RGD Reference Report - AT4 receptor is insulin-regulated membrane aminopeptidase: potential mechanisms of memory enhancement. - Rat Genome Database

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AT4 receptor is insulin-regulated membrane aminopeptidase: potential mechanisms of memory enhancement.

Authors: Albiston, AL  Mustafa, T  McDowall, SG  Mendelsohn, FA  Lee, J  Chai, SY 
Citation: Albiston AL, etal., Trends Endocrinol Metab. 2003 Mar;14(2):72-7.
RGD ID: 1581864
Pubmed: PMID:12591177   (View Abstract at PubMed)

Although angiotensin IV (Ang IV) was thought initially to be an inactive product of Ang II degradation, it was subsequently shown that the hexapeptide markedly enhances learning and memory in normal rodents and reverses the memory deficits seen in animal models of amnesia. These central nervous system effects of Ang IV are mediated by binding to a specific site, known as the AT(4) receptor, which is found in appreciable levels throughout the brain and is concentrated particularly in regions involved in cognition. This field of research was redefined by the identification of the AT(4) receptor as the transmembrane enzyme, insulin-regulated membrane aminopeptidase (IRAP). Here, we explore the potential mechanisms by which Ang IV binding to IRAP leads to the facilitation of learning and memory.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
LNPEPHumanangiotensin IV signaling pathway  TAS  RGD 
LnpepRatangiotensin IV signaling pathway  TAS  RGD 
LnpepMouseangiotensin IV signaling pathway  ISOLnpep (Rattus norvegicus) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Lnpep  (leucyl and cystinyl aminopeptidase)

Genes (Mus musculus)
Lnpep  (leucyl/cystinyl aminopeptidase)

Genes (Homo sapiens)
LNPEP  (leucyl and cystinyl aminopeptidase)


Additional Information