Rnpep (arginyl aminopeptidase) - Rat Genome Database

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Gene: Rnpep (arginyl aminopeptidase) Rattus norvegicus
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Symbol: Rnpep
Name: arginyl aminopeptidase
RGD ID: 621137
Description: Enables metalloaminopeptidase activity; peptide binding activity; and transition metal ion binding activity. Involved in negative regulation of blood pressure; protein processing; and retina development in camera-type eye. Located in external side of plasma membrane; extracellular space; and secretory granule. Used to study hypertension. Biomarker of hypertension. Orthologous to human RNPEP (arginyl aminopeptidase); PARTICIPATES IN angiotensin IV signaling pathway; renin-angiotensin cascade pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aminopeptidase B; AP-B; arginine aminopeptidase; arginyl aminopeptidase (aminopeptidase B); cytosol aminopeptidase IV
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bp328 Bp396
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81349,251,259 - 49,271,440 (-)NCBIGRCr8
mRatBN7.21346,699,458 - 46,717,829 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1346,699,463 - 46,717,998 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1349,306,528 - 49,324,611 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01350,594,605 - 50,612,686 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01347,860,650 - 47,879,132 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01352,092,863 - 52,124,006 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1352,092,859 - 52,111,363 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01357,144,697 - 57,163,164 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41348,267,923 - 48,286,295 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11348,281,967 - 48,300,338 (-)NCBI
Celera1347,022,135 - 47,040,506 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
RnpepRatExperimental Mammary Neoplasms  IEP 1582109protein:increased expression:serumRGD 
RnpepRathypertension  IEP 2325942protein:increased expression:adrenal gland and neurohypophysisRGD 
RnpepRathypertension  IMP 2325950 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
RnpepRatfamilial adult myoclonic epilepsy 5  ISORNPEP (Homo sapiens)8554872ClinVar Annotator: match by term: Epilepsy more ...ClinVarPMID:28492532
RnpepRatgastrointestinal stromal tumor  ISORNPEP (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
RnpepRatHypokalemic Periodic Paralysis, Type 1  ISORNPEP (Homo sapiens)8554872ClinVar Annotator: match by term: Hypokalemic periodic paralysis and type 1ClinVarPMID:28492532
RnpepRatparathyroid carcinoma  ISORNPEP (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
RnpepRatExperimental Mammary Neoplasms  ISORNPEP (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16619500

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
RnpepRat1,2-dimethylhydrazine multiple interactionsISORnpep (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of RNPEP mRNACTDPMID:22206623
RnpepRat17alpha-ethynylestradiol affects expressionISORnpep (Mus musculus)6480464Ethinyl Estradiol affects the expression of RNPEP mRNACTDPMID:17555576
RnpepRat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of RNPEP mRNACTDPMID:17557909
RnpepRat17alpha-ethynylestradiol multiple interactionsISORnpep (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RNPEP mRNACTDPMID:17942748
RnpepRat17alpha-ethynylestradiol increases expressionISORnpep (Mus musculus)6480464Ethinyl Estradiol results in increased expression of RNPEP mRNACTDPMID:17942748
RnpepRat17beta-estradiol increases expressionISORnpep (Mus musculus)6480464Estradiol results in increased expression of RNPEP mRNACTDPMID:39298647
RnpepRat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISORNPEP (Homo sapiens)64804642 more ...CTDPMID:31675489
RnpepRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISORnpep (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RNPEP mRNACTDPMID:17942748
RnpepRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of RNPEP mRNACTDPMID:34747641
RnpepRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISORnpep (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of RNPEP mRNACTDPMID:18343893 and PMID:21570461
RnpepRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISORnpep (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of RNPEP mRNACTDPMID:15328365
RnpepRat2,3,7,8-Tetrachlorodibenzofuran affects expressionISORnpep (Mus musculus)64804642 more ...CTDPMID:18343893
RnpepRat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of RNPEP mRNACTDPMID:21346803
RnpepRat2,6-dimethoxyphenol multiple interactionsISORNPEP (Homo sapiens)6480464[Sodium Chloride co-treated with pyrogallol 1 and 3-dimethyl ether] results in decreased expression of and affects the localization of RNPEP proteinCTDPMID:38598786
RnpepRat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of RNPEP mRNACTDPMID:21346803
RnpepRat2-naphthylamine increases metabolic processingEXP 6480464RNPEP protein results in increased metabolism of 2-Naphthylamine analogCTDPMID:11732752
RnpepRat2-naphthylamine increases metabolic processingISORNPEP (Homo sapiens)6480464RNPEP protein results in increased metabolism of 2-Naphthylamine analogCTDPMID:11732752
RnpepRat3,3',4,4',5-pentachlorobiphenyl increases expressionEXP 64804643 more ...CTDPMID:23196670
RnpepRat4,4'-diaminodiphenylmethane increases expressionISORnpep (Mus musculus)64804644 and 4'-diaminodiphenylmethane results in increased expression of RNPEP mRNACTDPMID:18648102
RnpepRat4,4'-sulfonyldiphenol increases expressionISORnpep (Mus musculus)6480464bisphenol S results in increased expression of RNPEP mRNACTDPMID:39298647

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Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
RnpepRatnegative regulation of blood pressure  IMP 2325950 RGD 
RnpepRatprotein processing involved_inNAS 2325944PMID:9405297UniProt 
RnpepRatprotein processing  IDA 1581649 RGD 
RnpepRatproteolysis involved_inICGO:00041772325944PMID:9405297UniProt 
RnpepRatproteolysis involved_inIEAInterPro:IPR0019301600115GO_REF:0000002InterProGO_REF:0000002
RnpepRatproteolysis involved_inIBAPANTHER:PTN000898489 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
RnpepRatproteolysis involved_inIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043
RnpepRatretina development in camera-type eye  IEP 2325937 RGD 

Cellular Component
1 to 9 of 9 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
RnpepRatexternal side of plasma membrane  IDA 2325944 RGD 
RnpepRatextracellular region located_inIDA 2325944PMID:9405297UniProt 
RnpepRatextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
RnpepRatextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
RnpepRatextracellular space is_active_inIBAPANTHER:PTN002906297 and Rnpep (Rattus norvegicus)1600115GO_REF:0000033GO_CentralGO_REF:0000033
RnpepRatextracellular space  IDA 1582109 RGD 
RnpepRatGolgi apparatus located_inNAS 2325944PMID:9405297UniProt 
RnpepRatplasma membrane located_inIDA 2325944PMID:9405297UniProt 
RnpepRatsecretory granule  IDA 2325936 RGD 
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Molecular Function
1 to 18 of 18 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
RnpepRataminopeptidase activity  IDA 729854 RGD 
RnpepRataminopeptidase activity enablesIEAEC:3.4.11.61600115GO_REF:0000003UniProtGO_REF:0000003
RnpepRataminopeptidase activity enablesIEAUniProtKB-KW:KW-00311600115GO_REF:0000043UniProtGO_REF:0000043
RnpepRataminopeptidase activity enablesIDA 2325944PMID:9405297UniProt 
RnpepRataminopeptidase activity  IDA 1581649 RGD 
RnpepRatcobalt ion binding  IDA 2325932 RGD 
RnpepRatcopper ion binding  IDA 2325932 RGD 
RnpepRathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
RnpepRatmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
RnpepRatmetalloaminopeptidase activity  IDA 2325932 RGD 
RnpepRatmetalloaminopeptidase activity enablesIBAPANTHER:PTN000898489 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
RnpepRatmetallopeptidase activity enablesIEAUniProtKB-KW:KW-04821600115GO_REF:0000043UniProtGO_REF:0000043
RnpepRatmetallopeptidase activity enablesIEAInterPro:IPR014782 and InterPro:IPR0152111600115GO_REF:0000002InterProGO_REF:0000002
RnpepRatpeptidase activity enablesIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043
RnpepRatpeptide binding  IDA 1581649 RGD 
RnpepRatzinc ion binding  IDA 2325932 RGD 
RnpepRatzinc ion binding enablesNAS 2325944PMID:9405297UniProt 
RnpepRatzinc ion binding enablesIEAInterPro:IPR014782 and InterPro:IPR0152111600115GO_REF:0000002InterProGO_REF:0000002
1 to 18 of 18 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
RnpepRatangiotensin IV signaling pathway  IDA 1581649 RGD 
RnpepRatrenin-angiotensin cascade pathway   IDA 1581649 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
RnpepRatalbuminuria  IAGP 12802369 RGD 
RnpepRatsalt-sensitive hypertension  IAGP 12802369 RGD 

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#
Reference Title
Reference Citation
1. Aminopeptidase B: a processing enzyme secreted and associated with the plasma membrane of rat pheochromocytoma (PC12) cells. Balogh A, etal., J Cell Sci. 1998 Jan;111 ( Pt 2):161-9.
2. Aminopeptidase B from the rat testis is a bifunctional enzyme structurally related to leukotriene-A4 hydrolase. Cadel S, etal., Proc Natl Acad Sci U S A 1997 Apr 1;94(7):2963-8.
3. Renin-angiotensin system-regulating aminopeptidase activities are modified in the pineal gland of rats with breast cancer induced by N-methyl-nitrosourea. Carrera MP, etal., Cancer Invest. 2006 Mar;24(2):149-53.
4. Congenic mapping and sequence analysis of the Renin locus. Flister MJ, etal., Hypertension. 2013 Apr;61(4):850-6. doi: 10.1161/HYPERTENSIONAHA.111.01008. Epub 2013 Mar 4.
5. Miniglucagon (MG)-generating endopeptidase, which processes glucagon into MG, is composed of N-arginine dibasic convertase and aminopeptidase B. Fontes G, etal., Endocrinology. 2005 Feb;146(2):702-12. Epub 2004 Nov 11.
6. Aminopeptidase B is structurally related to leukotriene-A4 hydrolase but is not a bifunctional enzyme with epoxide hydrolase activity. Fukasawa KM, etal., Biochem J 1999 May 1;339 ( Pt 3):497-502.
7. Molecular cloning and expression of rat liver aminopeptidase B. Fukasawa KM, etal., J Biol Chem 1996 Nov 29;271(48):30731-5.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Characterization of the metal-binding site in aminopeptidase B. Hirose J, etal., Biol Pharm Bull. 2006 Dec;29(12):2378-82.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Expression of aminopeptidase B in the developing and adult rat retina. Piesse C, etal., Exp Eye Res. 2004 Nov;79(5):639-48.
14. Insulin-regulated aminopeptidase/placental leucil Aminopeptidase (IRAP/P-lAP) and angiotensin IV-forming activities are modified in serum of rats with breast cancer induced by N-methyl-nitrosourea. Pilar Carrera M, etal., Anticancer Res. 2006 Mar-Apr;26(2A):1011-4.
15. Activities of aminopeptidases in a rat saline model of volume hypertension. Prieto I, etal., Horm Metab Res. 1998 May;30(5):246-8.
16. Developmental and ageing changes in aminopeptidase activities in selected tissues of the rat. Ramirez M, etal., Experientia. 1993 Apr 15;49(4):300-3.
17. Soluble and membrane-bound leucyl- and arginyl-aminopeptidase activities in subcellular fractions of young and adult rat brains. Ramirez M, etal., Rev Esp Fisiol. 1990 Dec;46(4):393-7.
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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PMID:10467730   PMID:12119107   PMID:18547641   PMID:18571504   PMID:19056867   PMID:19199708   PMID:21237246   PMID:23376485   PMID:23533145   PMID:27068509   PMID:32357304  



Rnpep
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81349,251,259 - 49,271,440 (-)NCBIGRCr8
mRatBN7.21346,699,458 - 46,717,829 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1346,699,463 - 46,717,998 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1349,306,528 - 49,324,611 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01350,594,605 - 50,612,686 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01347,860,650 - 47,879,132 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01352,092,863 - 52,124,006 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1352,092,859 - 52,111,363 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01357,144,697 - 57,163,164 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41348,267,923 - 48,286,295 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11348,281,967 - 48,300,338 (-)NCBI
Celera1347,022,135 - 47,040,506 (-)NCBICelera
Cytogenetic Map13q13NCBI
RNPEP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381201,982,648 - 202,006,143 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1201,982,372 - 202,006,147 (+)EnsemblGRCh38hg38GRCh38
GRCh371201,951,776 - 201,975,271 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361200,218,389 - 200,241,898 (+)NCBINCBI36Build 36hg18NCBI36
Build 341198,683,422 - 198,706,931NCBI
Celera1175,075,517 - 175,099,029 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1173,117,652 - 173,141,163 (+)NCBIHuRef
CHM1_11203,373,998 - 203,397,522 (+)NCBICHM1_1
T2T-CHM13v2.01201,240,334 - 201,263,798 (+)NCBIT2T-CHM13v2.0
Rnpep
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391135,190,447 - 135,211,765 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1135,190,450 - 135,211,822 (-)EnsemblGRCm39 Ensembl
GRCm381135,262,699 - 135,284,423 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1135,262,712 - 135,284,084 (-)EnsemblGRCm38mm10GRCm38
MGSCv371137,159,276 - 137,180,661 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361137,079,123 - 137,100,445 (-)NCBIMGSCv36mm8
Celera1137,887,970 - 137,909,160 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map158.43NCBI
Rnpep
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540638,103,426 - 38,122,358 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540638,103,701 - 38,122,162 (+)NCBIChiLan1.0ChiLan1.0
RNPEP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2147,376,889 - 47,400,418 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1147,341,586 - 47,366,097 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01177,579,349 - 177,602,865 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11181,881,128 - 181,904,334 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1181,880,404 - 181,903,906 (+)Ensemblpanpan1.1panPan2
RNPEP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.17966,563 - 985,169 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl7966,607 - 984,714 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha71,018,226 - 1,036,397 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.07974,388 - 992,561 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl7974,388 - 992,593 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.17962,438 - 980,611 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.071,070,635 - 1,088,791 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.071,094,644 - 1,112,818 (-)NCBIUU_Cfam_GSD_1.0
Rnpep
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934473,269,882 - 73,290,311 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365672,504,537 - 2,525,018 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365672,504,544 - 2,524,977 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RNPEP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1024,218,139 - 24,235,518 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11024,218,144 - 24,235,520 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21028,635,318 - 28,639,788 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RNPEP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12527,401,749 - 27,426,371 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2527,401,757 - 27,426,410 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605528,184,309 - 28,208,990 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rnpep
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248078,737,839 - 8,754,414 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Rnpep
76 total Variants

Predicted Target Of
Summary Value
Count of predictions:158
Count of miRNA genes:119
Interacting mature miRNAs:129
Transcripts:ENSRNOT00000009198
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134372077062022792Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat

1 to 10 of 35 rows
D13Hmgc24  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21346,706,087 - 46,706,205 (+)MAPPERmRatBN7.2
Rnor_6.01352,099,496 - 52,099,613NCBIRnor6.0
Rnor_5.01357,151,330 - 57,151,447UniSTSRnor5.0
RGSC_v3.41348,274,553 - 48,274,670UniSTSRGSC3.4
Celera1347,028,765 - 47,028,882UniSTS
Cytogenetic Map13q13UniSTS
BF400237  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21346,710,130 - 46,710,311 (+)MAPPERmRatBN7.2
Rnor_6.01352,103,539 - 52,103,719NCBIRnor6.0
Rnor_5.01357,155,373 - 57,155,553UniSTSRnor5.0
RGSC_v3.41348,278,596 - 48,278,776UniSTSRGSC3.4
Celera1347,032,808 - 47,032,988UniSTS
RH 3.4 Map13163.8UniSTS
Cytogenetic Map13q13UniSTS
BF386633  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21346,703,639 - 46,703,836 (+)MAPPERmRatBN7.2
Rnor_6.01352,097,048 - 52,097,244NCBIRnor6.0
Rnor_5.01357,148,882 - 57,149,078UniSTSRnor5.0
RGSC_v3.41348,272,105 - 48,272,301UniSTSRGSC3.4
Celera1347,026,317 - 47,026,513UniSTS
RH 3.4 Map13168.1UniSTS
Cytogenetic Map13q13UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000009198   ⟹   ENSRNOP00000009198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1346,699,463 - 46,717,998 (-)Ensembl
Rnor_6.0 Ensembl1352,092,859 - 52,111,363 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115357   ⟹   ENSRNOP00000091649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1346,699,463 - 46,717,998 (-)Ensembl
RefSeq Acc Id: NM_031097   ⟹   NP_112359
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81349,251,259 - 49,269,630 (-)NCBI
mRatBN7.21346,699,458 - 46,717,829 (-)NCBI
Rnor_6.01352,092,866 - 52,111,237 (-)NCBI
Rnor_5.01357,144,697 - 57,163,164 (-)NCBI
RGSC_v3.41348,267,923 - 48,286,295 (-)RGD
Celera1347,022,135 - 47,040,506 (-)RGD
Sequence:
RefSeq Acc Id: XM_063272636   ⟹   XP_063128706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81349,251,259 - 49,271,440 (-)NCBI
1 to 9 of 9 rows
Protein RefSeqs NP_001416590 (Get FASTA)   NCBI Sequence Viewer  
  NP_112359 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128706 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB52971 (Get FASTA)   NCBI Sequence Viewer  
  AAH61718 (Get FASTA)   NCBI Sequence Viewer  
  BAA13413 (Get FASTA)   NCBI Sequence Viewer  
  EDM09701 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009198
GenBank Protein O09175 (Get FASTA)   NCBI Sequence Viewer  
1 to 9 of 9 rows
RefSeq Acc Id: NP_112359   ⟸   NM_031097
- UniProtKB: G3V6V1 (UniProtKB/TrEMBL),   A6ICE6 (UniProtKB/TrEMBL),   Q6P7D2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009198   ⟸   ENSRNOT00000009198
Ensembl Acc Id: ENSRNOP00000091649   ⟸   ENSRNOT00000115357
RefSeq Acc Id: XP_063128706   ⟸   XM_063272636
- Peptide Label: isoform X1
- UniProtKB: A6ICE6 (UniProtKB/TrEMBL),   G3V6V1 (UniProtKB/TrEMBL),   Q6P7D2 (UniProtKB/TrEMBL)
Name Modeler Protein Id AA Range Protein Structure
AF-O09175-F1-model_v2 AlphaFold O09175 1-650 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698841
Promoter ID:EPDNEW_R9365
Type:initiation region
Name:Rnpep_1
Description:arginyl aminopeptidase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01352,111,259 - 52,111,319EPDNEW


1 to 40 of 41 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-18212 BioCyc
Ensembl Genes ENSRNOG00000006720 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000009198 ENTREZGENE
Gene3D-CATH 1.10.390.10 UniProtKB/Swiss-Prot
  1.25.40.320 UniProtKB/Swiss-Prot
  2.60.40.1730 UniProtKB/Swiss-Prot
  3.30.2010.30 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5598331 IMAGE-MGC_LOAD
InterPro Aminopeptidase_N-like_N UniProtKB/Swiss-Prot
  Aminopeptidase_N-like_N UniProtKB/Swiss-Prot
  ARM-type_fold UniProtKB/Swiss-Prot
  LTA4H_cat UniProtKB/Swiss-Prot
  M1_LTA-4_hydro/amino_C_sf UniProtKB/Swiss-Prot
  M1_LTA4H UniProtKB/Swiss-Prot
  Peptidase_M1 UniProtKB/Swiss-Prot
  Peptidase_M1_C UniProtKB/Swiss-Prot
  Peptidase_M1_dom UniProtKB/Swiss-Prot
  Peptidase_M4/M1_CTD_sf UniProtKB/Swiss-Prot
KEGG Report rno:81761 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72412 IMAGE-MGC_LOAD
NCBI Gene 81761 ENTREZGENE
PANTHER PTHR45726 UniProtKB/Swiss-Prot
  PTHR45726:SF1 UniProtKB/Swiss-Prot
Pfam Leuk-A4-hydro_C UniProtKB/Swiss-Prot
  Peptidase_M1 UniProtKB/Swiss-Prot
  Peptidase_M1_N UniProtKB/Swiss-Prot
PhenoGen Rnpep PhenoGen
PRINTS ALADIPTASE UniProtKB/Swiss-Prot
PROSITE ZINC_PROTEASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006720 RatGTEx
SMART Leuk-A4-hydro_C UniProtKB/Swiss-Prot
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot
  SSF48371 UniProtKB/Swiss-Prot
  SSF63737 UniProtKB/Swiss-Prot
UniProt A0A8I6GJU0 ENTREZGENE, UniProtKB/TrEMBL
  A6ICE6 ENTREZGENE, UniProtKB/TrEMBL
  AMPB_RAT UniProtKB/Swiss-Prot
  G3V6V1 ENTREZGENE, UniProtKB/TrEMBL
  O09175 ENTREZGENE
  Q6P7D2 ENTREZGENE, UniProtKB/TrEMBL
1 to 40 of 41 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Rnpep  arginyl aminopeptidase  Rnpep  arginyl aminopeptidase (aminopeptidase B)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Rnpep  arginyl aminopeptidase (aminopeptidase B)    aminopeptidase B  Name updated 1299863 APPROVED
2002-08-07 Rnpep  aminopeptidase B      Symbol and Name status set to provisional 70820 PROVISIONAL