|
G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
multiple interactions decreases response to substance |
ISO |
GSTP1 protein promotes the reaction [ABCC1 protein results in decreased susceptibility to Ethacrynic Acid] |
CTD |
PMID:10900222 |
|
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
|
|
G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
increases transport |
ISO |
ABCC2 protein results in increased transport of Ethacrynic Acid |
CTD |
PMID:16316932 |
|
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
|
|
G |
Akr1c1 |
aldo-keto reductase family 1, member C1 |
increases expression |
ISO |
Ethacrynic Acid results in increased expression of AKR1C1 mRNA |
CTD |
PMID:9973208 |
|
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
|
|
G |
Akr7a2 |
aldo-keto reductase family 7, member A2 |
multiple interactions |
ISO |
Ethacrynic Acid inhibits the reaction [4-nitrobenzaldehyde affects the reduction of AKR7A5 protein] |
CTD |
PMID:12604212 |
|
NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909
|
|
G |
Bcl2l1 |
Bcl2-like 1 |
increases expression multiple interactions |
ISO |
Ethacrynic Acid results in increased expression of BCL2L1 protein [arsenic trioxide co-treated with Ethacrynic Acid] results in increased expression of BCL2L1 protein |
CTD |
PMID:23082001 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
|
|
G |
Birc5 |
baculoviral IAP repeat-containing 5 |
multiple interactions |
ISO |
[arsenic trioxide co-treated with Ethacrynic Acid] results in decreased expression of BIRC5 protein |
CTD |
PMID:23082001 |
|
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP3 protein; [MCL1 mutant form results in increased susceptibility to [Ethacrynic Acid co-treated with arsenic trioxide]] which results in increased cleavage of CASP3 protein; GSTP1 mutant form promotes the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP3 protein] |
CTD |
PMID:23082001 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp8 |
caspase 8 |
multiple interactions increases cleavage |
ISO |
[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP8 protein Ethacrynic Acid results in increased cleavage of CASP8 protein |
CTD |
PMID:23082001 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
|
|
G |
Casp9 |
caspase 9 |
increases cleavage multiple interactions |
ISO |
Ethacrynic Acid results in increased cleavage of CASP9 protein arsenic trioxide promotes the reaction [Ethacrynic Acid results in increased cleavage of CASP9 protein]; GSTP1 mutant form promotes the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP9 protein]; MCL1 mutant form promotes the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP9 protein] |
CTD |
PMID:23082001 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
G |
Cat |
catalase |
multiple interactions |
ISO |
CAT mutant form promotes the reaction [arsenic trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of MCL1 protein]] |
CTD |
PMID:23082001 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Cbr1 |
carbonyl reductase 1 |
multiple interactions |
ISO |
Ethacrynic Acid inhibits the reaction [CBR1 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] |
CTD |
PMID:11306090 |
|
NCBI chr11:32,860,618...32,862,981
Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393
|
|
G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
Ethacrynic Acid results in decreased expression of CCND1 mRNA |
CTD |
PMID:20011538 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
Ethacrynic Acid results in increased expression of CDKN1A mRNA |
CTD |
PMID:25817893 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
|
|
G |
Cflar |
CASP8 and FADD-like apoptosis regulator |
multiple interactions decreases expression |
ISO |
arsenic trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of CFLAR protein] |
CTD |
PMID:23082001 |
|
NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression multiple interactions |
ISO EXP |
Ethacrynic Acid results in increased expression of CYP1A1 mRNA Ethacrynic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] |
CTD |
PMID:9973208 PMID:18493746 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
|
|
G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [Ethacrynic Acid results in increased expression of DDIT3 mRNA]; Glutathione inhibits the reaction [Ethacrynic Acid results in increased expression of DDIT3 mRNA] Ethacrynic Acid results in increased expression of DDIT3 mRNA; Ethacrynic Acid results in increased expression of DDIT3 protein |
CTD |
PMID:17171638 PMID:25817893 PMID:35724838 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
|
|
G |
Fn1 |
fibronectin 1 |
decreases expression |
ISO |
Ethacrynic Acid results in decreased expression of FN1 mRNA |
CTD |
PMID:20011538 |
|
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
|
|
G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
Ethacrynic Acid results in increased expression of FOS mRNA |
CTD |
PMID:10407097 PMID:12946577 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
|
|
G |
Fzd5 |
frizzled class receptor 5 |
increases expression |
ISO |
Ethacrynic Acid results in increased expression of FZD5 mRNA |
CTD |
PMID:20011538 |
|
NCBI chr 9:66,117,370...66,119,127
Ensembl chr 9:66,113,112...66,121,457
|
|
G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions |
ISO |
[GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Ethacrynic Acid |
CTD |
PMID:10900222 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
|
|
G |
Gclm |
glutamate cysteine ligase, modifier subunit |
multiple interactions |
ISO |
[GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Ethacrynic Acid |
CTD |
PMID:10900222 |
|
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
|
|
G |
Gsta1 |
glutathione S-transferase alpha 1 |
decreases response to substance affects metabolic processing multiple interactions increases expression |
ISO EXP |
GSTA1 protein results in decreased susceptibility to Ethacrynic Acid GSTA1 protein affects the metabolism of Ethacrynic Acid analog [GSTA1 protein binds to GSTA2 protein] which affects the metabolism of Ethacrynic Acid Ethacrynic Acid results in increased expression of GSTA1 mRNA |
CTD |
PMID:1985777 PMID:9799558 PMID:9877184 PMID:12781783 |
|
NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
|
|
G |
Gsta2 |
glutathione S-transferase alpha 2 |
affects metabolic processing multiple interactions |
EXP |
GSTA2 protein affects the metabolism of Ethacrynic Acid [GSTA1 protein binds to GSTA2 protein] which affects the metabolism of Ethacrynic Acid |
CTD |
PMID:9877184 |
|
NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
|
|
G |
Gsta4 |
glutathione S-transferase alpha 4 |
increases expression affects metabolic processing |
EXP |
Ethacrynic Acid results in increased expression of GSTA4 mRNA; Ethacrynic Acid results in increased expression of GSTA4 protein GSTA4 protein affects the metabolism of Ethacrynic Acid |
CTD |
PMID:2619714 PMID:9799558 |
|
NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182
|
|
G |
Gstm1 |
glutathione S-transferase mu 1 |
affects metabolic processing |
ISO |
GSTM1 protein affects the metabolism of Ethacrynic Acid |
CTD |
PMID:12069689 |
|
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
|
|
G |
Gstp1 |
glutathione S-transferase pi 1 |
decreases activity multiple interactions increases expression affects metabolic processing decreases response to substance |
ISO EXP |
Ethacrynic Acid analog results in decreased activity of GSTP1 protein; Ethacrynic Acid results in decreased activity of GSTP1 protein Ethacrynic Acid binds to and results in decreased activity of GSTP1 protein; Ethacrynic Acid inhibits the reaction [Chlorophyllides inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]]; Ethacrynic Acid inhibits the reaction [GSTP1 protein affects the metabolism of Isotretinoin]; Ethacrynic Acid inhibits the reaction [GSTP1 protein results in decreased susceptibility to Etoposide]; Ethacrynic Acid inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]; GSTP1 mutant form promotes the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP3 protein]; GSTP1 mutant form promotes the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP9 protein]; GSTP1 mutant form promotes the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein]; GSTP1 protein promotes the reaction [ABCC1 protein results in decreased susceptibility to Ethacrynic Acid]; GSTP1 protein results in decreased susceptibility to [arsenic trioxide co-treated with Ethacrynic Acid]; Pyrimethamine inhibits the reaction [GSTP1 protein affects the metabolism of and results in decreased activity of Ethacrynic Acid]; Quinidine inhibits the reaction [GSTP1 protein affects the metabolism of and results in decreased activity of Ethacrynic Acid]; Quinine inhibits the reaction [GSTP1 protein affects the metabolism of and results in decreased activity of Ethacrynic Acid]; Tetracycline inhibits the reaction [GSTP1 protein affects the metabolism of and results in decreased activity of Ethacrynic Acid] Ethacrynic Acid results in increased expression of GSTP1 protein GSTP1 protein affects the metabolism of Ethacrynic Acid analog GSTP1 protein results in decreased susceptibility to Ethacrynic Acid |
CTD |
PMID:2619714 PMID:2747627 PMID:9463521 PMID:9806904 PMID:9877184 PMID:10900222 PMID:11807801 PMID:12781783 PMID:14556662 PMID:15911318 PMID:15999103 PMID:23082001 PMID:23769903 More...
|
|
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
|
|
G |
Gstt2 |
glutathione S-transferase theta 2 |
affects metabolic processing |
EXP |
GSTT2 protein affects the metabolism of Ethacrynic Acid |
CTD |
PMID:2114406 |
|
NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288
|
|
G |
Gstz1 |
glutathione S-transferase zeta 1 |
affects metabolic processing |
ISO |
GSTZ1 protein affects the metabolism of Ethacrynic Acid |
CTD |
PMID:9396740 |
|
NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284
|
|
G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [Ethacrynic Acid results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Ethacrynic Acid results in increased expression of HMOX1 protein]; Deferoxamine inhibits the reaction [Ethacrynic Acid affects the localization of HMOX1 protein]; Deferoxamine inhibits the reaction [Ethacrynic Acid results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [Ethacrynic Acid results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [Ethacrynic Acid results in increased expression of HMOX1 protein] Ethacrynic Acid results in increased expression of HMOX1 mRNA; Ethacrynic Acid results in increased expression of HMOX1 protein |
CTD |
PMID:20934533 PMID:25817893 PMID:26945724 PMID:35724838 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G |
Hsf1 |
heat shock transcription factor 1 |
increases activity |
ISO |
Ethacrynic Acid results in increased activity of HSF1 protein |
CTD |
PMID:34170685 |
|
NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
|
|
G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
Ethacrynic Acid inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Ethacrynic Acid inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] |
CTD |
PMID:35724838 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
Ethacrynic Acid inhibits the reaction [IL1B protein affects the localization of NFKBIA protein]; Ethacrynic Acid inhibits the reaction [IL1B protein affects the localization of RELA protein]; Ethacrynic Acid inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Ethacrynic Acid inhibits the reaction [IL1B protein results in increased expression of TNFAIP3 protein] |
CTD |
PMID:35724838 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
[Ethacrynic Acid co-treated with arsenic trioxide] results in increased phosphorylation of JUN protein; pyrazolanthrone inhibits the reaction [[Ethacrynic Acid co-treated with arsenic trioxide] results in increased phosphorylation of JUN protein] |
CTD |
PMID:23082001 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
|
|
G |
Lef1 |
lymphoid enhancer binding factor 1 |
decreases expression affects binding |
ISO |
Ethacrynic Acid results in decreased expression of LEF1 mRNA Ethacrynic Acid binds to LEF1 protein |
CTD |
PMID:20011538 |
|
NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
|
|
G |
Map2k1 |
mitogen activated protein kinase kinase 1 |
increases expression |
ISO |
Ethacrynic Acid results in increased expression of MAP2K1 protein |
CTD |
PMID:14556662 |
|
NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
|
|
G |
Mapk14 |
mitogen activated protein kinase 14 |
decreases expression |
ISO |
Ethacrynic Acid results in decreased expression of MAPK14 protein |
CTD |
PMID:14556662 |
|
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
increases expression |
ISO |
Ethacrynic Acid results in increased expression of MAPK3 protein |
CTD |
PMID:14556662 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
decreases expression |
ISO |
Ethacrynic Acid results in decreased expression of MAPK8 protein |
CTD |
PMID:14556662 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
|
|
G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
multiple interactions decreases expression |
ISO |
[MCL1 mutant form results in increased susceptibility to [Ethacrynic Acid co-treated with arsenic trioxide]] which results in increased cleavage of CASP3 protein; Acetylcysteine inhibits the reaction [arsenic trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of MCL1 protein]]; arsenic trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of MCL1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [arsenic trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of MCL1 protein]]; CAT mutant form promotes the reaction [arsenic trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of MCL1 protein]]; MCL1 mutant form promotes the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP9 protein]; MCL1 mutant form promotes the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein]; MCL1 mutant form results in increased susceptibility to [Ethacrynic Acid co-treated with arsenic trioxide]; pyrazolanthrone inhibits the reaction [arsenic trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of MCL1 protein]] |
CTD |
PMID:23082001 |
|
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions increases expression affects response to substance affects localization |
ISO |
NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to Ethacrynic Acid] Ethacrynic Acid results in increased expression of NFE2L2 protein [NFE2L2 affects the susceptibility to sulforaphane] which affects the susceptibility to Ethacrynic Acid Ethacrynic Acid affects the localization of NFE2L2 protein Ethacrynic Acid results in increased expression of and affects the localization of NFE2L2 protein; ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [Ethacrynic Acid affects the localization of NFE2L2 protein]] |
CTD |
PMID:19303893 PMID:20932822 PMID:20934533 PMID:25817893 PMID:26945724 PMID:35724838 More...
|
|
NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
Ethacrynic Acid inhibits the reaction [IL1B protein affects the localization of NFKBIA protein]; Ethacrynic Acid inhibits the reaction [TNF protein affects the localization of NFKBIA protein] |
CTD |
PMID:35724838 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
|
|
G |
Ngf |
nerve growth factor |
increases expression |
ISO |
Ethacrynic Acid results in increased expression of NGF mRNA |
CTD |
PMID:10407097 |
|
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
Ethacrynic Acid promotes the reaction [Potassium Cyanide results in increased expression of NOS2 protein] |
CTD |
PMID:16933320 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein]; GSTP1 mutant form promotes the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein]; MCL1 mutant form promotes the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein] |
CTD |
PMID:23082001 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
Ethacrynic Acid inhibits the reaction [IL1B protein affects the localization of RELA protein]; Ethacrynic Acid inhibits the reaction [TNF protein affects the localization of RELA protein] |
CTD |
PMID:35724838 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Slc12a2 |
solute carrier family 12 member 2 |
decreases activity multiple interactions |
ISO |
Ethacrynic Acid results in decreased activity of SLC12A2 protein Ethacrynic Acid inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium] |
CTD |
PMID:29959396 |
|
NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440
|
|
G |
Srxn1 |
sulfiredoxin 1 |
increases expression |
ISO |
Ethacrynic Acid results in increased expression of SRXN1 protein |
CTD |
PMID:35724838 |
|
NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
Ethacrynic Acid inhibits the reaction [TNF protein affects the localization of NFKBIA protein]; Ethacrynic Acid inhibits the reaction [TNF protein affects the localization of RELA protein]; Ethacrynic Acid inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Ethacrynic Acid inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein] |
CTD |
PMID:35724838 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Tnfaip3 |
TNF alpha induced protein 3 |
increases expression multiple interactions |
ISO |
Ethacrynic Acid results in increased expression of TNFAIP3 protein Ethacrynic Acid inhibits the reaction [IL1B protein results in increased expression of TNFAIP3 protein]; Ethacrynic Acid inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein] |
CTD |
PMID:35724838 |
|
NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
|
|
G |
Tp53 |
tumor protein p53 |
affects localization |
ISO |
Ethacrynic Acid affects the localization of TP53 protein |
CTD |
PMID:25817893 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
|
|
G |
Xiap |
X-linked inhibitor of apoptosis |
multiple interactions |
ISO |
[arsenic trioxide co-treated with Ethacrynic Acid] results in decreased expression of XIAP protein |
CTD |
PMID:23082001 |
|
NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
|
|