HAND2 (heart and neural crest derivatives expressed 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: HAND2 (heart and neural crest derivatives expressed 2) Canis lupus familiaris
Analyze
Symbol: HAND2
Name: heart and neural crest derivatives expressed 2
RGD ID: 12228227
Description: ENCODES a protein that exhibits E-box binding (ortholog); transcription cis-regulatory region binding (ortholog); transcription coactivator binding (ortholog); INVOLVED IN adult heart development (ortholog); apoptotic process (ortholog); apoptotic process involved in heart morphogenesis (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); atrial fibrillation (ortholog); Cardiomegaly (ortholog); FOUND IN chromatin (inferred); nucleus (inferred); protein-containing complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DHAND; heart- and neural crest derivatives-expressed protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12524,140,496 - 24,143,143 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2524,141,243 - 24,152,958 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2524,791,105 - 24,793,938 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02524,303,930 - 24,306,779 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2524,304,712 - 24,306,732 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12524,249,725 - 24,252,576 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02524,141,364 - 24,144,207 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02524,290,187 - 24,293,030 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult heart development  (IEA,ISO)
apoptotic process  (IEA,ISO)
apoptotic process involved in heart morphogenesis  (IEA,ISO)
cardiac neural crest cell development involved in outflow tract morphogenesis  (IEA)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (IEA,ISO)
cardiac right ventricle formation  (IEA)
cartilage morphogenesis  (IEA,ISO)
cell proliferation involved in outflow tract morphogenesis  (IEA,ISO)
cellular response to retinoic acid  (ISO)
coronary artery morphogenesis  (IEA,ISO)
determination of heart left/right asymmetry  (IEA,ISO)
embryonic digit morphogenesis  (IEA,ISO)
embryonic skeletal system development  (IEA)
epithelial cell apoptotic process  (IEA,ISO)
heart development  (IBA,IEA,ISO)
heart looping  (IEA,ISO)
heart morphogenesis  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
mesenchymal cell proliferation  (IEA,ISO)
mesenchyme development  (IEA,ISO)
negative regulation of cardiac muscle cell apoptotic process  (IEA)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of epithelial cell apoptotic process  (IEA,ISO)
negative regulation of gene expression  (IEA)
negative regulation of osteoblast differentiation  (IEA,ISO)
neural crest cell development  (IEA,ISO)
norepinephrine biosynthetic process  (IEA,ISO)
odontogenesis of dentin-containing tooth  (IEA,ISO)
osteoblast differentiation  (IEA,ISO)
outflow tract morphogenesis  (IEA)
peripheral nervous system neuron development  (IEA,ISO)
positive regulation of cardiac muscle hypertrophy  (IEA)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of p38MAPK cascade  (IEA)
positive regulation of semaphorin-plexin signaling pathway  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
primary palate development  (IEA,ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of secondary heart field cardioblast proliferation  (IEA)
regulation of tissue remodeling  (IEA)
regulation of transcription by RNA polymerase II  (IBA)
roof of mouth development  (IEA,ISO)
suckling behavior  (IEA,ISO)
sympathetic nervous system development  (IEA,ISO)
thymus development  (IEA)
tongue development  (IEA,ISO)
visceral serous pericardium development  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:25403511   PMID:30032202  


Genomics

Comparative Map Data
HAND2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12524,140,496 - 24,143,143 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2524,141,243 - 24,152,958 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2524,791,105 - 24,793,938 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02524,303,930 - 24,306,779 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2524,304,712 - 24,306,732 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12524,249,725 - 24,252,576 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02524,141,364 - 24,144,207 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02524,290,187 - 24,293,030 (-)NCBIUU_Cfam_GSD_1.0
HAND2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384173,526,091 - 173,530,229 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4173,524,969 - 173,530,229 (-)EnsemblGRCh38hg38GRCh38
GRCh374174,447,242 - 174,451,380 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364174,684,227 - 174,687,953 (-)NCBINCBI36Build 36hg18NCBI36
Build 344174,820,849 - 174,825,309NCBI
Celera4171,772,735 - 171,776,461 (-)NCBICelera
Cytogenetic Map4q34.1NCBI
HuRef4170,194,314 - 170,197,710 (-)NCBIHuRef
CHM1_14174,424,466 - 174,428,102 (-)NCBICHM1_1
T2T-CHM13v2.04176,865,882 - 176,870,021 (-)NCBIT2T-CHM13v2.0
Hand2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39857,774,018 - 57,777,552 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl857,774,018 - 57,777,668 (+)EnsemblGRCm39 Ensembl
GRCm38857,320,983 - 57,324,517 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl857,320,983 - 57,324,633 (+)EnsemblGRCm38mm10GRCm38
MGSCv37859,799,780 - 59,803,314 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36860,214,046 - 60,216,006 (+)NCBIMGSCv36mm8
Celera859,958,813 - 59,962,384 (+)NCBICelera
Cytogenetic Map8B2NCBI
cM Map829.8NCBI
Hand2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81637,928,145 - 37,931,488 (-)NCBIGRCr8
mRatBN7.21632,917,448 - 32,920,791 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1632,917,823 - 32,919,891 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1636,510,401 - 36,513,743 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01639,921,734 - 39,925,076 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01636,141,350 - 36,144,691 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01636,371,489 - 36,373,551 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1636,371,489 - 36,373,546 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01636,173,054 - 36,174,762 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41636,324,327 - 36,348,104 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11636,324,401 - 36,326,112 (-)NCBI
Celera1632,856,614 - 32,879,368 (-)NCBICelera
Cytogenetic Map16p11NCBI
Hand2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540333,478,924 - 33,481,608 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540333,478,034 - 33,481,613 (+)NCBIChiLan1.0ChiLan1.0
HAND2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23171,287,522 - 171,291,148 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14171,668,587 - 171,672,033 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04165,755,000 - 165,758,735 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14177,990,362 - 177,992,861 (-)NCBIpanpan1.1PanPan1.1panPan2
Hand2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494324,277,871 - 24,281,346 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365164,692,926 - 4,695,632 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365164,692,926 - 4,695,625 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HAND2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1416,459,971 - 16,462,207 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11416,460,089 - 16,462,979 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21417,528,431 - 17,531,096 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HAND2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17119,635,697 - 119,639,415 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7119,634,741 - 119,638,546 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603799,666,888 - 99,670,603 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hand2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247695,033,932 - 5,038,343 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247695,035,669 - 5,038,333 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HAND2
34 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 32 21 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000012546   ⟹   ENSCAFP00000011616
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2524,141,243 - 24,152,958 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845030394   ⟹   ENSCAFP00845023837
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2524,304,712 - 24,306,732 (-)Ensembl
RefSeq Acc Id: XM_022410028   ⟹   XP_022265736
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12524,140,496 - 24,143,143 (-)NCBI
Dog10K_Boxer_Tasha2524,791,105 - 24,793,938 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038435206   ⟹   XP_038291134
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02524,303,930 - 24,306,779 (-)NCBI
RefSeq Acc Id: XM_038510149   ⟹   XP_038366077
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12524,249,725 - 24,252,576 (-)NCBI
RefSeq Acc Id: XM_038573605   ⟹   XP_038429533
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02524,290,187 - 24,293,030 (-)NCBI
RefSeq Acc Id: XM_038637914   ⟹   XP_038493842
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02524,141,364 - 24,144,207 (-)NCBI
RefSeq Acc Id: XP_022265736   ⟸   XM_022410028
- UniProtKB: A0A8C0P2Z2 (UniProtKB/TrEMBL),   A0A8C0KHD4 (UniProtKB/TrEMBL),   A0A8I3PA17 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000011616   ⟸   ENSCAFT00000012546
RefSeq Acc Id: XP_038366077   ⟸   XM_038510149
RefSeq Acc Id: XP_038493842   ⟸   XM_038637914
RefSeq Acc Id: XP_038291134   ⟸   XM_038435206
- UniProtKB: A0A8C0P2Z2 (UniProtKB/TrEMBL),   A0A8C0KHD4 (UniProtKB/TrEMBL),   A0A8I3PA17 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038429533   ⟸   XM_038573605
- UniProtKB: A0A8C0KHD4 (UniProtKB/TrEMBL),   A0A8C0P2Z2 (UniProtKB/TrEMBL),   A0A8I3PA17 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845023837   ⟸   ENSCAFT00845030394
Protein Domains
bHLH

Promoters
RGD ID:13687759
Promoter ID:EPDNEW_C5827
Type:single initiation site
Name:HAND2_1
Description:heart and neural crest derivatives expressed 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12524,143,350 - 24,143,410EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007858 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030019231 UniProtKB/TrEMBL
  ENSCAFG00040021067 UniProtKB/TrEMBL
  ENSCAFG00845017182 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000012546.6 UniProtKB/TrEMBL
  ENSCAFT00030035365.1 UniProtKB/TrEMBL
  ENSCAFT00040039033.1 UniProtKB/TrEMBL
  ENSCAFT00845030394 ENTREZGENE
  ENSCAFT00845030394.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/TrEMBL
  E-box_TF_Regulators UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene HAND2 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST UniProtKB/TrEMBL
  HEART- AND NEURAL CREST DERIVATIVES-EXPRESSED PROTEIN 2 UniProtKB/TrEMBL
Pfam HLH UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/TrEMBL
UniProt A0A8C0KHD4 ENTREZGENE
  A0A8C0P2Z2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PA17 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:58305 ENTREZGENE