Pja2 (praja ring finger ubiquitin ligase 2) - Rat Genome Database

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Gene: Pja2 (praja ring finger ubiquitin ligase 2) Rattus norvegicus
Analyze
Symbol: Pja2
Name: praja ring finger ubiquitin ligase 2
RGD ID: 620273
Description: Predicted to enable protein kinase A catalytic subunit binding activity; protein kinase A regulatory subunit binding activity; and ubiquitin protein ligase activity. Involved in long-term memory and regulation of protein kinase A signaling. Predicted to be located in cytoplasm; cytoskeleton; and plasma membrane. Orthologous to human PJA2 (praja ring finger ubiquitin ligase 2); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E3 ubiquitin-protein ligase Praja-2; E3 ubiquitin-protein ligase Praja2; MGC91486; Neurodap1; praja 2, RING-H2 motif containing; praja ring finger 2; praja ring finger 2, E3 ubiquitin protein ligase; praja-2; praja2; protein carrying the RING-H2 sequence motif; RING-type E3 ubiquitin transferase Praja-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.29103,956,678 - 104,006,763 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9103,956,678 - 104,006,783 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9112,357,465 - 112,407,536 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.09117,482,305 - 117,532,383 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.09115,823,383 - 115,873,457 (-)NCBIRnor_WKY
Rnor_6.09111,998,204 - 112,048,847 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9111,998,203 - 112,027,240 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09111,539,413 - 111,590,056 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.49103,002,778 - 103,054,007 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.19103,212,259 - 103,263,487 (-)NCBI
Celera9101,357,596 - 101,407,181 (-)NCBICelera
Cytogenetic Map9q37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Control of PKA stability and signalling by the RING ligase praja2. Lignitto L, etal., Nat Cell Biol. 2011 Apr;13(4):412-22. doi: 10.1038/ncb2209. Epub 2011 Mar 20.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. A novel RING-H2 motif protein downregulated by axotomy: its characteristic localization at the postsynaptic density of axosomatic synapse. Nakayama M, etal., J Neurosci 1995 Jul;15(7 Pt 2):5238-48.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:28471450  


Genomics

Comparative Map Data
Pja2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.29103,956,678 - 104,006,763 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9103,956,678 - 104,006,783 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9112,357,465 - 112,407,536 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.09117,482,305 - 117,532,383 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.09115,823,383 - 115,873,457 (-)NCBIRnor_WKY
Rnor_6.09111,998,204 - 112,048,847 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9111,998,203 - 112,027,240 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09111,539,413 - 111,590,056 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.49103,002,778 - 103,054,007 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.19103,212,259 - 103,263,487 (-)NCBI
Celera9101,357,596 - 101,407,181 (-)NCBICelera
Cytogenetic Map9q37NCBI
PJA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385109,334,722 - 109,409,974 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5109,334,713 - 109,409,974 (-)EnsemblGRCh38hg38GRCh38
GRCh375108,670,423 - 108,745,675 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365108,698,309 - 108,773,574 (-)NCBINCBI36Build 36hg18NCBI36
Build 345108,698,317 - 108,773,469NCBI
Celera5104,609,971 - 104,684,311 (-)NCBICelera
Cytogenetic Map5q21.3NCBI
HuRef5103,843,957 - 103,918,776 (-)NCBIHuRef
CHM1_15108,103,469 - 108,179,081 (-)NCBICHM1_1
T2T-CHM13v2.05109,838,178 - 109,914,589 (-)NCBIT2T-CHM13v2.0
Pja2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391764,588,001 - 64,638,878 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1764,588,000 - 64,638,911 (-)EnsemblGRCm39 Ensembl
GRCm381764,281,006 - 64,331,883 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1764,281,005 - 64,331,916 (-)EnsemblGRCm38mm10GRCm38
MGSCv371764,630,355 - 64,681,223 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361793,072,176 - 93,123,044 (+)NCBIMGSCv36mm8
Celera1768,597,047 - 68,647,778 (-)NCBICelera
Cytogenetic Map17E1.1NCBI
Pja2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554185,450,908 - 5,490,926 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554185,429,038 - 5,493,393 (+)NCBIChiLan1.0ChiLan1.0
PJA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15110,497,245 - 110,568,089 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5110,497,245 - 110,541,354 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05104,688,464 - 104,759,669 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PJA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.132,689,238 - 2,797,142 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl32,751,201 - 2,794,381 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha34,133,715 - 4,201,873 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.032,621,748 - 2,689,506 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl32,621,815 - 2,824,358 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.132,569,566 - 2,637,463 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.032,597,214 - 2,665,347 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.032,733,135 - 2,801,502 (+)NCBIUU_Cfam_GSD_1.0
Pja2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213157,518,082 - 157,589,344 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365314,021,711 - 4,068,459 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365314,022,175 - 4,093,404 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PJA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2114,319,991 - 114,558,272 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12114,319,972 - 114,675,761 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22118,924,428 - 118,961,796 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PJA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12312,753,505 - 12,825,279 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2312,753,513 - 12,796,482 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660361,392,914 - 1,467,294 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pja2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474327,254,436 - 27,301,934 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474327,251,937 - 27,331,213 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pja2
150 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:120
Count of miRNA genes:102
Interacting mature miRNAs:110
Transcripts:ENSRNOT00000021258
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat

Markers in Region
RH133870  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.29103,958,612 - 103,958,807 (+)MAPPERmRatBN7.2
Rnor_6.09112,000,139 - 112,000,333NCBIRnor6.0
Rnor_5.09111,541,348 - 111,541,542UniSTSRnor5.0
RGSC_v3.49103,004,711 - 103,004,905UniSTSRGSC3.4
Celera9101,359,531 - 101,359,725UniSTS
Cytogenetic Map9q37UniSTS
RH144228  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.29103,957,569 - 103,957,829 (+)MAPPERmRatBN7.2
Rnor_6.09111,999,096 - 111,999,355NCBIRnor6.0
Rnor_5.09111,540,305 - 111,540,564UniSTSRnor5.0
RGSC_v3.49103,003,668 - 103,003,927UniSTSRGSC3.4
Celera9101,358,488 - 101,358,747UniSTS
Cytogenetic Map9q37UniSTS
AI447901  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.29103,956,718 - 103,956,810 (+)MAPPERmRatBN7.2
Rnor_6.09111,998,245 - 111,998,336NCBIRnor6.0
Rnor_5.09111,539,454 - 111,539,545UniSTSRnor5.0
RGSC_v3.49103,002,817 - 103,002,908UniSTSRGSC3.4
Celera9101,357,637 - 101,357,728UniSTS
Cytogenetic Map9q37UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000021258   ⟹   ENSRNOP00000021258
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl9103,956,678 - 104,006,763 (-)Ensembl
Rnor_6.0 Ensembl9112,000,590 - 112,027,155 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080962   ⟹   ENSRNOP00000072362
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl9103,956,695 - 104,006,783 (-)Ensembl
Rnor_6.0 Ensembl9111,998,203 - 112,027,240 (-)Ensembl
RefSeq Acc Id: NM_001277278   ⟹   NP_001264207
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.29103,956,678 - 104,006,763 (-)NCBI
Rnor_6.09111,998,204 - 112,048,847 (-)NCBI
Rnor_5.09111,539,413 - 111,590,056 (-)NCBI
Celera9101,357,596 - 101,407,181 (-)NCBI
Sequence:
RefSeq Acc Id: NM_138896   ⟹   NP_620251
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.29103,956,678 - 104,006,763 (-)NCBI
Rnor_6.09111,998,204 - 112,048,847 (-)NCBI
Rnor_5.09111,539,413 - 111,590,056 (-)NCBI
RGSC_v3.49103,002,778 - 103,054,007 (-)RGD
Celera9101,357,596 - 101,407,181 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596266   ⟹   XP_017451755
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.29103,956,678 - 104,005,160 (-)NCBI
Rnor_6.09111,998,204 - 112,047,244 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039082999   ⟹   XP_038938927
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.29103,956,678 - 104,005,049 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_620251   ⟸   NM_138896
- Peptide Label: isoform 1
- UniProtKB: Q63364 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001264207   ⟸   NM_001277278
- Peptide Label: isoform 2
- UniProtKB: Q63364 (UniProtKB/Swiss-Prot),   A0A0H2UHM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451755   ⟸   XM_017596266
- Peptide Label: isoform X1
- UniProtKB: Q63364 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021258   ⟸   ENSRNOT00000021258
RefSeq Acc Id: ENSRNOP00000072362   ⟸   ENSRNOT00000080962
RefSeq Acc Id: XP_038938927   ⟸   XM_039082999
- Peptide Label: isoform X1
- UniProtKB: Q63364 (UniProtKB/Swiss-Prot)
Protein Domains
RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63364-F1-model_v2 AlphaFold Q63364 1-707 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620273 AgrOrtholog
BioCyc Gene G2FUF-26517 BioCyc
Ensembl Genes ENSRNOG00000015528 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000021258 ENTREZGENE
  ENSRNOP00000021258.5 UniProtKB/TrEMBL
  ENSRNOP00000072362 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021258 ENTREZGENE
  ENSRNOT00000021258.8 UniProtKB/TrEMBL
  ENSRNOT00000080962 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7105756 IMAGE-MGC_LOAD
InterPro Praja-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:192256 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91486 IMAGE-MGC_LOAD
NCBI Gene 192256 ENTREZGENE
PANTHER PTHR15710:SF5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam zf-RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pja2 PhenoGen
PROSITE ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHM9 ENTREZGENE, UniProtKB/TrEMBL
  PJA2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Pja2  praja ring finger ubiquitin ligase 2  Pja2  praja ring finger 2, E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-10 Pja2  praja ring finger 2, E3 ubiquitin protein ligase  Pja2  praja ring finger 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Pja2  praja ring finger 2  Pja2  praja 2, RING-H2 motif containing  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Pja2  praja 2, RING-H2 motif containing  Neurodap1  protein carrying the RING-H2 sequence motif  Symbol and Name updated 1299863 APPROVED
2002-08-07 Neurodap1  rotein carrying the RING-H2 sequence motif      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the endoplasmic reticulum and Golgi apparatus 633395