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N-tosyl-L-phenylalanyl chloromethyl ketone - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:N-tosyl-L-phenylalanyl chloromethyl ketone
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Accession:CHEBI:9642 term browser browse the term
Definition:The N-tosyl derivative of L-phenylalanyl chloromethyl ketone.
Synonyms:exact_synonym: N-[(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]-4-methylbenzenesulfonamide
 related_synonym: Formula=C17H18ClNO3S;   InChI=1S/C17H18ClNO3S/c1-13-7-9-15(10-8-13)23(21,22)19-16(17(20)12-18)11-14-5-3-2-4-6-14/h2-10,16,19H,11-12H2,1H3/t16-/m0/s1;   InChIKey=MQUQNUAYKLCRME-INIZCTEOSA-N;   L-1-Tosylamido-2-phenylethyl chloromethyl ketone;   N-Tosyl-L-phenylalanine chloromethyl ketone;   SMILES=Cc1ccc(cc1)S(=O)(=O)N[C@@H](Cc1ccccc1)C(=O)CCl;   TPCK;   Tos-Phe-CH2Cl;   Tosylphenylalanyl chloromethyl ketone;   l-N-(alpha-(Chloroacetyl)phenethyl)-p-toluenesulfonamide
 xref: Beilstein:6895141;   CAS:402-71-1;   KEGG:C02088
 xref_mesh: MESH:D014108

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N-tosyl-L-phenylalanyl chloromethyl ketone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of ABCA1 mRNA] CTD PMID:12010990 NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions
affects localization 		ISO Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone affects the localization of AIFM1 protein] CTD PMID:19679660 NCBI chr  X:132,528,107...132,567,237
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein results in increased phosphorylation of AKT1 protein] CTD PMID:17136479 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member decreases activity EXP Tosylphenylalanyl Chloromethyl Ketone results in decreased activity of ALDH2 protein CTD PMID:11142365 NCBI chr12:40,610,244...40,643,220
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO
EXP 		Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]] CTD PMID:10567916 NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [bisphenol A results in decreased expression of APOA1 mRNA]; Tosylphenylalanyl Chloromethyl Ketone promotes the reaction [APOA1 protein results in increased expression of APOE mRNA]; Tosylphenylalanyl Chloromethyl Ketone promotes the reaction [APOA1 protein results in increased expression of CETP mRNA]; Tosylphenylalanyl Chloromethyl Ketone promotes the reaction [APOA1 protein results in increased secretion of APOE protein]; Tosylphenylalanyl Chloromethyl Ketone promotes the reaction [APOA1 protein results in increased secretion of CETP protein] CTD PMID:22056562 PMID:31842455 NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Apoe apolipoprotein E multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone promotes the reaction [APOA1 protein results in increased expression of APOE mRNA]; Tosylphenylalanyl Chloromethyl Ketone promotes the reaction [APOA1 protein results in increased secretion of APOE protein] CTD PMID:22056562 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases cleavage
multiple interactions 		ISO Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of BCL2 protein
Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of BCL2 protein] 		CTD PMID:19679660 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression
multiple interactions 		ISO Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of BIRC2 protein
Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of BIRC2 protein] 		CTD PMID:19679660 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions
decreases expression 		ISO Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of BIRC3 protein] CTD PMID:19679660 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions 		ISO Tosylphenylalanyl Chloromethyl Ketone results in increased activity of CASP3 protein
Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of and results in increased activity of CASP3 protein; TP53 protein promotes the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased activity of CASP3 protein] 		CTD PMID:12821135 PMID:19679660 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of and results in increased activity of CASP7 protein; TP53 protein promotes the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased activity of CASP7 protein] CTD PMID:12821135 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:19679660 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression 		ISO
EXP 		Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Chloroquine results in increased expression of CCL2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Glucose results in increased secretion of CCL2 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased expression of CCL2 mRNA]
Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of CCL2 mRNA
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] 		CTD PMID:12016129 PMID:12846738 PMID:15139008 PMID:16600694 PMID:18706406 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Tosylphenylalanyl Chloromethyl Ketone results in increased expression of CDKN1A protein CTD PMID:12821135 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Acetaldehyde results in increased expression of COL1A1 mRNA] CTD PMID:17952619 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin results in decreased localization of CTNNB1 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin results in increased degradation of and results in decreased activity of CTNNB1 protein] CTD PMID:17030184 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ctsd cathepsin D increases expression ISO Tosylphenylalanyl Chloromethyl Ketone results in increased expression of CTSD protein CTD PMID:10772776 NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Tosylphenylalanyl Chloromethyl Ketone results in increased expression of GCLC mRNA CTD PMID:22851183 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Tosylphenylalanyl Chloromethyl Ketone results in increased expression of GCLM mRNA CTD PMID:22851183 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Hax1 HCLS1 associated protein X-1 multiple interactions
decreases response to substance
decreases expression 		ISO Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of HAX1 protein]
HAX1 results in decreased susceptibility to Tosylphenylalanyl Chloromethyl Ketone
Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of HAX1 mRNA; Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of HAX1 protein 		CTD PMID:19679660 NCBI chr 2:175,434,242...175,437,926
Ensembl chr 2:175,434,238...175,437,714 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP
ISO 		Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [resveratrol results in increased expression of HMOX1 mRNA]
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [resveratrol results in increased expression of HMOX1 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [resveratrol results in increased expression of HMOX1 protein] 		CTD PMID:15588712 PMID:15965080 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of ICAM1 mRNA CTD PMID:11735124 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein promotes the reaction [RELA protein results in increased phosphorylation of IKBKG protein]] CTD PMID:17136479 NCBI chr  X:157,358,279...157,397,563
Ensembl chr  X:152,216,596...152,239,499 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased activity of NFKB1 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased activity of RELA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased expression of CCL2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased expression of CXCL8 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased expression of IL6 mRNA] CTD PMID:12016129 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1A protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein promotes the reaction [RELA protein results in increased phosphorylation of IKBKG protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein results in increased activity of RELA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein results in increased phosphorylation of AKT1 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein results in increased phosphorylation of PDPK1 protein]
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA] 		CTD PMID:12010990 PMID:17136479 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP 		Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased expression of IL6 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL6 protein results in increased phosphorylation of and results in increased activity of STAT3 protein]
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Acetaldehyde results in increased expression of IL6 mRNA]
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]] 		CTD PMID:10616907 PMID:10814840 PMID:12016129 PMID:15601679 PMID:17952619 More... NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of ITGAM protein] CTD PMID:10739673 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity ISO Tosylphenylalanyl Chloromethyl Ketone results in decreased activity of MMP9 protein CTD PMID:22033475 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects response to substance ISO NFE2L2 protein affects the susceptibility to Tosylphenylalanyl Chloromethyl Ketone CTD PMID:22851183 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO
EXP 		Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased activity of NFKB1 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [platycodin D results in increased activity of [NFKB1 protein binds to RELA protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Acetaldehyde results in increased activity of [NFKB1 protein binds to RELA protein]]
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased localization of [RELA protein co-treated with NFKB1 protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of NFKB1 protein] 		CTD PMID:10416616 PMID:10616907 PMID:11094054 PMID:12016129 PMID:16631160 More... NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases degradation
decreases phosphorylation 		ISO
EXP 		[Tosylphenylalanyl Chloromethyl Ketone results in decreased activity of RELA protein] inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; [Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of RELA protein] inhibits the reaction [TGFB1 protein results in increased phosphorylation of NFKBIA protein]
Tosylphenylalanyl Chloromethyl Ketone results in decreased degradation of NFKBIA protein
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]
Tosylphenylalanyl Chloromethyl Ketone results in decreased phosphorylation of NFKBIA protein
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Acetaldehyde results in increased degradation of NFKBIA protein] 		CTD PMID:9580637 PMID:10381628 PMID:10921504 PMID:12574206 PMID:15687330 More... NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nfkbib NFKB inhibitor beta multiple interactions
decreases phosphorylation 		ISO Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased phosphorylation of NFKBIB protein]; Cysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased phosphorylation of NFKBIB protein] CTD PMID:10381628 NCBI chr 1:93,173,817...93,181,387
Ensembl chr 1:84,046,295...84,053,862 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] CTD PMID:15601679 PMID:18449507 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Tosylphenylalanyl Chloromethyl Ketone results in increased expression of NQO1 mRNA CTD PMID:22851183 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nrg1 neuregulin 1 multiple interactions EXP Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [NRG1 protein results in increased transport of Glucose] CTD PMID:14711829 NCBI chr16:65,954,084...67,007,484
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage 		ISO Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of PARP1 protein] CTD PMID:19679660 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pde5a phosphodiesterase 5A decreases expression EXP Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of PDE5A mRNA CTD PMID:12466227 NCBI chr 2:213,542,822...213,687,638
Ensembl chr 2:210,858,063...210,999,701 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 multiple interactions
decreases activity 		ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein results in increased phosphorylation of PDPK1 protein]
Tosylphenylalanyl Chloromethyl Ketone results in decreased activity of PDPK1 protein 		CTD PMID:17136479 NCBI chr10:13,610,000...13,687,226
Ensembl chr10:13,105,498...13,174,623 		JBrowse link
G Plau plasminogen activator, urokinase decreases expression ISO Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of PLAU protein CTD PMID:10467400 NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA] CTD PMID:9580637 PMID:17944529 PMID:18449507 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects activity
decreases activity 		ISO
EXP 		[Tosylphenylalanyl Chloromethyl Ketone results in decreased activity of RELA protein] inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; [Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of RELA protein] inhibits the reaction [TGFB1 protein results in increased phosphorylation of NFKBIA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased activity of RELA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein promotes the reaction [RELA protein results in increased phosphorylation of IKBKG protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein results in increased activity of RELA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [platycodin D results in increased activity of [NFKB1 protein binds to RELA protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased activity of RELA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased transport of RELA protein]
Tosylphenylalanyl Chloromethyl Ketone affects the activity of RELA protein
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased localization of [RELA protein co-treated with NFKB1 protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of RELA protein]
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Acetaldehyde results in increased activity of [NFKB1 protein binds to RELA protein]] 		CTD PMID:10416616 PMID:10467400 PMID:10616907 PMID:10640779 PMID:11094054 More... NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of SCARB1 mRNA] CTD PMID:12010990 NCBI chr12:36,957,302...37,023,982
Ensembl chr12:31,296,156...31,362,647 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL6 protein results in increased phosphorylation of and results in increased activity of STAT3 protein] CTD PMID:10616907 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Sts steroid sulfatase multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402 		JBrowse link
G Tcf4 transcription factor 4 multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]] CTD PMID:17030184 NCBI chr18:62,941,739...63,288,126
Ensembl chr18:62,943,782...63,284,425 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of RELA protein] inhibits the reaction [TGFB1 protein results in increased phosphorylation of NFKBIA protein] CTD PMID:16288038 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Tosylphenylalanyl Chloromethyl Ketone results in decreased activity of RELA protein] inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased activity of RELA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of SOD2 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased transport of RELA protein]
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of NFKB1 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of RELA protein] 		CTD PMID:7476933 PMID:9580637 PMID:10416616 PMID:10616907 PMID:10640779 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases response to substance
decreases expression 		ISO Tosylphenylalanyl Chloromethyl Ketone results in decreased phosphorylation of and results in increased activity of TP53 protein; TP53 protein promotes the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased activity of CASP3 protein]; TP53 protein promotes the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased activity of CASP7 protein]
TP53 protein results in increased susceptibility to Tosylphenylalanyl Chloromethyl Ketone
Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of TRP53 protein 		CTD PMID:11536013 PMID:12821135 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of VCAM1 mRNA CTD PMID:11735124 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions
increases cleavage 		ISO Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of XIAP protein] CTD PMID:19679660 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      biological role 20814
        aetiopathogenetic role 19855
          genotoxin 17984
            mutagen 17876
              alkylating agent 14504
                N-tosyl-L-phenylalanyl chloromethyl ketone 53
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    main group molecular entity 20777
                      s-block molecular entity 20573
                        hydrogen molecular entity 20557
                          hydrides 19691
                            organic hydride 19080
                              organic fundamental parent 19080
                                hydrocarbon 18734
                                  cyclic hydrocarbon 17323
                                    monocyclic hydrocarbon 6256
                                      annulene 5908
                                        aromatic annulene 5908
                                          benzene 5908
                                            alkylbenzene 3594
                                              methylbenzene 3430
                                                toluene 3302
                                                  benzyl group 2706
                                                    phenylalanine 2706
                                                      L-phenylalanine 2427
                                                        L-phenylalanyl group 53
                                                          N-tosyl-L-phenylalanyl chloromethyl ketone 53
paths to the root