Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-methoxy-17beta-estradiol
go back to main search page
Accession:CHEBI:28955 term browser browse the term
Definition:A 17beta-hydroxy steroid, being 17beta-estradiol methoxylated at C-2.
Synonyms:exact_synonym: 2-methoxyestra-1,3,5(10)-triene-3,17beta-diol
 related_synonym: 1,3,5(10)-ESTRATRIEN-2,3,17-BETA-TRIOL 2-METHYL ETHER;   2-Hydroxyestradol 2-methyl ether;   2-Methoxyestradiol-17beta;   2-methoxyestradiol;   Formula=C19H26O3;   InChI=1S/C19H26O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,18,20-21H,3-8H2,1-2H3/t12-,13+,15-,18-,19-/m0/s1;   InChIKey=CQOQDQWUFQDJMK-SSTWWWIQSA-N;   Panzem;   SMILES=[H][C@]12CC[C@]3(C)[C@@H](O)CC[C@@]3([H])[C@]1([H])CCc1cc(O)c(OC)cc21
 alt_id: CHEBI:1187;   CHEBI:19675;   CHEBI:42274
 xref: CAS:362-07-2;   KEGG:C05302;   LIPID_MAPS_instance:LMST02010035
 xref_mesh: MESH:C022830
 xref: PMID:12543804;   PMID:16828472;   PMID:16969706;   PMID:18566218;   PMID:19228747;   PMID:19577796;   PMID:20499131;   PMID:20960192;   PMID:9018099;   Patent:CA2499254;   Patent:CN1672746;   Patent:JP2005270658;   Patent:US2009104246;   Reaxys:3147966


show annotations for term's descendants           Sort by:
 
2-methoxy-17beta-estradiol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO 2-Methoxyestradiol inhibits the reaction [Quercetin results in decreased phosphorylation of AKT1 protein]; [Quercetin co-treated with 2-Methoxyestradiol] results in decreased phosphorylation of AKT1 protein; Quercetin inhibits the reaction [2-Methoxyestradiol results in decreased phosphorylation of AKT1 protein] CTD PMID:26011145 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Aqp1 aquaporin 1 affects expression EXP 2-Methoxyestradiol affects the expression of AQP1 protein CTD PMID:21092735 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
JBrowse link
G Aqp4 aquaporin 4 affects expression EXP 2-Methoxyestradiol affects the expression of AQP4 protein CTD PMID:21092735 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
JBrowse link
G Bad BCL2-associated agonist of cell death decreases phosphorylation ISO 2-Methoxyestradiol results in decreased phosphorylation of BAD protein CTD PMID:23967052 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP 2-Methoxyestradiol inhibits the reaction [testosterone enanthate results in decreased expression of BAX mRNA] CTD PMID:30154949 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
EXP
ISO
2-Methoxyestradiol inhibits the reaction [testosterone enanthate results in increased expression of BCL2 mRNA]
2-Methoxyestradiol results in decreased expression of BCL2 protein
CTD PMID:17418156 PMID:30154949 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases expression
ISO 2-Methoxyestradiol results in increased cleavage of CASP3 protein
2-Methoxyestradiol promotes the reaction [Quercetin results in increased cleavage of CASP3 protein]; Arsenic Trioxide promotes the reaction [2-Methoxyestradiol results in increased expression of CASP3 protein modified form]; Quercetin promotes the reaction [2-Methoxyestradiol results in increased cleavage of CASP3 protein]
CTD PMID:23967052 PMID:26011145 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases expression
multiple interactions
ISO 2-Methoxyestradiol results in increased expression of CASP7 protein modified form
Arsenic Trioxide promotes the reaction [2-Methoxyestradiol results in increased expression of CASP7 protein modified form]
CTD PMID:23967052 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 increases expression ISO 2-Methoxyestradiol results in increased expression of CASP8 protein modified form CTD PMID:23967052 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases expression ISO 2-Methoxyestradiol results in increased expression of CASP9 protein modified form CTD PMID:23967052 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO 2-Methoxyestradiol results in decreased expression of CCNA2 protein CTD PMID:23967052 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 multiple interactions
increases expression
ISO 2-Methoxyestradiol results in increased expression of and results in increased activity of CCNB1 protein
2-Methoxyestradiol results in increased expression of CCNB1 protein
CTD PMID:16356831 PMID:23967052 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO 2-Methoxyestradiol results in decreased expression of CCND1 protein CTD PMID:23967052 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO 2-Methoxyestradiol results in decreased expression of CCND3 protein CTD PMID:23967052 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Ccne2 cyclin E2 decreases expression ISO 2-Methoxyestradiol results in decreased expression of CCNE2 protein CTD PMID:23967052 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO 2-Methoxyestradiol results in decreased expression of and affects the phosphorylation of CDC25C protein CTD PMID:23967052 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases phosphorylation ISO 2-Methoxyestradiol results in decreased phosphorylation of CDK1 protein CTD PMID:23967052 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO 2-Methoxyestradiol results in decreased expression of CDK2 protein CTD PMID:23967052 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO 2-Methoxyestradiol results in decreased expression of CDK4 protein CTD PMID:23967052 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO 2-Methoxyestradiol results in increased expression of CDKN1B protein CTD PMID:23967052 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Comt catechol-O-methyltransferase affects chemical synthesis ISO COMT protein affects the chemical synthesis of 2-Methoxyestradiol CTD PMID:15377160 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Ctf1 cardiotrophin 1 multiple interactions ISO 2-Methoxyestradiol inhibits the reaction [cobaltous chloride results in increased expression of CTF1 protein]; 2-Methoxyestradiol inhibits the reaction [Vitamin K 3 results in increased expression of CTF1 protein] CTD PMID:16507596 NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression
ISO 2-Methoxyestradiol inhibits the reaction [CTNNB1 protein results in decreased susceptibility to Bortezomib]
2-Methoxyestradiol results in decreased expression of CTNNB1 mRNA; 2-Methoxyestradiol results in decreased expression of CTNNB1 protein
CTD PMID:18485479 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases abundance
ISO Tetrachlorodibenzodioxin promotes the reaction [CYP1A1 protein results in increased abundance of 2-Methoxyestradiol]; Tetradecanoylphorbol Acetate inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CYP1A1 protein results in increased abundance of 2-Methoxyestradiol]] CTD PMID:9706865 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Egf epidermal growth factor decreases expression ISO 2-Methoxyestradiol results in decreased expression of EGF mRNA; 2-Methoxyestradiol results in decreased expression of EGF protein CTD PMID:30779072 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO 2-Methoxyestradiol results in decreased expression of EGFR mRNA; 2-Methoxyestradiol results in decreased expression of EGFR protein CTD PMID:30779072 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Epo erythropoietin decreases expression
multiple interactions
EXP 2-Methoxyestradiol results in decreased expression of EPO protein
2-Methoxyestradiol promotes the reaction [methylmercuric chloride results in decreased expression of EPO protein]; 2-Methoxyestradiol promotes the reaction [Methylmercury Compounds results in decreased expression of EPO protein]
CTD PMID:31850806 PMID:32461003 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G H2ax H2A.X variant histone increases expression ISO 2-Methoxyestradiol results in increased expression of H2AX protein modified form CTD PMID:23967052 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression
EXP
ISO
2-Methoxyestradiol inhibits the reaction [testosterone enanthate results in increased expression of HIF1A protein]; 2-Methoxyestradiol promotes the reaction [methylmercuric chloride results in decreased expression of HIF1A protein]; 2-Methoxyestradiol promotes the reaction [Methylmercury Compounds results in decreased expression of HIF1A protein]
2-Methoxyestradiol inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]
2-Methoxyestradiol results in decreased expression of HIF1A protein
2-Methoxyestradiol inhibits the reaction [Glucose results in increased expression of HIF1A protein]
CTD PMID:21617913 PMID:28624453 PMID:30154949 PMID:31850806 PMID:32461003 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 decreases response to substance
multiple interactions
ISO HSD17B2 protein results in decreased susceptibility to 2-Methoxyestradiol
[HSD17B2 protein results in increased metabolism of and results in decreased activity of 2-Methoxyestradiol] which results in increased chemical synthesis of 2-methoxyestrone
CTD PMID:16397246 NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202
JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP 2-Methoxyestradiol inhibits the reaction [testosterone enanthate results in increased expression of IL1A protein] CTD PMID:30154949 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP 2-Methoxyestradiol inhibits the reaction [testosterone enanthate results in increased expression of IL1B protein] CTD PMID:30154949 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Nanog Nanog homeobox multiple interactions ISO 2-Methoxyestradiol inhibits the reaction [Curcumin results in increased expression of NANOG mRNA] CTD PMID:25822711 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO 2-Methoxyestradiol results in increased expression of PARP1 protein modified form CTD PMID:23967052 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pou5f1 POU class 5 homeobox 1 multiple interactions ISO 2-Methoxyestradiol inhibits the reaction [Curcumin results in increased expression of POU5F1 mRNA] CTD PMID:25822711 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Prdx4 peroxiredoxin 4 increases expression ISO 2-Methoxyestradiol results in increased expression of PRDX4 protein CTD PMID:18272409 NCBI chr  X:40,026,762...40,044,066
Ensembl chr  X:40,026,651...40,044,066
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 2-Methoxyestradiol inhibits the reaction [cobaltous chloride results in increased expression of PTGS2 mRNA]; 2-Methoxyestradiol inhibits the reaction [cobaltous chloride results in increased expression of PTGS2 protein] CTD PMID:28624453 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP 2-Methoxyestradiol inhibits the reaction [testosterone enanthate results in increased expression of RELA protein] CTD PMID:30154949 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases expression
multiple interactions
EXP 2-Methoxyestradiol results in decreased expression of SLC2A1 protein
2-Methoxyestradiol promotes the reaction [methylmercuric chloride results in decreased expression of SLC2A1 protein]; 2-Methoxyestradiol promotes the reaction [Methylmercury Compounds results in decreased expression of SLC2A1 protein]
CTD PMID:31850806 PMID:32461003 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Smad2 SMAD family member 2 multiple interactions EXP 2-Methoxyestradiol inhibits the reaction [testosterone enanthate results in increased phosphorylation of SMAD2 protein] CTD PMID:30154949 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Sod2 superoxide dismutase 2 increases response to substance
affects response to substance
multiple interactions
ISO SOD2 protein results in increased susceptibility to 2-Methoxyestradiol
SOD2 protein affects the susceptibility to 2-Methoxyestradiol
2-Methoxyestradiol inhibits the reaction [Curcumin results in increased expression of SOD2 mRNA]
CTD PMID:17895890 PMID:22547077 PMID:25822711 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation
affects sulfation
ISO SULT1A1 protein results in increased sulfation of 2-Methoxyestradiol
SULT1A1 gene polymorphism affects the sulfation of 2-Methoxyestradiol
CTD PMID:16517757 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP 2-Methoxyestradiol inhibits the reaction [testosterone enanthate results in increased expression of TGFB1 protein] CTD PMID:30154949 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO 2-Methoxyestradiol inhibits the reaction [Glucose results in decreased expression of TJP1 protein] CTD PMID:21617913 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tubb4a tubulin, beta 4A class IVa decreases expression ISO 2-Methoxyestradiol results in decreased expression of TUBB4A mRNA alternative form; 2-Methoxyestradiol results in decreased expression of TUBB4A protein alternative form CTD PMID:15924336 NCBI chr 9:1,917,841...1,925,286
Ensembl chr 9:1,917,845...1,925,291
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of 2-Methoxyestradiol CTD PMID:15117964 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of 2-Methoxyestradiol CTD PMID:15117964 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of 2-Methoxyestradiol CTD PMID:15117964 NCBI chr 9:88,696,981...88,808,465 JBrowse link
G Vegfa vascular endothelial growth factor A affects expression
decreases expression
multiple interactions
EXP
ISO
2-Methoxyestradiol affects the expression of VEGFA protein
2-Methoxyestradiol results in decreased expression of VEGFA protein
2-Methoxyestradiol promotes the reaction [methylmercuric chloride results in decreased expression of VEGFA protein]; 2-Methoxyestradiol promotes the reaction [Methylmercury Compounds results in decreased expression of VEGFA protein]
2-Methoxyestradiol results in decreased expression of VEGFA mRNA; 2-Methoxyestradiol results in decreased expression of VEGFA protein
2-Methoxyestradiol inhibits the reaction [Glucose results in increased expression of VEGFA protein]
2-Methoxyestradiol promotes the reaction [Quercetin results in decreased expression of VEGFA mRNA]; 2-Methoxyestradiol promotes the reaction [Quercetin results in decreased expression of VEGFA protein]; Quercetin promotes the reaction [2-Methoxyestradiol results in decreased expression of VEGFA mRNA]; Quercetin promotes the reaction [2-Methoxyestradiol results in decreased expression of VEGFA protein]
CTD PMID:21092735 PMID:21617913 PMID:26011145 PMID:31850806 PMID:32461003 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO 2-Methoxyestradiol results in decreased expression of XIAP protein CTD PMID:16356831 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19757
      biological role 19757
        biochemical role 19377
          metabolite 19352
            2-methoxy-17beta-estradiol 50
              2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronide) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    p-block element atom 19704
                      carbon group element atom 19626
                        carbon atom 19616
                          organic molecular entity 19616
                            organic molecule 19556
                              organic cyclic compound 19347
                                organic polycyclic compound 16534
                                  steroid 13057
                                    steroid fundamental parent 12693
                                      estrane 10032
                                        estradiol 9881
                                          17beta-estradiol 9881
                                            2-methoxy-17beta-estradiol 50
                                              2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronide) 0
paths to the root