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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:renin-angiotensin cascade pathway
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Accession:PW:0000492 term browser browse the term
Definition:The renin-angiotensin cascade (RAS) generates a number of bioactive peptides with diverse physiological and pathophysiological functions. RAS exerts vasoconstriction, vasodilation or vascular remodeling, cell proliferation or anti-proliferation effects, depending on which angiotensin peptide generates the signaling. Some of these features are also shared by the kallikrein-kinin system (KKS); the two systems can interact and cross-talk.
Synonyms:related_synonym: KEGG:04614;   RAS system signaling pathway
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renin-angiotensin cascade pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme ISO
IEA
IMP 		KEGG
RGD		 PMID:15638741 PMID:10642323 rno:04614, RGD:1581742, RGD:1581953 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942 		JBrowse link
G Ace2 angiotensin converting enzyme 2 ISO
IEA 		KEGG
RGD		 PMID:15638741 PMID:16520407 rno:04614, RGD:1581742, RGD:1581931 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:33,925,458...33,971,596 		JBrowse link
G Agt angiotensinogen IDA
IEA
IMP
ISO 		KEGG
RGD		 PMID:12242043 PMID:11282364 PMID:15638741 rno:04614, RGD:1581651, RGD:1582105, RGD:1581742 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a TAS
IEA 		KEGG
RGD		 PMID:16141358 rno:04614, RGD:1581847 NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660 		JBrowse link
G Agtr1b angiotensin II receptor, type 1b TAS
IEA 		KEGG
RGD		 PMID:16141358 rno:04614, RGD:1581847 NCBI chr 2:104,774,005...104,849,262
Ensembl chr 2:104,773,930...104,849,310 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 TAS
IEA 		KEGG
RGD		 PMID:15158138 rno:04614, RGD:1581855 NCBI chr  X:116,914,320...116,918,504
Ensembl chr  X:116,913,656...116,918,745 		JBrowse link
G Anpep alanyl aminopeptidase, membrane IDA
IEA 		KEGG
RGD		 PMID:16537183 rno:04614, RGD:1581649 NCBI chr 1:143,176,645...143,219,447
Ensembl chr 1:143,176,645...143,195,101 		JBrowse link
G Atp6ap2 ATPase H+ transporting accessory protein 2 ISO RGD PMID:18376005 RGD:5132617 NCBI chr  X:12,856,708...12,883,670
Ensembl chr  X:12,855,859...12,905,875 		JBrowse link
G Cma1 chymase 1 TAS
IEA 		KEGG
RGD		 PMID:15638741 rno:04614, RGD:1581742 NCBI chr15:33,387,351...33,390,133
Ensembl chr15:33,387,351...33,390,133 		JBrowse link
G Cpa3 carboxypeptidase A3 IEA KEGG rno:04614 NCBI chr 2:104,641,619...104,673,253
Ensembl chr 2:104,641,621...104,673,237 		JBrowse link
G Ctsa cathepsin A IEA KEGG rno:04614 NCBI chr 3:173,988,443...173,994,320
Ensembl chr 3:173,988,460...173,995,539 		JBrowse link
G Ctsg cathepsin G IEA KEGG rno:04614 NCBI chr15:33,901,230...33,907,596
Ensembl chr15:33,901,754...33,907,596 		JBrowse link
G Enpep glutamyl aminopeptidase IDA
IEA
ISO 		KEGG
RGD		 PMID:16537183 PMID:15638741 rno:04614, RGD:1581649, RGD:1581742 NCBI chr 2:220,456,258...220,526,218
Ensembl chr 2:220,456,278...220,526,218 		JBrowse link
G Igf2r insulin-like growth factor 2 receptor IDA
TAS 		RGD PMID:11247783 PMID:16672920 RGD:1581738, RGD:1581739 NCBI chr 1:50,526,878...50,615,265
Ensembl chr 1:50,526,878...50,615,265 		JBrowse link
G Lnpep leucyl and cystinyl aminopeptidase TAS
IEA
IMP 		KEGG
RGD		 PMID:15687842 PMID:11282364 rno:04614, RGD:1581849, RGD:1582105 NCBI chr 1:66,931,712...67,027,610
Ensembl chr 1:66,931,712...67,027,610 		JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor TAS
IEA
ISO 		KEGG
RGD		 PMID:15687842 PMID:16520407 rno:04614, RGD:1581849, RGD:1581931 NCBI chr 1:50,428,064...50,459,537
Ensembl chr 1:50,425,257...50,500,561 		JBrowse link
G Mcpt8l2 mast cell protease 8-like 2 IEA KEGG rno:04614 NCBI chr15:33,718,389...33,731,960 JBrowse link
G Mcpt8l3 mast cell protease 8-like 3 IEA KEGG rno:04614 NCBI chr15:33,673,264...33,676,288
Ensembl chr15:33,673,314...33,676,299 		JBrowse link
G Mme membrane metallo-endopeptidase ISO
IEA
IMP 		KEGG
RGD		 PMID:15638741 PMID:10642323 PMID:16520407 rno:04614, RGD:1581742, RGD:1581953, RGD:1581931 NCBI chr 2:149,806,826...149,957,381
Ensembl chr 2:149,872,291...149,953,463 		JBrowse link
G Nln neurolysin IEA KEGG rno:04614 NCBI chr 2:36,867,436...36,966,749
Ensembl chr 2:36,853,551...36,966,680 		JBrowse link
G Ren renin IDA
IEA
ISO
TAS 		KEGG
RGD		 PMID:12242043 PMID:15638741 PMID:16672920 PMID:11247783 rno:04614, RGD:1581651, RGD:1581742, RGD:1581739, RGD:1581738 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543 		JBrowse link
G Renbp renin binding protein IDA RGD PMID:11726282 RGD:5132613 NCBI chr  X:156,812,785...156,821,860
Ensembl chr  X:156,812,411...156,821,838 		JBrowse link
G Rnpep arginyl aminopeptidase IDA RGD PMID:16537183 RGD:1581649 NCBI chr13:49,251,259...49,271,440
Ensembl chr13:49,251,264...49,269,799 		JBrowse link
G Thop1 thimet oligopeptidase 1 IEA KEGG rno:04614 NCBI chr 7:9,283,617...9,295,957
Ensembl chr 7:9,283,617...9,295,957 		JBrowse link
angiotensin (1-7) signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme IMP
ISO 		RGD PMID:10642323 PMID:15283675 RGD:1581953, RGD:1598433 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942 		JBrowse link
G Ace2 angiotensin converting enzyme 2 ISO RGD PMID:15638741 RGD:1581742 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:33,925,458...33,971,596 		JBrowse link
G Agt angiotensinogen IMP RGD PMID:15951342 RGD:1581938 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor IMP
ISO 		RGD PMID:15951342 PMID:16520407 RGD:1581938, RGD:1581931 NCBI chr 1:50,428,064...50,459,537
Ensembl chr 1:50,425,257...50,500,561 		JBrowse link
G Mme membrane metallo-endopeptidase ISO
IMP 		RGD PMID:15638741 PMID:10642323 PMID:16520407 RGD:1581742, RGD:1581953, RGD:1581931 NCBI chr 2:149,806,826...149,957,381
Ensembl chr 2:149,872,291...149,953,463 		JBrowse link
angiotensin II signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme ISO RGD PMID:15638741 RGD:1581742 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942 		JBrowse link
G Agt angiotensinogen TAS RGD PMID:16141358 RGD:1581847 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a TAS RGD PMID:15590154 RGD:1579760 NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 TAS RGD PMID:14657020 RGD:1566502 NCBI chr  X:116,914,320...116,918,504
Ensembl chr  X:116,913,656...116,918,745 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IEP RGD PMID:14684844 RGD:1582323 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Cma1 chymase 1 IMP RGD PMID:15869764 RGD:1581745 NCBI chr15:33,387,351...33,390,133
Ensembl chr15:33,387,351...33,390,133 		JBrowse link
G Jak2 Janus kinase 2 IMP RGD PMID:16269269 RGD:1600094 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762 		JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 IEP RGD PMID:12661921 RGD:1580992 NCBI chr 4:164,612,460...164,635,082
Ensembl chr 4:164,612,463...164,634,598 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 IDA RGD PMID:14585963 RGD:1581775 NCBI chr10:13,610,000...13,687,226
Ensembl chr10:13,610,063...13,679,181 		JBrowse link
G Pla2g6 phospholipase A2 group VI IMP RGD PMID:17613534 RGD:12910844 NCBI chr 7:112,731,803...112,771,978
Ensembl chr 7:112,731,803...112,771,609 		JBrowse link
G Prkcz protein kinase C, zeta IMP RGD PMID:16113073 RGD:1642674 NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:171,101,774...171,212,674 		JBrowse link
angiotensin II signaling pathway via AT1 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen TAS RGD PMID:16141358 RGD:1581847 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a TAS
IMP
IDA 		RGD PMID:10977869 PMID:12446719 PMID:9287353 PMID:14559250 RGD:1581825, RGD:629553, RGD:5133683, RGD:2316188 NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660 		JBrowse link
G Agtr1b angiotensin II receptor, type 1b TAS RGD PMID:10977869 RGD:1581825 NCBI chr 2:104,774,005...104,849,262
Ensembl chr 2:104,773,930...104,849,310 		JBrowse link
G Agtrap angiotensin II receptor-associated protein IMP RGD PMID:17875818 RGD:2314353 NCBI chr 5:163,790,565...163,802,174
Ensembl chr 5:163,791,887...163,802,174 		JBrowse link
G Arap1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 IDA RGD PMID:14559250 RGD:2316188 NCBI chr 1:165,160,701...165,226,219
Ensembl chr 1:165,160,678...165,226,218 		JBrowse link
G Arrb1 arrestin, beta 1 ISO RGD PMID:16304060 RGD:5133417 NCBI chr 1:163,249,654...163,321,711
Ensembl chr 1:163,250,157...163,340,859 		JBrowse link
G Arrb2 arrestin, beta 2 ISO RGD PMID:16304060 RGD:5133417 NCBI chr10:55,645,539...55,653,485
Ensembl chr10:55,645,357...55,653,487 		JBrowse link
G Gna11 G protein subunit alpha 11 ISO RGD PMID:16141358 RGD:1581847 NCBI chr 7:8,814,285...8,828,628
Ensembl chr 7:8,814,327...8,830,558 		JBrowse link
G Gnaq G protein subunit alpha q ISO RGD PMID:16141358 RGD:1581847 NCBI chr 1:222,852,453...223,098,754
Ensembl chr 1:222,852,097...223,126,742 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO RGD PMID:16304060 RGD:5133417 NCBI chr 1:211,010,259...211,031,013
Ensembl chr 1:211,009,978...211,031,015 		JBrowse link
G Grk3 G protein-coupled receptor kinase 3 ISO RGD PMID:16304060 RGD:5133417 NCBI chr12:49,285,228...49,395,803
Ensembl chr12:49,285,263...49,395,802 		JBrowse link
G Grk5 G protein-coupled receptor kinase 5 ISO RGD PMID:16304060 RGD:5133417 NCBI chr 1:270,014,314...270,208,294
Ensembl chr 1:270,014,282...270,204,928 		JBrowse link
G Grk6 G protein-coupled receptor kinase 6 ISO RGD PMID:16304060 RGD:5133417 NCBI chr17:9,182,160...9,198,380
Ensembl chr17:9,182,160...9,197,954 		JBrowse link
G Jak2 Janus kinase 2 IDA
IMP 		RGD PMID:9287353 PMID:9314843 RGD:5133683, RGD:6478796 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 ISO RGD PMID:12588881 RGD:5133418 NCBI chr13:58,350,063...58,352,666
Ensembl chr13:58,349,163...58,352,697 		JBrowse link
G Tyk2 tyrosine kinase 2 IMP RGD PMID:9314843 RGD:6478796 NCBI chr 8:27,918,054...27,943,319
Ensembl chr 8:27,916,496...27,943,278 		JBrowse link
angiotensin II signaling pathway via AT2 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen IMP
ISO
TAS 		RGD PMID:16286564 PMID:22949090 PMID:16286568 RGD:1582434, RGD:7401256, RGD:1582435 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 TAS
ISO 		RGD PMID:10977869 PMID:22949090 RGD:1581825, RGD:7401256 NCBI chr  X:116,914,320...116,918,504
Ensembl chr  X:116,913,656...116,918,745 		JBrowse link
G Cnksr1 connector enhancer of kinase suppressor of Ras 1 ISO RGD PMID:20889352 RGD:5133679 NCBI chr 5:151,731,222...151,742,049
Ensembl chr 5:151,731,224...151,742,203 		JBrowse link
G Dusp1 dual specificity phosphatase 1 TAS RGD PMID:18804122 RGD:5133675 NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 ISO RGD PMID:20889352 RGD:5133679 NCBI chr 7:1,579,079...1,600,379
Ensembl chr 7:1,579,816...1,601,120 		JBrowse link
G Gnai2 G protein subunit alpha i2 ISO RGD PMID:22949090 RGD:7401256 NCBI chr 8:117,167,045...117,187,652
Ensembl chr 8:117,167,045...117,187,622 		JBrowse link
G Gnai3 G protein subunit alpha i3 ISO RGD PMID:22949090 RGD:7401256 NCBI chr 2:198,430,920...198,468,874 JBrowse link
G Mtus1 microtubule associated scaffold protein 1 ISO RGD PMID:20889352 RGD:5133679 NCBI chr16:57,905,991...58,051,466
Ensembl chr16:57,906,128...58,051,474 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 ISO RGD PMID:18804122 RGD:5133675 NCBI chr 4:159,212,320...159,237,069
Ensembl chr 4:159,212,320...159,237,069 		JBrowse link
G Slc9a6 solute carrier family 9 member A6 ISO RGD PMID:20889352 RGD:5133679 NCBI chr  X:139,468,045...139,524,111
Ensembl chr  X:139,458,127...139,524,109 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 ISO RGD PMID:20889352 RGD:5133679 NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:19,409,631...19,459,547 		JBrowse link
G Zbtb16 zinc finger and BTB domain containing 16 ISO RGD PMID:20889352 RGD:5133679 NCBI chr 8:57,885,886...58,073,507
Ensembl chr 8:57,891,081...58,073,507 		JBrowse link
angiotensin III signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen TAS RGD PMID:11295571 RGD:1582124 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a TAS RGD PMID:11295571 RGD:1582124 NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660 		JBrowse link
G Agtr1b angiotensin II receptor, type 1b TAS RGD PMID:11295571 RGD:1582124 NCBI chr 2:104,774,005...104,849,262
Ensembl chr 2:104,773,930...104,849,310 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 TAS RGD PMID:11295571 RGD:1582124 NCBI chr  X:116,914,320...116,918,504
Ensembl chr  X:116,913,656...116,918,745 		JBrowse link
G Enpep glutamyl aminopeptidase IDA RGD PMID:16537183 RGD:1581649 NCBI chr 2:220,456,258...220,526,218
Ensembl chr 2:220,456,278...220,526,218 		JBrowse link
angiotensin III signaling pathway via AT1 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen IMP RGD PMID:11100981 RGD:1582152 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
angiotensin III signaling pathway via AT2 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen IMP RGD PMID:16380540 RGD:1582118 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 IMP RGD PMID:16380540 RGD:1582118 NCBI chr  X:116,914,320...116,918,504
Ensembl chr  X:116,913,656...116,918,745 		JBrowse link
angiotensin IV signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen IMP RGD PMID:11282364 RGD:1582105 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Anpep alanyl aminopeptidase, membrane IDA RGD PMID:16537183 RGD:1581649 NCBI chr 1:143,176,645...143,219,447
Ensembl chr 1:143,176,645...143,195,101 		JBrowse link
G Lnpep leucyl and cystinyl aminopeptidase TAS
IMP 		RGD PMID:12591177 PMID:11282364 RGD:1581864, RGD:1582105 NCBI chr 1:66,931,712...67,027,610
Ensembl chr 1:66,931,712...67,027,610 		JBrowse link
G Rnpep arginyl aminopeptidase IDA RGD PMID:16537183 RGD:1581649 NCBI chr13:49,251,259...49,271,440
Ensembl chr13:49,251,264...49,269,799 		JBrowse link
angiotensin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen ISS RGD PMID:12676165 RGD:1566511 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    classic metabolic pathway 1853
      peptide and protein metabolic pathway 78
        peptide and protein hormone metabolic pathway 62
          renin-angiotensin cascade pathway 52
            angiotensin signaling pathway + 41
paths to the root