N4bp1 (NEDD4 binding protein 1) - Rat Genome Database
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Gene: N4bp1 (NEDD4 binding protein 1) Mus musculus
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Symbol: N4bp1
Name: NEDD4 binding protein 1
RGD ID: 1313053
MGI Page MGI
Description: Predicted to have RNA binding activity. Involved in cellular response to UV; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and negative regulation of protein ubiquitination. Localizes to PML body and nucleolus. Orthologous to human N4BP1 (NEDD4 binding protein 1); INTERACTS WITH 1,2-dimethylhydrazine; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI481586; C81621; MGC7607; NEDD4-binding protein 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39887,567,764 - 87,612,489 (-)NCBIGRCm39mm39
GRCm38886,841,136 - 86,885,296 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl886,808,160 - 86,885,258 (-)EnsemblGRCm38mm10GRCm38
MGSCv37889,365,038 - 89,409,157 (-)NCBIGRCm37mm9NCBIm37
MGSCv36889,731,243 - 89,793,420 (-)NCBImm8
Celera891,109,318 - 91,153,508 (-)NCBICelera
Cytogenetic Map8C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleolus  (IDA)
nucleus  (IBA,IDA)
PML body  (IBA,IDA)

Molecular Function

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10725249   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11717310   PMID:12466851   PMID:12477932   PMID:12520002   PMID:14610273   PMID:15368895   PMID:16141072  
PMID:16141073   PMID:16337426   PMID:16602821   PMID:17592138   PMID:18799693   PMID:19749746   PMID:20233849   PMID:21062905   PMID:21267068   PMID:21427086   PMID:21873635   PMID:28190767  
PMID:29676259  


Genomics

Comparative Map Data
N4bp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39887,567,764 - 87,612,489 (-)NCBIGRCm39mm39
GRCm38886,841,136 - 86,885,296 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl886,808,160 - 86,885,258 (-)EnsemblGRCm38mm10GRCm38
MGSCv37889,365,038 - 89,409,157 (-)NCBIGRCm37mm9NCBIm37
MGSCv36889,731,243 - 89,793,420 (-)NCBImm8
Celera891,109,318 - 91,153,508 (-)NCBICelera
Cytogenetic Map8C3NCBI
N4BP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1648,538,726 - 48,620,148 (-)EnsemblGRCh38hg38GRCh38
GRCh381648,538,726 - 48,610,214 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371648,572,637 - 48,644,125 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361647,130,138 - 47,201,621 (-)NCBINCBI36hg18NCBI36
Celera1633,082,817 - 33,154,845 (-)NCBI
Cytogenetic Map16q12.1NCBI
HuRef1634,461,906 - 34,534,177 (-)NCBIHuRef
CHM1_11649,979,544 - 50,051,027 (-)NCBICHM1_1
N4bp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01921,218,123 - 21,268,539 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1921,218,465 - 21,266,964 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01932,227,654 - 32,278,065 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41921,560,480 - 21,607,541 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11921,565,106 - 21,612,408 (+)NCBI
Celera1920,095,810 - 20,146,806 (+)NCBICelera
Cytogenetic Map19p11NCBI
N4bp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554746,796,066 - 6,814,906 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554746,796,068 - 6,814,906 (+)NCBIChiLan1.0ChiLan1.0
N4BP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11647,698,353 - 47,769,755 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1647,698,353 - 47,769,755 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01628,809,881 - 28,881,352 (-)NCBIMhudiblu_PPA_v0panPan3
N4BP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl266,544,677 - 66,561,560 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1266,544,665 - 66,565,858 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
N4bp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364751,743,205 - 1,765,466 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
N4BP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl636,122,035 - 36,174,536 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1636,122,189 - 36,177,965 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2631,414,695 - 31,466,654 (+)NCBISscrofa10.2Sscrofa10.2susScr3
N4BP1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1534,351,845 - 34,423,152 (-)NCBI
ChlSab1.1 Ensembl534,347,979 - 34,422,887 (-)Ensembl
N4bp1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249142,319,809 - 2,369,128 (-)NCBI

Position Markers
RH127110  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38886,844,355 - 86,844,578UniSTSGRCm38
MGSCv37889,368,254 - 89,368,477UniSTSGRCm37
Celera891,112,552 - 91,112,775UniSTS
Cytogenetic Map8C3UniSTS
Whitehead/MRC_RH81032.09UniSTS
AI481586  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38886,841,248 - 86,841,371UniSTSGRCm38
MGSCv37889,365,147 - 89,365,270UniSTSGRCm37
Celera891,109,427 - 91,109,550UniSTS
Cytogenetic Map8C3UniSTS
Whitehead/MRC_RH81028.35UniSTS
UniSTS:235959  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38886,861,179 - 86,861,410UniSTSGRCm38
MGSCv37889,385,078 - 89,385,309UniSTSGRCm37
Celera891,129,382 - 91,129,613UniSTS
Cytogenetic Map8C3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined878518613112518703Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879082178113082403Mouse
12904012Cfq10_mconditioned fear QTL 10 (mouse)88006677589014359Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881092664115092664Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)881619151115619151Mouse
1301766Desp1_mdespair 1 (mouse)Not determined884759576118759741Mouse
1302049Heal1_mwound healing/regeneration 1 (mouse)Not determined885716921119717069Mouse
1301253Skmw2_mskeletal muscle weight 2 (mouse)Not determined885716921119717069Mouse
10045619Heal14_mwound healing/regeneration 14 (mouse)Not determined885716921119717069Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1729
Count of miRNA genes:705
Interacting mature miRNAs:883
Transcripts:ENSMUST00000034074
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_030563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006531516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006531517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004934903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA444325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC163288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK044775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK134934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC111031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM951093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ134294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX122841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX240926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000034074   ⟹   ENSMUSP00000034074
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl886,841,139 - 86,885,258 (-)Ensembl
RefSeq Acc Id: ENSMUST00000209389
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl886,808,160 - 86,844,045 (-)Ensembl
RefSeq Acc Id: ENSMUST00000210029
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl886,844,319 - 86,852,420 (-)Ensembl
RefSeq Acc Id: NM_030563   ⟹   NP_085040
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39887,567,767 - 87,611,886 (-)NCBI
GRCm38886,841,139 - 86,885,258 (-)NCBI
MGSCv37889,365,038 - 89,409,157 (-)RGD
Celera891,109,318 - 91,153,508 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006531516   ⟹   XP_006531579
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39887,567,764 - 87,612,489 (-)NCBI
GRCm38886,841,937 - 86,885,296 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006531517   ⟹   XP_006531580
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39887,567,764 - 87,612,489 (-)NCBI
GRCm38886,841,136 - 86,885,296 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036154391   ⟹   XP_036010284
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39887,568,565 - 87,604,866 (-)NCBI
RefSeq Acc Id: XM_036154392   ⟹   XP_036010285
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39887,568,565 - 87,610,258 (-)NCBI
RefSeq Acc Id: XM_036154393   ⟹   XP_036010286
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39887,570,941 - 87,604,866 (-)NCBI
RefSeq Acc Id: XR_004934903
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39887,567,764 - 87,612,489 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_085040   ⟸   NM_030563
- UniProtKB: Q6A037 (UniProtKB/Swiss-Prot),   Q5EBQ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006531580   ⟸   XM_006531517
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006531579   ⟸   XM_006531516
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000034074   ⟸   ENSMUST00000034074
RefSeq Acc Id: XP_036010285   ⟸   XM_036154392
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036010284   ⟸   XM_036154391
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036010286   ⟸   XM_036154393
- Peptide Label: isoform X4
Protein Domains
RNase_Zc3h12a

Promoters
RGD ID:8667789
Promoter ID:EPDNEW_M11926
Type:initiation region
Name:N4bp1_1
Description:Mus musculus NEDD4 binding protein 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38886,885,271 - 86,885,331EPDNEW
RGD ID:6842498
Promoter ID:MM_KWN:55181
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:AK008378_2010110E17RIK,   ENSMUST00000034074,   ENSMUST00000098530,   NM_030563
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36889,408,401 - 89,409,382 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2136825 AgrOrtholog
Ensembl Genes ENSMUSG00000031652 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000034074 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000034074 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro KH_dom_type_1_sf UniProtKB/Swiss-Prot
  RNase_Zc3h12_NYN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:80750 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2136825 ENTREZGENE
NCBI Gene 80750 ENTREZGENE
Pfam RNase_Zc3h12a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen N4bp1 PhenoGen
Superfamily-SCOP SSF54791 UniProtKB/Swiss-Prot
UniGene Mm.25117 ENTREZGENE
  Mm.428374 ENTREZGENE
UniProt N4BP1_MOUSE UniProtKB/Swiss-Prot
  Q5EBQ4 ENTREZGENE, UniProtKB/TrEMBL
  Q6A037 ENTREZGENE
  Q8C8N1_MOUSE UniProtKB/TrEMBL
  Q99KT2_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3TCI4 UniProtKB/Swiss-Prot
  Q3UH87 UniProtKB/Swiss-Prot
  Q3UY69 UniProtKB/Swiss-Prot