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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alkylating agent
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Accession:CHEBI:22333 term browser browse the term
Definition:Highly reactive chemical that introduces alkyl radicals into biologically active molecules and thereby prevents their proper functioning. It could be used as an antineoplastic agent, but it might be very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. It could also be used as a component of poison gases.



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    Path 1
    Term Annotations click to browse term
      CHEBI ontology 19860
        role 19832
          biological role 19830
            aetiopathogenetic role 19209
              genotoxin 17677
                mutagen 17591
                  alkylating agent 14335
                    1,2-dimethylhydrazine 9981
                    2,5-bis(2-hydroxyethylamino)-3,6-diaziridinylbenzoquinone 0
                    2,5-bis(aziridin-1-yl)-1,4-benzoquinone 1
                    2-aminoacrylic acid + 0
                    2-chloroethyl methanesulfonate 0
                    2-fluoroethyl methanesulfonate 0
                    3-bromopyruvic acid 17
                    4-hydroperoxycyclophosphamide 74
                    4-hydroxycyclophosphamide 10
                    D-mannitol 1,6-bis(methanesulfonate) 0
                    L-mannitol 1,6-bis(methanesulfonate) 0
                    MTIC 0
                    N-ethyl-N-nitrosourea 514
                    N-methyl-N'-nitro-N-nitrosoguanidine 311
                    N-methyl-N-nitrosourea 357
                    N-tosyl-L-phenylalanyl chloromethyl ketone 53
                    S-(chloromethyl)glutathione 0
                    acrylamide 5956
                    anthramycin 0
                    apholate 0
                    aziridine + 0
                    bis(2-chloroethyl) sulfide 1356
                    bis(chloromethyl) ether 0
                    bromoethane 1
                    busulfan 85
                    carmustine 471
                    chlorambucil 52
                    chloroacetic acid + 29
                    colibactin 0
                    cyclophosphamide + 766
                    cyclophosphamide hydrate 0
                    dacarbazine + 23
                    diaziquone 3
                    diazomethane 0
                    diethyl sulfate 18
                    dimethyl sulfate 5
                    dimethyl sulfoxide + 332
                    dimethylmyleran 0
                    esperamicin A1 0
                    estramustine + 3
                    etanidazole 1
                    ethyl methanesulfonate 2178
                    fotemustine 11
                    hex-3-yne-2,5-diyl bis(methanesulfonate) 0
                    hexane-2,5-diyl bis(methanesulfonate) 0
                    hycanthone mesylate 0
                    ifosfamide 248
                    iodoacetic acid 31
                    lomustine 10
                    mechlorethamine + 163
                    melphalan 275
                    methyl methanesulfonate 3657
                    mitomycin A 0
                    mitomycin C + 407
                    nimustine 24
                    nitrogen mustard + 1365
                    pipobroman 0
                    semustine 2
                    temozolomide 3063
                    tilimycin 0
                    tomaymycin + 0
                    trabectedin 28
                    tretamine 0
                    triaziquone 0
                    trimethyl phosphite 0
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