MAMMALIAN PHENOTYPE - ANNOTATIONS
The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term: epidermal hyperplasia
Accession: MP:0001222
browse the term
Definition: increase in the number of normal cells in normal arrangement in the epidermis, typically resulting in increased thickness
Synonyms: exact_synonym: hyperplastic epidermal layer
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Acer1
alkaline ceramidase 1
IAGP
MGI
PMID:27126290
NCBI chr17:57,260,490...57,289,126
Ensembl chr17:57,260,490...57,289,126
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Akt1
thymoma viral proto-oncogene 1
IAGP
MGI
PMID:31194862
NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
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Ass1
argininosuccinate synthetase 1
IAGP
MGI
PMID:20724589
NCBI chr 2:31,360,282...31,410,682
Ensembl chr 2:31,360,219...31,410,684
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Atf2
activating transcription factor 2
IAGP
MGI
PMID:18227516
NCBI chr 2:73,646,853...73,723,094
Ensembl chr 2:73,646,853...73,722,983
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Cask
calcium/calmodulin dependent serine protein kinase
IAGP
MGI
PMID:8494785
NCBI chr X:13,383,319...13,713,020
Ensembl chr X:13,383,319...13,717,606
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Casp8
caspase 8
IAGP
MGI
PMID:21135236
NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
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Cav1
caveolin 1, caveolae protein
IAGP
MGI
PMID:12759258
NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451
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Cd109
CD109 antigen
IAGP
MGI
PMID:22846721
NCBI chr 9:78,522,828...78,623,542
Ensembl chr 9:78,522,828...78,623,535
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Cdc42
cell division cycle 42
IAGP
MGI
PMID:16510873
NCBI chr 4:137,047,011...137,085,007
Ensembl chr 4:137,047,007...137,085,031
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Cdkn2a
cyclin dependent kinase inhibitor 2A
IAGP
MGI
PMID:21088222
NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890
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Cdsn
corneodesmosin
IAGP
MGI
PMID:19596793
NCBI chr17:35,854,044...35,867,811
Ensembl chr17:35,863,025...35,868,077
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Cebpa
CCAAT/enhancer binding protein alpha
IAGP
MGI
PMID:20352127
NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353
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Cebpb
CCAAT/enhancer binding protein beta
IAGP
MGI
PMID:20352127
NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338
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Chuk
conserved helix-loop-helix ubiquitous kinase
IAGP
MGI
PMID:10195895 PMID:10195896 PMID:18772111
NCBI chr19:44,061,773...44,095,940
Ensembl chr19:44,061,774...44,095,919
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Csnk1a1
casein kinase 1, alpha 1
IAGP
MGI
PMID:28878021
NCBI chr18:61,687,307...61,723,391
Ensembl chr18:61,688,345...61,723,132
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Cst6
cystatin E/M
IAGP
MGI
PMID:9212754
NCBI chr19:5,394,733...5,399,602
Ensembl chr19:5,394,733...5,399,602
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Ctnnd1
catenin delta 1
IAGP
MGI
PMID:18809907
NCBI chr 2:84,417,440...84,489,321
Ensembl chr 2:84,430,415...84,481,109 Ensembl chr 2:84,430,415...84,481,109
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Ctse
cathepsin E
IAGP
MGI
PMID:14769879
NCBI chr 1:131,566,052...131,603,245
Ensembl chr 1:131,566,044...131,603,243
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Ctsl
cathepsin L
IAGP
MGI
PMID:10199917 PMID:11023992 PMID:12163394 PMID:15154914 PMID:25222295
NCBI chr13:64,509,704...64,518,586
Ensembl chr13:64,507,151...64,518,704
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Cyld
CYLD lysine 63 deubiquitinase
IAGP
MGI
PMID:16713561
NCBI chr 8:89,423,506...89,478,574
Ensembl chr 8:89,423,675...89,478,573
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Dgat1
diacylglycerol O-acyltransferase 1
IAGP
MGI
PMID:19028692
NCBI chr15:76,386,215...76,396,167
Ensembl chr15:76,386,215...76,396,153
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Dicer1
dicer 1, ribonuclease type III
IAGP
MGI
PMID:22434867
NCBI chr12:104,654,001...104,718,331
Ensembl chr12:104,654,001...104,718,211
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Dkc1
dyskeratosis congenita 1, dyskerin
IAGP
MGI
PMID:12522253
NCBI chr X:74,139,460...74,153,382
Ensembl chr X:74,139,460...74,153,383
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Dlx3
distal-less homeobox 3
IAGP
MGI
PMID:18684741
NCBI chr11:95,010,943...95,016,122
Ensembl chr11:95,010,945...95,016,122
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Drosha
drosha, ribonuclease type III
IAGP
MGI
PMID:22434867
NCBI chr15:12,824,893...12,935,377
Ensembl chr15:12,824,901...12,935,377
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Dsc1
desmocollin 1
IAGP
MGI
PMID:11714727
NCBI chr18:20,216,528...20,247,830
Ensembl chr18:20,217,241...20,247,928
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Dsc3
desmocollin 3
IAGP
MGI
PMID:18682494
NCBI chr18:20,093,987...20,135,465
Ensembl chr18:20,093,987...20,135,408
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Dsg4
desmoglein 4
IAGP
MGI
PMID:8752833
NCBI chr18:20,569,234...20,606,191
Ensembl chr18:20,569,232...20,604,878
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E4f1
E4F transcription factor 1
IAGP
MGI
PMID:21088222
NCBI chr17:24,662,752...24,674,366
Ensembl chr17:24,662,752...24,689,287
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Ercc3
excision repair cross-complementing rodent repair deficiency, complementation group 3
IAGP
MGI
PMID:19114557
NCBI chr18:32,373,357...32,403,206
Ensembl chr18:32,373,353...32,403,204
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Errfi1
ERBB receptor feedback inhibitor 1
IAGP
MGI
PMID:16648858 PMID:17987665
NCBI chr 4:150,938,253...150,953,346
Ensembl chr 4:150,938,376...150,953,349
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Ezh1
enhancer of zeste 1 polycomb repressive complex 2 subunit
IAGP
MGI
PMID:21317239
NCBI chr11:101,081,941...101,117,268
Ensembl chr11:101,081,941...101,117,289
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Ezh2
enhancer of zeste 2 polycomb repressive complex 2 subunit
IAGP
MGI
PMID:21317239
NCBI chr 6:47,507,208...47,613,843
Ensembl chr 6:47,507,073...47,572,275
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Fbn1
fibrillin 1
IAGP
MGI
PMID:24107997
NCBI chr 2:125,142,514...125,348,417
Ensembl chr 2:125,142,514...125,349,913
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Fbxo11
F-box protein 11
IAGP
MGI
PMID:25827072
NCBI chr17:88,298,287...88,373,473
Ensembl chr17:88,298,287...88,372,719
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Fgfr2
fibroblast growth factor receptor 2
IAGP
MGI
PMID:22585574
NCBI chr 7:129,764,181...129,868,538
Ensembl chr 7:129,764,181...132,725,079
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Foxp3
forkhead box P3
IAGP
MGI
PMID:2053595
NCBI chr X:7,445,915...7,461,482
Ensembl chr X:7,439,883...7,461,484
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Gata3
GATA binding protein 3
IAGP
MGI
PMID:17151017
NCBI chr 2:9,861,889...9,894,845
Ensembl chr 2:9,861,889...9,894,845
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Gjb2
gap junction protein, beta 2
IAGP
MGI
PMID:20926451
NCBI chr14:57,336,059...57,342,159
Ensembl chr14:57,336,057...57,342,159
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Gjb3
gap junction protein, beta 3
IAGP
MGI
PMID:17446259
NCBI chr 4:127,219,028...127,224,633
Ensembl chr 4:127,219,028...127,224,637
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Gk5
glycerol kinase 5
IAGP
MGI
PMID:28607088
NCBI chr 9:96,001,379...96,066,680
Ensembl chr 9:96,001,415...96,066,661
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Gpx8
glutathione peroxidase 8 (putative)
IEA
MGI
NCBI chr13:113,179,287...113,182,944
Ensembl chr13:113,179,287...113,182,944
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Grhl3
grainyhead like transcription factor 3
IAGP
MGI
PMID:16949565 PMID:21245842 PMID:22094257
NCBI chr 4:135,269,199...135,300,943
Ensembl chr 4:135,269,199...135,300,941
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Gsdma3
gasdermin A3
IAGP
MGI
PMID:22155111
NCBI chr11:98,517,175...98,529,627
Ensembl chr11:98,517,186...98,529,052
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Gt(ROSA)26Sor
gene trap ROSA 26, Philippe Soriano
IAGP
MGI
PMID:16977322 PMID:26099023
NCBI chr 6:113,044,389...113,054,205
Ensembl chr 6:113,043,843...113,055,336
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Gtf2ird1
general transcription factor II I repeat domain-containing 1
IAGP
MGI
PMID:22198572
NCBI chr 5:134,386,515...134,485,628
Ensembl chr 5:134,386,510...134,485,570
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Hdac1
histone deacetylase 1
IAGP
MGI
PMID:23792463
NCBI chr 4:129,409,897...129,436,516
Ensembl chr 4:129,409,897...129,436,506
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Hr
lysine demethylase and nuclear receptor corepressor
IAGP
MGI
PMID:21020475
NCBI chr14:70,789,644...70,810,988
Ensembl chr14:70,789,652...70,810,988
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Ikbkb
inhibitor of kappaB kinase beta
IAGP
MGI
PMID:24211183
NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605
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Il22ra1
interleukin 22 receptor, alpha 1
IAGP
MGI
PMID:24211183
NCBI chr 4:135,455,470...135,482,694
Ensembl chr 4:135,455,483...135,479,451
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Itgb1
integrin beta 1 (fibronectin receptor beta)
IAGP
MGI
PMID:19424505
NCBI chr 8:129,412,135...129,460,060
Ensembl chr 8:129,412,135...129,459,681
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Itgb2
integrin beta 2
IAGP
MGI
PMID:8700894 PMID:9653089
NCBI chr10:77,366,164...77,401,542
Ensembl chr10:77,366,086...77,401,542
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Itgb3
integrin beta 3
IAGP
MGI
PMID:24107997
NCBI chr11:104,498,826...104,561,302
Ensembl chr11:104,498,826...104,561,302
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Jag2
jagged 2
IEA
MGI
NCBI chr12:112,871,439...112,893,437
Ensembl chr12:112,871,439...112,893,396
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Kras
Kirsten rat sarcoma viral oncogene homolog
IAGP
MGI
PMID:21502497
NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965
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Krt10
keratin 10
IAGP
MGI
PMID:24751727
NCBI chr11:99,276,080...99,288,631
Ensembl chr11:99,276,080...99,280,190
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Krt2
keratin 2
IAGP
MGI
PMID:24751727
NCBI chr15:101,719,124...101,727,391
Ensembl chr15:101,719,124...101,726,604
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Lamc2
laminin, gamma 2
IAGP
MGI
PMID:20336083
NCBI chr 1:152,998,502...153,062,193
Ensembl chr 1:152,998,502...153,062,193
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Lbr
lamin B receptor
IAGP
MGI
PMID:12490533
NCBI chr 1:181,642,880...181,669,933
Ensembl chr 1:181,642,900...181,670,611
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Lmna
lamin A
IAGP
MGI
PMID:20376364
NCBI chr 3:88,388,455...88,413,842
Ensembl chr 3:88,387,454...88,417,263
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Lrig1
leucine-rich repeats and immunoglobulin-like domains 1
IAGP
MGI
PMID:12067728 PMID:24652767
NCBI chr 6:94,581,510...94,677,205
Ensembl chr 6:94,581,510...94,677,139
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Ly6a
lymphocyte antigen 6 family member A
IAGP
MGI
PMID:15477599
NCBI chr15:74,866,726...74,869,880
Ensembl chr15:74,866,726...74,869,880
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Mapk9
mitogen-activated protein kinase 9
IAGP
MGI
PMID:15375216
NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248
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Mob1a
MOB kinase activator 1A
IAGP
MGI
PMID:23143302
NCBI chr 6:83,303,016...83,320,758
Ensembl chr 6:83,302,998...83,320,758
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Mob1b
MOB kinase activator 1B
IAGP
MGI
PMID:23143302
NCBI chr 5:88,868,730...88,906,314
Ensembl chr 5:88,868,714...88,912,079
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Mpzl3
myelin protein zero-like 3
IAGP
MGI
PMID:15482472 PMID:24531688
NCBI chr 9:44,966,479...44,988,735
Ensembl chr 9:44,966,484...44,988,734
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N4bp1
NEDD4 binding protein 1
IAGP
MGI
PMID:32971525
NCBI chr 8:87,567,764...87,612,489
Ensembl chr 8:87,534,788...87,611,886
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Nab1
Ngfi-A binding protein 1
IAGP
MGI
PMID:16136673
NCBI chr 1:52,494,146...52,539,553
Ensembl chr 1:52,496,453...52,539,838
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Nab2
Ngfi-A binding protein 2
IAGP
MGI
PMID:16136673
NCBI chr10:127,496,787...127,502,572
Ensembl chr10:127,496,787...127,504,437
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Nfkbiz
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta
IAGP
MGI
PMID:18441309
NCBI chr16:55,631,740...55,659,018
Ensembl chr16:55,631,738...55,659,262
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Notch1
notch 1
IAGP
MGI
PMID:15525534
NCBI chr 2:26,347,914...26,393,834
Ensembl chr 2:26,347,915...26,406,675
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Notch2
notch 2
IAGP
MGI
PMID:15525534
NCBI chr 3:97,920,854...98,057,683
Ensembl chr 3:97,920,843...98,057,677
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Otulin
OTU deubiquitinase with linear linkage specificity
IAGP
MGI
PMID:34625556
NCBI chr15:27,606,005...27,630,793
Ensembl chr15:27,542,721...27,630,779
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Pdpk1
3-phosphoinositide dependent protein kinase 1
IAGP
MGI
PMID:26099023
NCBI chr17:24,292,654...24,370,957
Ensembl chr17:24,292,654...24,369,898
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Pkp3
plakophilin 3
IAGP
MGI
PMID:18079750
NCBI chr 7:140,658,202...140,670,424
Ensembl chr 7:140,658,131...140,670,423
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Pla2g4e
phospholipase A2, group IVE
IAGP
MGI
PMID:35478358
NCBI chr 2:119,996,893...120,075,816
Ensembl chr 2:119,996,893...120,075,816
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Plcl1
phospholipase C-like 1
IAGP
MGI
PMID:24591640
NCBI chr 1:55,442,722...55,793,444
Ensembl chr 1:55,445,080...55,793,444
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Pnpla1
patatin-like phospholipase domain containing 1
IAGP
MGI
PMID:28248300
NCBI chr17:29,077,262...29,109,282
Ensembl chr17:29,077,385...29,109,283
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Polr2a
polymerase (RNA) II (DNA directed) polypeptide A
IAGP
MGI
PMID:21088222
NCBI chr11:69,624,823...69,649,459
Ensembl chr11:69,624,823...69,649,463
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Ppard
peroxisome proliferator activator receptor delta
IAGP
MGI
PMID:10866668
NCBI chr17:28,451,715...28,520,446
Ensembl chr17:28,451,674...28,520,448
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Ppp1r13l
protein phosphatase 1, regulatory subunit 13 like
IAGP
MGI
PMID:21930934
NCBI chr 7:19,093,639...19,112,465
Ensembl chr 7:19,093,674...19,112,458
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Ppp2r5a
protein phosphatase 2, regulatory subunit B', alpha
IAGP
MGI
PMID:29190822
NCBI chr 1:191,084,178...191,129,238
Ensembl chr 1:191,084,172...191,135,469
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Prkca
protein kinase C, alpha
IAGP
MGI
PMID:16103087
NCBI chr11:107,824,213...108,237,360
Ensembl chr11:107,824,213...108,234,754
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Prkch
protein kinase C, eta
IAGP
MGI
PMID:12750259
NCBI chr12:73,631,570...73,824,959
Ensembl chr12:73,631,570...73,824,959
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Psen1
presenilin 1
IAGP
MGI
PMID:15128703 PMID:15525534
NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973
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Psen2
presenilin 2
IAGP
MGI
PMID:15128703 PMID:15525534
NCBI chr 1:180,054,569...180,091,030
Ensembl chr 1:180,054,569...180,091,003
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Ptch2
patched 2
IAGP
MGI
PMID:16914743
NCBI chr 4:116,953,253...116,973,298
Ensembl chr 4:116,953,272...116,973,298
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Pten
phosphatase and tensin homolog
IAGP
MGI
PMID:16204035
NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560
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Rabgef1
RAB guanine nucleotide exchange factor (GEF) 1
IAGP
MGI
PMID:15235600
NCBI chr 5:130,200,644...130,243,178
Ensembl chr 5:130,200,639...130,243,183
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Rag1
recombination activating 1
IAGP
MGI
PMID:16880407
NCBI chr 2:101,468,597...101,479,877
Ensembl chr 2:101,468,627...101,479,846
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Rag2
recombination activating gene 2
IAGP
MGI
PMID:26099023
NCBI chr 2:101,455,057...101,462,873
Ensembl chr 2:101,455,063...101,462,874
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Rassf9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
IAGP
MGI
PMID:21445300
NCBI chr10:102,348,083...102,385,598
Ensembl chr10:102,348,083...102,385,597
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Rb1
RB transcriptional corepressor 1
IAGP
MGI
PMID:16103190
NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262
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Rbl1
RB transcriptional corepressor like 1
IAGP
MGI
PMID:12702649
NCBI chr 2:156,987,813...157,046,454
Ensembl chr 2:156,987,813...157,046,454
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Rbl2
RB transcriptional corepressor like 2
IAGP
MGI
PMID:12702649
NCBI chr 8:91,796,685...91,850,472
Ensembl chr 8:91,796,685...91,850,472
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Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
IAGP
MGI
PMID:20713516
NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
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Relb
avian reticuloendotheliosis viral (v-rel) oncogene related B
IAGP
MGI
PMID:10940923
NCBI chr 7:19,340,142...19,363,352
Ensembl chr 7:19,340,142...19,363,363
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Ripk4
receptor-interacting serine-threonine kinase 4
IAGP
MGI
PMID:12194825
NCBI chr16:97,543,133...97,564,979
Ensembl chr16:97,543,133...97,564,987
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Rxra
retinoid X receptor alpha
IAGP
MGI
PMID:16199515
NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969
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Rxrb
retinoid X receptor beta
IAGP
MGI
PMID:16199515
NCBI chr17:34,250,786...34,257,377
Ensembl chr17:34,250,786...34,257,373
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Sav1
salvador family WW domain containing 1
IAGP
MGI
PMID:18369314
NCBI chr12:70,011,786...70,033,864
Ensembl chr12:70,011,786...70,033,776
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Sdr9c7
4short chain dehydrogenase/reductase family 9C, member 7
IAGP
MGI
PMID:31671075
NCBI chr10:127,734,404...127,747,630
Ensembl chr10:127,734,387...127,747,630
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Sfn
stratifin
IAGP
MGI
PMID:16239341
NCBI chr 4:133,327,867...133,329,163
Ensembl chr 4:133,327,867...133,329,479
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Sharpin
SHANK-associated RH domain interacting protein
IAGP
MGI
PMID:8362989
NCBI chr15:76,231,240...76,235,310
Ensembl chr15:76,231,240...76,235,311
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Shh
sonic hedgehog
IAGP
MGI
PMID:9768360
NCBI chr 5:28,661,838...28,672,099
Ensembl chr 5:28,661,813...28,672,254
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Sox21
SRY (sex determining region Y)-box 21
IAGP
MGI
PMID:19470461
NCBI chr14:118,470,645...118,474,442
Ensembl chr14:118,470,644...118,474,442
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Sptlc2
serine palmitoyltransferase, long chain base subunit 2
IAGP
MGI
PMID:23633022
NCBI chr12:87,351,832...87,435,129
Ensembl chr12:87,351,832...87,435,129
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Stat6
signal transducer and activator of transcription 6
IAGP
MGI
PMID:18441309
NCBI chr10:127,478,855...127,496,856
Ensembl chr10:127,478,855...127,496,826
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Taf4
TATA-box binding protein associated factor 4
IAGP
MGI
PMID:17626060
NCBI chr 2:179,553,945...179,618,519
Ensembl chr 2:179,553,945...179,618,439
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Terf1
telomeric repeat binding factor 1
IAGP
MGI
PMID:19679647
NCBI chr 1:15,875,634...15,914,283
Ensembl chr 1:15,875,870...15,914,276
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Tnfrsf1a
tumor necrosis factor receptor superfamily, member 1a
IAGP
MGI
PMID:18772111 PMID:24211183
NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447
G
Tnfrsf4
tumor necrosis factor receptor superfamily, member 4
IAGP
MGI
PMID:26099023
NCBI chr 4:156,098,049...156,101,070
Ensembl chr 4:156,098,300...156,101,069
G
Ttc7
tetratricopeptide repeat domain 7
IAGP
MGI
PMID:15155459
NCBI chr17:87,590,328...87,689,197
Ensembl chr17:87,590,314...87,689,197
G
Vhl
von Hippel-Lindau tumor suppressor
IAGP
MGI
PMID:16977322
NCBI chr 6:113,600,955...113,608,595
Ensembl chr 6:113,600,920...113,608,594
G
Wasl
WASP like actin nucleation promoting factor
IAGP
MGI
PMID:28779153
NCBI chr 6:24,613,809...24,665,185
Ensembl chr 6:24,613,804...24,665,008
G
Wdr1
WD repeat domain 1
IAGP
MGI
PMID:17515402
NCBI chr 5:38,684,149...38,720,265
Ensembl chr 5:38,684,156...38,720,564
G
Xpc
xeroderma pigmentosum, complementation group C
IAGP
MGI
PMID:17127714
NCBI chr 6:91,466,287...91,492,870
Ensembl chr 6:91,466,287...91,492,870
G
Zdhhc13
zinc finger, DHHC domain containing 13
IAGP
MGI
PMID:20548961
NCBI chr 7:48,438,751...48,477,188
Ensembl chr 7:48,438,751...48,477,188
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