RNPEP (arginyl aminopeptidase) - Rat Genome Database

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Gene: RNPEP (arginyl aminopeptidase) Canis lupus familiaris
Analyze
Symbol: RNPEP
Name: arginyl aminopeptidase
RGD ID: 12095077
Description: ENCODES a protein that exhibits aminopeptidase activity (ortholog); cobalt ion binding (ortholog); copper ion binding (ortholog); INVOLVED IN negative regulation of blood pressure (ortholog); protein processing (ortholog); retina development in camera-type eye (ortholog); PARTICIPATES IN angiotensin IV signaling pathway; renin-angiotensin cascade pathway; ASSOCIATED WITH Experimental Mammary Neoplasms (ortholog); familial adult myoclonic epilepsy 5 (ortholog); gastrointestinal stromal tumor (ortholog); FOUND IN external side of plasma membrane (ortholog); extracellular region (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: aminopeptidase B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.17966,563 - 985,169 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl7966,607 - 984,714 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha71,018,226 - 1,036,397 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.07974,388 - 992,561 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl7974,388 - 992,593 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.17962,438 - 980,611 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.071,070,635 - 1,088,791 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.071,094,644 - 1,112,818 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
RNPEP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.17966,563 - 985,169 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl7966,607 - 984,714 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha71,018,226 - 1,036,397 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.07974,388 - 992,561 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl7974,388 - 992,593 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.17962,438 - 980,611 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.071,070,635 - 1,088,791 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.071,094,644 - 1,112,818 (-)NCBIUU_Cfam_GSD_1.0
RNPEP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381201,982,648 - 202,006,143 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1201,982,372 - 202,006,147 (+)EnsemblGRCh38hg38GRCh38
GRCh371201,951,776 - 201,975,271 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361200,218,389 - 200,241,898 (+)NCBINCBI36Build 36hg18NCBI36
Build 341198,683,422 - 198,706,931NCBI
Celera1175,075,517 - 175,099,029 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1173,117,652 - 173,141,163 (+)NCBIHuRef
CHM1_11203,373,998 - 203,397,522 (+)NCBICHM1_1
T2T-CHM13v2.01201,240,334 - 201,263,798 (+)NCBIT2T-CHM13v2.0
Rnpep
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391135,190,447 - 135,211,765 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1135,190,450 - 135,211,822 (-)EnsemblGRCm39 Ensembl
GRCm381135,262,699 - 135,284,423 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1135,262,712 - 135,284,084 (-)EnsemblGRCm38mm10GRCm38
MGSCv371137,159,276 - 137,180,661 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361137,079,123 - 137,100,445 (-)NCBIMGSCv36mm8
Celera1137,887,970 - 137,909,160 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map158.43NCBI
Rnpep
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81349,251,259 - 49,271,440 (-)NCBIGRCr8
mRatBN7.21346,699,458 - 46,717,829 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1346,699,463 - 46,717,998 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1349,306,528 - 49,324,611 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01350,594,605 - 50,612,686 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01347,860,650 - 47,879,132 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01352,092,863 - 52,124,006 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1352,092,859 - 52,111,363 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01357,144,697 - 57,163,164 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41348,267,923 - 48,286,295 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11348,281,967 - 48,300,338 (-)NCBI
Celera1347,022,135 - 47,040,506 (-)NCBICelera
Cytogenetic Map13q13NCBI
Rnpep
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540638,103,426 - 38,122,358 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540638,103,701 - 38,122,162 (+)NCBIChiLan1.0ChiLan1.0
RNPEP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2147,376,889 - 47,400,418 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1147,341,586 - 47,366,097 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01177,579,349 - 177,602,865 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11181,881,128 - 181,904,334 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1181,880,404 - 181,903,906 (+)Ensemblpanpan1.1panPan2
Rnpep
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934473,269,882 - 73,290,311 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365672,504,537 - 2,525,018 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365672,504,544 - 2,524,977 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RNPEP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1024,218,139 - 24,235,518 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11024,218,144 - 24,235,520 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21028,635,318 - 28,639,788 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RNPEP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12527,401,749 - 27,426,371 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2527,401,757 - 27,426,410 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605528,184,309 - 28,208,990 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rnpep
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248078,737,839 - 8,754,414 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RNPEP
116 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000016772   ⟹   ENSCAFP00000015520
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl7966,607 - 984,714 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000065945   ⟹   ENSCAFP00000053989
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl7966,607 - 984,714 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000091579   ⟹   ENSCAFP00000066415
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl7966,607 - 984,714 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845029011   ⟹   ENSCAFP00845022819
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl7974,388 - 992,593 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845029032   ⟹   ENSCAFP00845022832
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl7974,388 - 992,593 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845029084   ⟹   ENSCAFP00845022875
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl7974,388 - 992,593 (-)Ensembl
RefSeq Acc Id: XM_038480564   ⟹   XP_038336492
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.17962,438 - 980,611 (-)NCBI
RefSeq Acc Id: XM_038541890   ⟹   XP_038397818
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.071,094,644 - 1,112,818 (-)NCBI
RefSeq Acc Id: XM_038606022   ⟹   XP_038461950
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.071,070,635 - 1,088,791 (-)NCBI
RefSeq Acc Id: XM_038670727   ⟹   XP_038526655
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.07974,388 - 992,561 (-)NCBI
RefSeq Acc Id: XM_547357   ⟹   XP_547357
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.17966,563 - 984,748 (-)NCBI
Dog10K_Boxer_Tasha71,018,226 - 1,036,397 (-)NCBI
Sequence:
RefSeq Acc Id: XP_547357   ⟸   XM_547357
- UniProtKB: A0A8C0KV18 (UniProtKB/TrEMBL),   A0A8C0LWF7 (UniProtKB/TrEMBL),   A0A8I3NUR2 (UniProtKB/TrEMBL),   A0A8C0KQK0 (UniProtKB/TrEMBL),   A0A8C0R9V1 (UniProtKB/TrEMBL),   A0A8I3P4T7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000066415   ⟸   ENSCAFT00000091579
Ensembl Acc Id: ENSCAFP00000015520   ⟸   ENSCAFT00000016772
Ensembl Acc Id: ENSCAFP00000053989   ⟸   ENSCAFT00000065945
RefSeq Acc Id: XP_038336492   ⟸   XM_038480564
RefSeq Acc Id: XP_038461950   ⟸   XM_038606022
RefSeq Acc Id: XP_038526655   ⟸   XM_038670727
- UniProtKB: A0A8C0KV18 (UniProtKB/TrEMBL),   A0A8C0LWF7 (UniProtKB/TrEMBL),   A0A8I3NUR2 (UniProtKB/TrEMBL),   A0A8C0KQK0 (UniProtKB/TrEMBL),   A0A8C0R9V1 (UniProtKB/TrEMBL),   A0A8I3P4T7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038397818   ⟸   XM_038541890
- UniProtKB: A0A8C0KQK0 (UniProtKB/TrEMBL),   A0A8C0KV18 (UniProtKB/TrEMBL),   A0A8C0LWF7 (UniProtKB/TrEMBL),   A0A8C0R9V1 (UniProtKB/TrEMBL),   A0A8I3NUR2 (UniProtKB/TrEMBL),   A0A8I3P4T7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845022832   ⟸   ENSCAFT00845029032
Ensembl Acc Id: ENSCAFP00845022819   ⟸   ENSCAFT00845029011
Ensembl Acc Id: ENSCAFP00845022875   ⟸   ENSCAFT00845029084
Protein Domains
Peptidase M1 leukotriene A4 hydrolase/aminopeptidase

Promoters
RGD ID:13683864
Promoter ID:EPDNEW_C1932
Type:initiation region
Name:RNPEP_1
Description:arginyl aminopeptidase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.17984,731 - 984,791EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010545 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030000884 UniProtKB/TrEMBL
  ENSCAFG00040003832 UniProtKB/TrEMBL
  ENSCAFG00845016328 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000016772.5 UniProtKB/TrEMBL
  ENSCAFT00000065945.2 UniProtKB/TrEMBL
  ENSCAFT00000091579.2 UniProtKB/TrEMBL
  ENSCAFT00030001573.1 UniProtKB/TrEMBL
  ENSCAFT00030001608.1 UniProtKB/TrEMBL
  ENSCAFT00040007362.1 UniProtKB/TrEMBL
  ENSCAFT00040007383.1 UniProtKB/TrEMBL
  ENSCAFT00040007422.1 UniProtKB/TrEMBL
  ENSCAFT00845029011 ENTREZGENE
  ENSCAFT00845029011.1 UniProtKB/TrEMBL
  ENSCAFT00845029032.1 UniProtKB/TrEMBL
  ENSCAFT00845029084.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.390.10 UniProtKB/TrEMBL
  1.25.40.320 UniProtKB/TrEMBL
  2.60.40.1730 UniProtKB/TrEMBL
  3.30.2010.30 UniProtKB/TrEMBL
InterPro Aminopeptidase_N-like_N UniProtKB/TrEMBL
  Aminopeptidase_N-like_N UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  LTA4H_cat UniProtKB/TrEMBL
  M1_LTA-4_hydro/amino_C_sf UniProtKB/TrEMBL
  M1_LTA4H UniProtKB/TrEMBL
  Peptidase_M1 UniProtKB/TrEMBL
  Peptidase_M1_C UniProtKB/TrEMBL
  Peptidase_M1_dom UniProtKB/TrEMBL
  Peptidase_M4/M1_CTD_sf UniProtKB/TrEMBL
KEGG Report cfa:490236 UniProtKB/TrEMBL
NCBI Gene RNPEP ENTREZGENE
PANTHER PTHR45726 UniProtKB/TrEMBL
  PTHR45726:SF1 UniProtKB/TrEMBL
Pfam Leuk-A4-hydro_C UniProtKB/TrEMBL
  Peptidase_M1 UniProtKB/TrEMBL
  Peptidase_M1_N UniProtKB/TrEMBL
PRINTS ALADIPTASE UniProtKB/TrEMBL
SMART Leuk-A4-hydro_C UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF48371 UniProtKB/TrEMBL
  SSF63737 UniProtKB/TrEMBL
UniProt A0A8C0KQK0 ENTREZGENE
  A0A8C0KV18 ENTREZGENE
  A0A8C0LWF7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QFD2_CANLF UniProtKB/TrEMBL
  A0A8C0R9V1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NUR2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NZM9_CANLF UniProtKB/TrEMBL
  A0A8I3P4T7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:45682 ENTREZGENE