RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Hemorrhagic Shock
Accession: DOID:9001708
browse the term
Definition: Acute hemorrhage or excessive fluid loss resulting in HYPOVOLEMIA.
Synonyms: primary_id: MESH:D012771
G
Adm
adrenomedullin
treatment
ISO IEP
RGD
PMID:18403050 PMID:15973109
RGD:7364987 , RGD:7364990
NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
G
Aldh1a7
aldehyde dehydrogenase family 1, subfamily A7
severity
IEP
mRNA:decreased expression:liver
RGD
PMID:23810746 PMID:21643955
RGD:14367884 , RGD:14367885
NCBI chr 1:218,201,443...218,241,410
G
Angpt1
angiopoietin 1
ISO
RGD
PMID:18344375
RGD:2316067
NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067
G
Arg2
arginase 2
IEP
protein:increased expression:aorta (rat)
RGD
PMID:20699748
RGD:4143274
NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378
G
Bad
BCL2-associated agonist of cell death
IEP
protein:decreased serine phosphorylation:lung
RGD
PMID:15345971
RGD:2292699
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
G
Bcl2
BCL2, apoptosis regulator
IEP
mRNA:increased expression:intestine
RGD
PMID:17693937
RGD:2293072
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Bcl2l1
Bcl2-like 1
IEP
protein:increased expression:liver, mitochondrion
RGD
PMID:17224795
RGD:1643525
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
G
Casp3
caspase 3
IEP
associated with Brain Injuries, Traumatic
RGD
PMID:29061477
RGD:13782298
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Casp8
caspase 8
IEP
associated with Brain Injuries, Traumatic
RGD
PMID:29061477
RGD:13782298
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
G
Cfh
complement factor H
treatment
ISO IEP
RGD
PMID:18403050 PMID:15973109 PMID:18496585
RGD:7364987 , RGD:7364990 , RGD:11041173
NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
G
Cnr1
cannabinoid receptor 1
IMP
mRNA, protein:increased expression:aorta, mesenteric artery
RGD
PMID:19493421
RGD:2314664
NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
G
Cul5
cullin 5
IEP
mRNA:altered expression:brain
RGD
PMID:12635525
RGD:2301433
NCBI chr 8:54,012,963...54,066,751
Ensembl chr 8:54,016,006...54,066,666
G
Cxcl1
C-X-C motif chemokine ligand 1
IEP ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:21192278 PMID:21168948
RGD:5128673
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
G
Cxcl2
C-X-C motif chemokine ligand 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21192278
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
G
Cxcl3
C-X-C motif chemokine ligand 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21192278
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
G
Epo
erythropoietin
treatment
ISO
RGD
PMID:20539178
RGD:10401059
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
G
Esr1
estrogen receptor 1
severity
IMP
RGD
PMID:20195535
RGD:4892252
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
G
Esr2
estrogen receptor 2
IDA
RGD
PMID:16859701
RGD:8694176
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
G
F2
coagulation factor II, thrombin
IEP
protein:decreased activity:blood (rat)
RGD
PMID:21550061
RGD:5132267
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
G
F8
coagulation factor VIII
IEP
protein:decreased expression:plasma
RGD
PMID:15748447
RGD:10450768
NCBI chr18:140,848...172,330
Ensembl chr18:140,955...171,857
G
Gfer
growth factor, augmenter of liver regeneration
ISO
RGD
PMID:23073658
RGD:9685733
NCBI chr10:13,718,489...13,721,782
Ensembl chr10:13,718,489...13,720,869
G
Gja1
gap junction protein, alpha 1
IEP
RGD
PMID:19077877
RGD:7207423
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
G
Gja5
gap junction protein, alpha 5
IEP
RGD
PMID:19077877
RGD:7207423
NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952
G
Glul
glutamate-ammonia ligase
treatment
IEP
RGD
PMID:12766648
RGD:401794596
NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108
G
Gpt
glutamic--pyruvic transaminase
treatment
IEP
RGD
PMID:16141011
RGD:401717565
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
G
Hmox1
heme oxygenase 1
severity
IMP IEP
RGD
PMID:20514418 PMID:20819606
RGD:10755719 , RGD:10755727
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Hp
haptoglobin
IEP
RGD
PMID:20016403
RGD:5147418
NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
G
Hspa1a
heat shock protein family A (Hsp70) member 1A
IEP
mRNA:increased expression:liver
RGD
PMID:22266570
RGD:7257601
NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
G
Icam1
intercellular adhesion molecule 1
ISO
mRNA, protein:increased expression:lung (mouse) CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:21192278 PMID:19828841
RGD:4145497
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
G
Ifng
interferon gamma
IEP
protein:increased expression:plasma
RGD
PMID:19439114
RGD:2311495
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
G
Il10
interleukin 10
IEP
protein:increased expression:serum, lymph
RGD
PMID:19160132
RGD:2311060
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
G
Il18
interleukin 18
ISO
protein:increased expression:plasma
RGD
PMID:23589298
RGD:14695541
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
G
Il1a
interleukin 1 alpha
IEP
mRNA:increased expression:lung
RGD
PMID:15580020
RGD:2311100
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
G
Il1b
interleukin 1 beta
severity
IEP
mRNA:increased expression:lung protein:increased expression:kidney, serum (rat)
RGD
PMID:15580020 PMID:17545943 PMID:21336199
RGD:2311100 , RGD:1626655 , RGD:7175325
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il4
interleukin 4
treatment
IEP
RGD
PMID:24986445
RGD:10402801
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
G
Il6
interleukin 6
IEP ISO
protein:increased expression:plasma CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:21192278 PMID:21168948
RGD:5128673
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Mapk1
mitogen activated protein kinase 1
IEP
protein: increased expression: lung and liver
RGD
PMID:22392145
RGD:7244173
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mmp9
matrix metallopeptidase 9
treatment
IEP
RGD
PMID:16141011
RGD:401717565
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
G
Mpo
myeloperoxidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21192278
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
G
Mtor
mechanistic target of rapamycin kinase
treatment
IDA
RGD
PMID:24204984
RGD:10041042
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
G
Myc
MYC proto-oncogene, bHLH transcription factor
treatment
IDA
RGD
PMID:22113495
RGD:7240568
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
G
Nfkbia
NFKB inhibitor alpha
treatment
IEP
RGD
PMID:11557243
RGD:127285020
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
G
Nos2
nitric oxide synthase 2
IEP
mRNA, protein:increased expression:multiple
RGD
PMID:15854664
RGD:1580937
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
G
Nos3
nitric oxide synthase 3
treatment
IEP
mRNA:increased expression: :multiple
RGD
PMID:15854664 PMID:29122552
RGD:1580937 , RGD:13450929
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
G
Otc
ornithine transcarbamylase
IEP
protein:increased activity:serum (rat)
RGD
PMID:17224795
RGD:1643525
NCBI chr X:12,453,834...12,529,954
Ensembl chr X:12,453,834...12,566,918
G
Rela
RELA proto-oncogene, NF-kB subunit
IEP ISO
protein:increased phosphorylation, altered location:nucleus, endothelial cell, lung protein:increased phosphorylation:nucleus, liver
RGD
PMID:17950078 PMID:17950083 PMID:18469645
RGD:2298842 , RGD:2298841 , RGD:2298781
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Sirt1
sirtuin 1
treatment
IMP IEP
protein:decreased expression:heart left ventricle
RGD
PMID:22113495 PMID:21554952
RGD:7240568 , RGD:9585770
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
G
Slc9a1
solute carrier family 9 member A1
IMP ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:17724433 PMID:19384202
RGD:6771334
NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624
G
Sod2
superoxide dismutase 2
treatment
IEP
RGD
PMID:26073907
RGD:26923954
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
G
Tfam
transcription factor A, mitochondrial
IEP
RGD
PMID:22469910
RGD:6767567
NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
G
Tgfb1
transforming growth factor, beta 1
treatment
IEP
RGD
PMID:16141011
RGD:401717565
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
G
Timp1
TIMP metallopeptidase inhibitor 1
treatment
IEP
RGD
PMID:16141011
RGD:401717565
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
G
Tlr4
toll-like receptor 4
severity
ISO
RGD
PMID:25049041
RGD:14697700
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
G
Tnf
tumor necrosis factor
treatment
IDA ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:21192278 PMID:24315526
RGD:10450602
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Trem1
triggering receptor expressed on myeloid cells 1
ameliorates
IDA
RGD
PMID:19333144
RGD:127284838
NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203
G
Vwf
von Willebrand factor
IEP
protein:decreased expression:plasma
RGD
PMID:15748447
RGD:10450768
NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all