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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alkylating agent
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Accession:CHEBI:22333 term browser browse the term
Definition:Highly reactive chemical that introduces alkyl radicals into biologically active molecules and thereby prevents their proper functioning. It could be used as an antineoplastic agent, but it might be very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. It could also be used as a component of poison gases.


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      CHEBI ontology 19765
        role 19738
          biological role 19736
            aetiopathogenetic role 19097
              genotoxin 17596
                mutagen 17508
                  alkylating agent 14288
                    1,2-dimethylhydrazine 9934
                    2,5-bis(2-hydroxyethylamino)-3,6-diaziridinylbenzoquinone 0
                    2,5-bis(aziridin-1-yl)-1,4-benzoquinone 1
                    2-aminoacrylic acid + 0
                    2-chloroethyl methanesulfonate 0
                    2-fluoroethyl methanesulfonate 0
                    3-bromopyruvic acid 17
                    4-hydroperoxycyclophosphamide 74
                    4-hydroxycyclophosphamide 10
                    D-mannitol 1,6-bis(methanesulfonate) 0
                    L-mannitol 1,6-bis(methanesulfonate) 0
                    MTIC 0
                    N-ethyl-N-nitrosourea 511
                    N-methyl-N'-nitro-N-nitrosoguanidine 303
                    N-methyl-N-nitrosourea 354
                    N-tosyl-L-phenylalanyl chloromethyl ketone 53
                    S-(chloromethyl)glutathione 0
                    acrylamide 5903
                    anthramycin 0
                    apholate 0
                    aziridine + 0
                    bis(2-chloroethyl) sulfide 1335
                    bis(chloromethyl) ether 0
                    bromoethane 1
                    busulfan 71
                    carmustine 471
                    chlorambucil 52
                    chloroacetic acid + 29
                    colibactin 0
                    cyclophosphamide + 748
                    cyclophosphamide hydrate 0
                    dacarbazine + 23
                    diaziquone 3
                    diazomethane 0
                    diethyl sulfate 18
                    dimethyl sulfate 5
                    dimethyl sulfoxide + 326
                    dimethylmyleran 0
                    esperamicin A1 0
                    estramustine + 3
                    etanidazole 1
                    ethyl methanesulfonate 2177
                    fotemustine 11
                    hex-3-yne-2,5-diyl bis(methanesulfonate) 0
                    hexane-2,5-diyl bis(methanesulfonate) 0
                    hycanthone mesylate 0
                    ifosfamide 247
                    iodoacetic acid 31
                    lomustine 10
                    mechlorethamine + 157
                    melphalan 274
                    methyl methanesulfonate 3655
                    mitomycin A 0
                    mitomycin C 406
                    nimustine 24
                    nitrogen mustard + 1349
                    pipobroman 0
                    semustine 2
                    temozolomide 3053
                    tilimycin 0
                    tomaymycin + 0
                    trabectedin 22
                    tretamine 0
                    triaziquone 0
                    trimethyl phosphite 0
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