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ONTOLOGY REPORT - ANNOTATIONS


Term:lung alveolus development
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Accession:GO:0048286 term browser browse the term
Definition:The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways.
Synonyms:exact_synonym: alveolarization;   alveologenesis


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lung alveolus development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca12 ATP binding cassette subfamily A member 12 NOT|acts_upstream_of_or_within ISO MGI:3528440 (MGI:3829841|PMID:18957418)
MGI:3809668 (MGI:3807143|PMID:18632686)
RGD PMID:18632686 PMID:18957418 MGI:3807143 MGI:3829841 NCBI chr 9:78,521,477...78,693,421
Ensembl chr 9:78,522,464...78,693,028
JBrowse link
G Ace angiotensin I converting enzyme IMP RGD PMID:22587910 RGD:6893470 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Ada adenosine deaminase acts_upstream_of_or_within ISO MGI:1857117|MGI:2683027 (MGI:1861066|PMID:10899903) RGD PMID:10899903 MGI:1861066 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947
JBrowse link
G Atp7a ATPase copper transporting alpha acts_upstream_of_or_within ISO MGI:1856097 (MGI:54141|PMID:937819) RGD PMID:937819 MGI:54141 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Atxn1 ataxin 1 acts_upstream_of_or_within ISO MGI:1918972|MGI:3694797 (MGI:5298126|PMID:22014525) RGD PMID:22014525 MGI:5298126 NCBI chr17:19,160,986...19,533,814
Ensembl chr17:19,249,952...19,533,814
JBrowse link
G Atxn1l ataxin 1-like acts_upstream_of_or_within ISO MGI:104783|MGI:1918972|MGI:5301616 (MGI:5298126|PMID:22014525) RGD PMID:22014525 MGI:5298126 NCBI chr19:41,932,356...41,939,456 JBrowse link
G Bmp4 bone morphogenetic protein 4 acts_upstream_of_or_within ISO (PMID:8674409) RGD PMID:8674409 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 involved_in ISO (MGI:3799581|PMID:18552156) RGD PMID:18552156 MGI:3799581 NCBI chr 9:66,568,074...66,683,019
Ensembl chr 9:66,568,074...66,676,494
JBrowse link
G Cic capicua transcriptional repressor acts_upstream_of_or_within ISO MGI:104783|MGI:3694797|MGI:4125985 (MGI:5298126|PMID:22014525) RGD PMID:22014525 MGI:5298126 NCBI chr 1:82,135,440...82,163,007
Ensembl chr 1:82,151,669...82,163,005
JBrowse link
G Dbn1 drebrin 1 IEP RGD PMID:15928322 RGD:10398812 NCBI chr17:9,679,511...9,693,878
Ensembl chr17:9,679,628...9,693,820
JBrowse link
G Edn2 endothelin 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:5519239 (MGI:5514104|PMID:23676500)
Ensembl
RGD
PMID:23676500 GO_REF:0000107 MGI:5514104 NCBI chr 5:139,098,472...139,106,396
Ensembl chr 5:139,100,898...139,105,792
JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:4366137|PMID:19710174)
UniProt
RGD
PMID:19710174 GO_REF:0000024 MGI:4366137 NCBI chr 5:167,951,564...167,966,011
Ensembl chr 5:167,952,728...167,966,009
JBrowse link
G Fgf10 fibroblast growth factor 10 acts_upstream_of_or_within ISO MGI:3629660|MGI:95523 (MGI:3688953|PMID:16989802), (MGI:3716020|PMID:17560563) RGD PMID:16989802 PMID:17560563 MGI:3688953 MGI:3716020 NCBI chr 2:51,673,480...51,747,533
Ensembl chr 2:51,672,722...51,750,369
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 acts_upstream_of_or_within ISO MGI:1099809|MGI:3629660 (MGI:3688953|PMID:16989802) RGD PMID:16989802 MGI:3688953 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
JBrowse link
G Flt4 Fms related receptor tyrosine kinase 4 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1856694 (MGI:5582954|PMID:24733830)
Ensembl
RGD
PMID:24733830 GO_REF:0000107 MGI:5582954 NCBI chr10:35,078,782...35,120,296
Ensembl chr10:35,078,726...35,121,599
JBrowse link
G Foxf1 forkhead box F1 acts_upstream_of_or_within ISO MGI:1929432 (MGI:2135612|PMID:11493558) RGD PMID:11493558 MGI:2135612 NCBI chr19:53,012,306...53,016,100
Ensembl chr19:53,012,332...53,016,086
JBrowse link
G Foxp2 forkhead box P2 acts_upstream_of_or_within ISO MGI:3584266 (MGI:3710027|PMID:17428829) RGD PMID:17428829 MGI:3710027 NCBI chr 4:41,364,441...41,944,685
Ensembl chr 4:41,364,441...41,942,023
JBrowse link
G Fzd1 frizzled class receptor 1 IEP RGD PMID:17911382 RGD:2304247 NCBI chr 4:26,470,864...26,475,262
Ensembl chr 4:26,470,864...26,475,262
JBrowse link
G Gh1 growth hormone 1 IMP RGD PMID:18985281 RGD:2315627 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Hopx HOP homeobox acts_upstream_of_or_within ISO MGI:2389244 (MGI:3709528|PMID:16510470) RGD PMID:16510470 MGI:3709528 NCBI chr14:33,354,803...33,362,547
Ensembl chr14:33,354,807...33,362,551
JBrowse link
G Hoxa5 homeo box A5 acts_upstream_of_or_within ISO MGI:2150397 (MGI:3606710|PMID:15295088), (MGI:3665532|PMID:17003488) RGD PMID:15295088 PMID:17003488 MGI:3606710 MGI:3665532 NCBI chr 4:82,170,383...82,174,788
Ensembl chr 4:82,170,387...82,173,207
JBrowse link
G Hs6st1 heparan sulfate 6-O-sulfotransferase 1 acts_upstream_of_or_within ISO MGI:3715259 (MGI:3715036|PMID:17405882) RGD PMID:17405882 MGI:3715036 NCBI chr 9:42,620,006...42,659,184
Ensembl chr 9:42,620,006...42,659,184
JBrowse link
G Igf1 insulin-like growth factor 1 acts_upstream_of_or_within ISO MGI:1926485|MGI:96787 (MGI:3640953|PMID:16691571) RGD PMID:16691571 MGI:3640953 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 involved_in ISO (MGI:3039207|PMID:15010534) RGD PMID:15010534 MGI:3039207 NCBI chr 9:80,154,230...80,166,813
Ensembl chr 9:80,150,211...80,167,033
JBrowse link
G Itgb6 integrin subunit beta 6 acts_upstream_of_or_within ISO MGI:1926484 (MGI:3040752|PMID:12634787) RGD PMID:12634787 MGI:3040752 NCBI chr 3:46,652,624...46,775,362
Ensembl chr 3:46,652,623...46,726,958
JBrowse link
G Kdr kinase insert domain receptor acts_upstream_of_or_within ISO (MGI:2181852|PMID:12053176) RGD PMID:12053176 MGI:2181852 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Lif LIF, interleukin 6 family cytokine involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:96432 (MGI:3640953|PMID:16691571)
Ensembl
RGD
PMID:16691571 GO_REF:0000107 MGI:3640953 NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642
JBrowse link
G Man1a2 mannosidase, alpha, class 1A, member 2 acts_upstream_of_or_within ISO MGI:3703789 (MGI:3703634|PMID:17121831) RGD PMID:17121831 MGI:3703634 NCBI chr 2:202,891,537...203,043,847
Ensembl chr 2:202,891,537...203,043,847
JBrowse link
G Man2a1 mannosidase, alpha, class 2A, member 1 acts_upstream_of_or_within ISO MGI:2150656 (MGI:3652665|PMID:16754854) RGD PMID:16754854 MGI:3652665 NCBI chr 9:112,293,388...112,451,677
Ensembl chr 9:112,293,388...112,451,677
JBrowse link
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 acts_upstream_of_or_within ISO MGI:3527900 (MGI:3796918|PMID:18324732) RGD PMID:18324732 MGI:3796918 NCBI chr10:14,259,394...14,299,276
Ensembl chr10:14,260,787...14,299,167
JBrowse link
G Mecp2 methyl CpG binding protein 2 IEP RGD PMID:21425435 RGD:8552971 NCBI chr  X:156,650,389...156,713,813
Ensembl chr  X:156,655,960...156,705,233
JBrowse link
G Mmp12 matrix metallopeptidase 12 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2386174 (MGI:3040752|PMID:12634787)
Ensembl
RGD
PMID:12634787 GO_REF:0000107 MGI:3040752 NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
JBrowse link
G Myocd myocardin involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3052940 (MGI:4941650|PMID:21357509)
Ensembl
RGD
PMID:21357509 GO_REF:0000107 MGI:4941650 NCBI chr10:51,682,053...51,781,458
Ensembl chr10:51,683,540...51,778,986
JBrowse link
G Pdgfa platelet derived growth factor subunit A involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
(MGI:1098909|PMID:9374392)
MGI:1926817|MGI:5548172 (MGI:3622881|PMID:11803579), (MGI:5543868|PMID:23938297)
UniProt
RGD
PMID:9374392 PMID:11803579 PMID:23938297 GO_REF:0000024 MGI:1098909 MGI:3622881 MGI:5543868 NCBI chr12:17,734,141...17,756,186
Ensembl chr12:17,734,133...17,755,285
JBrowse link
G Pdpn podoplanin acts_upstream_of_or_within ISO MGI:2657021 (MGI:3703126|PMID:16869965) RGD PMID:16869965 MGI:3703126 NCBI chr 5:161,947,137...161,981,441
Ensembl chr 5:161,947,137...161,981,441
JBrowse link
G Pgr progesterone receptor involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3032652 (MGI:5576858|PMID:24190884)
Ensembl
RGD
PMID:24190884 GO_REF:0000107 MGI:5576858 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Phf14 PHD finger protein 14 acts_upstream_of_or_within ISO MGI:5426539 (MGI:5426441|PMID:22730381) RGD PMID:22730381 MGI:5426441 NCBI chr 4:38,241,189...38,420,199
Ensembl chr 4:38,240,728...38,420,205
JBrowse link
G Pkdcc protein kinase domain containing, cytoplasmic involved_in ISO (MGI:4438146|PMID:19465597) RGD PMID:19465597 MGI:4438146 NCBI chr 6:6,427,657...6,436,974
Ensembl chr 6:6,427,657...6,436,974
JBrowse link
G Psen2 presenilin 2 acts_upstream_of_or_within ISO MGI:2149117 (MGI:1346745|PMID:10518543) RGD PMID:10518543 MGI:1346745 NCBI chr13:98,513,600...98,539,347
Ensembl chr13:98,513,570...98,530,724
JBrowse link
G Pthlh parathyroid hormone-like hormone acts_upstream_of_or_within ISO MGI:2154515 (MGI:3042805|PMID:15162506) RGD PMID:15162506 MGI:3042805 NCBI chr 4:181,663,425...181,674,181 JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 acts_upstream_of_or_within ISO MGI:4364357 (MGI:5486592|PMID:23583643) RGD PMID:23583643 MGI:5486592 NCBI chr 3:21,621,976...21,676,789
Ensembl chr 3:21,623,041...21,670,014
JBrowse link
G Selenon selenoprotein N acts_upstream_of_or_within ISO (MGI:5494499|PMID:23325319) RGD PMID:23325319 MGI:5494499 NCBI chr 5:152,748,497...152,765,489
Ensembl chr 5:152,750,284...152,762,165
JBrowse link
G Sftpd surfactant protein D involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:9751757)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:9751757 GO_REF:0000024 GO_REF:0000107 NCBI chr16:18,753,535...18,766,100
Ensembl chr16:18,745,458...18,766,174
JBrowse link
G Slc7a11 solute carrier family 7 member 11 acts_upstream_of_or_within ISO MGI:3608695 (MGI:5469541|PMID:23085521) RGD PMID:23085521 MGI:5469541 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Slfn4 schlafen family member 4 IEP RGD PMID:17911382 RGD:2304247 NCBI chr10:70,411,686...70,435,162
Ensembl chr10:70,411,738...70,435,156
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1856877 (MGI:5469952|PMID:22945695)
Ensembl
RGD
PMID:22945695 GO_REF:0000107 MGI:5469952 NCBI chr19:38,237,963...38,321,572
Ensembl chr19:38,237,965...38,321,528
JBrowse link
G Sox2 SRY-box transcription factor 2 acts_upstream_of_or_within ISO (MGI:3795352|PMID:18374910) RGD PMID:18374910 MGI:3795352 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
JBrowse link
G Stk40 serine/threonine kinase 40 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:5496282 (MGI:5486391|PMID:23293024)
Ensembl
RGD
PMID:23293024 GO_REF:0000107 MGI:5486391 NCBI chr 5:144,112,612...144,150,653
Ensembl chr 5:144,114,012...144,150,647
JBrowse link
G Stra6 signaling receptor and transporter of retinol STRA6 involved_in ISO (PMID:17273977) RGD PMID:17273977 NCBI chr 8:62,925,364...62,944,438
Ensembl chr 8:62,925,357...62,944,437
JBrowse link
G Tcf21 transcription factor 21 involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
MGI:2148207 (MGI:1347485|PMID:10572052)
UniProt
RGD
PMID:10572052 GO_REF:0000024 MGI:1347485 NCBI chr 1:23,906,717...23,909,576
Ensembl chr 1:23,906,717...23,909,566
JBrowse link
G Tgfb1 transforming growth factor, beta 1 acts_upstream_of_or_within ISO (MGI:3040752|PMID:12634787) RGD PMID:12634787 MGI:3040752 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb3 transforming growth factor, beta 3 involved_in ISO (MGI:77427|PMID:7493022) RGD PMID:7493022 MGI:77427 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Tmem38b transmembrane protein 38B acts_upstream_of_or_within ISO MGI:3716065 (MGI:3850579|PMID:19515693) RGD PMID:19515693 MGI:3850579 NCBI chr 5:70,639,156...70,675,055
Ensembl chr 5:70,639,156...70,675,054
JBrowse link
G Tmtc3 transmembrane O-mannosyltransferase targeting cadherins 3 acts_upstream_of_or_within ISO MGI:4124060 (MGI:5300435|PMID:21956870) RGD PMID:21956870 MGI:5300435 NCBI chr 7:40,171,957...40,217,056
Ensembl chr 7:40,171,963...40,217,056
JBrowse link
G Tns3 tensin 3 acts_upstream_of_or_within ISO MGI:3574415 (MGI:3531231|PMID:15733665) RGD PMID:15733665 MGI:3531231 NCBI chr14:88,673,922...88,907,874
Ensembl chr14:88,673,881...88,886,198
JBrowse link
G Vegfa vascular endothelial growth factor A IMP RGD PMID:16230500 RGD:1580552 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Wnt5a Wnt family member 5A IEP RGD PMID:17911382 RGD:2304247 NCBI chr16:4,469,451...4,490,271
Ensembl chr16:4,469,468...4,489,860
JBrowse link
G Zfp157 zinc finger protein 157 acts_upstream_of_or_within ISO MGI:4124834 (MGI:5424261|PMID:22588720) RGD PMID:22588720 MGI:5424261 NCBI chr12:18,461,283...18,495,871
Ensembl chr12:18,464,781...18,487,178
JBrowse link
alveolar primary septum development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Stra6 signaling receptor and transporter of retinol STRA6 involved_in ISO
IEA
(PMID:17273977)
GO_REF:0000107
RGD
Ensembl
PMID:17273977 GO_REF:0000107 NCBI chr 8:62,925,364...62,944,438
Ensembl chr 8:62,925,357...62,944,437
JBrowse link
alveolar secondary septum development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgfr3 fibroblast growth factor receptor 3 acts_upstream_of_or_within ISO MGI:95525 (MGI:1309575|PMID:9716527) RGD PMID:9716527 MGI:1309575 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 acts_upstream_of_or_within ISO MGI:95524 (MGI:1309575|PMID:9716527) RGD PMID:9716527 MGI:1309575 NCBI chr17:9,990,072...10,004,339
Ensembl chr17:9,990,078...10,004,321
JBrowse link
G Foxa1 forkhead box A1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2653543 (MGI:3613241|PMID:16214823)
Ensembl
RGD
PMID:16214823 GO_REF:0000107 MGI:3613241 NCBI chr 6:78,516,579...78,549,669
Ensembl chr 6:78,545,804...78,549,669
JBrowse link
lung saccule development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asxl1 ASXL transcriptional regulator 1 acts_upstream_of_or_within ISO MGI:4431878 (MGI:5585348|PMID:24860998) RGD PMID:24860998 MGI:5585348 NCBI chr 3:148,832,231...148,902,356
Ensembl chr 3:148,837,814...148,900,452
JBrowse link
G Creb1 cAMP responsive element binding protein 1 acts_upstream_of_or_within ISO MGI:4999627 (MGI:4950818|PMID:21408140) RGD PMID:21408140 MGI:4950818 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Fgf10 fibroblast growth factor 10 involved_in ISO (PMID:17071719) RGD PMID:17071719 NCBI chr 2:51,673,480...51,747,533
Ensembl chr 2:51,672,722...51,750,369
JBrowse link
G Gata6 GATA binding protein 6 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:108067 (MGI:3695537|PMID:17164424)
Ensembl
RGD
PMID:17164424 GO_REF:0000107 MGI:3695537 NCBI chr18:2,415,821...2,447,087
Ensembl chr18:2,416,552...2,446,338
JBrowse link
G Ltbp3 latent transforming growth factor beta binding protein 3 acts_upstream_of_or_within ISO MGI:2180017 (MGI:3584290|PMID:16049328) RGD PMID:16049328 MGI:3584290 NCBI chr 1:221,099,155...221,116,096
Ensembl chr 1:221,099,998...221,116,096
JBrowse link
G Nkx2-1 NK2 homeobox 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:107516 (MGI:3695537|PMID:17164424)
Ensembl
RGD
PMID:17164424 GO_REF:0000107 MGI:3695537 NCBI chr 6:77,418,096...77,423,383
Ensembl chr 6:77,418,096...77,421,286
JBrowse link
G Ptges3 prostaglandin E synthase 3 acts_upstream_of_or_within ISO MGI:3701300 (MGI:3714109|PMID:17438133) RGD PMID:17438133 MGI:3714109 NCBI chr 7:2,479,267...2,497,024
Ensembl chr 7:2,479,311...2,497,013
JBrowse link
positive regulation of lung alveolus development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Epas1 endothelial PAS domain protein 1 IEP RGD PMID:23962064 RGD:10395379 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19612
    developmental process 6792
      anatomical structure development 6265
        lung alveolus development 68
          lung saccule development + 11
          negative regulation of lung alveolus development 0
          positive regulation of lung alveolus development 1
          regulation of lung alveolus development + 1
Path 2
Term Annotations click to browse term
  biological_process 19612
    developmental process 6792
      anatomical structure development 6265
        multicellular organism development 5747
          system development 5290
            animal organ development 4054
              respiratory tube development 266
                lung development 263
                  lung alveolus development 68
                    lung saccule development + 11
                    negative regulation of lung alveolus development 0
                    positive regulation of lung alveolus development 1
                    regulation of lung alveolus development + 1
paths to the root