ONTOLOGY REPORT - ANNOTATIONS
Term: p38MAPK cascade
Accession: GO:0038066
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Definition: A MAPK cascade containing at least the p38MAPK (MAPK14) MAP kinase, or Hog1 in yeast. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of p38MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The p38MAPK cascade is activated by stress signals, including hyperosmolarity, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation.
Synonyms: exact_synonym: p38 MAPK cascade; p38 cascade
narrow_synonym: osmosensory signaling MAPK cascade
related_synonym: MAPK14 cascade
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Atf2
activating transcription factor 2
involved_in
IEA ISO
GO_REF:0000107 MGI:2443472|MGI:3720850|MGI:3842320 (PMID:17699753), (PMID:19948881), (PMID:21533046)
Ensembl RGD
PMID:17699753 PMID:19948881 PMID:21533046
GO_REF:0000107
NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
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Atf7
activating transcription factor 7
involved_in
ISO
MGI:109349 (PMID:17699753)
RGD
PMID:17699753
NCBI chr 7:133,660,491...133,750,902
Ensembl chr 7:133,663,294...133,750,848
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Becn1
beclin 1
IMP
RGD
PMID:27769861
RGD:329853763
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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Fgfr3
fibroblast growth factor receptor 3
acts_upstream_of_or_within
ISO
MGI:2135670 (PMID:20053668)
RGD
PMID:20053668
NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341
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Kcnj8
potassium inwardly-rectifying channel, subfamily J, member 8
acts_upstream_of_or_within
ISO
MGI:3720053 (PMID:29540778)
RGD
PMID:29540778
NCBI chr 4:175,508,908...175,515,829
Ensembl chr 4:175,508,912...175,515,603
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Lgals9
galectin 9
involved_in
ISO
(PMID:16116184)
RGD
PMID:16116184
NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
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Map1lc3a
microtubule-associated protein 1 light chain 3 alpha
IMP
RGD
PMID:27769861
RGD:329853763
NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
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Map2k3
mitogen activated protein kinase kinase 3
involved_in
ISO
(PMID:22696064)
RGD
PMID:22696064
NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492
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Map2k6
mitogen-activated protein kinase kinase 6
involved_in
ISO
(PMID:11460167)
RGD
PMID:11460167
NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293
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Map3k20
mitogen-activated protein kinase kinase kinase 20
involved_in
ISS ISO
GO_REF:0000024 (MGI:5901799|PMID:27598200) (PMID:11836244), (PMID:15737997), (PMID:32610081), (PMID:35857590)
UniProt RGD
PMID:11836244 PMID:15737997 PMID:27598200 PMID:32610081 PMID:35857590
GO_REF:0000024 MGI:5901799
NCBI chr 3:57,130,539...57,289,943
Ensembl chr 3:57,130,551...57,289,626
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Map3k5
mitogen-activated protein kinase kinase kinase 5
involved_in
ISO
(MGI:5320687|PMID:22337877)
RGD
PMID:22337877
MGI:5320687
NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
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Map3k7
mitogen activated protein kinase kinase kinase 7
involved_in
ISO
(PMID:11460167)
RGD
PMID:11460167
NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
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Mapk11
mitogen-activated protein kinase 11
involved_in
ISO
(PMID:10330143)
RGD
PMID:10330143
NCBI chr 7:120,218,471...120,225,488
Ensembl chr 7:120,218,478...120,225,395
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Mapk14
mitogen activated protein kinase 14
involved_in
ISS IEA ISO
GO_REF:0000024 GO_REF:0000107 (PMID:10330143) GO_REF:0000002 (MGI:5526919|PMID:22847234)
UniProt Ensembl RGD InterPro
PMID:10330143 PMID:22847234
GO_REF:0000002 GO_REF:0000024 GO_REF:0000107 MGI:5526919
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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Mapkapk2
MAPK activated protein kinase 2
acts_upstream_of_or_within
ISO
(PMID:24020373)
RGD
PMID:24020373
NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457
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Nr2c2
nuclear receptor subfamily 2, group C, member 2
involved_in
ISO
(MGI:5320687|PMID:22337877)
RGD
PMID:22337877
MGI:5320687
NCBI chr 4:124,610,216...124,666,813
Ensembl chr 4:124,608,960...124,661,902
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Zfp36
zinc finger protein 36
involved_in
ISS ISO IEA
GO_REF:0000024 (MGI:5784995|PMID:11533235) GO_REF:0000107
UniProt RGD Ensembl
PMID:11533235
GO_REF:0000024 GO_REF:0000107 MGI:5784995
NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
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Zfp36l1
zinc finger protein 36, C3H type-like 1
involved_in
ISS ISO
GO_REF:0000024 (MGI:5784987|PMID:17889962)
UniProt RGD
PMID:17889962
GO_REF:0000024 MGI:5784987
NCBI chr 6:98,930,705...98,935,748
Ensembl chr 6:98,930,718...98,935,748
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Cyld
CYLD lysine 63 deubiquitinase
involved_in
ISS ISO
GO_REF:0000024 (PMID:29291351) (MGI:6162308|PMID:29291351)
UniProt RGD
PMID:29291351
GO_REF:0000024 MGI:6162308
NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658
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Dlg1
discs large MAGUK scaffold protein 1
involved_in
ISO IEA
(PMID:20551903) GO_REF:0000107
RGD Ensembl
PMID:20551903
GO_REF:0000107
NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689
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Dusp1
dual specificity phosphatase 1
involved_in
ISO IBA
(PMID:22991462) GO_REF:0000033
RGD GO_Central
PMID:22991462
GO_REF:0000033
NCBI chr10:16,680,478...16,683,275
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Dusp10
dual specificity phosphatase 10
involved_in
ISO
(PMID:10391943)
RGD
PMID:10391943
NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716
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Ezr
ezrin
involved_in
ISO IEA
(PMID:20551903) GO_REF:0000107
RGD Ensembl
PMID:20551903
GO_REF:0000107
NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
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Mir20a
microRNA 20a
involved_in
ISO
(PMID:22696064)
RGD
PMID:22696064
NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168
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Ptpn22
protein tyrosine phosphatase, non-receptor type 22
involved_in
ISO
(PMID:23991106) (MGI:5640942|PMID:23991106)
RGD
PMID:23991106
MGI:5640942
NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779
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Trem2
triggering receptor expressed on myeloid cells 2
involved_in
ISO
(MGI:6695687|PMID:31900229)
RGD
PMID:31900229
MGI:6695687
NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170
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Ager
advanced glycosylation end product-specific receptor
involved_in
ISO IEA
ComplexPortal:CPX-1134|UniProtKB:P10749 (PMID:20739563) GO_REF:0000107
RGD Ensembl
PMID:20739563
GO_REF:0000107
NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
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Arhgef2
Rho/Rac guanine nucleotide exchange factor 2
involved_in
ISO
(PMID:23389627)
RGD
PMID:23389627
NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355
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Bmp2
bone morphogenetic protein 2
involved_in
IEA ISO
GO_REF:0000107 (PMID:22540193)
Ensembl RGD
PMID:22540193
GO_REF:0000107
NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
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Bmp4
bone morphogenetic protein 4
involved_in
ISO IEA
(PMID:17600318) GO_REF:0000107
RGD Ensembl
PMID:17600318
GO_REF:0000107
NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
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Ccr2
C-C motif chemokine receptor 2
IDA
RGD
PMID:18584881
RGD:2303073
NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
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Gadd45a
growth arrest and DNA-damage-inducible, alpha
involved_in
ISO IEA
(PMID:9827804) GO_REF:0000107
RGD Ensembl
PMID:9827804
GO_REF:0000107
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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Gadd45b
growth arrest and DNA-damage-inducible, beta
involved_in
ISO
(PMID:9827804)
RGD
PMID:9827804
NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
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Gadd45g
growth arrest and DNA-damage-inducible, gamma
involved_in
ISO
(PMID:9827804)
RGD
PMID:9827804
NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
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Gdf6
growth differentiation factor 6
involved_in
ISS ISO
GO_REF:0000024 (MGI:5751611|PMID:26774823)
UniProt RGD
PMID:26774823
GO_REF:0000024 MGI:5751611
NCBI chr 5:22,996,246...23,012,567
Ensembl chr 5:22,996,246...23,012,567
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Gsn
gelsolin
IMP
RGD
PMID:24505034
RGD:329333013
NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
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Hand2
heart and neural crest derivatives expressed 2
involved_in
IEA ISO
GO_REF:0000107 (PMID:24161931)
Ensembl RGD
PMID:24161931
GO_REF:0000107
NCBI chr16:32,917,448...32,920,791
Ensembl chr16:32,917,823...32,919,891
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Il1b
interleukin 1 beta
involved_in
ISO IEA
ComplexPortal:CPX-1134|UniProtKB:Q15109 (MGI:5902681|PMID:20739563) GO_REF:0000107
RGD Ensembl
PMID:20739563
GO_REF:0000107 MGI:5902681
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Kcnn4
potassium calcium-activated channel subfamily N member 4
IMP
RGD
PMID:28679649
RGD:329955564
NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340
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Lep
leptin
involved_in
ISS IBA ISO
GO_REF:0000024 GO_REF:0000033 (PMID:24340098)
UniProt GO_Central RGD
PMID:24340098
GO_REF:0000024 GO_REF:0000033
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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Map3k3
mitogen activated protein kinase kinase kinase 3
acts_upstream_of_or_within
ISO
(PMID:10700190)
RGD
PMID:10700190
NCBI chr10:91,020,174...91,088,852
Ensembl chr10:91,020,174...91,088,848
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Map3k4
mitogen activated protein kinase kinase kinase 4
involved_in
ISO
(PMID:9305639)
RGD
PMID:9305639
NCBI chr 1:48,431,801...48,519,358
Ensembl chr 1:48,431,830...48,519,358
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Map3k5
mitogen-activated protein kinase kinase kinase 5
IMP
RGD
PMID:20716917
RGD:10412640
NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
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Met
MET proto-oncogene, receptor tyrosine kinase
acts_upstream_of_or_within
ISO
MGI:3041135 (PMID:23994610)
RGD
PMID:23994610
NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
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Mfhas1
multifunctional ROCO family signaling regulator 1
involved_in
ISO
(PMID:28471450)
RGD
PMID:28471450
NCBI chr16:56,545,462...56,633,649
Ensembl chr16:56,546,207...56,633,743
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Mink1
misshapen-like kinase 1
involved_in
ISO
(MGI:1354211|PMID:10708748)
RGD
PMID:10708748
MGI:1354211
NCBI chr10:55,278,293...55,330,782
Ensembl chr10:55,278,391...55,330,782
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Mir181a2
microRNA 181a-2
involved_in
ISO
(PMID:23993976)
RGD
PMID:23993976
NCBI chr 3:22,615,845...22,615,961
Ensembl chr 3:22,615,845...22,615,961
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Mir181b1
microRNA 181b-1
involved_in
ISO
(PMID:23993976)
RGD
PMID:23993976
NCBI chr13:49,485,688...49,485,797
Ensembl chr13:49,485,688...49,485,797
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Mir181b2
microRNA 181b-2
involved_in
ISO
(PMID:23993976)
RGD
PMID:23993976
NCBI chr 3:22,616,948...22,617,035
Ensembl chr 3:22,616,948...22,617,035
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Mir181d
microRNA 181d
involved_in
ISO
(PMID:23993976)
RGD
PMID:23993976
NCBI chr19:23,983,706...23,983,788
Ensembl chr19:23,983,706...23,983,788
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Ncf1
neutrophil cytosolic factor 1
involved_in
ISO
(PMID:26514923)
RGD
PMID:26514923
NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
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Oprk1
opioid receptor, kappa 1
IDA
RGD
PMID:16648139
RGD:9831415
NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
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Pja2
praja ring finger ubiquitin ligase 2
involved_in
ISS ISO
GO_REF:0000024 (PMID:28471450)
UniProt RGD
PMID:28471450
GO_REF:0000024
NCBI chr 9:103,956,678...104,006,763
Ensembl chr 9:103,956,678...104,006,783
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Prmt1
protein arginine methyltransferase 1
involved_in
IDA
PMID:23483889
BHF-UCL
PMID:23483889
RGD:10047341
NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345
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Rell1
RELT-like 1
involved_in
ISO IBA
(PMID:28688764) GO_REF:0000033
RGD GO_Central
PMID:28688764
GO_REF:0000033
NCBI chr14:44,318,640...44,378,541
Ensembl chr14:44,303,009...44,378,500
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Rell2
RELT-like 2
involved_in
ISS IBA IEA ISO
GO_REF:0000024 GO_REF:0000033 GO_REF:0000002 (PMID:28688764)
UniProt GO_Central InterPro RGD
PMID:28688764
GO_REF:0000002 GO_REF:0000024 GO_REF:0000033
NCBI chr18:29,789,996...29,793,986
Ensembl chr18:29,790,415...29,793,986
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Sash1
SAM and SH3 domain containing 1
acts_upstream_of_or_within
ISO
(PMID:23776175)
RGD
PMID:23776175
NCBI chr 1:3,119,915...3,418,536
Ensembl chr 1:3,121,332...3,439,870
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Sphk1
sphingosine kinase 1
involved_in
ISS IEA ISO
GO_REF:0000024 GO_REF:0000107 (PMID:23935096)
UniProt Ensembl RGD
PMID:23935096
GO_REF:0000024 GO_REF:0000107
NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
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Spi1
Spi-1 proto-oncogene
involved_in
ISO
(MGI:6478061|PMID:28912174)
RGD
PMID:28912174
MGI:6478061
NCBI chr 3:77,059,744...77,093,730
Ensembl chr 3:77,073,012...77,092,393
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Stk39
serine threonine kinase 39
involved_in
ISO IMP
(PMID:10980603)
RGD
PMID:10980603 PMID:10980603
RGD:727300
NCBI chr 3:52,913,583...53,179,060
Ensembl chr 3:52,913,585...53,179,060
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Vegfa
vascular endothelial growth factor A
involved_in
ISO IEA
(PMID:18386220) GO_REF:0000107
RGD Ensembl
PMID:18386220
GO_REF:0000107
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Xdh
xanthine dehydrogenase
involved_in
ISO IEA
(PMID:18386220) GO_REF:0000107
RGD Ensembl
PMID:18386220
GO_REF:0000107
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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Zc3h12a
zinc finger CCCH type containing 12A
involved_in
ISO
(PMID:24048733)
RGD
PMID:24048733
NCBI chr 5:137,376,562...137,385,351
Ensembl chr 5:137,376,564...137,385,351
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Ager
advanced glycosylation end product-specific receptor
involved_in
ISO IBA
ComplexPortal:CPX-1134 (MGI:6094326|PMID:18367618) GO_REF:0000033
RGD GO_Central
PMID:18367618
GO_REF:0000033 MGI:6094326
NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
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Cav3
caveolin 3
acts_upstream_of_or_within
ISO
(PMID:21182936)
RGD
PMID:21182936
NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137
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Dab2ip
DAB2 interacting protein
involved_in
ISS IEA ISO
GO_REF:0000024 GO_REF:0000107 (MGI:4453088|PMID:19948740)
UniProt Ensembl RGD
PMID:19948740
GO_REF:0000024 GO_REF:0000107 MGI:4453088
NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280
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Hgf
hepatocyte growth factor
involved_in acts_upstream_of_or_within
IEA ISO
GO_REF:0000107 (PMID:23994610)
Ensembl RGD
PMID:23994610
GO_REF:0000107
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
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Lgals9
galectin 9
NOT|involved_in
ISO
(PMID:24465902)
RGD
PMID:24465902
NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
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Per1
period circadian regulator 1
involved_in
IMP
PMID:24447840
UniProt
PMID:24447840
RGD:8655527
NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431
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Phlpp1
PH domain and leucine rich repeat protein phosphatase 1
involved_in
ISO IEA
(PMID:17386267) GO_REF:0000107
RGD Ensembl
PMID:17386267
GO_REF:0000107
NCBI chr13:22,308,532...22,530,978
Ensembl chr13:22,308,548...22,530,977
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Rasgrp1
RAS guanyl releasing protein 1
NOT|involved_in
ISO
(PMID:19933860)
RGD
PMID:19933860
NCBI chr 3:104,168,549...104,230,107
Ensembl chr 3:104,170,013...104,230,056
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Trpv4
transient receptor potential cation channel, subfamily V, member 4
NOT|involved_in
ISO
(MGI:5440106|PMID:23021218)
RGD
PMID:23021218
MGI:5440106
NCBI chr12:41,938,533...41,977,517
Ensembl chr12:41,938,560...41,977,517
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Ulk4
unc-51 like kinase 4
acts_upstream_of_or_within
ISO
(PMID:24284070)
RGD
PMID:24284070
NCBI chr 8:120,670,879...120,966,026
Ensembl chr 8:120,670,866...120,966,924
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