Hand2 (heart and neural crest derivatives expressed 2) - Rat Genome Database

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Gene: Hand2 (heart and neural crest derivatives expressed 2) Rattus norvegicus
Analyze
Symbol: Hand2
Name: heart and neural crest derivatives expressed 2
RGD ID: 621207
Description: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and transcription coactivator binding activity. Involved in cellular response to organic cyclic compound; cellular response to retinoic acid; and heart development. Predicted to be located in nucleus. Predicted to be part of chromatin and transcription regulator complex. Orthologous to human HAND2 (heart and neural crest derivatives expressed 2); INTERACTS WITH 3,7-dihydropurine-6-thione; acetamide; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2; dHand protein; heart and neural crest derivatives expressed transcript 2; heart- and neural crest derivatives-expressed protein 2; heart- and neural crest derivatives-expressed protein 2-like; LOC103693947
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81637,928,145 - 37,931,488 (-)NCBIGRCr8
mRatBN7.21632,917,448 - 32,920,791 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1632,917,823 - 32,919,891 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1636,510,401 - 36,513,743 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01639,921,734 - 39,925,076 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01636,141,350 - 36,144,691 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01636,371,489 - 36,373,551 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1636,371,489 - 36,373,546 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01636,173,054 - 36,174,762 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41636,324,327 - 36,348,104 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11636,324,401 - 36,326,112 (-)NCBI
Celera1632,856,614 - 32,879,368 (-)NCBICelera
Cytogenetic Map16p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult heart development  (IEA,ISO)
angiogenesis  (IEA)
apoptotic process  (ISO)
apoptotic process involved in heart morphogenesis  (IEA,ISO)
cardiac neural crest cell development involved in outflow tract morphogenesis  (ISO)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (IEA,ISO)
cardiac right ventricle formation  (IEA,ISO)
cartilage morphogenesis  (IEA,ISO)
cell proliferation involved in outflow tract morphogenesis  (IEA,ISO)
cellular response to organic cyclic compound  (IEP)
cellular response to retinoic acid  (IEP)
coronary artery morphogenesis  (IEA,ISO)
determination of heart left/right asymmetry  (ISO)
embryonic digit morphogenesis  (IEA,ISO)
embryonic skeletal system development  (IEA,ISO)
epithelial cell apoptotic process  (IEA,ISO)
heart development  (IBA,IEP,ISO)
heart looping  (IEA,ISO)
heart morphogenesis  (ISO)
in utero embryonic development  (IEA,ISO)
mesenchymal cell proliferation  (IEA,ISO)
mesenchyme development  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (IEA,ISO)
negative regulation of epithelial cell apoptotic process  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of osteoblast differentiation  (IEA,ISO)
neural crest cell development  (ISO)
norepinephrine biosynthetic process  (IEA,ISO)
odontogenesis of dentin-containing tooth  (IEA,ISO)
osteoblast differentiation  (IEA,ISO)
outflow tract morphogenesis  (ISO)
peripheral nervous system neuron development  (IEA,ISO)
positive regulation of cardiac muscle hypertrophy  (IEA,ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of p38MAPK cascade  (IEA,ISO)
positive regulation of semaphorin-plexin signaling pathway  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
primary palate development  (IEA,ISO)
regulation of DNA-templated transcription  (ISO)
regulation of secondary heart field cardioblast proliferation  (IEA,ISO)
regulation of tissue remodeling  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA)
roof of mouth development  (ISO)
suckling behavior  (IEA,ISO)
sympathetic nervous system development  (IEA,ISO)
thymus development  (IEA,ISO)
tongue development  (IEA,ISO)
visceral serous pericardium development  (IEA,ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Upregulation of embryonic transcription factors in right ventricular hypertrophy. Bar H, etal., Basic Res Cardiol. 2003 Sep;98(5):285-94. Epub 2003 Apr 16.
2. The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism. Dai YS, etal., J Biol Chem 2002 Jul 5;277(27):24390-8.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Regulation of dHAND protein expression by all-trans retinoic acid through ET-1/ETAR signaling in H9c2 cells. Li W and Li Y, J Cell Biochem. 2006 Oct 1;99(2):478-84.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Proteasome-mediated degradation of the coactivator p300 impairs cardiac transcription. Poizat C, etal., Mol Cell Biol. 2000 Dec;20(23):8643-54.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. HAND1 and HAND2 are expressed in the adult-rodent heart and are modulated during cardiac hypertrophy. Thattaliyath BD, etal., Biochem Biophys Res Commun 2002 Oct 4;297(4):870-5.
13. Cooperative interaction between the basic helix-loop-helix transcription factor dHAND and myocyte enhancer factor 2C regulates myocardial gene expression. Zang MX, etal., J Biol Chem. 2004 Dec 24;279(52):54258-63. Epub 2004 Oct 14.
14. Cooperative activation of atrial naturetic peptide promoter by dHAND and MEF2C. Zang MX, etal., J Cell Biochem. 2004 Dec 15;93(6):1255-66.
Additional References at PubMed
PMID:9171826   PMID:9576835   PMID:9671575   PMID:9878849   PMID:11076755   PMID:11784028   PMID:11812799   PMID:12070084   PMID:12392994   PMID:15351717   PMID:15576406   PMID:16145670  
PMID:16280598   PMID:17507395   PMID:17531968   PMID:17764670   PMID:19008477   PMID:19144722   PMID:19341725   PMID:20144608   PMID:21241805   PMID:21350214   PMID:23284944   PMID:24161931  


Genomics

Comparative Map Data
Hand2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81637,928,145 - 37,931,488 (-)NCBIGRCr8
mRatBN7.21632,917,448 - 32,920,791 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1632,917,823 - 32,919,891 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1636,510,401 - 36,513,743 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01639,921,734 - 39,925,076 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01636,141,350 - 36,144,691 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01636,371,489 - 36,373,551 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1636,371,489 - 36,373,546 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01636,173,054 - 36,174,762 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41636,324,327 - 36,348,104 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11636,324,401 - 36,326,112 (-)NCBI
Celera1632,856,614 - 32,879,368 (-)NCBICelera
Cytogenetic Map16p11NCBI
HAND2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384173,526,091 - 173,530,229 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4173,524,969 - 173,530,229 (-)EnsemblGRCh38hg38GRCh38
GRCh374174,447,242 - 174,451,380 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364174,684,227 - 174,687,953 (-)NCBINCBI36Build 36hg18NCBI36
Build 344174,820,849 - 174,825,309NCBI
Celera4171,772,735 - 171,776,461 (-)NCBICelera
Cytogenetic Map4q34.1NCBI
HuRef4170,194,314 - 170,197,710 (-)NCBIHuRef
CHM1_14174,424,466 - 174,428,102 (-)NCBICHM1_1
T2T-CHM13v2.04176,865,882 - 176,870,021 (-)NCBIT2T-CHM13v2.0
Hand2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39857,774,018 - 57,777,552 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl857,774,018 - 57,777,668 (+)EnsemblGRCm39 Ensembl
GRCm38857,320,983 - 57,324,517 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl857,320,983 - 57,324,633 (+)EnsemblGRCm38mm10GRCm38
MGSCv37859,799,780 - 59,803,314 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36860,214,046 - 60,216,006 (+)NCBIMGSCv36mm8
Celera859,958,813 - 59,962,384 (+)NCBICelera
Cytogenetic Map8B2NCBI
cM Map829.8NCBI
Hand2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540333,478,924 - 33,481,608 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540333,478,034 - 33,481,613 (+)NCBIChiLan1.0ChiLan1.0
HAND2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23171,287,522 - 171,291,148 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14171,668,587 - 171,672,033 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04165,755,000 - 165,758,735 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14177,990,362 - 177,992,861 (-)NCBIpanpan1.1PanPan1.1panPan2
HAND2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12524,140,496 - 24,143,143 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2524,141,243 - 24,152,958 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2524,791,105 - 24,793,938 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02524,303,930 - 24,306,779 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2524,304,712 - 24,306,732 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12524,249,725 - 24,252,576 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02524,141,364 - 24,144,207 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02524,290,187 - 24,293,030 (-)NCBIUU_Cfam_GSD_1.0
Hand2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494324,277,871 - 24,281,346 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365164,692,926 - 4,695,632 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365164,692,926 - 4,695,625 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HAND2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1416,459,971 - 16,462,207 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11416,460,089 - 16,462,979 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21417,528,431 - 17,531,096 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HAND2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17119,635,697 - 119,639,415 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7119,634,741 - 119,638,546 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603799,666,888 - 99,670,603 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hand2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247695,033,932 - 5,038,343 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247695,035,669 - 5,038,333 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hand2
13 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:111
Count of miRNA genes:94
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000030765
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163195152060148445Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat

Markers in Region
UniSTS:478956  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21632,919,324 - 32,919,444 (+)MAPPERmRatBN7.2
Rnor_6.01636,372,988 - 36,373,107NCBIRnor6.0
Rnor_5.01636,174,553 - 36,174,672UniSTSRnor5.0
RGSC_v3.41636,325,826 - 36,325,945UniSTSRGSC3.4
Celera1632,858,113 - 32,858,232UniSTS
Cytogenetic Map16p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 42 8 6 6 21
Low 1 1 44 35 10 35 1 1 4 10 6 1
Below cutoff 4 8 4 6 13 7 2 4 4

Sequence


Ensembl Acc Id: ENSRNOT00000079552   ⟹   ENSRNOP00000074299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1632,917,823 - 32,919,891 (-)Ensembl
Rnor_6.0 Ensembl1636,371,489 - 36,373,546 (-)Ensembl
RefSeq Acc Id: NM_022696   ⟹   NP_073187
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81637,928,145 - 37,931,488 (-)NCBI
mRatBN7.21632,917,448 - 32,920,791 (-)NCBI
Rnor_6.01636,371,489 - 36,373,551 (-)NCBI
Rnor_5.01636,173,054 - 36,174,762 (-)NCBI
RGSC_v3.41636,324,327 - 36,348,104 (-)RGD
Celera1632,856,614 - 32,879,368 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_073187 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA69332 (Get FASTA)   NCBI Sequence Viewer  
  EDL87163 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074299
  ENSRNOP00000074299.2
  ENSRNOP00055016828
  ENSRNOP00060009026
  ENSRNOP00065004534
GenBank Protein P61295 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_073187   ⟸   NM_022696
- UniProtKB: P61295 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074299   ⟸   ENSRNOT00000079552
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P61295-F1-model_v2 AlphaFold P61295 1-217 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621207 AgrOrtholog
BioCyc Gene G2FUF-11527 BioCyc
Ensembl Genes ENSRNOG00000060448 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055012257 UniProtKB/Swiss-Prot
  ENSRNOG00060007290 UniProtKB/Swiss-Prot
  ENSRNOG00065004432 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000079552 UniProtKB/TrEMBL
  ENSRNOT00000079552.2 UniProtKB/Swiss-Prot
  ENSRNOT00055020850 UniProtKB/Swiss-Prot
  ENSRNOT00060011981 UniProtKB/Swiss-Prot
  ENSRNOT00065006452 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64637 UniProtKB/Swiss-Prot
NCBI Gene 64637 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEART- AND NEURAL CREST DERIVATIVES-EXPRESSED PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hand2 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000060448 RatGTEx
  ENSRNOG00055012257 RatGTEx
  ENSRNOG00060007290 RatGTEx
  ENSRNOG00065004432 RatGTEx
SMART HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K7Q4_RAT UniProtKB/TrEMBL
  A6KIV6_RAT UniProtKB/TrEMBL
  HAND2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O95300 UniProtKB/Swiss-Prot
  O95301 UniProtKB/Swiss-Prot
  P97833 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Hand2  heart and neural crest derivatives expressed 2  LOC103693947  heart- and neural crest derivatives-expressed protein 2-like  Data merged from RGD:9128462 737654 PROVISIONAL
2014-08-25 LOC103693947  heart- and neural crest derivatives-expressed protein 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-10-17 Hand2  heart and neural crest derivatives expressed 2  Hand2  heart and neural crest derivatives expressed transcript 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Hand2  heart and neural crest derivatives expressed transcript 2    dHand protein  Name updated 1299863 APPROVED
2002-08-07 Hand2  dHand protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction bHLH domain interacts with the GATA4 C-terminal zinc finger domain and with the CH3 domain of p300 727369