17alpha-ethynylestradiol affects expression EXP 6480464 Ethinyl Estradiol affects the expression of RNPEP mRNA CTD PMID:17555576 17alpha-ethynylestradiol increases expression ISO RGD:621137 6480464 Ethinyl Estradiol results in increased expression of RNPEP mRNA CTD PMID:17557909 17alpha-ethynylestradiol multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RNPEP mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of RNPEP mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RNPEP mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of RNPEP mRNA CTD PMID:18343893 , PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of RNPEP mRNA CTD PMID:15328365 2,3,7,8-Tetrachlorodibenzofuran affects expression EXP 6480464 2 more ... CTD PMID:18343893 2,4-dinitrotoluene affects expression ISO RGD:621137 6480464 2, 4-dinitrotoluene affects the expression of RNPEP mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression ISO RGD:621137 6480464 2, 6-dinitrotoluene affects the expression of RNPEP mRNA CTD PMID:21346803 2-naphthylamine increases metabolic processing ISO RGD:621137 6480464 RNPEP protein results in increased metabolism of 2-Naphthylamine analog CTD PMID:11732752 2-naphthylamine increases metabolic processing ISO RGD:733030 6480464 RNPEP protein results in increased metabolism of 2-Naphthylamine analog CTD PMID:11732752 3,3',4,4',5-pentachlorobiphenyl increases expression ISO RGD:621137 6480464 3 more ... CTD PMID:23196670 4,4'-diaminodiphenylmethane increases expression EXP 6480464 4, 4'-diaminodiphenylmethane results in increased expression of RNPEP mRNA CTD PMID:18648102 alpha-hexachlorocyclohexane decreases expression ISO RGD:621137 6480464 alpha-hexachlorocyclohexane results in decreased expression of RNPEP mRNA CTD PMID:16940010 alpha-hexachlorocyclohexane increases expression ISO RGD:621137 6480464 alpha-hexachlorocyclohexane results in increased expression of RNPEP mRNA CTD PMID:16940010 alpha-hexachlorocyclohexane affects expression ISO RGD:621137 6480464 alpha-hexachlorocyclohexane affects the expression of RNPEP mRNA CTD PMID:16940010 ammonium chloride affects expression ISO RGD:621137 6480464 Ammonium Chloride affects the expression of RNPEP mRNA CTD PMID:16483693 antirheumatic drug decreases expression ISO RGD:733030 6480464 Antirheumatic Agents results in decreased expression of RNPEP mRNA CTD PMID:24449571 arsenous acid multiple interactions ISO RGD:733030 6480464 Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to RNPEP protein] CTD PMID:26598702 arsenous acid increases expression ISO RGD:733030 6480464 Arsenic Trioxide results in increased expression of RNPEP protein CTD PMID:25419056 bisphenol A affects expression ISO RGD:621137 6480464 bisphenol A affects the expression of RNPEP mRNA CTD PMID:25181051 bisphenol A increases methylation ISO RGD:621137 6480464 bisphenol A results in increased methylation of RNPEP gene CTD PMID:28505145 cadmium dichloride increases expression ISO RGD:733030 6480464 Cadmium Chloride results in increased expression of RNPEP protein CTD PMID:24527689 choline multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of RNPEP gene CTD PMID:20938992 cisplatin multiple interactions ISO RGD:733030 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of RNPEP mRNA CTD PMID:27392435 cisplatin increases expression ISO RGD:733030 6480464 Cisplatin results in increased expression of RNPEP mRNA CTD PMID:27392435 clofibrate multiple interactions EXP 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of RNPEP mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of RNPEP mRNA] CTD PMID:17585979 copper(II) sulfate decreases expression ISO RGD:733030 6480464 Copper Sulfate results in decreased expression of RNPEP mRNA CTD PMID:19549813 cyclosporin A decreases expression ISO RGD:733030 6480464 Cyclosporine results in decreased expression of RNPEP mRNA CTD PMID:20106945 , PMID:25562108 dehydroepiandrosterone decreases expression ISO RGD:621137 6480464 Dehydroepiandrosterone results in decreased expression of RNPEP mRNA CTD PMID:16940010 diarsenic trioxide increases expression ISO RGD:733030 6480464 Arsenic Trioxide results in increased expression of RNPEP protein CTD PMID:25419056 diarsenic trioxide multiple interactions ISO RGD:733030 6480464 Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to RNPEP protein] CTD PMID:26598702 dibutyl phthalate decreases expression ISO RGD:621137 6480464 Dibutyl Phthalate results in decreased expression of RNPEP mRNA CTD PMID:21266533 dichlorine multiple interactions ISO RGD:621137 6480464 [Ozone co-treated with Chlorine] results in decreased expression of RNPEP mRNA CTD PMID:18636392 elemental selenium increases expression ISO RGD:733030 6480464 Selenium results in increased expression of RNPEP mRNA CTD PMID:19244175 ethanol multiple interactions ISO RGD:621137 6480464 [Fish Oils co-treated with Ethanol] results in increased expression of RNPEP mRNA CTD PMID:17347304 ethanol affects expression EXP 6480464 Ethanol affects the expression of RNPEP mRNA CTD PMID:30319688 ethyl methanesulfonate increases expression ISO RGD:733030 6480464 Ethyl Methanesulfonate results in increased expression of RNPEP mRNA CTD PMID:23649840 flavonoids decreases expression ISO RGD:621137 6480464 Flavonoids results in decreased expression of RNPEP mRNA CTD PMID:18035473 folic acid multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of RNPEP gene CTD PMID:20938992 gamma-hexachlorocyclohexane decreases expression ISO RGD:621137 6480464 Hexachlorocyclohexane results in decreased expression of RNPEP mRNA CTD PMID:17785943 genistein multiple interactions ISO RGD:733030 6480464 ESR2 promotes the reaction [Genistein results in increased expression of RNPEP protein] CTD PMID:20884965 genistein increases expression ISO RGD:733030 6480464 Genistein results in increased expression of RNPEP protein CTD PMID:20884965 L-methionine multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of RNPEP gene CTD PMID:20938992 methyl methanesulfonate increases expression ISO RGD:733030 6480464 Methyl Methanesulfonate results in increased expression of RNPEP mRNA CTD PMID:23649840 ozone multiple interactions ISO RGD:621137 6480464 [Ozone co-treated with Chlorine] results in decreased expression of RNPEP mRNA CTD PMID:18636392 p-toluidine increases expression ISO RGD:621137 6480464 4-toluidine results in increased expression of RNPEP mRNA CTD PMID:27638505 paracetamol multiple interactions EXP 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of RNPEP mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of RNPEP mRNA] CTD PMID:17585979 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of RNPEP mRNA CTD PMID:17562736 pentachlorophenol increases expression EXP 6480464 Pentachlorophenol results in increased expression of RNPEP mRNA CTD PMID:23892564 phenobarbital multiple interactions EXP 6480464 NR1I3 protein affects the reaction [Phenobarbital results in increased expression of RNPEP mRNA] CTD PMID:19482888 phenobarbital affects expression ISO RGD:733030 6480464 Phenobarbital affects the expression of RNPEP mRNA CTD PMID:19159669 phenobarbital increases expression EXP 6480464 Phenobarbital results in increased expression of RNPEP mRNA CTD PMID:19482888 pirimiphos-methyl decreases activity ISO RGD:621137 6480464 pirimiphos methyl results in decreased activity of RNPEP protein CTD PMID:9204212 selenium atom increases expression ISO RGD:733030 6480464 Selenium results in increased expression of RNPEP mRNA CTD PMID:19244175 Soman decreases expression ISO RGD:621137 6480464 Soman results in decreased expression of RNPEP mRNA CTD PMID:19281266 tamoxifen affects expression EXP 6480464 Tamoxifen affects the expression of RNPEP mRNA CTD PMID:17555576 tetracycline increases expression EXP 6480464 Tetracycline results in increased expression of RNPEP mRNA CTD PMID:16917069 trimellitic anhydride increases expression EXP 6480464 trimellitic anhydride results in increased expression of RNPEP mRNA CTD PMID:19042947 valproic acid decreases expression ISO RGD:733030 6480464 Valproic Acid results in decreased expression of RNPEP mRNA CTD PMID:29154799 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of RNPEP mRNA CTD PMID:17292431
Biological Process
negative regulation of blood pressure ISO RGD:621137 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 negative regulation of blood pressure IBA PANTHER:PTN000164306 , RGD:621137 2290270 (PMID:21873635) GO_Central PMID:21873635 proteolysis ISO RGD:621137 2290270 RGD GO_REF:0000096, MGI:MGI:4417868
Cellular Component
external side of plasma membrane ISO RGD:621137 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 extracellular region ISO RGD:621137 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 extracellular region IBA PANTHER:PTN000164306 , RGD:621137 2290270 (PMID:21873635) GO_Central PMID:21873635 extracellular space ISO RGD:621137 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 Golgi apparatus ISO RGD:621137 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 neuron projection ISO RGD:621137 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 plasma membrane ISO RGD:621137 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 plasma membrane IBA PANTHER:PTN000164306 , RGD:621137 2290270 (PMID:21873635) GO_Central PMID:21873635 secretory granule ISO RGD:621137 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 secretory granule IBA PANTHER:PTN000164306 , RGD:621137 2290270 (PMID:21873635) GO_Central PMID:21873635
Molecular Function
aminopeptidase activity ISO RGD:621137 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 cobalt ion binding ISO RGD:621137 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 copper ion binding ISO RGD:621137 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 hydrolase activity IEA UniProtKB-KW:KW-0378 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 metal ion binding IEA UniProtKB-KW:KW-0479 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 metalloaminopeptidase activity ISO RGD:621137 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 metallopeptidase activity IEA InterPro:IPR014782 , InterPro:IPR015211 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 metallopeptidase activity IEA UniProtKB-KW:KW-0482 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 peptidase activity IEA UniProtKB-KW:KW-0645 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 peptide binding ISO RGD:621137 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 zinc ion binding ISO RGD:621137 2290270 RGD GO_REF:0000096, MGI:MGI:4417868