Pnpla1 (patatin-like phospholipase domain containing 1) - Rat Genome Database

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Gene: Pnpla1 (patatin-like phospholipase domain containing 1) Mus musculus
Analyze
Symbol: Pnpla1
Name: patatin-like phospholipase domain containing 1
RGD ID: 1622661
MGI Page MGI
Description: Enables omega-hydroxyceramide transacylase activity. A structural constituent of skin epidermis. Involved in establishment of skin barrier; keratinocyte differentiation; and omega-hydroxyceramide biosynthetic process. Predicted to be active in cytoplasm; lipid droplet; and membrane. Is expressed in epidermis. Used to study autosomal recessive congenital ichthyosis 10. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 10. Orthologous to human PNPLA1 (patatin like phospholipase domain containing 1); INTERACTS WITH 1,2-dichloroethane; benzo[a]pyrene; carbon nanotube.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: omega-hydroxyceramide transacylase; patatin-like phospholipase domain-containing protein 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391729,077,262 - 29,109,282 (+)NCBIGRCm39mm39
GRCm39 Ensembl1729,077,385 - 29,109,283 (+)Ensembl
GRCm381728,858,286 - 28,890,308 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1728,858,411 - 28,890,309 (+)EnsemblGRCm38mm10GRCm38
MGSCv371728,995,356 - 29,027,253 (+)NCBIGRCm37mm9NCBIm37
MGSCv361728,586,000 - 28,617,897 (+)NCBImm8
Celera1729,412,978 - 29,445,667 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
lipid droplet  (IBA)
membrane  (IBA)

References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21677750   PMID:21873635   PMID:27267404  
PMID:27626380   PMID:27751867   PMID:28248300   PMID:28369476   PMID:31356814   PMID:31578523  


Genomics

Comparative Map Data
Pnpla1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391729,077,262 - 29,109,282 (+)NCBIGRCm39mm39
GRCm39 Ensembl1729,077,385 - 29,109,283 (+)Ensembl
GRCm381728,858,286 - 28,890,308 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1728,858,411 - 28,890,309 (+)EnsemblGRCm38mm10GRCm38
MGSCv371728,995,356 - 29,027,253 (+)NCBIGRCm37mm9NCBIm37
MGSCv361728,586,000 - 28,617,897 (+)NCBImm8
Celera1729,412,978 - 29,445,667 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
PNPLA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl636,243,203 - 36,313,955 (+)EnsemblGRCh38hg38GRCh38
GRCh38636,242,523 - 36,313,955 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37636,210,945 - 36,281,732 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36636,318,923 - 36,384,350 (+)NCBINCBI36hg18NCBI36
Build 34636,318,922 - 36,384,350NCBI
Celera637,765,485 - 37,830,961 (+)NCBI
Cytogenetic Map6p21.31NCBI
HuRef635,930,494 - 35,995,688 (+)NCBIHuRef
CHM1_1636,212,708 - 36,278,194 (+)NCBICHM1_1
Pnpla1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2206,918,446 - 6,951,650 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl206,917,931 - 6,952,375 (+)Ensembl
Rnor_6.0206,101,061 - 6,143,762 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl206,102,277 - 6,143,707 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0208,355,252 - 8,393,878 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4207,139,384 - 7,173,440 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1207,139,610 - 7,172,044 (+)NCBI
Celera208,471,789 - 8,505,049 (+)NCBICelera
Cytogenetic Map20p12NCBI
Pnpla1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554374,008,545 - 4,048,033 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554374,008,814 - 4,047,895 (+)NCBIChiLan1.0ChiLan1.0
PNPLA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1637,002,466 - 37,067,190 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl637,002,466 - 37,067,190 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0635,828,778 - 35,872,129 (+)NCBIMhudiblu_PPA_v0panPan3
PNPLA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1125,377,430 - 5,423,556 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl125,377,430 - 5,423,556 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha125,397,344 - 5,443,474 (+)NCBI
ROS_Cfam_1.0125,725,170 - 5,771,521 (+)NCBI
UMICH_Zoey_3.1125,381,148 - 5,427,257 (+)NCBI
UNSW_CanFamBas_1.0125,458,997 - 5,505,125 (+)NCBI
UU_Cfam_GSD_1.0125,559,044 - 5,605,194 (+)NCBI
Pnpla1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494640,859,983 - 40,899,613 (+)NCBI
SpeTri2.0NW_00493647623,066,840 - 23,100,126 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PNPLA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl731,988,396 - 32,025,245 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1731,987,596 - 32,025,673 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2736,888,056 - 36,925,909 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PNPLA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11735,808,652 - 35,854,069 (-)NCBI
ChlSab1.1 Ensembl1735,814,590 - 35,851,985 (-)Ensembl
Vero_WHO_p1.0NW_02366604436,225,386 - 36,266,877 (+)NCBI
Pnpla1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475421,370,872 - 21,410,804 (-)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302100Circp2_mcircadian photosensitivity 2 (mouse)Not determined17128979566Mouse
12910527Nrq1a_mnoise-induced hearing loss resistant QTL 1a (mouse)17128979566Mouse
12910528Nrq1_mnoise-induced hearing loss resistant QTL 1 (mouse)17128979566Mouse
13524851Asrq8_macoustic startle response 8 (mouse)17130809908Mouse
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17312791337128037Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17392461548559063Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined480447745359340Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17480447746158776Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17480447747574740Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined480447765330362Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17667496240674962Mouse
4141608Phl1_mprogressive hearing loss 1 (mouse)Not determined17765701129268449Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17836594042366175Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17836594042366175Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined17986241186688972Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171065914544659245Mouse
4142342Lfnq4_mlung function QTL 4 (mouse)Not determined1098759739053168Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1166699745667145Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171177921045779210Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171206732483054339Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171223281346232813Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171242798746427987Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171390439847904522Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171484267848842786Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171484267848842786Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171484267848842786Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171484267848842786Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171660074750600869Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171660074750600869Mouse
1301505Tir1_mtrypanosome infection response 1 (mouse)Not determined171660074750600869Mouse
1302038Radpf1_mradiation pulmonary fibrosis 1 (mouse)Not determined171661519333600869Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171681096950811104Mouse
1302042Acsns3_mAngiostrongylus costaricensis nematode susceptibility 3 (mouse)Not determined171724323451243371Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171724323451243371Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171724323451243371Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171724323451243371Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171724323451243371Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171795643651959238Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171819938152202007Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171820316552205351Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171883413352834133Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172430185958301973Mouse
10412198Sst5_msusceptibility to tuberculosis 5 (mouse)Not determined172485760955405969Mouse
10412196Bbaa28_mB.burgdorferi-associated arthritis 28 (mouse)Not determined172536594043665344Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172574029459740461Mouse
1558758Kcal2_mkilocalorie 2 (mouse)Not determined172618203852604676Mouse
1300602Eye2_meye weight 2 (mouse)Not determined172628636340794146Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172657408160574223Mouse
12904013Cfq12_mconditioned fear QTL 12 (mouse)172660980730445981Mouse
11075105Modc1_mmodifier of Odc1 (mouse)172749681845311728Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172750432261504322Mouse
10045977Tir9_mtrypanosome infection response 9 (mouse)Not determined172765914543574223Mouse
1300703Uvbi2_mUVB induced immunosuppression 2 (mouse)Not determined172831148062311728Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1713
Count of miRNA genes:563
Interacting mature miRNAs:663
Transcripts:ENSMUST00000056866, ENSMUST00000114737
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000056866   ⟹   ENSMUSP00000050123
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1729,077,385 - 29,109,283 (+)Ensembl
GRCm38.p6 Ensembl1728,858,411 - 28,890,309 (+)Ensembl
RefSeq Acc Id: ENSMUST00000114737
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1729,077,492 - 29,101,785 (+)Ensembl
GRCm38.p6 Ensembl1728,858,518 - 28,882,811 (+)Ensembl
RefSeq Acc Id: NM_001034885   ⟹   NP_001030057
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391729,077,385 - 29,109,282 (+)NCBI
GRCm381728,858,411 - 28,890,308 (+)NCBI
MGSCv371728,995,356 - 29,027,253 (+)RGD
Celera1729,412,978 - 29,445,667 (+)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006524581   ⟹   XP_006524644
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391729,083,624 - 29,107,602 (+)NCBI
GRCm381728,864,733 - 28,888,628 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006524582   ⟹   XP_006524645
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391729,083,624 - 29,107,602 (+)NCBI
GRCm381728,864,733 - 28,888,628 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006524585   ⟹   XP_006524648
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391729,077,262 - 29,107,663 (+)NCBI
GRCm381728,858,286 - 28,888,689 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001030057   ⟸   NM_001034885
- UniProtKB: Q3V1D5 (UniProtKB/Swiss-Prot),   B2KF06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006524648   ⟸   XM_006524585
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006524645   ⟸   XM_006524582
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006524644   ⟸   XM_006524581
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000050123   ⟸   ENSMUST00000056866
Protein Domains
PNPLA

Promoters
RGD ID:13675386
Promoter ID:EPDNEW_M21842
Type:initiation region
Name:Pnpla1_1
Description:Mus musculus patatin-like phospholipase domain containing 1 ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381728,858,481 - 28,858,541EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3617850 AgrOrtholog
Ensembl Genes ENSMUSG00000043286 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000050123 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000056866 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Acyl_Trfase/lysoPLipase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLPL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PNPLA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:433091 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:3617850 ENTREZGENE
NCBI Gene 433091 ENTREZGENE
PANTHER PTHR12406 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Patatin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pnpla1 PhenoGen
PROSITE PNPLA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52151 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2KF06 ENTREZGENE, UniProtKB/TrEMBL
  PLPL1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE