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ONTOLOGY REPORT - ANNOTATIONS


Term:lung alveolus development
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Accession:GO:0048286 term browser browse the term
Definition:The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways.
Synonyms:exact_synonym: alveolarization;   alveologenesis



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lung alveolus development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca12 ATP binding cassette subfamily A member 12 NOT|acts_upstream_of_or_within ISO MGI:3528440 (PMID:18957418)
MGI:3809668 (PMID:18632686)
RGD PMID:18632686 PMID:18957418 NCBI chr 9:72,822,661...72,995,748
Ensembl chr 9:72,823,350...72,996,049
JBrowse link
G Ace angiotensin I converting enzyme IMP RGD PMID:22587910 RGD:6893470 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ada adenosine deaminase involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857117|MGI:2683027 (PMID:10899903)
Ensembl
RGD
PMID:10899903 GO_REF:0000107 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
JBrowse link
G Atp7a ATPase copper transporting alpha acts_upstream_of_or_within ISO MGI:1856097 (PMID:937819) RGD PMID:937819 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354
JBrowse link
G Atxn1 ataxin 1 acts_upstream_of_or_within ISO MGI:1918972|MGI:3694797 (PMID:22014525) RGD PMID:22014525 NCBI chr17:18,737,491...19,142,360
Ensembl chr17:18,737,533...19,142,360
JBrowse link
G Atxn1l ataxin 1 like acts_upstream_of_or_within ISO MGI:104783|MGI:1918972|MGI:5301616 (PMID:22014525) RGD PMID:22014525 NCBI chr19:37,700,341...37,711,529
Ensembl chr19:37,700,106...37,711,538
JBrowse link
G Bloc1s6 biogenesis of lysosomal organelles complex 1 subunit 6 acts_upstream_of_or_within ISO MGI:1856982 (PMID:16439805), (PMID:19381131) RGD PMID:16439805 PMID:19381131 NCBI chr 3:109,816,397...109,826,528
Ensembl chr 3:109,816,366...109,828,308
JBrowse link
G Bmp4 bone morphogenetic protein 4 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:8674409)
GO_REF:0000107
RGD
Ensembl
PMID:8674409 GO_REF:0000107 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 involved_in ISO (MGI:3799581|PMID:18552156) RGD PMID:18552156 MGI:3799581 NCBI chr 9:61,192,718...61,307,280
Ensembl chr 9:61,190,566...61,301,809
JBrowse link
G Cic capicua transcriptional repressor acts_upstream_of_or_within ISO MGI:104783|MGI:3694797|MGI:4125985 (PMID:22014525) RGD PMID:22014525 NCBI chr 1:80,853,920...80,880,537
Ensembl chr 1:80,853,920...80,880,532
JBrowse link
G Cldn18 claudin 18 involved_in ISO (MGI:5775869|PMID:24787463) RGD PMID:24787463 MGI:5775869 NCBI chr 8:100,246,499...100,265,797
Ensembl chr 8:100,247,633...100,273,351
JBrowse link
G Col6a1 collagen type VI alpha 1 chain acts_upstream_of_or_within ISO MGI:2153356 (PMID:31837950) RGD PMID:31837950 NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597
JBrowse link
G Dbn1 drebrin 1 IEP RGD PMID:15928322 RGD:10398812 NCBI chr17:9,150,608...9,164,982
Ensembl chr17:9,150,659...9,164,984
JBrowse link
G Edn2 endothelin 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:5519239 (PMID:23676500)
Ensembl
RGD
PMID:23676500 GO_REF:0000107 NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:133,751,217...133,756,814
JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:4366137|PMID:19710174)
UniProt
Ensembl
RGD
PMID:19710174 GO_REF:0000024 GO_REF:0000107 MGI:4366137 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282
JBrowse link
G Fbn1 fibrillin 1 acts_upstream_of_or_within ISO MGI:1857348 (PMID:16439805) RGD PMID:16439805 NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889
JBrowse link
G Fgf10 fibroblast growth factor 10 acts_upstream_of_or_within ISO MGI:3629660|MGI:95523 (PMID:16989802), (PMID:17560563) RGD PMID:16989802 PMID:17560563 NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 acts_upstream_of_or_within ISO MGI:1099809|MGI:3629660 (PMID:16989802) RGD PMID:16989802 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
JBrowse link
G Flt4 Fms related receptor tyrosine kinase 4 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1856694 (PMID:24733830)
Ensembl
RGD
PMID:24733830 GO_REF:0000107 NCBI chr10:33,913,725...33,954,770
Ensembl chr10:33,913,608...33,954,770
JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit acts_upstream_of_or_within ISO (PMID:28818870) RGD PMID:28818870 NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034
JBrowse link
G Foxf1 forkhead box F1 acts_upstream_of_or_within ISO MGI:1929432 (PMID:11493558) RGD PMID:11493558 NCBI chr19:49,153,949...49,157,741
Ensembl chr19:49,153,699...49,157,738
JBrowse link
G Foxp2 forkhead box P2 acts_upstream_of_or_within ISO MGI:3584266 (PMID:17428829) RGD PMID:17428829 NCBI chr 4:43,133,827...43,712,442
Ensembl chr 4:43,133,912...43,711,683
JBrowse link
G Fzd1 frizzled class receptor 1 IEP RGD PMID:17911382 RGD:2304247 NCBI chr 4:29,310,303...29,314,701
Ensembl chr 4:29,310,091...29,312,643
Ensembl chr 4:29,310,091...29,312,643
JBrowse link
G Gh1 growth hormone 1 IMP RGD PMID:18985281 RGD:2315627 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
JBrowse link
G Hopx HOP homeobox acts_upstream_of_or_within ISO MGI:2389244 (PMID:16510470) RGD PMID:16510470 NCBI chr14:31,055,912...31,082,909
Ensembl chr14:31,075,148...31,082,909
JBrowse link
G Hoxa5 homeo box A5 acts_upstream_of_or_within ISO MGI:2150397 (PMID:15295088), (PMID:17003488) RGD PMID:15295088 PMID:17003488 NCBI chr 4:81,302,341...81,306,234
Ensembl chr 4:81,302,353...81,306,234
JBrowse link
G Hs6st1 heparan sulfate 6-O-sulfotransferase 1 acts_upstream_of_or_within ISO MGI:3715259 (PMID:17405882) RGD PMID:17405882 NCBI chr 9:38,283,502...38,322,684
Ensembl chr 9:38,282,395...38,322,683
JBrowse link
G Igf1 insulin-like growth factor 1 acts_upstream_of_or_within ISO MGI:1926485|MGI:96787 (PMID:16691571) RGD PMID:16691571 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 involved_in ISO (MGI:3039207|PMID:15010534) RGD PMID:15010534 MGI:3039207 NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156
JBrowse link
G Itgb6 integrin subunit beta 6 acts_upstream_of_or_within ISO MGI:1926484 (PMID:12634787) RGD PMID:12634787 NCBI chr 3:45,046,295...45,170,532
Ensembl chr 3:45,048,044...45,121,671
JBrowse link
G Kdr kinase insert domain receptor involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:12053176)
Ensembl
RGD
PMID:12053176 GO_REF:0000107 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Lif LIF, interleukin 6 family cytokine acts_upstream_of_or_within ISO MGI:96432 (PMID:16691571) RGD PMID:16691571 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
JBrowse link
G Man1a2 mannosidase, alpha, class 1A, member 2 acts_upstream_of_or_within ISO MGI:3703789 (PMID:17121831) RGD PMID:17121831 NCBI chr 2:187,947,484...188,096,332
Ensembl chr 2:187,951,617...188,096,332
JBrowse link
G Man2a1 mannosidase, alpha, class 2A, member 1 acts_upstream_of_or_within ISO MGI:2150656 (PMID:16754854) RGD PMID:16754854 NCBI chr 9:104,252,001...104,408,349
Ensembl chr 9:104,252,001...104,408,349
JBrowse link
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3527900 (PMID:18324732)
Ensembl
RGD
PMID:18324732 GO_REF:0000107 NCBI chr10:13,918,417...13,958,335
Ensembl chr10:13,918,400...13,958,273
JBrowse link
G Mecp2 methyl CpG binding protein 2 IEP RGD PMID:21425435 RGD:8552971 NCBI chr  X:151,781,177...151,844,687
Ensembl chr  X:151,789,930...151,844,689
JBrowse link
G Meg3 maternally expressed 3 acts_upstream_of_or_within ISO MGI:3842511 (PMID:19264764) RGD PMID:19264764 NCBI chr 6:128,491,808...128,524,010 JBrowse link
G Mmp12 matrix metallopeptidase 12 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2386174 (PMID:12634787)
Ensembl
RGD
PMID:12634787 GO_REF:0000107 NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611
JBrowse link
G Myocd myocardin involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3052940 (PMID:21357509)
Ensembl
RGD
PMID:21357509 GO_REF:0000107 NCBI chr10:49,833,219...49,928,806
Ensembl chr10:49,836,641...49,927,627
JBrowse link
G Nkiras1 NFKB inhibitor interacting Ras-like 1 acts_upstream_of_or_within ISO MGI:1919216 (PMID:25220458) RGD PMID:25220458 NCBI chr15:7,493,531...7,503,758
Ensembl chr15:7,493,531...7,503,854
JBrowse link
G Nkiras2 NFKB inhibitor interacting Ras-like 2 acts_upstream_of_or_within ISO MGI:1916971 (PMID:25220458) RGD PMID:25220458 NCBI chr10:85,554,704...85,562,072
Ensembl chr10:85,557,944...85,562,072
JBrowse link
G Pdgfa platelet derived growth factor subunit A involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
MGI:1926817|MGI:5548172 (PMID:11803579), (PMID:23938297)
(MGI:1098909|PMID:9374392)
UniProt
RGD
PMID:9374392 PMID:11803579 PMID:23938297 GO_REF:0000024 MGI:1098909 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497
JBrowse link
G Pdpn podoplanin acts_upstream_of_or_within ISO MGI:2657021 (PMID:16869965) RGD PMID:16869965 NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656
JBrowse link
G Pgr progesterone receptor involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3032652 (PMID:24190884)
Ensembl
RGD
PMID:24190884 GO_REF:0000107 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Phf14 PHD finger protein 14 acts_upstream_of_or_within ISO MGI:5426539 (PMID:22730381) RGD PMID:22730381 NCBI chr 4:40,009,691...40,195,877
Ensembl chr 4:40,009,264...40,195,885
JBrowse link
G Pkdcc protein kinase domain containing, cytoplasmic involved_in ISO (MGI:4438146|PMID:19465597) RGD PMID:19465597 MGI:4438146 NCBI chr 6:11,455,686...11,465,002
Ensembl chr 6:11,455,686...11,465,556
JBrowse link
G Psen2 presenilin 2 acts_upstream_of_or_within ISO MGI:2149117 (PMID:10518543) RGD PMID:10518543 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174
JBrowse link
G Pthlh parathyroid hormone-like hormone acts_upstream_of_or_within ISO MGI:2154515 (PMID:15162506) RGD PMID:15162506 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 acts_upstream_of_or_within ISO MGI:4364357 (PMID:23583643) RGD PMID:23583643 NCBI chr 3:21,121,531...21,186,711
Ensembl chr 3:21,110,679...21,179,933
JBrowse link
G Selenon selenoprotein N acts_upstream_of_or_within ISO (PMID:23325319) RGD PMID:23325319 NCBI chr 5:146,748,638...146,764,656
Ensembl chr 5:146,748,652...146,763,059
JBrowse link
G Sftpd surfactant protein D involved_in ISS
ISO
GO_REF:0000024
(PMID:9751757)
UniProt
RGD
PMID:9751757 GO_REF:0000024 NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927
JBrowse link
G Slc7a11 solute carrier family 7 member 11 acts_upstream_of_or_within ISO MGI:3608695 (PMID:23085521) RGD PMID:23085521 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Slfn4 schlafen family member 4 IEP RGD PMID:17911382 RGD:2304247 NCBI chr10:67,994,601...68,018,141
Ensembl chr10:68,000,028...68,018,138
Ensembl chr10:68,000,028...68,018,138
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1856877 (PMID:22945695)
Ensembl
RGD
PMID:22945695 GO_REF:0000107 NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749
JBrowse link
G Sox2 SRY-box transcription factor 2 acts_upstream_of_or_within ISO (PMID:18374910) RGD PMID:18374910 NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338
JBrowse link
G Stk40 serine/threonine kinase 40 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:5496282 (PMID:23293024)
Ensembl
RGD
PMID:23293024 GO_REF:0000107 NCBI chr 5:138,380,049...138,417,802
Ensembl chr 5:138,381,159...138,417,796
JBrowse link
G Stra6 signaling receptor and transporter of retinol STRA6 involved_in ISO (PMID:17273977) RGD PMID:17273977 NCBI chr 8:58,548,899...58,568,861
Ensembl chr 8:58,549,736...58,568,860
JBrowse link
G Tcf21 transcription factor 21 involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
MGI:2148207 (PMID:10572052)
UniProt
RGD
PMID:10572052 GO_REF:0000024 NCBI chr 1:22,701,353...22,704,212
Ensembl chr 1:22,701,353...22,704,202
JBrowse link
G Tgfb1 transforming growth factor, beta 1 acts_upstream_of_or_within ISO (PMID:12634787) RGD PMID:12634787 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfb3 transforming growth factor, beta 3 involved_in ISO (MGI:77427|PMID:7493022) RGD PMID:7493022 MGI:77427 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
JBrowse link
G Tmem38b transmembrane protein 38B acts_upstream_of_or_within ISO MGI:3716065 (PMID:19515693) RGD PMID:19515693 NCBI chr 5:68,460,304...68,496,026
Ensembl chr 5:68,460,304...68,496,025
JBrowse link
G Tmtc3 transmembrane O-mannosyltransferase targeting cadherins 3 acts_upstream_of_or_within ISO MGI:4124060 (PMID:21956870) RGD PMID:21956870 NCBI chr 7:35,264,886...35,310,010
Ensembl chr 7:35,264,892...35,310,385
JBrowse link
G Tns3 tensin 3 acts_upstream_of_or_within ISO MGI:3574415 (PMID:15733665) RGD PMID:15733665 NCBI chr14:83,173,649...83,405,671
Ensembl chr14:83,173,649...83,405,998
JBrowse link
G Vegfa vascular endothelial growth factor A IMP RGD PMID:16230500 RGD:1580552 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Wnt5a Wnt family member 5A IEP RGD PMID:17911382 RGD:2304247 NCBI chr16:3,697,032...3,718,230
Ensembl chr16:3,697,032...3,718,234
JBrowse link
G Zfp157 zinc finger protein 157 acts_upstream_of_or_within ISO MGI:4124834 (PMID:22588720) RGD PMID:22588720 NCBI chr12:16,248,230...16,279,459
Ensembl chr12:16,248,230...16,270,698
JBrowse link
alveolar primary septum development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Stra6 signaling receptor and transporter of retinol STRA6 involved_in ISO
IEA
(PMID:17273977)
GO_REF:0000107
RGD
Ensembl
PMID:17273977 GO_REF:0000107 NCBI chr 8:58,548,899...58,568,861
Ensembl chr 8:58,549,736...58,568,860
JBrowse link
alveolar secondary septum development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgfr3 fibroblast growth factor receptor 3 acts_upstream_of_or_within ISO MGI:95525 (PMID:9716527) RGD PMID:9716527 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341
JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 acts_upstream_of_or_within ISO MGI:95524 (PMID:9716527) RGD PMID:9716527 NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242
JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:28818870)
Ensembl
RGD
PMID:28818870 GO_REF:0000107 NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034
JBrowse link
G Foxa1 forkhead box A1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2653543 (PMID:16214823)
Ensembl
RGD
PMID:16214823 GO_REF:0000107 NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188
JBrowse link
lung saccule development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asxl1 ASXL transcriptional regulator 1 acts_upstream_of_or_within ISO MGI:4431878 (PMID:24860998) RGD PMID:24860998 NCBI chr 3:141,814,012...141,881,526
Ensembl chr 3:141,813,433...141,881,538
JBrowse link
G Creb1 cAMP responsive element binding protein 1 acts_upstream_of_or_within ISO MGI:4999627 (PMID:21408140) RGD PMID:21408140 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Fgf10 fibroblast growth factor 10 involved_in ISO (PMID:17071719) RGD PMID:17071719 NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866
JBrowse link
G Gata6 GATA binding protein 6 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:108067 (PMID:17164424)
Ensembl
RGD
PMID:17164424 GO_REF:0000107 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532
JBrowse link
G Ltbp3 latent transforming growth factor beta binding protein 3 acts_upstream_of_or_within ISO MGI:2180017 (PMID:16049328) RGD PMID:16049328 NCBI chr 1:203,029,412...203,045,975
Ensembl chr 1:203,029,877...203,045,975
JBrowse link
G Nkx2-1 NK2 homeobox 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:107516 (PMID:17164424)
Ensembl
RGD
PMID:17164424 GO_REF:0000107 NCBI chr 6:73,996,601...74,001,483
Ensembl chr 6:73,996,601...73,999,791
JBrowse link
G Ptges3 prostaglandin E synthase 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3701300 (PMID:17438133)
Ensembl
RGD
PMID:17438133 GO_REF:0000107 NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084
JBrowse link
G Tnrc6c trinucleotide repeat containing adaptor 6C acts_upstream_of_or_within ISO MGI:4001992 (PMID:28811219) RGD PMID:28811219 NCBI chr10:102,908,958...102,979,543
Ensembl chr10:102,868,828...102,978,194
JBrowse link
positive regulation of lung alveolus development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Epas1 endothelial PAS domain protein 1 IEP RGD PMID:23962064 RGD:10395379 NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228
JBrowse link

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Term Annotations click to browse term
  biological_process 20292
    developmental process 7042
      anatomical structure development 6550
        lung alveolus development 77
          lung saccule development + 13
          negative regulation of lung alveolus development 0
          positive regulation of lung alveolus development 1
          regulation of lung alveolus development + 1
Path 2
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  biological_process 20292
    developmental process 7042
      anatomical structure development 6550
        multicellular organism development 5276
          tube development 1343
            respiratory tube development 287
              lung development 284
                lung alveolus development 77
                  lung saccule development + 13
                  negative regulation of lung alveolus development 0
                  positive regulation of lung alveolus development 1
                  regulation of lung alveolus development + 1
paths to the root