RGD Reference Report - Protective role of heme oxygenase 1 in the intestinal tissue injury in hemorrhagic shock in rats. - Rat Genome Database

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Protective role of heme oxygenase 1 in the intestinal tissue injury in hemorrhagic shock in rats.

Authors: Inoue, K  Takahashi, T  Uehara, K  Shimuzu, H  Ido, K  Morimatsu, H  Omori, E  Katayama, H  Akagi, R  Morita, K 
Citation: Inoue K, etal., Shock. 2008 Feb;29(2):252-61.
RGD ID: 2293072
Pubmed: PMID:17693937   (View Abstract at PubMed)
DOI: DOI:10.1097/shk.0b013e3180cab913   (Journal Full-text)

Heme oxygenase (HO) 1 is inducible by a variety of oxidative stress and is thought to play an important role in the protection of tissues from oxidative injuries. Because hemorrhagic shock (HS) is an oxidative stress that results in tissue injury, we examined in this study the role of HO-1 induction in intestinal tissue injuries in a rat model of HS. The levels of HO-1 were significantly increased after HS both at transcriptional and protein levels in mucosal epithelial cells in the duodenum, jejunum, and colon, whereas their expression in the ileum was hardly detectable and not increased at all by the treatment. In contrast, HS-induced mucosal inflammation and apoptotic cell death in the duodenum, jejunum, and colon were far less than those observed in ileum as judged by the levels of expression of TNF-alpha, iNOS, activated caspase 3, and Bcl-2. Of note, inhibition of HO activity by tin-mesoporphyrin resulted in an aggravation of HS-induced tissue inflammation and apoptotic cell death. These findings indicate that HO-1 expression in the intestine is regulated in a highly site-specific manner after HS, and that HO-1 induction plays a fundamental role in protecting mucosal cells of the intestine from oxidative damages induced by HS.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
BCL2HumanHemorrhagic Shock  ISOBcl2 (Rattus norvegicus)mRNA:increased expression:intestineRGD 
Bcl2RatHemorrhagic Shock  IEP mRNA:increased expression:intestineRGD 
Bcl2MouseHemorrhagic Shock  ISOBcl2 (Rattus norvegicus)mRNA:increased expression:intestineRGD 

Objects Annotated

Genes (Rattus norvegicus)
Bcl2  (BCL2, apoptosis regulator)

Genes (Mus musculus)
Bcl2  (B cell leukemia/lymphoma 2)

Genes (Homo sapiens)
BCL2  (BCL2 apoptosis regulator)


Additional Information