Sav1 (salvador family WW domain containing 1) - Rat Genome Database

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Gene: Sav1 (salvador family WW domain containing 1) Mus musculus
Analyze
Symbol: Sav1
Name: salvador family WW domain containing 1
RGD ID: 1316339
MGI Page MGI
Description: Predicted to enable several functions, including identical protein binding activity; signaling receptor binding activity; and signaling receptor complex adaptor activity. Involved in hippo signaling. Acts upstream of or within several processes, including epithelial cell differentiation; negative regulation of cell population proliferation; and positive regulation of fat cell differentiation. Predicted to be located in cytosol and nucleus. Predicted to be active in cell-cell junction; cytoplasm; and dendrite. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Used to study colonic disease and hepatocellular carcinoma. Orthologous to human SAV1 (salvador family WW domain containing protein 1); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 1700040G09Rik; 45 kDa WW domain protein; mWW45; Salv; salvador homolog 1; Sav; WW domain-containing protein 3; WW domain-containing protein 4; WW45; Wwp3; Wwp4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391270,011,786 - 70,034,915 (-)NCBIGRCm39mm39
GRCm39 Ensembl1270,011,786 - 70,033,776 (-)Ensembl
GRCm381269,965,009 - 69,988,141 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1269,965,012 - 69,987,002 (-)EnsemblGRCm38mm10GRCm38
MGSCv371271,065,999 - 71,087,989 (-)NCBIGRCm37mm9NCBIm37
MGSCv361270,883,617 - 70,905,607 (-)NCBImm8
Celera1271,066,736 - 71,086,376 (-)NCBICelera
Cytogenetic Map12C2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal enterocyte morphology  (IAGP)
abnormal enterocyte proliferation  (IAGP)
abnormal epidermis stratum basale morphology  (IAGP)
abnormal epidermis stratum granulosum morphology  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal intestinal enteroendocrine cell morphology  (IAGP)
abnormal intestinal goblet cell morphology  (IAGP)
abnormal keratinocyte differentiation  (IAGP)
abnormal large intestine crypts of Lieberkuhn morphology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal lung development  (IAGP)
abnormal oval cell morphology  (IAGP)
abnormal oval cell physiology  (IAGP)
abnormal placental labyrinth vasculature morphology  (IAGP)
abnormal portal lobule morphology  (IAGP)
abnormal small intestinal microvillus morphology  (IAGP)
abnormal small intestinal villus morphology  (IAGP)
abnormal small intestine crypts of Lieberkuhn morphology  (IAGP)
bile duct hyperplasia  (IAGP)
colon polyps  (IAGP)
decreased survivor rate  (IAGP)
disorganized suprabasal layer  (IAGP)
enlarged liver  (IAGP)
epidermal hyperplasia  (IAGP)
fetal growth retardation  (IAGP)
impaired skin barrier function  (IAGP)
increased carcinoma incidence  (IAGP)
increased enterocyte cell number  (IAGP)
increased hepatoblastoma incidence  (IAGP)
increased hepatocellular carcinoma incidence  (IAGP)
increased hepatocyte proliferation  (IAGP)
increased hepatoma incidence  (IAGP)
increased liver adenoma incidence  (IAGP)
increased liver tumor incidence  (IAGP)
increased liver weight  (IAGP)
increased lymphoma incidence  (IAGP)
increased osteosarcoma incidence  (IAGP)
increased ovary tumor incidence  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
lung epithelium hyperplasia  (IAGP)
parakeratosis  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
retina hyperplasia  (IAGP)
underdeveloped hair follicles  (IAGP)
References

Additional References at PubMed
PMID:10349636   PMID:11027580   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:15489334   PMID:16141072   PMID:16141073   PMID:17239860   PMID:18369314   PMID:19786569  
PMID:20080689   PMID:20404163   PMID:21041407   PMID:21163252   PMID:21512031   PMID:21677750   PMID:21873635   PMID:22292086   PMID:23555292   PMID:24255096   PMID:25943351   PMID:26131558  
PMID:26193883   PMID:26913567   PMID:26980762   PMID:27550469   PMID:28195124   PMID:28320873   PMID:28486106   PMID:28581498   PMID:28976966   PMID:29400692   PMID:29891559   PMID:30327349  
PMID:30582455   PMID:30910359   PMID:30944303   PMID:31138677   PMID:32469866  


Genomics

Comparative Map Data
Sav1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391270,011,786 - 70,034,915 (-)NCBIGRCm39mm39
GRCm39 Ensembl1270,011,786 - 70,033,776 (-)Ensembl
GRCm381269,965,009 - 69,988,141 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1269,965,012 - 69,987,002 (-)EnsemblGRCm38mm10GRCm38
MGSCv371271,065,999 - 71,087,989 (-)NCBIGRCm37mm9NCBIm37
MGSCv361270,883,617 - 70,905,607 (-)NCBImm8
Celera1271,066,736 - 71,086,376 (-)NCBICelera
Cytogenetic Map12C2NCBI
SAV1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1450,632,058 - 50,668,306 (-)EnsemblGRCh38hg38GRCh38
GRCh381450,633,104 - 50,668,306 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371451,100,298 - 51,135,024 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361450,170,110 - 50,204,773 (-)NCBINCBI36hg18NCBI36
Build 341450,170,109 - 50,204,773NCBI
Celera1430,967,387 - 31,002,030 (-)NCBI
Cytogenetic Map14q22.1NCBI
HuRef1431,225,872 - 31,260,642 (-)NCBIHuRef
CHM1_11451,038,840 - 51,073,614 (-)NCBICHM1_1
Sav1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2688,478,536 - 88,500,121 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl688,478,539 - 88,499,968 (-)Ensembl
Rnor_6.0692,376,470 - 92,398,678 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl692,376,093 - 92,398,525 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06101,825,584 - 101,846,408 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4692,081,608 - 92,101,975 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1692,084,683 - 92,105,492 (-)NCBI
Celera686,974,336 - 86,994,740 (-)NCBICelera
Cytogenetic Map6q24NCBI
Sav1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540912,200,721 - 12,220,410 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540912,200,721 - 12,221,520 (+)NCBIChiLan1.0ChiLan1.0
SAV1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11449,525,687 - 49,560,347 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1449,525,687 - 49,560,347 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01431,223,140 - 31,257,871 (-)NCBIMhudiblu_PPA_v0panPan3
SAV1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1827,034,606 - 27,061,926 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl827,022,628 - 27,062,611 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha826,788,420 - 26,815,739 (-)NCBI
ROS_Cfam_1.0827,212,701 - 27,240,724 (-)NCBI
UMICH_Zoey_3.1826,868,220 - 26,896,193 (-)NCBI
UNSW_CanFamBas_1.0826,941,329 - 26,968,924 (-)NCBI
UU_Cfam_GSD_1.0827,285,743 - 27,313,496 (-)NCBI
Sav1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864059,213,993 - 59,236,456 (-)NCBI
SpeTri2.0NW_00493649514,955,234 - 14,977,720 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SAV1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1180,395,544 - 180,434,384 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11180,404,871 - 180,434,458 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21200,696,535 - 200,724,804 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SAV1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12427,710,256 - 27,747,638 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2427,711,970 - 27,747,647 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605316,021,200 - 16,056,413 (-)NCBIVero_WHO_p1.0
Sav1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473118,262,110 - 18,282,386 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
AI414330  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381269,987,429 - 69,987,508UniSTSGRCm38
MGSCv371271,088,416 - 71,088,495UniSTSGRCm37
Celera1271,088,875 - 71,088,954UniSTS
Cytogenetic Map12C3UniSTS
Whitehead/MRC_RH12651.81UniSTS
UniSTS:236861  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381269,967,445 - 69,967,892UniSTSGRCm38
MGSCv371271,068,432 - 71,068,879UniSTSGRCm37
Celera1271,069,169 - 71,069,616UniSTS
Cytogenetic Map12C2UniSTS
Cytogenetic Map12C3UniSTS
Ppp2r2a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371271,082,925 - 71,083,074UniSTSGRCm37
MGSCv371271,082,766 - 71,083,175UniSTSGRCm37
MGSCv371467,641,123 - 67,641,275UniSTSGRCm37
Celera1271,083,662 - 71,083,811UniSTS
Celera1464,777,472 - 64,777,624UniSTS
Celera1271,083,503 - 71,083,912UniSTS
cM Map14 UniSTS
Ppp2r2a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381467,022,286 - 67,022,438UniSTSGRCm38
GRCm381269,981,938 - 69,982,087UniSTSGRCm38
MGSCv371467,641,123 - 67,641,275UniSTSGRCm37
MGSCv371271,082,925 - 71,083,074UniSTSGRCm37
Celera1464,777,472 - 64,777,624UniSTS
Celera1271,083,662 - 71,083,811UniSTS
Cytogenetic Map14D1UniSTS
Cytogenetic Map12C3UniSTS
Ppp2r2a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381269,981,779 - 69,982,188UniSTSGRCm38
MGSCv371271,082,766 - 71,083,175UniSTSGRCm37
Celera1271,083,503 - 71,083,912UniSTS
Cytogenetic Map14D1UniSTS
Cytogenetic Map12C3UniSTS
cM Map14 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142234Tmc1m3_mTmc1 modifier 3 (mouse)Not determined12536844076984429Mouse
27226753Femd7_mfemur midshaft diameter 7, 10 week (mouse)12950000084100000Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121161000097210000Mouse
1558978Cplaq10_mcircadian period of locomotor activity 10 (mouse)Not determined121529102578993590Mouse
1301574Lmblgq5_mlimb length QTL 5 (mouse)Not determined121754644680910109Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235235497109969809Mouse
1357479Splwt1_mspleen weight 1 (mouse)Not determined124164639290920752Mouse
1357757Lnopy2_mlens opacity 2 (mouse)Not determined125279985286800022Mouse
1357749Vtbt13_mvertebral trabecular bone trait 13 (mouse)Not determined125308522887085371Mouse
12832727Ahrq1_mairway hyperresponsiveness QTL 1 (mouse)125464912582619165Mouse
4140993Tglq2b_mtriglyceride QTL 2b (mouse)Not determined125529146189291675Mouse
9850127Tglq6_mtriglyceride QTL6 (mouse)Not determined125529146189291675Mouse
27226728Tibl20_mtibia length 20, 16 week (mouse)125910000093900000Mouse
27226776Tibl6_mtibia length 6, 5 week (mouse)126060000092700000Mouse
10043948Pbft6_mpercent body fat 6 (mouse)Not determined126115865395158653Mouse
1301476Pbwg12_mpostnatal body weight growth 12 (mouse)Not determined126199339095993590Mouse
27226797Scvln19_msacral vertebrae length 2, 16 week (mouse)126210000099500000Mouse
10043895Bw20_mbody weight QTL 20 (mouse)Not determined126226147896261478Mouse
1301046Par3_mpulmonary adenoma resistance 3 (mouse)Not determined126390993497910109Mouse
1301337Cdcs8_mcytokine deficiency colitis susceptibility 8 (mouse)Not determined126464230998642455Mouse
1300633Cdcs7_mcytokine deficiency colitis susceptibility 7 (mouse)Not determined126464230998642455Mouse
14746976Manh73_mmandible shape 73 (mouse)126581035799810357Mouse
27226771Tibl14_mtibia length 14, 10 week (mouse)126830000098800000Mouse
27226793Feml10_mfemur length 10, 5 week (mouse)1268300000113400000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:227
Count of miRNA genes:199
Interacting mature miRNAs:208
Transcripts:ENSMUST00000021467
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000021467   ⟹   ENSMUSP00000021467
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1270,011,786 - 70,033,776 (-)Ensembl
GRCm38.p6 Ensembl1269,965,012 - 69,987,002 (-)Ensembl
RefSeq Acc Id: ENSMUST00000220735
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1270,011,822 - 70,024,657 (-)Ensembl
GRCm38.p6 Ensembl1269,965,048 - 69,977,883 (-)Ensembl
RefSeq Acc Id: ENSMUST00000222827
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1270,029,887 - 70,031,031 (-)Ensembl
GRCm38.p6 Ensembl1269,983,113 - 69,984,257 (-)Ensembl
RefSeq Acc Id: NM_022028   ⟹   NP_071311
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391270,011,786 - 70,033,776 (-)NCBI
GRCm381269,965,012 - 69,987,002 (-)ENTREZGENE
MGSCv371271,065,999 - 71,087,989 (-)RGD
Celera1271,066,736 - 71,086,376 (-)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030246842   ⟹   XP_030102702
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391270,011,786 - 70,034,915 (-)NCBI
GRCm381269,965,009 - 69,988,141 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_071311   ⟸   NM_022028
- UniProtKB: Q8VEB2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030102702   ⟸   XM_030246842
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000021467   ⟸   ENSMUST00000021467
Protein Domains
SARAH   WW

Promoters
RGD ID:8678436
Promoter ID:EPDNEW_M17249
Type:initiation region
Name:Sav1_1
Description:Mus musculus salvador family WW domain containing 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381269,987,089 - 69,987,149EPDNEW
RGD ID:6823380
Promoter ID:MM_KWN:11837
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_022028
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361271,087,521 - 71,088,382 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1927144 AgrOrtholog
Ensembl Genes ENSMUSG00000021067 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000021467 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000021467 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro SARAH_dom UniProtKB/Swiss-Prot
  Sav UniProtKB/Swiss-Prot
  WW_dom UniProtKB/Swiss-Prot
  WW_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:64010 UniProtKB/Swiss-Prot
MGD MGI:1927144 ENTREZGENE
NCBI Gene 64010 ENTREZGENE
PANTHER PTHR47522 UniProtKB/Swiss-Prot
Pfam PF00397 UniProtKB/Swiss-Prot
PhenoGen Sav1 PhenoGen
PROSITE SARAH UniProtKB/Swiss-Prot
  WW_DOMAIN_2 UniProtKB/Swiss-Prot
SMART SM00456 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51045 UniProtKB/Swiss-Prot
UniProt Q8VEB2 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q9D9N9 UniProtKB/Swiss-Prot
  Q9ER46 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-29 Sav1  salvador family WW domain containing 1    salvador homolog 1 (Drosophila)  Symbol and/or name change 5135510 APPROVED