The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A C-glycosyl comprising beta-D-glucose in which the anomeric hydroxy group is replaced by a 4-chloro-3-(4-ethoxybenzyl)phenyl group. Used (in the form of its propanediol monohydrate) to improve glycemic control, along with diet and exercise, in adults with type 2 diabetes.
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of ACTA2 protein]; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of ACTA2 protein]; Metformin promotes the reaction [dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of ACTA2 protein]]
[SRT1460 co-treated with dapagliflozin] inhibits the reaction [IL1B protein results in increased expression of ADAMTS5 protein]; dapagliflozin inhibits the reaction [IL1B protein results in increased expression of ADAMTS5 protein]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of AKT1 protein]; [dapagliflozin co-treated with Vildagliptin] inhibits the reaction [Dietary Fats results in decreased phosphorylation of AKT1 protein]; dapagliflozin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT1 protein]; dapagliflozin inhibits the reaction [Dietary Fats results in decreased phosphorylation of AKT1 protein]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of ATF6 protein]
[SRT1460 co-treated with dapagliflozin] inhibits the reaction [IL1B protein results in increased expression of BAX protein]; [Thapsigargin co-treated with dapagliflozin] inhibits the reaction [IL1B protein results in increased expression of BAX protein]; [Vildagliptin co-treated with dapagliflozin] inhibits the reaction [Dietary Fats results in increased expression of BAX protein]; dapagliflozin inhibits the reaction [Dietary Fats results in increased expression of BAX protein]; dapagliflozin inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; dapagliflozin inhibits the reaction [IL1B protein results in increased expression of BAX protein]; dapagliflozin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX protein]
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein]; [dapagliflozin co-treated with Vildagliptin] inhibits the reaction [Dietary Fats results in decreased expression of BCL2 protein]; [SRT1460 co-treated with dapagliflozin] inhibits the reaction [IL1B protein results in decreased expression of BCL2 protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein]; dapagliflozin inhibits the reaction [Dietary Fats results in decreased expression of BCL2 protein]; dapagliflozin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; dapagliflozin inhibits the reaction [IL1B protein results in decreased expression of BCL2 protein]; dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of BCL2 protein]; STAT3 protein promotes the reaction [dapagliflozin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CASP1 protein]; dapagliflozin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CASP1 protein]
[SRT1460 co-treated with dapagliflozin] inhibits the reaction [IL1B protein results in increased cleavage of CASP3 protein]; dapagliflozin inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein modified form]; dapagliflozin inhibits the reaction [IL1B protein results in increased cleavage of CASP3 protein]; dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of and results in increased cleavage of CASP3 protein]; SRT1460 promotes the reaction [dapagliflozin inhibits the reaction [IL1B protein results in increased cleavage of CASP3 protein]]
dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]; dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]]; Metformin promotes the reaction [dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CCL2 protein]; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of CCL2 protein]
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CD36 protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CD36 protein]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of CDH1 protein]; dapagliflozin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of CDH1 protein]
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CYCS protein]
dapagliflozin inhibits the reaction [IL1B protein results in increased expression of DDIT3 mRNA]; dapagliflozin inhibits the reaction [IL1B protein results in increased expression of DDIT3 protein]
dapagliflozin inhibits the reaction [IL1B protein results in increased expression of EIF2AK3 mRNA]; Thapsigargin inhibits the reaction [dapagliflozin inhibits the reaction [IL1B protein results in increased expression of EIF2AK3 mRNA]]
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of FASN protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of FASN protein]
Atorvastatin promotes the reaction [dapagliflozin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of GJA1 protein]]; dapagliflozin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of GJA1 protein]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of GPT protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of GPT protein]
dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]; dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]]; Metformin promotes the reaction [dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]]
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of HMOX1 protein]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of IL1B protein]; [SRT1460 co-treated with dapagliflozin] inhibits the reaction [IL1B protein results in decreased expression of BCL2 protein]; [SRT1460 co-treated with dapagliflozin] inhibits the reaction [IL1B protein results in increased cleavage of CASP3 protein]; [SRT1460 co-treated with dapagliflozin] inhibits the reaction [IL1B protein results in increased expression of ADAMTS5 protein]; [SRT1460 co-treated with dapagliflozin] inhibits the reaction [IL1B protein results in increased expression of BAX protein]; [SRT1460 co-treated with dapagliflozin] inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; [Thapsigargin co-treated with dapagliflozin] inhibits the reaction [IL1B protein results in increased expression of BAX protein]; dapagliflozin inhibits the reaction [IL1B protein results in decreased expression of BCL2 protein]; dapagliflozin inhibits the reaction [IL1B protein results in decreased expression of SIRT1 mRNA]; dapagliflozin inhibits the reaction [IL1B protein results in decreased expression of SIRT1 protein]; dapagliflozin inhibits the reaction [IL1B protein results in increased cleavage of CASP3 protein]; dapagliflozin inhibits the reaction [IL1B protein results in increased expression of ADAMTS5 protein]; dapagliflozin inhibits the reaction [IL1B protein results in increased expression of ATF4 mRNA]; dapagliflozin inhibits the reaction [IL1B protein results in increased expression of BAX protein]; dapagliflozin inhibits the reaction [IL1B protein results in increased expression of DDIT3 mRNA]; dapagliflozin inhibits the reaction [IL1B protein results in increased expression of DDIT3 protein]; dapagliflozin inhibits the reaction [IL1B protein results in increased expression of EIF2A mRNA]; dapagliflozin inhibits the reaction [IL1B protein results in increased expression of EIF2AK3 mRNA]; dapagliflozin inhibits the reaction [IL1B protein results in increased expression of HSPA5 mRNA]; dapagliflozin inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; SRT1460 promotes the reaction [dapagliflozin inhibits the reaction [IL1B protein results in increased cleavage of CASP3 protein]]; Thapsigargin inhibits the reaction [dapagliflozin inhibits the reaction [IL1B protein results in decreased expression of SIRT1 mRNA]]; Thapsigargin inhibits the reaction [dapagliflozin inhibits the reaction [IL1B protein results in increased expression of EIF2AK3 mRNA]]; Thapsigargin inhibits the reaction [dapagliflozin inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of INS1 protein]; dapagliflozin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of INS1 protein]; dapagliflozin inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]; dapagliflozin promotes the reaction [Vildagliptin inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]]
[dapagliflozin co-treated with Vildagliptin] inhibits the reaction [Dietary Fats results in decreased phosphorylation of INSR protein]; dapagliflozin inhibits the reaction [Dietary Fats results in decreased phosphorylation of INSR protein]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of LCN2 protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of LCN2 protein]; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of LCN2 protein]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased lipidation of MAP1LC3B protein]
[SRT1460 co-treated with dapagliflozin] inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; dapagliflozin inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; Thapsigargin inhibits the reaction [dapagliflozin inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of and results in increased phosphorylation of MTOR protein]; dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of MTOR protein]
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of NFE2L2 protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of NFE2L2 protein]; dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid affects the expression of NFE2L2 protein]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of NLRP3 protein]
dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of OGA protein]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of PLIN2 protein]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PPARA protein]
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PPARGC1A protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PPARGC1A protein]
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of and results in increased phosphorylation of PRKCA protein]
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PRKCZ protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PRKCZ protein]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of PTGS2 protein]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of RELA protein]; [dapagliflozin co-treated with Vildagliptin] inhibits the reaction [Dietary Fats results in increased phosphorylation of RELA protein]; dapagliflozin inhibits the reaction [Dietary Fats results in increased phosphorylation of RELA protein]; dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of RELA protein]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SIRT1 protein]; dapagliflozin inhibits the reaction [IL1B protein results in decreased expression of SIRT1 mRNA]; dapagliflozin inhibits the reaction [IL1B protein results in decreased expression of SIRT1 protein]; Thapsigargin inhibits the reaction [dapagliflozin inhibits the reaction [IL1B protein results in decreased expression of SIRT1 mRNA]]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of SQSTM1 protein]; dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SQSTM1 protein]
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of SREBF1 protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of SREBF1 protein]
dapagliflozin inhibits the reaction [Doxorubicin results in decreased expression of STAT3 protein]; STAT3 protein promotes the reaction [dapagliflozin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]] dapagliflozin results in increased expression of STAT3 protein
dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein]; dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein]]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of TNF protein]; dapagliflozin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of TNF protein]; dapagliflozin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TNF protein]; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein]; dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein]]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of VIM protein]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of WT1 protein]
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