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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61928
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hif1a
Name: hypoxia inducible factor 1 subunit alpha
Acc ID: CHEBI:28955
Term: 2-methoxy-17beta-estradiol
Definition: A 17beta-hydroxy steroid, being 17beta-estradiol methoxylated at C-2.
Chemical ID: MESH:C022830
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hif1adecreases expressionEXP 6480464CTD2-Methoxyestradiol results in decreased expression of HIF1A proteinPMID:31850806 PMID:32461003
Hif1amultiple interactionsEXP 6480464CTD2-Methoxyestradiol inhibits the reaction [testosterone enanthate results in increased expression of HIF1A protein]; 2-Methoxyestradiol promotes the reaction [methylmercuric chloride results in decreased expression of HIF1A protein]; 2-Methoxyestradiol promotes the reaction [Methylmercury Compounds results in decreased expression of HIF1A protein]PMID:30154949 PMID:31850806 PMID:32461003
Hif1amultiple interactionsISOHif1a (Mus musculus)6480464CTD2-Methoxyestradiol inhibits the reaction [Glucose results in increased expression of HIF1A protein]PMID:21617913
Hif1amultiple interactionsISOHIF1A (Homo sapiens)6480464CTD2-Methoxyestradiol inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]PMID:28624453
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