Mir181b1 (microRNA 181b-1) - Rat Genome Database

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Gene: Mir181b1 (microRNA 181b-1) Rattus norvegicus
Analyze
Symbol: Mir181b1
Name: microRNA 181b-1
RGD ID: 2325561
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Predicted to be involved in several processes, including miRNA-mediated post-transcriptional gene silencing; regulation of defense response; and regulation of signal transduction. Predicted to act upstream of or within cellular response to forskolin; long-term synaptic potentiation; and regulation of gene expression. Orthologous to human MIR181B1 (microRNA 181b-1); INTERACTS WITH atrazine; cisplatin; hexanal.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-181b-1; Mir181b-1; rno-mir-181b-1
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81352,037,228 - 52,037,337 (+)NCBIGRCr8
mRatBN7.21349,485,688 - 49,485,797 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1349,485,688 - 49,485,797 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1352,093,370 - 52,093,479 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01353,381,254 - 53,381,363 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01350,648,344 - 50,648,453 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01354,952,903 - 54,953,012 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1354,952,903 - 54,953,012 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01359,986,236 - 59,986,345 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1349,771,552 - 49,771,661 (+)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MicroRNA deregulation in human thyroid papillary carcinomas. Pallante P, etal., Endocr Relat Cancer. 2006 Jun;13(2):497-508. doi: 10.1677/erc.1.01209.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:17604727   PMID:17805466   PMID:18762567   PMID:20403161   PMID:21993888   PMID:25858512   PMID:26239160   PMID:26586707   PMID:26617745   PMID:29608948   PMID:29808547  
PMID:30431062   PMID:31002155   PMID:34076811   PMID:38154211  


Genomics

Comparative Map Data
Mir181b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81352,037,228 - 52,037,337 (+)NCBIGRCr8
mRatBN7.21349,485,688 - 49,485,797 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1349,485,688 - 49,485,797 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1352,093,370 - 52,093,479 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01353,381,254 - 53,381,363 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01350,648,344 - 50,648,453 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01354,952,903 - 54,953,012 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1354,952,903 - 54,953,012 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01359,986,236 - 59,986,345 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1349,771,552 - 49,771,661 (+)NCBICelera
Cytogenetic Map13q13NCBI
MIR181B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381198,858,873 - 198,858,982 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1198,858,873 - 198,858,982 (-)EnsemblGRCh38hg38GRCh38
GRCh371198,828,002 - 198,828,111 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361197,094,624 - 197,094,733 (-)NCBINCBI36Build 36hg18NCBI36
Celera1171,950,530 - 171,950,639 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1169,995,197 - 169,995,306 (-)NCBIHuRef
CHM1_11200,250,237 - 200,250,346 (-)NCBICHM1_1
T2T-CHM13v2.01198,117,513 - 198,117,622 (-)NCBIT2T-CHM13v2.0
Mir181b-1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391137,894,377 - 137,894,456 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1137,894,377 - 137,894,456 (+)EnsemblGRCm39 Ensembl
GRCm381137,966,639 - 137,966,718 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1137,966,639 - 137,966,718 (+)EnsemblGRCm38mm10GRCm38
MGSCv371139,863,216 - 139,863,295 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1140,611,658 - 140,611,737 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map160.68NCBI
MIR181D
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12048,593,158 - 48,593,221 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2048,467,207 - 48,467,270 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02049,111,396 - 49,111,459 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12048,321,894 - 48,321,957 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02048,748,803 - 48,748,866 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02048,991,857 - 48,991,920 (-)NCBIUU_Cfam_GSD_1.0
MIR181B-1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1021,696,492 - 21,696,571 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11021,696,492 - 21,696,571 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21026,426,857 - 26,426,936 (-)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:4237
Count of gene targets:2619
Count of transcripts:2828
Interacting mature miRNAs:rno-miR-181b-1-3p, rno-miR-181b-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134372077062022792Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 18 18
Low 18 24 3 33 3 9 9 54 12 40 24 9
Below cutoff 24 8 6 6 6 6 18 17 6

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000053713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1349,485,688 - 49,485,797 (+)Ensembl
Rnor_6.0 Ensembl1354,952,903 - 54,953,012 (+)Ensembl
RefSeq Acc Id: NR_031899
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81352,037,228 - 52,037,337 (+)NCBI
mRatBN7.21349,485,688 - 49,485,797 (+)NCBI
Rnor_6.01354,952,903 - 54,953,012 (+)NCBI
Rnor_5.01359,986,236 - 59,986,345 (+)NCBI
Celera1349,771,552 - 49,771,661 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325561 AgrOrtholog
BioCyc Gene G2FUF-18112 BioCyc
Ensembl Genes ENSRNOG00000035590 Ensembl
miRBase MI0000926 ENTREZGENE
NCBI Gene 100314040 ENTREZGENE
PhenoGen Mir181b1 PhenoGen
RatGTEx ENSRNOG00000035590 RatGTEx
RNAcentral URS0000229622 RNACentral
  URS0000605E00 RNACentral
  URS000075EB4A RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir181b1  microRNA 181b-1  Mir181b-1  microRNA mir-181b-1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir181b-1  microRNA mir-181b-1      Symbol and Name status set to provisional 70820 PROVISIONAL