ML-7 - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	ML-7	go back to main search page
Accession:	CHEBI:78761	browse the term
Definition:	An N-sulfonyldiazepane resullting from the formal condensation of 5-iodo-1-naphthylsulfonic acid with one of the nitrogens of 1,4-diazepane. It is a selective inhibitor of myosin light chain kinase (EC 2.7.11.18).
Synonyms:	exact_synonym:	1-[(5-iodo-1-naphthyl)sulfonyl]hexahydro-1H-1,4-diazepine
	related_synonym:	1-[(5-iodo-1-naphthyl)sulfonyl]-1,4-diazepane; Formula=C15H17IN2O2S; InChI=1S/C15H17IN2O2S/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18/h1-2,4-7,17H,3,8-11H2; InChIKey=GEHJIACZUFWBTK-UHFFFAOYSA-N; ML7; SMILES=Ic1cccc2c(cccc12)S(=O)(=O)N1CCCNCC1
	xref:	CAS:109376-83-2; LINCS:LSM-4095
	xref_mesh:	MESH:C070571
	xref:	PMID:1879528; PMID:3108259; Reaxys:8570442

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Genes (57)

ML-7

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actin alpha 2, smooth muscle

decreases expression
affects localization

ML 7 results in decreased expression of ACTA2
ML 7 affects the localization of ACTA2 protein

PMID:11591817 PMID:11868461

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

AKT serine/threonine kinase 1

multiple interactions

ML 7 results in decreased susceptibility to [quinocetone results in increased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

BCL2 associated X, apoptosis regulator

multiple interactions

[ML 7 co-treated with quinocetone] results in increased expression of BAX protein; ML 7 results in increased susceptibility to [quinocetone results in increased expression of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCAR1 scaffold protein, Cas family member

decreases phosphorylation

ML 7 results in decreased phosphorylation of BCAR1 protein

NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907

G

BCL2, apoptosis regulator

multiple interactions

[ML 7 co-treated with quinocetone] results in decreased expression of BCL2 protein; ML 7 results in increased susceptibility to [quinocetone results in decreased expression of BCL2 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

baculoviral IAP repeat-containing 5

decreases expression

ML 7 results in decreased expression of BIRC5 protein

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

caspase 3

multiple interactions

[ML 7 co-treated with quinocetone] results in increased cleavage of CASP3 protein; [ML 7 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein; FADD protein affects the reaction [[ML 7 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein]

PMID:16723733 PMID:26446980

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions

[ML 7 co-treated with quinocetone] results in increased cleavage of CASP8 protein; ML 7 results in increased susceptibility to [quinocetone results in increased cleavage of CASP8 protein]

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions

[ML 7 co-treated with quinocetone] results in increased cleavage of CASP9 protein; ML 7 results in increased susceptibility to [quinocetone results in increased cleavage of CASP9 protein]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

cyclin A2

multiple interactions

ML 7 inhibits the reaction [EGF protein results in increased expression of CCNA2 protein]

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin D1

multiple interactions
decreases expression

ML 7 inhibits the reaction [EGF protein results in increased expression of CCND1 mRNA]; ML 7 inhibits the reaction [EGF protein results in increased expression of CCND1 protein]
ML 7 results in decreased expression of CCND1 protein

PMID:16799973 PMID:18710790

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin E1

multiple interactions

ML 7 inhibits the reaction [EGF protein results in increased expression of CCNE1 protein]

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cadherin 1

decreases activity
affects localization

ML 7 results in decreased activity of CDH1 protein
ML 7 affects the localization of CDH1 protein

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cyclin-dependent kinase 1

multiple interactions

ML 7 inhibits the reaction [EGF protein results in increased expression of CDK1 protein]

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase inhibitor 1A

decreases expression

ML 7 results in decreased expression of CDKN1A protein

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

increases expression

ML 7 results in increased expression of CDKN1B protein

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

collagen type XVII alpha 1 chain

affects localization

ML 7 affects the localization of COL17A1 protein

NCBI chr 1:246,530,589...246,577,559
Ensembl chr 1:246,531,367...246,577,632

G

colony stimulating factor 2

affects activity

ML 7 affects the activity of CSF2 protein

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

catenin beta 1

affects localization
decreases expression

ML 7 affects the localization of CTNNB1 protein
ML 7 results in decreased expression of CTNNB1 protein

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

C-X-C motif chemokine ligand 12

multiple interactions

ML 7 inhibits the reaction [CXCL12 protein results in increased phosphorylation of MYL9 protein]

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

dystonin

affects localization

ML 7 affects the localization of DST protein

NCBI chr 9:36,135,657...36,529,617
Ensembl chr 9:36,135,284...36,529,615

G

epidermal growth factor

multiple interactions

ML 7 inhibits the reaction [EGF protein affects the localization of MYL9 protein modified form]; ML 7 inhibits the reaction [EGF protein results in increased expression of CCNA2 protein]; ML 7 inhibits the reaction [EGF protein results in increased expression of CCND1 mRNA]; ML 7 inhibits the reaction [EGF protein results in increased expression of CCND1 protein]; ML 7 inhibits the reaction [EGF protein results in increased expression of CCNE1 protein]; ML 7 inhibits the reaction [EGF protein results in increased expression of CDK1 protein]; ML 7 inhibits the reaction [EGF protein results in increased expression of FOS protein]; ML 7 inhibits the reaction [EGF protein results in increased expression of JUN protein]; ML 7 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

coagulation factor II, thrombin

multiple interactions
decreases activity
affects activity

ML 7 inhibits the reaction [F2 protein results in increased phosphorylation of MYL9 protein]
[ML 7 results in decreased activity of MYLK protein] which results in decreased activity of F2 protein
ML 7 affects the activity of F2 protein

PMID:1643115 PMID:14557824 PMID:15284075 PMID:16675616

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

Fas associated via death domain

multiple interactions

FADD protein affects the reaction [[ML 7 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein]

NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ML 7 inhibits the reaction [EGF protein results in increased expression of FOS protein]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

hexosaminidase subunit beta

multiple interactions

ML 7 inhibits the reaction [Ionomycin results in increased secretion of HEXB protein]

NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223

G

interleukin 17A

multiple interactions

ML 7 inhibits the reaction [IL17A protein results in increased phosphorylation of MYL9 protein]

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

integrin subunit alpha 3

multiple interactions

ML 7 affects the localization of [ITGA3 protein binds to ITGB1 protein]

NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118

G

integrin subunit alpha 6

multiple interactions

ML 7 affects the localization of [ITGA6 protein binds to ITGB4 protein]

NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428

G

integrin subunit alpha M

multiple interactions

ML 7 inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAM protein]

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

integrin subunit beta 1

multiple interactions
decreases activity

ML 7 affects the localization of [ITGA3 protein binds to ITGB1 protein]
ML 7 results in decreased activity of ITGB1 protein

PMID:14691950 PMID:16723733

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

G

integrin subunit beta 4

multiple interactions

ML 7 affects the localization of [ITGA6 protein binds to ITGB4 protein]

NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ML 7 inhibits the reaction [EGF protein results in increased expression of JUN protein]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

laminin subunit alpha 3

affects localization

ML 7 affects the localization of LAMA3 protein

NCBI chr18:3,523,168...3,751,722
Ensembl chr18:3,523,133...3,751,353

G

mitogen activated protein kinase 1

decreases phosphorylation
multiple interactions

ML 7 results in decreased phosphorylation of MAPK1 protein
[ML 7 co-treated with quinocetone] results in increased phosphorylation of MAPK1 protein; ML 7 results in increased susceptibility to [quinocetone results in increased phosphorylation of MAPK1 protein]

PMID:18710790 PMID:26446980

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

multiple interactions

[ML 7 co-treated with quinocetone] results in increased phosphorylation of MAPK14 protein; ML 7 results in increased susceptibility to [quinocetone results in increased phosphorylation of MAPK14 protein]

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

decreases phosphorylation

ML 7 results in decreased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

[ML 7 co-treated with quinocetone] results in increased phosphorylation of MAPK8 protein

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

myeloperoxidase

multiple interactions
decreases activity

ML 7 inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein]
ML 7 results in decreased activity of MPO protein

PMID:15863634 PMID:19374788

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

ML 7 results in decreased expression of MYC protein

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

myosin heavy chain 2

affects localization
decreases activity

ML 7 affects the localization of MYH2 protein
ML 7 results in decreased activity of MYH2 protein

NCBI chr10:51,856,738...51,883,236
Ensembl chr10:51,856,738...51,883,236

G

myosin light chain 7

multiple interactions
decreases phosphorylation

ML 7 inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein]
ML 7 results in decreased phosphorylation of MYL7 protein

NCBI chr14:80,780,684...80,783,259
Ensembl chr14:80,779,776...80,783,244

G

myosin light chain 9

multiple interactions
decreases expression
decreases phosphorylation

[ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein; ML 7 inhibits the reaction [CXCL12 protein results in increased phosphorylation of MYL9 protein]; ML 7 inhibits the reaction [F2 protein results in increased phosphorylation of MYL9 protein]; ML 7 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MYL9 protein]
ML 7 results in decreased expression of MYL9 protein modified form
ML 7 results in decreased phosphorylation of MYL9 protein
[[ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein] which results in increased secretion of REN protein; [ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein; ML 7 inhibits the reaction [Deamino Arginine Vasopressin results in increased phosphorylation of MYL9 protein]; ML 7 inhibits the reaction [EGF protein affects the localization of MYL9 protein modified form]; ML 7 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MYL9 protein]
ML 7 inhibits the reaction [IL17A protein results in increased phosphorylation of MYL9 protein]

PMID:1643115 PMID:7503253 PMID:9618396 PMID:11751986 PMID:12745062 More...

NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333

G

myosin light chain kinase

multiple interactions
decreases activity

[ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein; [ML 7 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein; FADD protein affects the reaction [[ML 7 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein]; ML 7 inhibits the reaction [Calcium deficiency results in increased activity of MYLK protein]; ML 7 inhibits the reaction [Ethanol results in increased activity of MYLK protein]
[ML 7 results in decreased activity of MYLK protein] which results in decreased activity of F2 protein; ML 7 results in decreased activity of MYLK protein
ML 7 inhibits the reaction [Lipopolysaccharides results in increased expression of MYLK mRNA]; ML 7 inhibits the reaction [Lipopolysaccharides results in increased expression of MYLK protein]; ML 7 inhibits the reaction [MYLK protein results in increased uptake of Glucose]
[[ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein] which results in increased secretion of REN protein; [ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein

PMID:1643115 PMID:9618396 PMID:10198341 PMID:10733514 PMID:11054866 More...

NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261

G

myogenic differentiation 1

decreases expression

ML 7 results in decreased expression of MYOD1 protein

NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554

G

myogenin

decreases expression

ML 7 results in decreased expression of MYOG protein

NCBI chr13:45,745,455...45,748,044
Ensembl chr13:45,745,436...45,748,039

G

neutrophil cytosolic factor 1

multiple interactions

ML 7 inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of NCF1 protein]; ML 7 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of NCF1 protein]

NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646

G

protein kinase C, beta

decreases expression

ML 7 results in decreased expression of PRKCB protein

NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536

G

protein tyrosine kinase 2

decreases phosphorylation

ML 7 results in decreased phosphorylation of PTK2 protein

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

Rac family small GTPase 1

decreases activity
increases activity

ML 7 results in decreased activity of RAC1 protein
ML 7 results in increased activity of RAC1 protein

PMID:12105187 PMID:12745062

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

G

renin

multiple interactions
increases secretion

[[ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein] which results in increased secretion of REN protein; calyculin A inhibits the reaction [ML 7 results in increased secretion of REN protein]; ML 7 inhibits the reaction [Calcium results in decreased secretion of REN protein]

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

ribosomal protein S6 kinase A5

decreases activity

ML 7 results in decreased activity of RPS6KA5 protein

NCBI chr 6:119,828,823...120,006,190
Ensembl chr 6:119,828,846...120,006,224

G

ribosomal protein S6 kinase B1

multiple interactions

ML 7 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]
ML 7 results in decreased susceptibility to [quinocetone results in increased phosphorylation of RPS6KB1 protein]

PMID:16799973 PMID:26446980

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

solute carrier family 2 member 2

multiple interactions
decreases activity
decreases expression

ML 7 inhibits the reaction [SLC2A2 protein results in increased uptake of Glucose]
ML 7 results in decreased activity of SLC2A2 protein
ML 7 results in decreased expression of SLC2A2 protein

NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933

G

tight junction protein 1

multiple interactions

ML 7 inhibits the reaction [Oxygen deficiency affects the localization of TJP1 protein]
ML 7 inhibits the reaction [Luteolin inhibits the reaction [decabromobiphenyl ether results in decreased expression of TJP1 protein]]

PMID:20164382 PMID:33675858

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

G

transient receptor potential cation channel, subfamily C, member 6

decreases activity

ML 7 results in decreased activity of TRPC6 protein

NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092

G

transient receptor potential cation channel, subfamily C, member 7

increases activity

ML 7 results in increased activity of TRPC7 protein

NCBI chr17:7,708,911...7,833,435
Ensembl chr17:7,709,583...7,833,435

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19832
chemical entity	19830
molecular entity	19830
polyatomic entity	19788
heteroatomic molecular entity	19744
halide	18638
organohalogen compound	18510
organoiodine compound	2399
ML-7	57
Path 2
Term	Annotations
CHEBI ontology	19832
subatomic particle	19830
composite particle	19830
hadron	19830
baryon	19830
nucleon	19830
atomic nucleus	19830
atom	19830
main group element atom	19780
p-block element atom	19780
chalcogen	19535
oxygen atom	19510
oxygen molecular entity	19510
hydroxides	19321
oxoacid	18746
chalcogen oxoacid	13770
sulfur oxoacid	13558
sulfonic acid	11597
sulfonic acid derivative	11597
sulfonamide	5301
N-sulfonyldiazepane	103
ML-7	57

paths to the root