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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alkylating agent
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Accession:CHEBI:22333 term browser browse the term
Definition:Highly reactive chemical that introduces alkyl radicals into biologically active molecules and thereby prevents their proper functioning. It could be used as an antineoplastic agent, but it might be very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. It could also be used as a component of poison gases.



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    Path 1
    Term Annotations click to browse term
      CHEBI ontology 19823
        role 19773
          biological role 19773
            aetiopathogenetic role 19050
              genotoxin 17478
                mutagen 17378
                  alkylating agent 14270
                    1,2-dimethylhydrazine 9972
                    2,5-bis(2-hydroxyethylamino)-3,6-diaziridinylbenzoquinone 0
                    2,5-bis(aziridin-1-yl)-1,4-benzoquinone 1
                    2-aminoacrylic acid + 0
                    2-chloroethyl methanesulfonate 0
                    2-fluoroethyl methanesulfonate 0
                    3-bromopyruvic acid 17
                    4-hydroperoxycyclophosphamide 74
                    4-hydroxycyclophosphamide 10
                    D-mannitol 1,6-bis(methanesulfonate) 0
                    L-mannitol 1,6-bis(methanesulfonate) 0
                    MTIC 0
                    N-ethyl-N-nitrosourea 513
                    N-methyl-N'-nitro-N-nitrosoguanidine 290
                    N-methyl-N-nitrosourea 354
                    N-tosyl-L-phenylalanyl chloromethyl ketone 53
                    S-(chloromethyl)glutathione 0
                    acrylamide 5870
                    anthramycin 0
                    apholate 0
                    aziridine + 0
                    bis(2-chloroethyl) sulfide 1324
                    bis(chloromethyl) ether 0
                    bromoethane 1
                    busulfan 61
                    carmustine 470
                    chlorambucil 51
                    chloroacetic acid + 29
                    colibactin 0
                    cyclophosphamide + 737
                    cyclophosphamide hydrate 0
                    dacarbazine 22
                    diaziquone 3
                    diazomethane 0
                    dimethyl sulfate 5
                    dimethyl sulfoxide + 317
                    dimethylmyleran 0
                    esperamicin A1 0
                    estramustine + 3
                    etanidazole 1
                    ethyl methanesulfonate 2170
                    fotemustine 11
                    hex-3-yne-2,5-diyl bis(methanesulfonate) 0
                    hexane-2,5-diyl bis(methanesulfonate) 0
                    hycanthone mesylate 0
                    ifosfamide 246
                    iodoacetic acid 27
                    lomustine 10
                    mechlorethamine + 89
                    melphalan 272
                    methyl methanesulfonate 3646
                    mitomycin A 0
                    mitomycin C 403
                    nimustine 24
                    nitrogen mustard + 1270
                    pipobroman 0
                    semustine 2
                    temozolomide 3034
                    tilimycin 0
                    tomaymycin + 0
                    trabectedin 22
                    tretamine 0
                    triaziquone 0
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