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Gene: Vhl (von Hippel-Lindau tumor suppressor) Mus musculus
Symbol: Vhl
Name: von Hippel-Lindau tumor suppressor
Description: Predicted to have enzyme binding activity; transcription factor binding activity; and ubiquitin ligase-substrate adaptor activity. Involved in several processes, including animal organ development; homeostasis of number of retina cells; and regulation of apoptotic process. Localizes to several cellular components, including Cul2-RING ubiquitin ligase complex; glutamatergic synapse; and nuclear lumen. Is expressed in several structures, including eye; genitourinary system; gut; heart; and nervous system. Used to study familial erythrocytosis 2; sudden infant death syndrome; and von Hippel-Lindau disease. Human ortholog(s) of this gene implicated in several diseases, including pancreatic cancer (multiple); pheochromocytoma; polycythemia (multiple); renal cell carcinoma; and von Hippel-Lindau disease. Orthologous to several human genes including VHL (von Hippel-Lindau tumor suppressor); PARTICIPATES IN altered hypoxia inducible factor pathway; hypoxia inducible factor pathway; proteasome degradation pathway involving cullin-dependent ubiquitin ligases; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: pVHL; Vhlh; von Hippel-Lindau disease tumor suppressor; von Hippel-Lindau syndrome homolog; von Hippel-Lindau syndrome protein homolog
Homo sapiens (human) : VHL (von Hippel-Lindau tumor suppressor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Vhl (von Hippel-Lindau tumor suppressor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Vhl (von Hippel-Lindau tumor suppressor)
Pan paniscus (bonobo/pygmy chimpanzee) : VHL (von Hippel-Lindau tumor suppressor)
Canis lupus familiaris (dog) : VHL (von Hippel-Lindau tumor suppressor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Vhl (von Hippel-Lindau tumor suppressor)
Sus scrofa (pig) : VHL (von Hippel-Lindau tumor suppressor)
Chlorocebus sabaeus (African green monkey) : VHL (von Hippel-Lindau tumor suppressor)
Heterocephalus glaber (naked mole-rat) : Vhl (von Hippel-Lindau tumor suppressor)
more info ...
Related Pseudogenes: Vhl-ps1  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl6113,623,959 - 113,631,633 (+)EnsemblGRCm38mm10GRCm38
GRCm386113,623,994 - 113,631,634 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv376113,574,015 - 113,581,627 (+)NCBIGRCm37mm9NCBIm37
MGSCv366113,589,798 - 113,597,410 (+)NCBImm8
Celera6115,450,882 - 115,458,459 (+)NCBICelera
Cytogenetic Map6E3NCBI
cM Map652.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Vhl
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11485
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.