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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621207
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hand2
Name: heart and neural crest derivatives expressed 2
Acc ID: CHEBI:67040
Term: S-adenosyl-L-methioninate
Definition: A sulfonium betaine that is a conjugate base of S-adenosyl-L-methionine obtained by the deprotonation of the carboxy group.
Chemical ID: MESH:D012436
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hand2multiple interactionsISOHand2 (Mus musculus)6480464CTD[Progesterone co-treated with S-Adenosylmethionine] results in increased methylation of HAND2 promoter; S-Adenosylmethionine inhibits the reaction [Progesterone results in increased expression of HAND2 mRNA]PMID:30892605
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