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Salvianolic acid A - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Salvianolic acid A
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Accession:CHEBI:9017 term browser browse the term
Definition:A stilbenoid that has formula C26H22O10.
Synonyms:related_synonym: Formula=C26H22O10;   InChI=1S/C26H22O10/c27-18-7-2-14(11-21(18)30)1-6-17-16(4-9-20(29)25(17)33)5-10-24(32)36-23(26(34)35)13-15-3-8-19(28)22(31)12-15/h1-12,23,27-31,33H,13H2,(H,34,35)/b6-1+,10-5+/t23-/m1/s1;   InChIKey=YMGFTDKNIWPMGF-UCPJVGPRSA-N;   SMILES=OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\\C=C\\c1ccc(O)c(O)c1\\C=C\\c1ccc(O)c(O)c1
 xref: CAS:96574-01-5;   KEGG:C10492;   KNApSAcK:C00002772
 xref_mesh: MESH:C066201


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Salvianolic acid A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of ACACA mRNA] CTD PMID:39047806 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions ISO salvianolic acid A inhibits the reaction [Palmitic Acid results in decreased expression of ACSL4 protein] CTD PMID:39047806 NCBI chr  X:110,739,633...110,803,416
Ensembl chr  X:105,942,799...106,006,427
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP
ISO
salvianolic acid A inhibits the reaction [PDGFB protein results in increased expression of ACTA2 protein]; salvianolic acid A inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]
salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of ACTA2 mRNA]
CTD PMID:19822164 PMID:39047806 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions ISO salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of ADGRE1 mRNA] CTD PMID:39047806 NCBI chr 9:2,329,398...2,484,959
Ensembl chr 9:2,242,474...2,398,000
JBrowse link
G Apoe apolipoprotein E multiple interactions ISO salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of ACACA mRNA]; salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of ACTA2 mRNA]; salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of ADGRE1 mRNA]; salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of CCL2 mRNA]; salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of CD36 mRNA]; salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of CD68 mRNA]; salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of COL3A1 mRNA]; salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of CPT1A protein]; salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of FASN mRNA]; salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of GPT protein]; salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of IGFBP1 mRNA]; salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of IGFBP1 protein]; salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of IL6 mRNA]; salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of LPL mRNA]; salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of LY6C1 mRNA]; salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of LY6G mRNA]; salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of PCK2 protein]; salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of PNPLA2 protein]; salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of PPARA mRNA]; salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of PPARA protein]; salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of SREBF1 mRNA]; salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of TGFB1 mRNA]; salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of TNF mRNA]; salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the phosphorylation of GSK3B protein] CTD PMID:39047806 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP salvianolic acid A inhibits the reaction [arsenic trioxide results in increased expression of BAD protein] CTD PMID:28391263 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP salvianolic acid A inhibits the reaction [arsenic trioxide results in increased expression of BAX protein] CTD PMID:28391263 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP salvianolic acid A inhibits the reaction [arsenic trioxide results in decreased expression of BCL2 protein] CTD PMID:28391263 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO
EXP
salvianolic acid A inhibits the reaction [Plant Extracts results in decreased expression of BCL2L1 protein]
salvianolic acid A inhibits the reaction [arsenic trioxide results in decreased expression of BCL2L1 protein]
CTD PMID:23993977 PMID:28391263 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
salvianolic acid A inhibits the reaction [Plant Extracts results in increased expression of CASP3 protein]
salvianolic acid A inhibits the reaction [arsenic trioxide results in increased expression of CASP3 protein]; salvianolic acid A inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]
CTD PMID:17244260 PMID:23993977 PMID:28391263 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase increases activity
multiple interactions
ISO
EXP
salvianolic acid A results in increased activity of CAT protein
salvianolic acid A inhibits the reaction [arsenic trioxide results in decreased activity of CAT protein]
CTD PMID:20882408 PMID:28391263 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of CCL2 mRNA] CTD PMID:39047806 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of CD36 mRNA] CTD PMID:39047806 NCBI chr 4:18,209,088...18,302,142
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Cd68 Cd68 molecule multiple interactions ISO salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of CD68 mRNA] CTD PMID:39047806 NCBI chr10:54,880,562...54,882,441
Ensembl chr10:54,381,815...54,383,697
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of COL3A1 mRNA] CTD PMID:39047806 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO dorsomorphin inhibits the reaction [salvianolic acid A inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of CPT1A protein]]; IGFBP1 protein affects the reaction [salvianolic acid A inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of CPT1A protein]]; salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of CPT1A protein]; salvianolic acid A inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of CPT1A protein] CTD PMID:39047806 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP salvianolic acid A inhibits the reaction [Thioacetamide results in increased expression of CYBB protein] CTD PMID:19822164 NCBI chr  X:16,030,596...16,065,065
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP salvianolic acid A inhibits the reaction [arsenic trioxide affects the localization of CYCS protein] CTD PMID:28391263 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO salvianolic acid A results in decreased activity of CYP2C8 protein CTD PMID:29689254
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO salvianolic acid A results in decreased activity of CYP2J2 protein CTD PMID:29689254 NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO salvianolic acid A inhibits the reaction [Lipopolysaccharides results in increased expression of DDIT3 protein] CTD PMID:31654708 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dnm1l dynamin 1-like multiple interactions ISO
EXP
salvianolic acid A inhibits the reaction [Arsenic Trioxide results in decreased expression of DNM1L protein] CTD PMID:29867492 NCBI chr11:98,084,049...98,135,663
Ensembl chr11:84,581,216...84,631,482
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO salvianolic acid A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of EIF2AK3 protein] CTD PMID:31654708 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO salvianolic acid A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of EIF2S1 protein] CTD PMID:31654708 NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of FASN mRNA] CTD PMID:39047806 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO salvianolic acid A inhibits the reaction [Palmitic Acid results in decreased expression of FTH1 protein] CTD PMID:39047806 NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:206,627,103...206,725,424
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of GPT protein] CTD PMID:39047806 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO salvianolic acid A inhibits the reaction [Palmitic Acid results in decreased expression of GPX4 protein] CTD PMID:39047806 NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the phosphorylation of GSK3B protein] CTD PMID:39047806 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Ifng interferon gamma multiple interactions ISO salvianolic acid A inhibits the reaction [Plant Extracts results in increased expression of IFNG protein] CTD PMID:23993977 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 multiple interactions ISO dorsomorphin inhibits the reaction [salvianolic acid A inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of IGFBP1 protein]]; IGFBP1 protein affects the reaction [salvianolic acid A inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of CPT1A protein]]; salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of IGFBP1 mRNA]; salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of IGFBP1 protein]; salvianolic acid A inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of IGFBP1 protein] CTD PMID:39047806 NCBI chr14:86,261,277...86,266,344
Ensembl chr14:82,047,415...82,052,482
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP salvianolic acid A inhibits the reaction [Thioacetamide results in increased expression of IL1B protein] CTD PMID:19822164 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO
salvianolic acid A inhibits the reaction [Thioacetamide results in increased expression of IL6 protein]
salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of IL6 mRNA]; salvianolic acid A inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; salvianolic acid A inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
CTD PMID:19822164 PMID:31654708 PMID:39047806 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lpl lipoprotein lipase multiple interactions ISO salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of LPL mRNA] CTD PMID:39047806 NCBI chr16:25,596,205...25,621,928
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO salvianolic acid A results in decreased phosphorylation of MAPK1 protein CTD PMID:29385302 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO salvianolic acid A results in decreased phosphorylation of MAPK3 protein CTD PMID:29385302 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO salvianolic acid A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein] CTD PMID:31654708 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mfn1 mitofusin 1 multiple interactions ISO
EXP
salvianolic acid A inhibits the reaction [Arsenic Trioxide results in increased expression of MFN1 protein] CTD PMID:29867492 NCBI chr 2:117,240,525...117,288,017
Ensembl chr 2:115,313,401...115,359,640
JBrowse link
G Mfn2 mitofusin 2 multiple interactions ISO
EXP
salvianolic acid A inhibits the reaction [Arsenic Trioxide results in increased expression of MFN2 protein] CTD PMID:29867492 NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
ISO salvianolic acid A results in decreased expression of and results in decreased activity of MMP2 protein; U 0126 promotes the reaction [salvianolic acid A results in decreased activity of MMP2 protein]
salvianolic acid A results in decreased expression of MMP2 mRNA
CTD PMID:29385302 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO salvianolic acid A inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein] CTD PMID:31654708 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO
salvianolic acid A inhibits the reaction [Thioacetamide results in increased expression of NOS2 protein]
salvianolic acid A inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD PMID:19822164 PMID:31654708 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions EXP
ISO
salvianolic acid A inhibits the reaction [Arsenic Trioxide results in increased expression of OPA1 protein] CTD PMID:29867492 NCBI chr11:84,612,943...84,690,025
Ensembl chr11:71,109,873...71,185,109
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP salvianolic acid A inhibits the reaction [arsenic trioxide results in increased expression of PARP1 protein] CTD PMID:28391263 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) multiple interactions ISO salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of PCK2 protein] CTD PMID:39047806 NCBI chr15:32,997,853...33,006,691
Ensembl chr15:29,027,894...29,037,283
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions EXP salvianolic acid A inhibits the reaction [PDGFB protein results in increased abundance of Hydrogen Peroxide]; salvianolic acid A inhibits the reaction [PDGFB protein results in increased expression of ACTA2 protein] CTD PMID:19822164 NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 multiple interactions ISO salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of PNPLA2 protein] CTD PMID:39047806 NCBI chr 1:205,982,279...205,987,361
Ensembl chr 1:196,552,723...196,557,805
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of PPARA mRNA]; salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of PPARA protein]; salvianolic acid A inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of PPARA protein] CTD PMID:39047806 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO
EXP
salvianolic acid A inhibits the reaction [Arsenic Trioxide results in decreased expression of PPARGC1A protein]; salvianolic acid A inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of PPARGC1A protein] CTD PMID:29867492 PMID:39047806 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO salvianolic acid A inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:31654708 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation ISO salvianolic acid A results in decreased phosphorylation of PTK2 protein CTD PMID:29385302 NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:105,126,728...105,331,783
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases phosphorylation ISO salvianolic acid A results in decreased phosphorylation of RAF1 protein CTD PMID:29385302 NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B multiple interactions ISO dorsomorphin inhibits the reaction [salvianolic acid A inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of SDHB protein]]; salvianolic acid A inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of SDHB protein] CTD PMID:39047806 NCBI chr 5:158,547,775...158,568,589
Ensembl chr 5:153,264,899...153,314,293
JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions ISO salvianolic acid A inhibits the reaction [Plant Extracts results in increased expression of SHC1 mRNA]; salvianolic acid A inhibits the reaction [Plant Extracts results in increased expression of SHC1 protein] CTD PMID:23993977 NCBI chr 2:177,135,649...177,147,257
Ensembl chr 2:174,837,930...174,849,536
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Plant Extracts promotes the reaction [salvianolic acid A results in increased expression of SIRT1 mRNA]; Plant Extracts promotes the reaction [salvianolic acid A results in increased expression of SIRT1 protein]; salvianolic acid A promotes the reaction [Plant Extracts results in increased expression of SIRT1 mRNA]; salvianolic acid A promotes the reaction [Plant Extracts results in increased expression of SIRT1 protein] CTD PMID:23993977 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Sod1 superoxide dismutase 1 increases activity ISO salvianolic acid A results in increased activity of SOD1 protein CTD PMID:20882408 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases phosphorylation ISO salvianolic acid A results in decreased phosphorylation of SRC protein CTD PMID:29385302 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of SREBF1 mRNA] CTD PMID:39047806 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions ISO salvianolic acid A inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of TFAM protein] CTD PMID:39047806 NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,356,197...17,368,292
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of TGFB1 mRNA] CTD PMID:39047806 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO salvianolic acid A inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein] CTD PMID:31654708 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
salvianolic acid A inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; salvianolic acid A inhibits the reaction [Thioacetamide results in increased expression of TNF protein]
salvianolic acid A affects the reaction [[Streptozocin co-treated with [APOE protein affects the susceptibility to Dietary Fats]] affects the expression of TNF mRNA]; salvianolic acid A inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; salvianolic acid A inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; salvianolic acid A inhibits the reaction [Plant Extracts results in increased expression of TNF protein]
CTD PMID:17244260 PMID:19822164 PMID:23993977 PMID:31654708 PMID:39047806 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    chemical entity 19885
      atom 19885
        nonmetal atom 19809
          carbon atom 19760
            organic molecular entity 19760
              olefinic compound 16967
                stilbenoid 8327
                  Salvianolic acid A 62
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      carbon group element atom 19763
                        carbon atom 19760
                          organic molecular entity 19760
                            organic molecule 19713
                              organic cyclic compound 19505
                                organic aromatic compound 19369
                                  stilbenoid 8327
                                    Salvianolic acid A 62
paths to the root