HAND2 (heart and neural crest derivatives expressed 2) - Rat Genome Database

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Gene: HAND2 (heart and neural crest derivatives expressed 2) Pan paniscus
Analyze
Symbol: HAND2
Name: heart and neural crest derivatives expressed 2
RGD ID: 11992677
Description: ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); E-box binding (ortholog); INVOLVED IN adult heart development (ortholog); apoptotic process (ortholog); apoptotic process involved in heart morphogenesis (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); atrial fibrillation (ortholog); Cardiomegaly (ortholog); FOUND IN chromatin (ortholog); nucleus (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: heart- and neural crest derivatives-expressed protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23171,287,522 - 171,291,148 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14171,668,587 - 171,672,033 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04165,755,000 - 165,758,735 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14177,990,362 - 177,992,861 (-)NCBIpanpan1.1PanPan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult heart development  (ISO)
apoptotic process  (ISO)
apoptotic process involved in heart morphogenesis  (ISO)
cardiac neural crest cell development involved in outflow tract morphogenesis  (ISO)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (ISO)
cardiac right ventricle formation  (ISO)
cartilage morphogenesis  (ISO)
cell proliferation involved in outflow tract morphogenesis  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to retinoic acid  (ISO)
coronary artery morphogenesis  (ISO)
determination of heart left/right asymmetry  (ISO)
embryonic digit morphogenesis  (ISO)
embryonic skeletal system development  (ISO)
epithelial cell apoptotic process  (ISO)
heart development  (ISO)
heart looping  (ISO)
heart morphogenesis  (ISO)
in utero embryonic development  (ISO)
mesenchymal cell proliferation  (ISO)
mesenchyme development  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of epithelial cell apoptotic process  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of osteoblast differentiation  (ISO)
neural crest cell development  (ISO)
norepinephrine biosynthetic process  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
osteoblast differentiation  (ISO)
outflow tract morphogenesis  (ISO)
peripheral nervous system neuron development  (ISO)
positive regulation of cardiac muscle hypertrophy  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of p38MAPK cascade  (ISO)
positive regulation of semaphorin-plexin signaling pathway  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
primary palate development  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of secondary heart field cardioblast proliferation  (ISO)
regulation of tissue remodeling  (ISO)
roof of mouth development  (ISO)
suckling behavior  (ISO)
sympathetic nervous system development  (ISO)
thymus development  (ISO)
tongue development  (ISO)
visceral serous pericardium development  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
HAND2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23171,287,522 - 171,291,148 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14171,668,587 - 171,672,033 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04165,755,000 - 165,758,735 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14177,990,362 - 177,992,861 (-)NCBIpanpan1.1PanPan1.1panPan2
HAND2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384173,526,091 - 173,530,229 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4173,524,969 - 173,530,229 (-)EnsemblGRCh38hg38GRCh38
GRCh374174,447,242 - 174,451,380 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364174,684,227 - 174,687,953 (-)NCBINCBI36Build 36hg18NCBI36
Build 344174,820,849 - 174,825,309NCBI
Celera4171,772,735 - 171,776,461 (-)NCBICelera
Cytogenetic Map4q34.1NCBI
HuRef4170,194,314 - 170,197,710 (-)NCBIHuRef
CHM1_14174,424,466 - 174,428,102 (-)NCBICHM1_1
T2T-CHM13v2.04176,865,882 - 176,870,021 (-)NCBIT2T-CHM13v2.0
Hand2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39857,774,018 - 57,777,552 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl857,774,018 - 57,777,668 (+)EnsemblGRCm39 Ensembl
GRCm38857,320,983 - 57,324,517 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl857,320,983 - 57,324,633 (+)EnsemblGRCm38mm10GRCm38
MGSCv37859,799,780 - 59,803,314 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36860,214,046 - 60,216,006 (+)NCBIMGSCv36mm8
Celera859,958,813 - 59,962,384 (+)NCBICelera
Cytogenetic Map8B2NCBI
cM Map829.8NCBI
Hand2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81637,928,145 - 37,931,488 (-)NCBIGRCr8
mRatBN7.21632,917,448 - 32,920,791 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1632,917,823 - 32,919,891 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1636,510,401 - 36,513,743 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01639,921,734 - 39,925,076 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01636,141,350 - 36,144,691 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01636,371,489 - 36,373,551 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1636,371,489 - 36,373,546 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01636,173,054 - 36,174,762 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41636,324,327 - 36,348,104 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11636,324,401 - 36,326,112 (-)NCBI
Celera1632,856,614 - 32,879,368 (-)NCBICelera
Cytogenetic Map16p11NCBI
Hand2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540333,478,924 - 33,481,608 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540333,478,034 - 33,481,613 (+)NCBIChiLan1.0ChiLan1.0
HAND2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12524,140,496 - 24,143,143 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2524,141,243 - 24,152,958 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2524,791,105 - 24,793,938 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02524,303,930 - 24,306,779 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2524,304,712 - 24,306,732 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12524,249,725 - 24,252,576 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02524,141,364 - 24,144,207 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02524,290,187 - 24,293,030 (-)NCBIUU_Cfam_GSD_1.0
Hand2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494324,277,871 - 24,281,346 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365164,692,926 - 4,695,632 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365164,692,926 - 4,695,625 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HAND2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1416,459,971 - 16,462,207 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11416,460,089 - 16,462,979 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21417,528,431 - 17,531,096 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HAND2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17119,635,697 - 119,639,415 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7119,634,741 - 119,638,546 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603799,666,888 - 99,670,603 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hand2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247695,033,932 - 5,038,343 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247695,035,669 - 5,038,333 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003846131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: XM_003846131   ⟹   XP_003846179
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v23171,287,522 - 171,291,148 (-)NCBI
NHGRI_mPanPan14171,668,587 - 171,672,033 (-)NCBI
Mhudiblu_PPA_v04165,755,000 - 165,758,735 (-)NCBI
PanPan1.14177,990,362 - 177,992,861 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003846179 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_003846179   ⟸   XM_003846131
- Sequence:


Additional Information

Database Acc Id Source(s)
NCBI Gene HAND2 ENTREZGENE