Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alkylating agent
go back to main search page
Accession:CHEBI:22333 term browser browse the term
Definition:Highly reactive chemical that introduces alkyl radicals into biologically active molecules and thereby prevents their proper functioning. It could be used as an antineoplastic agent, but it might be very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. It could also be used as a component of poison gases.


show annotations for term's descendants           Sort by:
 





Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19791
    role 19738
      biological role 19738
        aetiopathogenetic role 18935
          genotoxin 16956
            mutagen 16772
              alkylating agent 13398
                1,2-dimethylhydrazine 9957
                2,5-bis(2-hydroxyethylamino)-3,6-diaziridinylbenzoquinone 0
                2,5-bis(aziridin-1-yl)-1,4-benzoquinone 1
                2-aminoacrylic acid + 0
                2-chloroethyl methanesulfonate 0
                2-fluoroethyl methanesulfonate 0
                3-bromopyruvic acid 17
                4-hydroperoxycyclophosphamide 74
                4-hydroxycyclophosphamide 9
                D-mannitol 1,6-bis(methanesulfonate) 0
                L-mannitol 1,6-bis(methanesulfonate) 0
                MTIC 0
                N-ethyl-N-nitrosourea 506
                N-methyl-N'-nitro-N-nitrosoguanidine 289
                N-methyl-N-nitrosourea 354
                N-tosyl-L-phenylalanyl chloromethyl ketone 53
                S-(chloromethyl)glutathione 0
                acrylamide 3785
                anthramycin 0
                aziridine + 0
                bis(2-chloroethyl) sulfide 1281
                bis(chloromethyl) ether 0
                busulfan 61
                carmustine 467
                chlorambucil 49
                chloroacetic acid + 28
                colibactin 0
                cyclophosphamide + 729
                cyclophosphamide hydrate 0
                dacarbazine 22
                diaziquone 3
                diazomethane 0
                dimethyl sulfate 5
                dimethyl sulfoxide + 310
                dimethylmyleran 0
                esperamicin A1 0
                estramustine + 3
                etanidazole 1
                ethyl methanesulfonate 2168
                fotemustine 10
                hex-3-yne-2,5-diyl bis(methanesulfonate) 0
                hexane-2,5-diyl bis(methanesulfonate) 0
                hycanthone mesylate 0
                ifosfamide 244
                iodoacetic acid 27
                lomustine 9
                mechlorethamine + 88
                melphalan 270
                methyl methanesulfonate 3640
                mitomycin A 0
                mitomycin C 403
                nimustine 24
                nitrogen mustard + 1259
                pipobroman 0
                semustine 2
                temozolomide 212
                tilimycin 0
                tomaymycin 0
                tretamine 0
                triaziquone 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.