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ONTOLOGY REPORT - ANNOTATIONS


Term:alkylating agent
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Accession:CHEBI:22333 term browser browse the term
Definition:Highly reactive chemical that introduces alkyl radicals into biologically active molecules and thereby prevents their proper functioning. It could be used as an antineoplastic agent, but it might be very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. It could also be used as a component of poison gases.


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  CHEBI ontology 19669
    role 19613
      biological role 19611
        aetiopathogenetic role 18766
          genotoxin 16034
            mutagen 15652
              alkylating agent 9016
                1,2-dimethylhydrazine 502
                2,5-bis(2-hydroxyethylamino)-3,6-diaziridinylbenzoquinone 0
                2,5-bis(aziridin-1-yl)-1,4-benzoquinone 1
                2-aminoacrylic acid + 0
                2-chloroethyl methanesulfonate 0
                2-fluoroethyl methanesulfonate 0
                3-bromopyruvic acid 17
                4-hydroperoxycyclophosphamide 74
                4-hydroxycyclophosphamide 9
                D-mannitol 1,6-bis(methanesulfonate) 0
                L-mannitol 1,6-bis(methanesulfonate) 0
                MTIC 0
                N-ethyl-N-nitrosourea 508
                N-methyl-N'-nitro-N-nitrosoguanidine 271
                N-methyl-N-nitrosourea 349
                N-tosyl-L-phenylalanyl chloromethyl ketone 53
                S-(chloromethyl)glutathione 0
                acrylamide 3780
                aziridine + 0
                bis(2-chloroethyl) sulfide 1277
                bis(chloromethyl) ether 0
                busulfan 57
                carmustine 465
                chlorambucil 50
                chloroacetic acid + 25
                cyclophosphamide + 702
                cyclophosphamide hydrate 0
                dacarbazine 22
                diaziquone 3
                diazomethane 0
                dimethyl sulfate 5
                dimethyl sulfoxide + 304
                dimethylmyleran 0
                esperamicin A1 0
                estramustine + 3
                etanidazole 1
                ethyl methanesulfonate 2173
                fotemustine 10
                hex-3-yne-2,5-diyl bis(methanesulfonate) 0
                hexane-2,5-diyl bis(methanesulfonate) 0
                hycanthone mesylate 0
                ifosfamide 237
                iodoacetic acid 9
                lomustine 9
                mechlorethamine + 83
                melphalan 270
                methyl methanesulfonate 3643
                mitomycin A 0
                mitomycin C 404
                nimustine 23
                nitrogen mustard + 1231
                pipobroman 0
                semustine 2
                temozolomide 210
                tretamine 0
                triaziquone 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.