Cdsn (corneodesmosin) - Rat Genome Database

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Gene: Cdsn (corneodesmosin) Mus musculus
Analyze
Symbol: Cdsn
Name: corneodesmosin
RGD ID: 1621174
MGI Page MGI
Description: Predicted to enable protein homodimerization activity. Predicted to be involved in several processes, including amyloid fibril formation; corneocyte desquamation; and negative regulation of cornification. Predicted to be located in desmosome. Is expressed in skin. Human ortholog(s) of this gene implicated in alopecia; hypotrichosis 2; and peeling skin syndrome 1. Orthologous to human CDSN (corneodesmosin).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI747712
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,854,044 - 35,867,811 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1735,863,025 - 35,868,077 (+)EnsemblGRCm39 Ensembl
GRCm381735,543,101 - 35,557,180 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,552,128 - 35,557,180 (+)EnsemblGRCm38mm10GRCm38
MGSCv371735,689,073 - 35,694,125 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361735,160,194 - 35,165,233 (+)NCBIMGSCv36mm8
Celera1739,067,633 - 39,072,920 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.7NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Comparative proteomic profiling of patients with atopic dermatitis based on history of eczema herpeticum infection and Staphylococcus aureus colonization. Broccardo CJ, etal., J Allergy Clin Immunol. 2011 Jan;127(1):186-93, 193.e1-11. doi: 10.1016/j.jaci.2010.10.033.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12819125   PMID:15466487   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16192310  
PMID:17130451   PMID:18166659   PMID:18436651   PMID:19596793   PMID:20880987   PMID:21873635   PMID:22951731   PMID:24006456   PMID:26993035   PMID:27551807   PMID:28095415   PMID:28369476  
PMID:28378742   PMID:28650975   PMID:29044125   PMID:29277537   PMID:30923192   PMID:32325033   PMID:34905516   PMID:37660780   PMID:38355793  


Genomics

Comparative Map Data
Cdsn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,854,044 - 35,867,811 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1735,863,025 - 35,868,077 (+)EnsemblGRCm39 Ensembl
GRCm381735,543,101 - 35,557,180 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,552,128 - 35,557,180 (+)EnsemblGRCm38mm10GRCm38
MGSCv371735,689,073 - 35,694,125 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361735,160,194 - 35,165,233 (+)NCBIMGSCv36mm8
Celera1739,067,633 - 39,072,920 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.7NCBI
CDSN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,115,087 - 31,120,446 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl631,115,087 - 31,120,446 (-)EnsemblGRCh38hg38GRCh38
GRCh37631,082,864 - 31,088,223 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,190,849 - 31,196,202 (-)NCBINCBI36Build 36hg18NCBI36
Build 34631,191,339 - 31,196,189NCBI
Celera632,683,083 - 32,688,466 (-)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef630,885,378 - 30,890,761 (-)NCBIHuRef
CHM1_1631,084,956 - 31,090,339 (-)NCBICHM1_1
T2T-CHM13v2.0630,982,815 - 30,988,170 (-)NCBIT2T-CHM13v2.0
Cdsn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8203,184,142 - 3,188,962 (-)NCBIGRCr8
mRatBN7.2203,179,432 - 3,184,252 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,179,438 - 3,184,250 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx203,240,743 - 3,245,574 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0203,245,714 - 3,250,545 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0203,269,983 - 3,274,788 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0203,704,626 - 3,707,266 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0205,792,983 - 5,795,590 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera20606,557 - 612,794 (-)NCBICelera
Cytogenetic Map20p12NCBI
Cdsn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955583958,668 - 964,149 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955583959,544 - 968,632 (-)NCBIChiLan1.0ChiLan1.0
CDSN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2545,676,973 - 45,682,857 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1641,640,163 - 41,646,043 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0630,861,199 - 30,867,082 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1631,726,602 - 31,731,976 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl631,727,090 - 31,731,976 (-)Ensemblpanpan1.1panPan2
CDSN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.112819,488 - 824,015 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl12820,467 - 823,986 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha12952,855 - 961,585 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.012128,294 - 132,529 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl12127,597 - 132,340 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.112823,625 - 827,971 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.012891,795 - 896,141 (-)NCBIUNSW_CanFamBas_1.0
Cdsn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494634,421,192 - 34,426,175 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936837787,301 - 791,388 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936837787,035 - 791,388 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDSN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,520,142 - 23,524,372 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1723,520,142 - 23,524,372 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2727,309,334 - 27,313,556 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDSN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11741,352,063 - 41,359,344 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604430,808,711 - 30,814,631 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdsn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475424,796,341 - 24,799,913 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475424,796,308 - 24,800,324 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cdsn
14 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:702
Count of miRNA genes:423
Interacting mature miRNAs:455
Transcripts:ENSMUST00000044804
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17334817537348299Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17397489048866091Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined485475245670266Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17485475246469702Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17485475247885665Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined485475265637357Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17689393640893936Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17858491442585149Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17858491442585149Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171087811944878219Mouse
4142342Lfnq4_mlung function QTL 4 (mouse)Not determined1120648439364059Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1188597145886119Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171199818445998184Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171245178746451787Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171264696146646961Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171412337248123496Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171506165249061760Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171506165249061760Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171506165249061760Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171506165249061760Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171681972150819843Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171681972150819843Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171702994351030078Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171746220851462345Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171746220851462345Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171746220851462345Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171746220851462345Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171817541252178214Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171841835752420983Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171842214152424327Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171914502553145025Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172461275058612864Mouse
10412198Sst5_msusceptibility to tuberculosis 5 (mouse)Not determined172507658355712970Mouse
10412196Bbaa28_mB.burgdorferi-associated arthritis 28 (mouse)Not determined172558491443976235Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172605118560051352Mouse
1558758Kcal2_mkilocalorie 2 (mouse)Not determined172640101252911704Mouse
1300602Eye2_meye weight 2 (mouse)Not determined172650533741105037Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172688497260885114Mouse
11075105Modc1_mmodifier of Odc1 (mouse)172771579245622654Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172781520961815209Mouse
10045977Tir9_mtrypanosome infection response 9 (mouse)Not determined172787811943885114Mouse
1300703Uvbi2_mUVB induced immunosuppression 2 (mouse)Not determined172862240662622654Mouse
1300589Myaa2_mmodifier of Yaa 2 (mouse)Not determined173013255564132666Mouse
4141357Mrdq1_mmodifier of retinal degeneration QTL 1 (mouse)Not determined3098790348039703Mouse
4140955Plgr1_mplague resistance locus 1 (mouse)Not determined3103350065033630Mouse
1300692Blmpf1_mbleomycin-induced pulmonary fibrosis 1 (mouse)Not determined173206165237644775Mouse
26884379Skwq5_mskull length QTL 5, 5 week (mouse)173311897454107028Mouse
1302189Dps3_mdelta power in slow-wave sleep 3 (mouse)Not determined173381972136250180Mouse
1300885Mbis4_mMycobacterium bovis-induced systemic lupus erythematosus 4 (mouse)Not determined173517581770165926Mouse

Markers in Region
AI747712  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381735,556,403 - 35,556,482UniSTSGRCm38
MGSCv371735,693,348 - 35,693,427UniSTSGRCm37
Celera1739,072,148 - 39,072,227UniSTS
Cytogenetic Map17B1UniSTS
Whitehead/MRC_RH17486.0UniSTS
Cdsn  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17B1UniSTS
cM Map17 UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000044804   ⟹   ENSMUSP00000048596
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1735,863,025 - 35,868,077 (+)Ensembl
GRCm38.p6 Ensembl1735,552,128 - 35,557,180 (+)Ensembl
RefSeq Acc Id: NM_001008424   ⟹   NP_001008424
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391735,863,071 - 35,867,811 (+)NCBI
GRCm381735,552,128 - 35,557,180 (+)NCBI
MGSCv371735,689,073 - 35,694,125 (+)RGD
Celera1739,067,633 - 39,072,920 (+)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001355275   ⟹   NP_001342204
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391735,854,044 - 35,867,811 (+)NCBI
GRCm381735,543,101 - 35,557,180 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001008424 (Get FASTA)   NCBI Sequence Viewer  
  NP_001342204 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH55373 (Get FASTA)   NCBI Sequence Viewer  
  BAE21475 (Get FASTA)   NCBI Sequence Viewer  
  EDL23222 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000048596
  ENSMUSP00000048596.8
GenBank Protein Q7TPC1 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001008424   ⟸   NM_001008424
- Peptide Label: isoform 1 precursor
- UniProtKB: E9QLN3 (UniProtKB/Swiss-Prot),   Q7TPC1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001342204   ⟸   NM_001355275
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000048596   ⟸   ENSMUST00000044804

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TPC1-F1-model_v2 AlphaFold Q7TPC1 1-561 view protein structure

Promoters
RGD ID:13675892
Promoter ID:EPDNEW_M22095
Type:multiple initiation site
Name:Cdsn_1
Description:Mus musculus corneodesmosin , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381735,552,174 - 35,552,234EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3505689 AgrOrtholog
Ensembl Genes ENSMUSG00000039518 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000044804 ENTREZGENE
  ENSMUST00000044804.8 UniProtKB/Swiss-Prot
InterPro Corneodesmosin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:386463 UniProtKB/Swiss-Prot
MGD MGI:3505689 ENTREZGENE
NCBI Gene 386463 ENTREZGENE
PANTHER CORNEODESMOSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23207 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cdsn PhenoGen
UniProt CDSN_MOUSE UniProtKB/Swiss-Prot
  E9QLN3 ENTREZGENE
  Q3V0M9_MOUSE UniProtKB/TrEMBL
  Q7TPC1 ENTREZGENE
UniProt Secondary E9QLN3 UniProtKB/Swiss-Prot