Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | gastrointestinal stromal tumor | | ISO | RGD:733030 | 8554872 | ClinVar Annotator: match by term: Gastrointestinal stromal tumor | ClinVar | PMID:28492532 | parathyroid carcinoma | | ISO | RGD:733030 | 8554872 | ClinVar Annotator: match by term: Parathyroid carcinoma | ClinVar | PMID:28492532 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Imported Disease Annotations - CTD
Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Gene Ontology Annotations Click to see Annotation Detail View
Biological Process
Cellular Component
Molecular Function
Molecular Pathway Annotations Click to see Annotation Detail View
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Phenotype Annotations Click to see Annotation Detail View
Mammalian Phenotype
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Biological Process
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Cellular Component
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Molecular Function
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Phenotype Annotations
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Aminopeptidase B: a processing enzyme secreted and associated with the plasma membrane of rat pheochromocytoma (PC12) cells. | Balogh A, etal., J Cell Sci. 1998 Jan;111 ( Pt 2):161-9. |
| 2. | Aminopeptidase B from the rat testis is a bifunctional enzyme structurally related to leukotriene-A4 hydrolase. | Cadel S, etal., Proc Natl Acad Sci U S A 1997 Apr 1;94(7):2963-8. |
| 3. | Renin-angiotensin system-regulating aminopeptidase activities are modified in the pineal gland of rats with breast cancer induced by N-methyl-nitrosourea. | Carrera MP, etal., Cancer Invest. 2006 Mar;24(2):149-53. |
| 4. | Congenic mapping and sequence analysis of the Renin locus. | Flister MJ, etal., Hypertension. 2013 Apr;61(4):850-6. doi: 10.1161/HYPERTENSIONAHA.111.01008. Epub 2013 Mar 4. |
| 5. | Miniglucagon (MG)-generating endopeptidase, which processes glucagon into MG, is composed of N-arginine dibasic convertase and aminopeptidase B. | Fontes G, etal., Endocrinology. 2005 Feb;146(2):702-12. Epub 2004 Nov 11. |
| 6. | Aminopeptidase B is structurally related to leukotriene-A4 hydrolase but is not a bifunctional enzyme with epoxide hydrolase activity. | Fukasawa KM, etal., Biochem J 1999 May 1;339 ( Pt 3):497-502. |
| 7. | Molecular cloning and expression of rat liver aminopeptidase B. | Fukasawa KM, etal., J Biol Chem 1996 Nov 29;271(48):30731-5. |
| 8. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 9. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
| 10. | Characterization of the metal-binding site in aminopeptidase B. | Hirose J, etal., Biol Pharm Bull. 2006 Dec;29(12):2378-82. |
| 11. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
| 12. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 13. | Expression of aminopeptidase B in the developing and adult rat retina. | Piesse C, etal., Exp Eye Res. 2004 Nov;79(5):639-48. |
| 14. | Insulin-regulated aminopeptidase/placental leucil Aminopeptidase (IRAP/P-lAP) and angiotensin IV-forming activities are modified in serum of rats with breast cancer induced by N-methyl-nitrosourea. | Pilar Carrera M, etal., Anticancer Res. 2006 Mar-Apr;26(2A):1011-4. |
| 15. | Activities of aminopeptidases in a rat saline model of volume hypertension. | Prieto I, etal., Horm Metab Res. 1998 May;30(5):246-8. |
| 16. | Developmental and ageing changes in aminopeptidase activities in selected tissues of the rat. | Ramirez M, etal., Experientia. 1993 Apr 15;49(4):300-3. |
| 17. | Soluble and membrane-bound leucyl- and arginyl-aminopeptidase activities in subcellular fractions of young and adult rat brains. | Ramirez M, etal., Rev Esp Fisiol. 1990 Dec;46(4):393-7. |
| 18. | GOA pipeline | RGD automated data pipeline |
| 19. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 20. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 21. | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
| 22. | Dysfunction of central angiotensinergic aminopeptidase activity in spontaneously hypertensive rats. | Wright JW, etal., Neurosci Lett. 1985 Nov 11;61(3):351-6. |
Additional References at PubMed
| PMID:10467730 | PMID:12119107 | PMID:18547641 | PMID:18571504 | PMID:19056867 | PMID:19199708 | PMID:21237246 | PMID:23376485 | PMID:23533145 | PMID:27068509 | PMID:32357304 |
Genomics
Candidate Gene Status
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Rnpep is a candidate Gene for QTL Bp328 |
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Rnpep is a candidate Gene for QTL Bp396 |
Comparative Map Data
| Rnpep (Rattus norvegicus - Norway rat) |
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| RNPEP (Homo sapiens - human) |
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| Rnpep (Mus musculus - house mouse) |
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| Rnpep (Chinchilla lanigera - long-tailed chinchilla) |
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| RNPEP (Pan paniscus - bonobo/pygmy chimpanzee) |
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| RNPEP (Canis lupus familiaris - dog) |
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| Rnpep (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| RNPEP (Sus scrofa - pig) |
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| RNPEP (Chlorocebus sabaeus - green monkey) |
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| Rnpep (Heterocephalus glaber - naked mole-rat) |
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Position Markers
| D13Hmgc24 |
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| BF400237 |
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| BF386633 |
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QTLs in Region (mRatBN7.2)
| The following QTLs overlap with this region. | | Full Report | | CSV | | TAB | | Printer | | Gviewer |