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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sodium-glucose transport protein subtype 2 inhibitor
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Accession:CHEBI:73273 term browser browse the term
Definition:An inhibitor that interferes with the action of sodium-glucose transport protein subtype 2.
Synonyms:related_synonym: SGLT2 inhibitor;   SGLT2 inhibitors;   sodium glucose co-transporter 2 inhibitor;   sodium glucose co-transporter 2 inhibitors;   sodium-glucose transport protein subtype 2 inhibitors
 xref: Wikipedia:SLC5A2


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canagliflozin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP Canagliflozin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased activity of ACHE protein]; Canagliflozin inhibits the reaction [Scopolamine results in increased activity of ACHE protein] CTD PMID:27566243 PMID:28837785 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 decreases expression
multiple interactions
EXP Canagliflozin results in decreased expression of CHRM1 protein
Canagliflozin affects the reaction [Scopolamine results in decreased expression of CHRM1 protein]
CTD PMID:28837785 NCBI chr 1:205,567,046...205,583,001
Ensembl chr 1:205,567,220...205,582,356
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression EXP Canagliflozin results in increased expression of HAVCR1 CTD PMID:25130857 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP Canagliflozin results in increased expression of LHB protein CTD PMID:25289773 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Pth parathyroid hormone decreases expression EXP Canagliflozin results in decreased expression of PTH protein CTD PMID:25289773 NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530
JBrowse link
G Slc5a2 solute carrier family 5 member 2 decreases activity ISO Canagliflozin results in decreased activity of SLC5A2 protein CTD PMID:21128592 NCBI chr 1:182,847,185...182,853,309
Ensembl chr 1:182,847,106...182,853,306
JBrowse link
dapagliflozin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of ACTA2 protein]; Metformin promotes the reaction [dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of ACTA2 protein]] CTD PMID:30551545 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of AGER protein] CTD PMID:33412153 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of AKT1 protein]; [dapagliflozin co-treated with Vildagliptin] inhibits the reaction [Dietary Fats results in decreased phosphorylation of AKT1 protein]; dapagliflozin inhibits the reaction [Dietary Fats results in decreased phosphorylation of AKT1 protein] CTD PMID:28807765 PMID:32259528 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP [Vildagliptin co-treated with dapagliflozin] inhibits the reaction [Dietary Fats results in increased expression of BAX protein]; dapagliflozin inhibits the reaction [Dietary Fats results in increased expression of BAX protein]; dapagliflozin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX protein] CTD PMID:28807765 PMID:33412153 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP [Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein]; [dapagliflozin co-treated with Vildagliptin] inhibits the reaction [Dietary Fats results in decreased expression of BCL2 protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein]; dapagliflozin inhibits the reaction [Dietary Fats results in decreased expression of BCL2 protein]; dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of BCL2 protein] CTD PMID:28807765 PMID:32259528 PMID:33412153 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Becn1 beclin 1 multiple interactions EXP dapagliflozin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BECN1 protein] CTD PMID:33412153 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Casp3 caspase 3 multiple interactions EXP dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of and results in increased cleavage of CASP3 protein] CTD PMID:33412153 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions EXP dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]; dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]]; Metformin promotes the reaction [dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]] CTD PMID:30551545 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of CCL2 protein] CTD PMID:30551545 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cd36 CD36 molecule multiple interactions EXP [Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CD36 protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CD36 protein] CTD PMID:32259528 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP [Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CYCS protein] CTD PMID:32259528 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Fasn fatty acid synthase multiple interactions EXP [Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of FASN protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of FASN protein] CTD PMID:32259528 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of GPT protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of GPT protein] CTD PMID:32259528 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]; dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]]; Metformin promotes the reaction [dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]] CTD PMID:30551545 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of HMGB1 protein] CTD PMID:33412153 NCBI chr12:5,973,062...5,978,565 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP [Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of HMOX1 protein] CTD PMID:32259528 PMID:33412153 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il10 interleukin 10 multiple interactions EXP dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10 protein] CTD PMID:33412153 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Insr insulin receptor multiple interactions EXP [dapagliflozin co-treated with Vildagliptin] inhibits the reaction [Dietary Fats results in decreased phosphorylation of INSR protein]; dapagliflozin inhibits the reaction [Dietary Fats results in decreased phosphorylation of INSR protein] CTD PMID:28807765 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Lcn2 lipocalin 2 multiple interactions EXP [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of LCN2 protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of LCN2 protein]; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of LCN2 protein] CTD PMID:30551545 PMID:32259528 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:33412153 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of MTOR protein] CTD PMID:33412153 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP [Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of NFE2L2 protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of NFE2L2 protein]; dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid affects the expression of NFE2L2 protein] CTD PMID:32259528 PMID:33412153 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions EXP dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in decreased expression of NPHS1 mRNA] CTD PMID:30551545 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078
JBrowse link
G Oga O-GlcNAcase multiple interactions EXP dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of OGA protein] CTD PMID:30551545 NCBI chr 1:244,598,285...244,633,835
Ensembl chr 1:244,598,292...244,634,359
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PPARA protein] CTD PMID:32259528 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP [Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PPARGC1A protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PPARGC1A protein] CTD PMID:32259528 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Prkca protein kinase C, alpha multiple interactions EXP [Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of and results in increased phosphorylation of PRKCA protein] CTD PMID:32259528 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prkcz protein kinase C, zeta multiple interactions EXP [Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PRKCZ protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PRKCZ protein] CTD PMID:32259528 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP [dapagliflozin co-treated with Vildagliptin] inhibits the reaction [Dietary Fats results in increased phosphorylation of RELA protein]; dapagliflozin inhibits the reaction [Dietary Fats results in increased phosphorylation of RELA protein]; dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of RELA protein] CTD PMID:28807765 PMID:33412153 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Slc5a2 solute carrier family 5 member 2 decreases activity ISO dapagliflozin results in decreased activity of SLC5A2 protein CTD PMID:21128592 NCBI chr 1:182,847,185...182,853,309
Ensembl chr 1:182,847,106...182,853,306
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SQSTM1 protein] CTD PMID:33412153 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP [Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of SREBF1 protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of SREBF1 protein] CTD PMID:32259528 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein]; dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein]] CTD PMID:30551545 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein]; dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein]] CTD PMID:30551545 PMID:33412153 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vnn1 vanin 1 multiple interactions EXP dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of VNN1 mRNA] CTD PMID:30551545 NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        biochemical role 19389
          sodium-glucose transport protein subtype 2 inhibitor 39
            Synjardy 0
            canagliflozin + 6
            canagliflozin hydrate 0
            dapagliflozin + 35
            dapagliflozin propanediol monohydrate 0
            empagliflozin + 0
paths to the root