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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:prazosin
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Accession:CHEBI:8364 term browser browse the term
Definition:A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
Synonyms:exact_synonym: 2-[4-(2-furoyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine
 related_synonym: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine;   2-(4-(2-Furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline;   Formula=C19H21N5O4;   InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);   InChIKey=IENZQIKPVFGBNW-UHFFFAOYSA-N;   SMILES=COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1;   prazosina;   prazosine;   prazosinum
 xref: Beilstein:768345;   CAS:19216-56-9;   DrugBank:DB00457;   Drug_Central:4209;   HMDB:HMDB0014600;   KEGG:C07368;   KEGG:D08411;   LINCS:LSM-3079
 xref_mesh: MESH:D011224
 xref: PMID:20825390;   Patent:GB1156973;   Patent:NL7206067;   Patent:US3511836;   Reaxys:768345;   Wikipedia:Prazosin


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prazosin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance
affects transport		 ISO ABCB1A protein affects the susceptibility to Prazosin
ABCB1A protein affects the transport of Prazosin
ABCB1 protein affects the transport of Prazosin		 CTD PMID:15502009 PMID:15616150 PMID:18322075 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Prazosin CTD PMID:15502009 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases export
affects transport		 ISO 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of Prazosin]; Elacridar inhibits the reaction [ABCG2 protein results in increased export of Prazosin]
6-OH-BDE-47 inhibits the reaction [ABCG2 protein results in increased export of Prazosin]
ABCG2 protein affects the transport of Prazosin		 CTD PMID:18322075 PMID:19056916 PMID:28031414 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Acta1 actin, alpha 1, skeletal muscle multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA] CTD PMID:17592507 NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742 		JBrowse link
G Adora1 adenosine A1 receptor multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein] CTD PMID:19966059 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801 		JBrowse link
G Adora2a adenosine A2a receptor multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein] CTD PMID:19966059 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386 		JBrowse link
G Adora3 adenosine A3 receptor multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein] CTD PMID:19966059 NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357 		JBrowse link
G Adra1a adrenoceptor alpha 1A multiple interactions
affects binding
increases expression
decreases activity		 ISO
EXP		 1-(2-(3-methoxyphenyl)ethyl)phenoxy-3-(dimethylamino)-2-propanol inhibits the reaction [Prazosin binds to ADRA1A protein]; alfuzosin inhibits the reaction [Prazosin binds to ADRA1A protein]; Epinephrine inhibits the reaction [ADRA1A protein binds to Prazosin]; Ketanserin inhibits the reaction [Prazosin binds to ADRA1A protein]; Norepinephrine inhibits the reaction [ADRA1A protein binds to Prazosin]; Oxymetazoline inhibits the reaction [ADRA1A protein binds to Prazosin]; Oxymetazoline inhibits the reaction [Prazosin binds to ADRA1A protein]; Prazosin binds to and results in decreased activity of ADRA1A protein; Prazosin inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]; sarpogrelate inhibits the reaction [Prazosin binds to ADRA1A protein]; xylometazoline inhibits the reaction [ADRA1A protein binds to Prazosin]
ADRA1A protein binds to Prazosin; Prazosin binds to ADRA1A protein
Prazosin results in increased expression of ADRA1A mRNA; Prazosin results in increased expression of ADRA1A protein
Prazosin binds to and affects the activity of ADRA1A protein; Prazosin binds to and results in decreased activity of ADRA1A protein; Prazosin inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]; Prazosin inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]
Prazosin results in decreased activity of ADRA1A protein		 CTD PMID:6310690 PMID:7536677 PMID:8183249 PMID:8196478 PMID:9639061 More... NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Adra1b adrenoceptor alpha 1B multiple interactions
increases expression
affects binding		 ISO
EXP		 1-(2-(3-methoxyphenyl)ethyl)phenoxy-3-(dimethylamino)-2-propanol inhibits the reaction [Prazosin binds to ADRA1B protein]; Epinephrine inhibits the reaction [ADRA1B protein binds to Prazosin]; Ketanserin inhibits the reaction [Prazosin binds to ADRA1B protein]; Norepinephrine inhibits the reaction [ADRA1B protein binds to Prazosin]; Oxymetazoline inhibits the reaction [ADRA1B protein binds to Prazosin]; sarpogrelate inhibits the reaction [Prazosin binds to ADRA1B protein]; xylometazoline inhibits the reaction [ADRA1B protein binds to Prazosin]
Prazosin results in increased expression of ADRA1B protein
Prazosin binds to and affects the activity of ADRA1B protein
ADRA1B protein binds to Prazosin; Prazosin binds to ADRA1B protein		 CTD PMID:8183249 PMID:9639061 PMID:11934817 PMID:11937776 PMID:20030735 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919 		JBrowse link
G Adra1d adrenoceptor alpha 1D multiple interactions
affects binding		 ISO
EXP		 1-(2-(3-methoxyphenyl)ethyl)phenoxy-3-(dimethylamino)-2-propanol inhibits the reaction [Prazosin binds to ADRA1D protein]; Epinephrine inhibits the reaction [ADRA1D protein binds to Prazosin]; Ketanserin inhibits the reaction [Prazosin binds to ADRA1D protein]; Norepinephrine inhibits the reaction [ADRA1D protein binds to Prazosin]; Oxymetazoline inhibits the reaction [ADRA1D protein binds to Prazosin]; sarpogrelate inhibits the reaction [Prazosin binds to ADRA1D protein]; xylometazoline inhibits the reaction [ADRA1D protein binds to Prazosin]
ADRA1D protein binds to Prazosin; Prazosin binds to ADRA1D protein
Prazosin binds to and affects the activity of ADRA1D protein		 CTD PMID:8183249 PMID:9294627 PMID:9639061 PMID:11937776 PMID:15493479 More... NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354 		JBrowse link
G Adra2a adrenoceptor alpha 2A multiple interactions ISO
EXP		 Prazosin inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]; Prazosin inhibits the reaction [Phenylephrine promotes the reaction [Brimonidine Tartrate binds to and results in increased activity of ADRA2A protein]]
Prazosin binds to and results in decreased activity of ADRA2A protein		 CTD PMID:8397342 PMID:10742289 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA] CTD PMID:11577024 PMID:17592507 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Avp arginine vasopressin increases expression EXP Prazosin results in increased expression of AVP protein CTD PMID:1791990 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Casp8 caspase 8 increases activity ISO Prazosin results in increased activity of CASP8 protein CTD PMID:26449523 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity ISO Prazosin results in increased activity of CASP9 protein CTD PMID:26449523 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Prazosin inhibits the reaction [Norepinephrine results in increased secretion of CCL5 protein] CTD PMID:16782692 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein] CTD PMID:15522277 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO Prazosin promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]
Prazosin results in increased expression of CYP1A1 mRNA		 CTD PMID:15627480 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]]; Prazosin promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; Prazosin promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein] CTD PMID:16510159 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Edn1 endothelin 1 multiple interactions EXP Prazosin inhibits the reaction [EDN1 protein results in increased expression of NPPA protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of EDN1 protein] CTD PMID:12513686 PMID:15007106 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO [Norepinephrine co-treated with Prazosin] results in decreased expression of FN1 protein CTD PMID:11821714 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO
EXP		 Prazosin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of FOS protein]
Prazosin inhibits the reaction [Amphetamine results in increased expression of FOS protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of FOS mRNA]		 CTD PMID:12560108 PMID:12955385 PMID:19225867 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased activity of G6PD protein]; Prazosin inhibits the reaction [norfenefrine results in increased activity of G6PD protein] CTD PMID:1378361 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO Prazosin inhibits the reaction [Acetaminophen results in increased expression of GCLC mRNA] CTD PMID:18071297 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Prazosin inhibits the reaction [Acetaminophen results in increased expression of HMOX1 mRNA] CTD PMID:18071297 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions EXP Prazosin inhibits the reaction [IGF1 protein results in decreased susceptibility to Norepinephrine] CTD PMID:17184500 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of JUN mRNA] CTD PMID:19225867 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in decreased secretion of and results in decreased expression of LHB protein] CTD PMID:3953791 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Lpl lipoprotein lipase multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of LPL mRNA] CTD PMID:9032464 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
affects activity		 ISO
EXP		 Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]
Prazosin affects the reaction [Norepinephrine results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Prazosin inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]
Prazosin affects the activity of MAPK1 protein		 CTD PMID:11693273 PMID:11804996 PMID:11880281 PMID:12513686 PMID:17306214 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 affects activity
multiple interactions		 EXP
ISO		 Prazosin affects the activity of MAPK3 protein
Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]
Prazosin inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]		 CTD PMID:11693273 PMID:11804996 PMID:11880281 PMID:12513686 PMID:17306214 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA] CTD PMID:15326086 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in decreased expression of MYH6 mRNA] CTD PMID:11577024 PMID:17592507 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA] CTD PMID:11577024 PMID:17592507 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP Prazosin inhibits the reaction [Cocaine results in increased phosphorylation of NCF1 protein] CTD PMID:15936005 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases activity ISO Prazosin results in decreased activity of NFE2L2 protein CTD PMID:30203046 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP		 Prazosin inhibits the reaction [carvedilol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [carvedilol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Prazosin inhibits the reaction [Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [Dopamine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Prazosin inhibits the reaction [Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Prazosin inhibits the reaction [Norepinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [Norepinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
Prazosin inhibits the reaction [Phenylephrine results in increased expression of NOS2 mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of NOS2 protein]		 CTD PMID:15753950 PMID:19439816 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP Prazosin inhibits the reaction [EDN1 protein results in increased expression of NPPA protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of NPPA mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of NPPA protein] CTD PMID:12513686 PMID:15240149 PMID:16714034 PMID:17592507 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Npy neuropeptide Y multiple interactions EXP [Prazosin co-treated with SCH 23390] inhibits the reaction [Phenylpropanolamine results in decreased expression of NPY protein] CTD PMID:21989786 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide increases expression EXP Prazosin results in increased expression of OXT protein CTD PMID:1791990 NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490 		JBrowse link
G Plcb1 phospholipase C beta 1 multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCB1 protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB1 protein] CTD PMID:16714034 PMID:19225867 NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869 		JBrowse link
G Plcb3 phospholipase C beta 3 multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCB3 protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB3 mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB3 protein] CTD PMID:16714034 PMID:19225867 NCBI chr 1:204,143,257...204,160,384
Ensembl chr 1:204,144,956...204,160,228 		JBrowse link
G Plcd1 phospholipase C, delta 1 multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCD1 protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCD1 protein] CTD PMID:16714034 PMID:19225867 NCBI chr 8:118,795,196...118,818,186
Ensembl chr 8:118,795,201...118,818,186 		JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCG1 protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCG1 mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCG1 protein] CTD PMID:16714034 PMID:19225867 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO [Propranolol co-treated with Prazosin] inhibits the reaction [Norepinephrine results in increased expression of PPARGC1A mRNA] CTD PMID:16513826 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ren renin decreases activity
increases activity
multiple interactions
increases transport		 ISO
EXP		 Prazosin results in decreased activity of REN protein
Prazosin results in increased activity of REN protein
Propranolol inhibits the reaction [Prazosin results in increased transport of REN protein]		 CTD PMID:3539430 PMID:6173514 PMID:6258839 PMID:7023672 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein] CTD PMID:12720544 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein] CTD PMID:12720544 NCBI chr 1:201,451,265...201,458,096
Ensembl chr 1:201,451,265...201,458,078 		JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form] CTD PMID:19168439 NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases activity
multiple interactions		 ISO Prazosin results in decreased activity of SLC22A1 protein
Prazosin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]		 CTD PMID:12110607 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Prazosin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions
decreases activity		 ISO Prazosin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
Prazosin results in decreased activity of SLC22A3 protein		 CTD PMID:12110607 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612 		JBrowse link
G Spn sialophorin decreases response to substance ISO SPN protein results in decreased susceptibility to Prazosin CTD PMID:18711009 NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of TGFB1 mRNA] CTD PMID:15326086 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of TGFB2 mRNA] CTD PMID:15326086 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of TGFB3 mRNA] CTD PMID:15326086 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of TIMP2 mRNA] CTD PMID:15326086 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Prazosin inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA] CTD PMID:17306214 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Tyr tyrosinase multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in increased activity of TYR protein] CTD PMID:15278367 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      application 19661
        pharmaceutical 19502
          drug 19502
            cardiovascular drug 8621
              antihypertensive agent 1945
                prazosin 59
                  prazosin hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            heteroorganic entity 19492
                              organochalcogen compound 19255
                                organooxygen compound 19172
                                  carbon oxoacid 18641
                                    carboxylic acid 18638
                                      carboacyl group 17698
                                        univalent carboacyl group 17698
                                          carbamoyl group 17548
                                            carboxamide 17548
                                              monocarboxylic acid amide 15680
                                                prazosin 59
                                                  prazosin hydrochloride 0
paths to the root