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Soluble and membrane-bound leucyl- and arginyl-aminopeptidase activities in subcellular fractions of young and adult rat brains.

Authors: Ramirez, M  Arechaga, G  Garcia, S  Sanchez, B  Lardelli, P  Gandarias, JM 
Citation: Ramirez M, etal., Rev Esp Fisiol. 1990 Dec;46(4):393-7.
Pubmed: (View Article at PubMed) PMID:2099537

The subcellular distribution of soluble and membrane-bound leucyl- and arginyl-aminopeptidase activities were analyzed in one and five month old rat brains using Leu- and Arg-2-naphthylamide as substrates. Both soluble leucyl- and arginyl-aminopeptidase activities showed the highest levels in the synaptosomal fraction in the two groups of rats. The highest levels of membrane-bound leucyl- and arginyl-aminopeptidase activities were found in the microsomal fraction in the two ages studied. There were no differences between the two ages in soluble leucyl- and arginyl-aminopeptidase activities. However, a significant decrease in both membrane-bound enzymatic activities was evidenced in the synaptosomal fraction of older rats. Developmental changes of these aminopeptidase activities in a determined subcellular localization, may reflect modifications in their effect on neuropeptides susceptible to be hydrolyzed in this particular location.

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RGD Object Information
RGD ID: 2325948
Created: 2010-06-15
Species: All species
Last Modified: 2010-06-15
Status: ACTIVE



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