Renbp (renin binding protein) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Renbp (renin binding protein) Rattus norvegicus
Analyze
Symbol: Renbp
Name: renin binding protein
RGD ID: 621688
Description: Enables several functions, including ATP binding activity; N-acylglucosamine 2-epimerase activity; and identical protein binding activity. Involved in N-acetylglucosamine metabolic process and N-acetylmannosamine metabolic process. Orthologous to human RENBP (renin binding protein); PARTICIPATES IN renin-angiotensin cascade pathway; amino sugar metabolic pathway; french type sialuria pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AGE; glcNAc 2-epimerase; N-acetyl-D-glucosamine 2-epimerase; N-acylglucosamine 2-epimerase; renin-binding protein; rnBP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X151,661,463 - 151,670,538 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX151,661,458 - 151,670,516 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX153,802,628 - 153,811,561 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X157,365,846 - 157,374,779 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X155,037,677 - 155,046,610 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X156,854,490 - 156,863,548 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,854,594 - 156,863,528 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,602,562 - 152,611,616 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,849,355 - 159,858,288 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X159,924,790 - 159,933,724 (-)NCBI
Celera1136,221,770 - 136,230,703 (+)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Genetic and molecular properties of human and rat renin-binding proteins with reference to the function of the leucine zipper motif. Inoue H, etal., J Biochem (Tokyo) 1991 Oct;110(4):493-500.
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. [Fatal bicycle accidents involving right turning heavy goods vehicles--forensic pathological findings]. Munkholm J, etal., Ugeskr Laeger. 2007 Jan 15;169(3):232-5.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Amino acid residues conferring the nucleotide binding properties of N-acetyl-D-glucosamine 2-epimerase (renin binding protein). Takahashi S, etal., Biomed Res. 2005 Jun;26(3):117-21.
13. Identification of a domain conferring nucleotide binding to the N-acetyl-d-glucosamine 2-epimerase (Renin binding protein). Takahashi S, etal., J Biochem (Tokyo) 2002 Apr;131(4):605-10.
14. Effects of nucleotides on N-acetyl-d-glucosamine 2-epimerases (renin-binding proteins): comparative biochemical studies. Takahashi S, etal., J Biochem. 2001 Dec;130(6):815-21.
Additional References at PubMed
PMID:1400260   PMID:6885739   PMID:10809771   PMID:12866502   PMID:19056867   PMID:22692205   PMID:23376485  


Genomics

Comparative Map Data
Renbp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X151,661,463 - 151,670,538 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX151,661,458 - 151,670,516 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX153,802,628 - 153,811,561 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X157,365,846 - 157,374,779 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X155,037,677 - 155,046,610 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X156,854,490 - 156,863,548 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,854,594 - 156,863,528 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,602,562 - 152,611,616 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,849,355 - 159,858,288 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X159,924,790 - 159,933,724 (-)NCBI
Celera1136,221,770 - 136,230,703 (+)NCBICelera
Cytogenetic MapXq37NCBI
RENBP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X153,935,269 - 153,944,643 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX153,935,269 - 153,944,687 (-)EnsemblGRCh38hg38GRCh38
GRCh37X153,200,722 - 153,210,095 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,853,917 - 152,863,426 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X152,721,569 - 152,731,079NCBI
CeleraX153,434,439 - 153,443,945 (-)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX141,853,485 - 141,862,600 (-)NCBIHuRef
CHM1_1X153,075,217 - 153,084,644 (-)NCBICHM1_1
T2T-CHM13v2.0X152,208,986 - 152,218,361 (-)NCBIT2T-CHM13v2.0
Renbp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X72,965,727 - 72,974,408 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX72,965,727 - 72,974,456 (-)EnsemblGRCm39 Ensembl
GRCm38X73,922,121 - 73,930,850 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX73,922,121 - 73,930,850 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X71,167,460 - 71,176,189 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X70,174,842 - 70,183,538 (-)NCBIMGSCv36mm8
CeleraX65,174,555 - 65,183,285 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.49NCBI
Renbp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955580609,964 - 615,027 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955580610,112 - 615,019 (-)NCBIChiLan1.0ChiLan1.0
RENBP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1X153,983,688 - 153,993,072 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X143,490,103 - 143,499,487 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X153,376,853 - 153,386,214 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX153,376,847 - 153,386,214 (-)Ensemblpanpan1.1panPan2
RENBP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X121,782,411 - 121,788,928 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX121,727,573 - 121,788,860 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX107,111,170 - 107,117,703 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X124,923,691 - 124,930,226 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX124,918,987 - 124,930,159 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X120,692,968 - 120,699,499 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X123,208,364 - 123,214,895 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X122,969,701 - 122,976,234 (-)NCBIUU_Cfam_GSD_1.0
Renbp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X119,079,621 - 119,086,182 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936809817,355 - 823,941 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936809817,392 - 823,926 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RENBP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX124,662,719 - 124,672,235 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X124,662,957 - 124,670,522 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X142,227,781 - 142,235,348 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RENBP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X128,359,313 - 128,369,070 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX128,359,396 - 128,368,581 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606566,229,335 - 66,239,931 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Renbp
6 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:127
Count of miRNA genes:94
Interacting mature miRNAs:102
Transcripts:ENSRNOT00000056337
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 2 9 12 10 29 29 11
Low 1 41 48 41 7 41 8 11 64 6 12 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000083442   ⟹   ENSRNOP00000069721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX151,661,458 - 151,670,516 (-)Ensembl
Rnor_6.0 EnsemblX156,854,594 - 156,863,528 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108606   ⟹   ENSRNOP00000078204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX151,665,749 - 151,670,516 (-)Ensembl
RefSeq Acc Id: NM_031095   ⟹   NP_112357
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X151,661,463 - 151,670,396 (-)NCBI
Rnor_6.0X156,854,610 - 156,863,543 (+)NCBI
Rnor_5.01152,602,562 - 152,611,616 (+)NCBI
RGSC_v3.4X159,849,355 - 159,858,288 (-)RGD
Celera1136,221,770 - 136,230,703 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039100090   ⟹   XP_038956018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X151,665,012 - 151,670,538 (-)NCBI
RefSeq Acc Id: NP_112357   ⟸   NM_031095
- UniProtKB: P51607 (UniProtKB/Swiss-Prot),   A0A8Z7NAG7 (UniProtKB/TrEMBL),   A6KRT2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069721   ⟸   ENSRNOT00000083442
RefSeq Acc Id: XP_038956018   ⟸   XM_039100090
- Peptide Label: isoform X1
- UniProtKB: A0A8I5XWW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000078204   ⟸   ENSRNOT00000108606

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51607-F1-model_v2 AlphaFold P51607 1-430 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13702051
Promoter ID:EPDNEW_R12575
Type:initiation region
Name:Renbp_1
Description:renin binding protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X156,854,574 - 156,854,634EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621688 AgrOrtholog
BioCyc Gene G2FUF-652 BioCyc
Ensembl Genes ENSRNOG00000054765 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000083442 ENTREZGENE
  ENSRNOT00000083442.2 UniProtKB/TrEMBL
  ENSRNOT00000108606 ENTREZGENE
  ENSRNOT00000108606.1 UniProtKB/TrEMBL
Gene3D-CATH 1.50.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 6-hairpin_glycosidase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6hp_glycosidase-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AGE/CE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AGE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81759 UniProtKB/Swiss-Prot
NCBI Gene 81759 ENTREZGENE
PANTHER N-ACYLGLUCOSAMINE 2-EPIMERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  N-ACYLGLUCOSAMINE-2-EPIMERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GlcNAc_2-epim UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Renbp PhenoGen
RatGTEx ENSRNOG00000054765 RatGTEx
Superfamily-SCOP SSF48208 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5XWW6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8Z7NAG7 ENTREZGENE, UniProtKB/TrEMBL
  A6KRT2 ENTREZGENE, UniProtKB/TrEMBL
  A6KRT3_RAT UniProtKB/TrEMBL
  A6KRT4_RAT UniProtKB/TrEMBL
  P51607 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Renbp  renin binding protein    renin-binding protein  Name updated 1299863 APPROVED
2002-08-07 Renbp  renin-binding protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation ATP binding is required for enzyme activity 727355