acts_upstream_of_or_within ISO MGI:2150397 (MGI:3606710|PMID:15295088), (MGI:3665532|PMID:17003488) RGD PMID:15295088 PMID:17003488 MGI:3606710 MGI:3665532 NCBI chr 4:81,302,341...81,306,234
Ensembl chr 4:81,302,353...81,306,234
JBrowse link
G Hs6st1 heparan sulfate 6-O-sulfotransferase 1 acts_upstream_of_or_within ISO MGI:3715259 (MGI:3715036|PMID:17405882) RGD PMID:17405882 MGI:3715036 NCBI chr 9:38,283,502...38,322,684
Ensembl chr 9:38,282,395...38,322,683
JBrowse link
G Igf1 insulin-like growth factor 1 acts_upstream_of_or_within ISO MGI:1926485|MGI:96787 (MGI:3640953|PMID:16691571) RGD PMID:16691571 MGI:3640953 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 involved_in ISO (MGI:3039207|PMID:15010534) RGD PMID:15010534 MGI:3039207 NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156
JBrowse link
G Itgb6 integrin subunit beta 6 acts_upstream_of_or_within ISO MGI:1926484 (MGI:3040752|PMID:12634787) RGD PMID:12634787 MGI:3040752 NCBI chr 3:45,046,295...45,170,532
Ensembl chr 3:45,048,044...45,121,671
JBrowse link
G Kdr kinase insert domain receptor acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2181852|PMID:12053176)
GO_REF:0000107
RGD
Ensembl
PMID:12053176 GO_REF:0000107 MGI:2181852 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Lif LIF, interleukin 6 family cytokine involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:96432 (MGI:3640953|PMID:16691571)
Ensembl
RGD
PMID:16691571 GO_REF:0000107 MGI:3640953 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
JBrowse link
G LOC103694328 alanine and glycine-rich protein-like involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr19:37,700,341...37,711,524
Ensembl chr19:37,700,106...37,711,538
JBrowse link
G Man1a2 mannosidase, alpha, class 1A, member 2 acts_upstream_of_or_within ISO MGI:3703789 (MGI:3703634|PMID:17121831) RGD PMID:17121831 MGI:3703634 NCBI chr 2:187,947,484...188,096,332
Ensembl chr 2:187,951,617...188,096,332
JBrowse link
G Man2a1 mannosidase, alpha, class 2A, member 1 acts_upstream_of_or_within ISO MGI:2150656 (MGI:3652665|PMID:16754854) RGD PMID:16754854 MGI:3652665 NCBI chr 9:104,252,001...104,408,349
Ensembl chr 9:104,252,001...104,408,349
JBrowse link
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 acts_upstream_of_or_within ISO MGI:3527900 (MGI:3796918|PMID:18324732) RGD PMID:18324732 MGI:3796918 NCBI chr10:13,918,417...13,958,335
Ensembl chr10:13,918,400...13,958,273
JBrowse link
G Mecp2 methyl CpG binding protein 2 IEP RGD PMID:21425435 RGD:8552971 NCBI chr  X:151,781,177...151,844,687
Ensembl chr  X:151,789,930...151,844,689
JBrowse link
G Mmp12 matrix metallopeptidase 12 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2386174 (MGI:3040752|PMID:12634787)
Ensembl
RGD
PMID:12634787 GO_REF:0000107 MGI:3040752 NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611
JBrowse link
G Myocd myocardin involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3052940 (MGI:4941650|PMID:21357509)
Ensembl
RGD
PMID:21357509 GO_REF:0000107 MGI:4941650 NCBI chr10:49,833,219...49,928,806
Ensembl chr10:49,836,641...49,927,627
JBrowse link
G Nkiras1 NFKB inhibitor interacting Ras-like 1 acts_upstream_of_or_within ISO MGI:1919216 (MGI:6274062|PMID:25220458) RGD PMID:25220458 MGI:6274062 NCBI chr15:7,492,806...7,503,828
Ensembl chr15:7,493,531...7,503,854
JBrowse link
G Nkiras2 NFKB inhibitor interacting Ras-like 2 acts_upstream_of_or_within ISO MGI:1916971 (MGI:6274062|PMID:25220458) RGD PMID:25220458 MGI:6274062 NCBI chr10:85,554,704...85,562,072
Ensembl chr10:85,557,944...85,562,072
JBrowse link
G Pdgfa platelet derived growth factor subunit A involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
(MGI:1098909|PMID:9374392)
MGI:1926817|MGI:5548172 (MGI:3622881|PMID:11803579), (MGI:5543868|PMID:23938297)
UniProt
RGD
PMID:9374392 PMID:11803579 PMID:23938297 GO_REF:0000024 MGI:1098909 MGI:3622881 MGI:5543868 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497
JBrowse link
G Pdpn podoplanin acts_upstream_of_or_within ISO MGI:2657021 (MGI:3703126|PMID:16869965) RGD PMID:16869965 MGI:3703126 NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656
JBrowse link
G Pgr progesterone receptor involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3032652 (MGI:5576858|PMID:24190884)
Ensembl
RGD
PMID:24190884 GO_REF:0000107 MGI:5576858 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Phf14 PHD finger protein 14 acts_upstream_of_or_within ISO MGI:5426539 (MGI:5426441|PMID:22730381) RGD PMID:22730381 MGI:5426441 NCBI chr 4:40,009,691...40,195,870
Ensembl chr 4:40,009,264...40,195,885
JBrowse link
G Pkdcc protein kinase domain containing, cytoplasmic involved_in ISO (MGI:4438146|PMID:19465597) RGD PMID:19465597 MGI:4438146 NCBI chr 6:11,455,686...11,465,002
Ensembl chr 6:11,455,686...11,465,556
JBrowse link
G Psen2 presenilin 2 acts_upstream_of_or_within ISO MGI:2149117 (MGI:1346745|PMID:10518543) RGD PMID:10518543 MGI:1346745 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174
JBrowse link
G Pthlh parathyroid hormone-like hormone acts_upstream_of_or_within ISO MGI:2154515 (MGI:3042805|PMID:15162506) RGD PMID:15162506 MGI:3042805 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 acts_upstream_of_or_within ISO MGI:4364357 (MGI:5486592|PMID:23583643) RGD PMID:23583643 MGI:5486592 NCBI chr 3:21,121,531...21,186,711
Ensembl chr 3:21,110,679...21,179,933
JBrowse link
G Selenon selenoprotein N acts_upstream_of_or_within ISO (MGI:5494499|PMID:23325319) RGD PMID:23325319 MGI:5494499 NCBI chr 5:146,748,638...146,764,656
Ensembl chr 5:146,748,652...146,763,059
JBrowse link
G Sftpd surfactant protein D involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:9751757)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:9751757 GO_REF:0000024 GO_REF:0000107 NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927
JBrowse link
G Slc7a11 solute carrier family 7 member 11 acts_upstream_of_or_within ISO MGI:3608695 (MGI:5469541|PMID:23085521) RGD PMID:23085521 MGI:5469541 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Slfn4 schlafen family member 4 IEP RGD PMID:17911382 RGD:2304247 NCBI chr10:67,994,601...68,018,141
Ensembl chr10:68,000,028...68,018,138
Ensembl chr10:68,000,028...68,018,138
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1856877 (MGI:5469952|PMID:22945695)
Ensembl
RGD
PMID:22945695 GO_REF:0000107 MGI:5469952 NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749
JBrowse link
G Sox2 SRY-box transcription factor 2 acts_upstream_of_or_within ISO (MGI:3795352|PMID:18374910) RGD PMID:18374910 MGI:3795352 NCBI chr 2:117,536,929...117,539,338
Ensembl chr 2:117,536,929...117,539,338
JBrowse link
G Stk40 serine/threonine kinase 40 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:5496282 (MGI:5486391|PMID:23293024)
Ensembl
RGD
PMID:23293024 GO_REF:0000107 MGI:5486391 NCBI chr 5:138,380,049...138,417,802
Ensembl chr 5:138,381,159...138,417,796
JBrowse link
G Stra6 signaling receptor and transporter of retinol STRA6 involved_in ISO (PMID:17273977) RGD PMID:17273977 NCBI chr 8:58,549,743...58,568,861
Ensembl chr 8:58,549,736...58,568,860
JBrowse link
G Tcf21 transcription factor 21 involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
MGI:2148207 (MGI:1347485|PMID:10572052)
UniProt
RGD
PMID:10572052 GO_REF:0000024 MGI:1347485 NCBI chr 1:22,701,353...22,704,212
Ensembl chr 1:22,701,353...22,704,202
JBrowse link
G Tgfb1 transforming growth factor, beta 1 acts_upstream_of_or_within ISO (MGI:3040752|PMID:12634787) RGD PMID:12634787 MGI:3040752 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfb3 transforming growth factor, beta 3 involved_in ISO (MGI:77427|PMID:7493022) RGD PMID:7493022 MGI:77427 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
JBrowse link
G Tmem38b transmembrane protein 38B acts_upstream_of_or_within ISO MGI:3716065 (MGI:3850579|PMID:19515693) RGD PMID:19515693 MGI:3850579 NCBI chr 5:68,460,304...68,496,026
Ensembl chr 5:68,460,304...68,496,025
JBrowse link
G Tmtc3 transmembrane O-mannosyltransferase targeting cadherins 3 acts_upstream_of_or_within ISO MGI:4124060 (MGI:5300435|PMID:21956870) RGD PMID:21956870 MGI:5300435 NCBI chr 7:35,264,886...35,310,010
Ensembl chr 7:35,264,892...35,310,385
JBrowse link
G Tns3 tensin 3 acts_upstream_of_or_within ISO MGI:3574415 (MGI:3531231|PMID:15733665) RGD PMID:15733665 MGI:3531231 NCBI chr14:83,173,649...83,405,671
Ensembl chr14:83,173,649...83,405,998
JBrowse link
G Vegfa vascular endothelial growth factor A IMP RGD PMID:16230500 RGD:1580552 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Wnt5a Wnt family member 5A IEP RGD PMID:17911382 RGD:2304247 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234
JBrowse link
G Zfp157 zinc finger protein 157 acts_upstream_of_or_within ISO MGI:4124834 (MGI:5424261|PMID:22588720) RGD PMID:22588720 MGI:5424261 NCBI chr12:16,248,230...16,279,459
Ensembl chr12:16,248,230...16,270,698
JBrowse link
alveolar primary septum development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Stra6 signaling receptor and transporter of retinol STRA6 involved_in ISO
IEA
(PMID:17273977)
GO_REF:0000107
RGD
Ensembl
PMID:17273977 GO_REF:0000107 NCBI chr 8:58,549,743...58,568,861
Ensembl chr 8:58,549,736...58,568,860
JBrowse link
alveolar secondary septum development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgfr3 fibroblast growth factor receptor 3 acts_upstream_of_or_within ISO MGI:95525 (MGI:1309575|PMID:9716527) RGD PMID:9716527 MGI:1309575 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341
JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 acts_upstream_of_or_within ISO MGI:95524 (MGI:1309575|PMID:9716527) RGD PMID:9716527 MGI:1309575 NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242
JBrowse link
G Foxa1 forkhead box A1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2653543 (MGI:3613241|PMID:16214823)
Ensembl
RGD
PMID:16214823 GO_REF:0000107 MGI:3613241 NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188
JBrowse link
lung saccule development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asxl1 ASXL transcriptional regulator 1 acts_upstream_of_or_within ISO MGI:4431878 (MGI:5585348|PMID:24860998) RGD PMID:24860998 MGI:5585348 NCBI chr 3:141,814,012...141,881,526
Ensembl chr 3:141,813,433...141,881,538
JBrowse link
G Creb1 cAMP responsive element binding protein 1 acts_upstream_of_or_within ISO MGI:4999627 (MGI:4950818|PMID:21408140) RGD PMID:21408140 MGI:4950818 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Fgf10 fibroblast growth factor 10 involved_in ISO (PMID:17071719) RGD PMID:17071719 NCBI chr 2:50,801,897...50,875,428
Ensembl chr 2:50,800,992...50,876,866
JBrowse link
G Gata6 GATA binding protein 6 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:108067 (MGI:3695537|PMID:17164424)
Ensembl
RGD
PMID:17164424 GO_REF:0000107 MGI:3695537 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532
JBrowse link
G Ltbp3 latent transforming growth factor beta binding protein 3 acts_upstream_of_or_within ISO MGI:2180017 (MGI:3584290|PMID:16049328) RGD PMID:16049328 MGI:3584290 NCBI chr 1:203,029,412...203,045,975
Ensembl chr 1:203,029,877...203,045,975
JBrowse link
G Nkx2-1 NK2 homeobox 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:107516 (MGI:3695537|PMID:17164424)
Ensembl
RGD
PMID:17164424 GO_REF:0000107 MGI:3695537 NCBI chr 6:73,996,601...74,001,483
Ensembl chr 6:73,996,601...73,999,791
JBrowse link
G Ptges3 prostaglandin E synthase 3 acts_upstream_of_or_within ISO MGI:3701300 (MGI:3714109|PMID:17438133) RGD PMID:17438133 MGI:3714109 NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084
JBrowse link
positive regulation of lung alveolus development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Epas1 endothelial PAS domain protein 1 IEP RGD PMID:23962064 RGD:10395379 NCBI chr 6:7,790,236...7,871,246
Ensembl chr 6:7,790,647...7,871,228
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19834
    developmental process 6965
      anatomical structure development 6376
        lung alveolus development 71
          lung saccule development + 11
          negative regulation of lung alveolus development 0
          positive regulation of lung alveolus development 1
          regulation of lung alveolus development + 1
Path 2
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  biological_process 19834
    developmental process 6965
      anatomical structure development 6376
        multicellular organism development 5800
          system development 5439
            animal organ development 4194
              respiratory tube development 274
                lung development 271
                  lung alveolus development 71
                    lung saccule development + 11
                    negative regulation of lung alveolus development 0
                    positive regulation of lung alveolus development 1
                    regulation of lung alveolus development + 1
paths to the root