Cyp1a1 (cytochrome P450, family 1, subfamily a, polypeptide 1) - Rat Genome Database

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Gene: Cyp1a1 (cytochrome P450, family 1, subfamily a, polypeptide 1) Rattus norvegicus
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Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
RGD ID: 2458
Description: Enables several functions, including heat shock protein binding activity; monooxygenase activity; and oxidoreductase activity, acting on diphenols and related substances as donors. Contributes to oxidoreductase activity. Involved in several processes, including 9-cis-retinoic acid biosynthetic process; hepatocyte differentiation; and xenobiotic metabolic process. Located in mitochondrial inner membrane. Biomarker of end stage renal disease; heart disease (multiple); hypertension (multiple); and renal cell carcinoma. Human ortholog(s) of this gene implicated in several diseases, including arthritis (multiple); diabetes mellitus (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human CYP1A1 (cytochrome P450 family 1 subfamily A member 1); PARTICIPATES IN phase I biotransformation pathway via cytochrome P450; gefitinib pharmacokinetics pathway; tamoxifen pharmacokinetics pathway; INTERACTS WITH (+)-alpha-Bisabolol; (+)-catechin; (+)-epicatechin-3-O-gallate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AHH; AHRR; aryl hydrocarbon hydroxylase; CP11; CYP1; Cyp45c; Cypc45c; CYPIA1; cytochrome P1-450; cytochrome P450 1A1; cytochrome P450 form 6; cytochrome P450 subfamily I (aromatic compound-inducible) member A1 (C6 form c) (C6 form c); cytochrome P450, 1a1; Cytochrome P450, subfamily I (aromatic compound-inducible), member A1 (C6, form c); cytochrome P450, subfamily I (aromatic compound-inducible), member A1 (C6, form c) (C6, form c); cytochrome P450-C; cytochrome P450-P1; cytochrome P450MT2; dioxin-inducible; flavoprotein-linked monooxygenase; hydroperoxy icosatetraenoate dehydratase; microsomal monooxygenase; P-450MC; P1-450; P450-C; P450DX; P450form6; P450MT2; xenobiotic monooxygenase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Cyp1a1em1Mcwi ; Cyp1a1em5Mcwi ; Cyp1a1em2Mcwi
Genetic Models: SS-Cyp1a1em1Mcwi ; SS-Cyp1a1em2Mcwi ; SS-Cyp1a1em5Mcwi
Is Marker For: Strains:   F344-Tg(Cyp1a1-Ren2)10Jmul
Candidate Gene For: Mcs4 Hcar3
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8866,991,940 - 66,998,014 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl866,991,970 - 66,998,012 (+)EnsemblGRCr8
mRatBN7.2858,096,021 - 58,102,130 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl858,096,077 - 58,102,125 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx863,629,083 - 63,635,108 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0861,906,655 - 61,912,680 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0859,771,206 - 59,777,229 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0862,472,087 - 62,478,122 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl862,472,095 - 62,478,147 (+)Ensemblrn6Rnor6.0
Rnor_5.0862,249,046 - 62,255,081 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4861,462,207 - 61,468,237 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera857,561,801 - 57,567,827 (+)NCBICelera
RGSC_v3.1861,481,260 - 61,487,291 (+)NCBI
RH 3.4 Map8671.2RGD
Cytogenetic Map8q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (IEP,ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
allergic contact dermatitis  (ISO)
allergic disease  (ISO)
ankylosing spondylitis  (ISO)
Arteritis  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
autism spectrum disorder  (ISO)
Behcet's disease  (ISO)
biliary tract cancer  (ISO)
Birth Weight  (ISO)
Bradycardia  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
bronchitis  (ISO)
Cardiac Fibrosis  (IEP)
Cardiomegaly  (IEP,ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Bronchitis  (ISO)
Chronic Intermittent Hypoxia  (IEP)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
clubfoot  (ISO)
colitis  (ISO)
contact dermatitis  (ISO)
cystic fibrosis  (ISO)
diabetes mellitus  (ISO)
Digestive System Neoplasms  (ISO)
dilated cardiomyopathy  (ISO)
Drug Eruptions  (ISO)
end stage renal disease  (IEP,ISO)
endometrial cancer  (ISO)
endometriosis  (ISO)
esophageal cancer  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Diabetes Mellitus  (IDA,ISO)
Experimental Liver Neoplasms  (IEP)
Fetal Growth Retardation  (IEP,ISO)
gallbladder cancer  (ISO)
Graves' disease  (ISO)
hamartoma  (ISO)
head and neck cancer  (ISO)
heart disease  (IEP)
Hematuria  (ISO)
hepatocellular carcinoma  (ISO)
Hepatomegaly  (ISO)
Hyperoxia  (IEP,ISO)
Hyperoxic Lung Injury  (IDA,ISO)
hypertension  (IEP,ISO)
Hypertriglyceridemia  (IEP)
hypertrophic cardiomyopathy  (IEP)
hypospadias  (ISO)
Inflammation  (IEP)
Jaundice  (IEP)
Keshan disease  (ISO)
Kidney Neoplasms  (ISO)
Liver Reperfusion Injury  (IEP)
long QT syndrome  (ISO)
lung cancer  (ISO)
Lung Injury  (ISO)
male infertility  (ISO)
Metabolic Side Effects of Drugs and Substances  (IEP)
Micronuclei, Chromosome-Defective  (ISO)
multiple myeloma  (ISO)
Nematode Infections  (IEP)
nephritis  (ISO)
Occupational Diseases  (ISO)
oral cavity cancer  (ISO)
oral squamous cell carcinoma  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
periodontitis  (ISO)
peripheral vascular disease  (ISO)
pneumonia  (ISO)
polycystic ovary syndrome  (ISO)
porphyria cutanea tarda  (ISO)
Prenatal Exposure Delayed Effects  (IEP)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
psoriatic arthritis  (ISO)
pulmonary hypertension  (IEP)
Pulmonary Hypertension, Hypoxia-Induced  (IEP)
reactive arthritis  (ISO)
renal cell carcinoma  (IEP,ISO)
Sepsis  (IEP)
Sinus Tachycardia  (ISO)
Sjogren's syndrome  (ISO)
Spontaneous Abortions  (ISO)
stomach cancer  (ISO)
systemic lupus erythematosus  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
Ventricular Remodeling  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-(S)-ar-turmerone  (ISO)
(+)-alpha-Bisabolol  (EXP)
(+)-beta-thujone  (ISO)
(+)-catechin  (EXP,ISO)
(+)-epicatechin-3-O-gallate  (EXP)
(+)-taxifolin  (ISO)
(+)-Tetrandrine  (ISO)
(-)-anisomycin  (ISO)
(-)-cotinine  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-noscapine  (ISO)
(-)-trans-epsilon-viniferin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(E)-cinnamyl alcohol  (ISO)
(R)-camphor  (ISO)
(R)-linalyl acetate  (ISO)
(R)-lipoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-colchicine  (EXP,ISO)
(S)-duloxetine hydrochloride  (ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
(Z)-3-butylidenephthalide  (ISO)
(Z)-ligustilide  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (EXP)
1,1-Dichloroethane  (EXP)
1,1-dichloroethene  (ISO)
1,10-phenanthroline  (EXP,ISO)
1,2,3,4,6,7,8-Heptachlorodibenzodioxin  (EXP,ISO)
1,2,3,4,6,7,8-Heptachlorodibenzofuran  (EXP,ISO)
1,2,3,4,7,8-Hexachlorodibenzofuran  (EXP,ISO)
1,2,3,4-tetrachlorodibenzodioxine  (EXP)
1,2,3,6,7,8-Hexachlorodibenzodioxin  (EXP,ISO)
1,2,3,7,8-Pentachlorodibenzodioxin  (EXP,ISO)
1,2,3,7,8-Pentachlorodibenzofuran  (ISO)
1,2,4-trichlorobenzene  (ISO)
1,2-dichlorobenzene  (EXP,ISO)
1,2-dichloroethene  (EXP)
1,2-naphthoquinone  (ISO)
1,3,5-trimethylbenzene  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,3-Dinitropyrene  (EXP,ISO)
1,3-thiazolidine-2,4-dione  (ISO)
1,4-benzoquinone  (ISO)
1,4-dichlorobenzene  (ISO)
1,4-dihydroxy-2-naphthoic acid  (ISO)
1,4-dithiothreitol  (ISO)
1,4-naphthoquinone  (ISO)
1,6-Dinitropyrene  (EXP,ISO)
1,7-phenanthroline  (EXP)
1,8-cineole  (ISO)
1,8-Dinitropyrene  (EXP,ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP)
1-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-2-(4-chlorophenoxy)ethanone  (ISO)
1-aminobenzotriazole  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-Cyano-2-hydroxy-3-butene  (EXP)
1-hydroxy-2-naphthoic acid  (ISO)
1-Hydroxypyrene  (ISO)
1-methylnaphthalene  (ISO)
1-methylphenanthrene  (EXP,ISO)
1-naphthol  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (EXP,ISO)
1-phenyl-1,2-propanedione  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-benzo[d]imidazole-2-thiol  (EXP)
2'-deoxyguanosine  (ISO)
2'-hydroxychalcone  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',4,5-tetrachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5,5'-Hexachlorobiphenyl  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (EXP,ISO)
2,3,3',4,4',5,5'-Heptachlorobiphenyl  (EXP)
2,3,3',4,4',5-Hexachlorobiphenyl  (EXP,ISO)
2,3,4,3',4'-Pentachlorobiphenyl  (EXP,ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP,ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-trinitrotoluene  (ISO)
2,4,6-Triphenyl-1-hexene  (ISO)
2,4-D  (EXP)
2,4-diaminotoluene  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dinitrophenol  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-Amino-3-methyl-9H-pyrido[2,3-b]indole  (EXP,ISO)
2-amino-4,6-dinitrotoluene  (EXP)
2-Amino-9H-pyrido[2,3-b]indole  (EXP,ISO)
2-aminobenzimidazole  (EXP)
2-aminophenol  (ISO)
2-aminopurine  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-hexenal  (ISO)
2-hydroxy-17beta-estradiol  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-methyl-1H-indole  (ISO)
2-methylnaphthalene  (ISO)
2-naphthol  (ISO)
2-naphthylamine  (ISO)
2-nitroanisole  (EXP,ISO)
2-nitrofluorene  (EXP)
2-nitrophenol  (EXP,ISO)
2-tert-butylhydroquinone  (ISO)
3',4'-dimethoxyflavone  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,3'-diindolylmethane  (EXP,ISO)
3,4,5,3',4',5'-Hexachlorobiphenyl  (EXP,ISO)
3,4,8-Trimethyl-1H,2H,3H-imidazo[4,5-F]quinoxalin-2-imine  (ISO)
3,4-dichloroaniline  (ISO)
3,4-dihydroxybenzoic acid  (EXP)
3-(1H-indol-3-yl)propanoic acid  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-Amino-1-methyl-5H-pyrido[4,3-b]indole  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methylcholanthrene  (EXP,ISO)
3-Methylchrysene  (ISO)
3-methyleneindolenine  (ISO)
3-Nitrobenzanthrone  (ISO)
3-Nitrofluoranthene  (ISO)
3-phenylprop-2-enal  (ISO)
4',5,7-trihydroxy-3'-methoxyflavone  (ISO)
4'-tert-Butyl-2',6'-dimethyl-3',5'-dinitroacetophenone  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4,7-diphenyl-1,10-phenanthroline  (ISO)
4,7-phenanthroline  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP,ISO)
4-[(1E)-1,2-diphenylbut-1-en-1-yl]phenol  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-Hydroxy-N-desmethyltamoxifen  (ISO)
4-Hydroxybenzyl isothiocyanate  (EXP)
4-hydroxychalcone  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-Hydroxytestosterone  (ISO)
4-Methylchrysene  (ISO)
4-nitroaniline  (EXP)
4-nitrophenol  (EXP)
4-tert-Octylphenol  (ISO)
5'-hydroxyomeprazole  (EXP)
5,6-Dehydrokawain  (ISO)
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole  (ISO)
5,7-dihydroxy-4'-methoxyflavone  (ISO)
5-(2-chloroethyl)-4-methylthiazole  (EXP)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (ISO)
5-fluorouracil  (EXP)
5-Hydroxyflavone  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
5-methoxyindole  (ISO)
5-Methylchrysene  (ISO)
6',7'-Dihydroxybergamottin  (EXP,ISO)
6-chrysenamine  (EXP,ISO)
6-hydroxyluteolin  (ISO)
6-Methylchrysene  (ISO)
6-Nitrobenzo[a]pyrene  (ISO)
6-Nitrochrysene  (ISO)
6-prenylnaringenin  (ISO)
680C91  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7-hydroxyflavone  (ISO)
7-ketocholesterol  (EXP,ISO)
7-Nitrobenz[a]anthracene  (ISO)
7H-Dibenzo[c,g]carbazole  (EXP,ISO)
8-Epidiosbulbin E acetate  (ISO)
9-Hydroxybenzo[a]pyrene  (ISO)
9-phenanthrol  (ISO)
AACOCF3  (ISO)
abacavir  (ISO)
abexinostat  (EXP)
acenaphthene  (ISO)
acenaphthylene  (EXP)
acenocoumarol  (ISO)
acephate  (ISO)
acetone  (EXP)
Acetyleugenol  (ISO)
acrolein  (ISO)
Actein  (ISO)
acteoside  (ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
alachlor  (EXP)
albendazole  (ISO)
aldehydo-D-glucose  (ISO)
aliskiren  (ISO)
alizarin  (ISO)
all-trans-4-hydroxyretinoic acid  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-acitretin  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
allocryptopine  (ISO)
almotriptan  (ISO)
Aloe emodin  (ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-naphthoflavone  (EXP,ISO)
alpha-pinene  (ISO)
Alpinetin  (ISO)
alternariol  (ISO)
Altertoxin II  (ISO)
alvocidib  (ISO)
Amaranth  (EXP)
amiloride  (ISO)
amiodarone  (EXP,ISO)
amitraz  (EXP)
amlodipine  (ISO)
ammonium chloride  (EXP)
amodiaquine  (ISO)
amphibole asbestos  (ISO)
ampicillin  (ISO)
andrographolide  (ISO)
anethole  (ISO)
angelicin  (EXP,ISO)
aniline  (ISO)
annomontine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
anthracene  (EXP,ISO)
anthraflavic acid  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
arecoline  (ISO)
aristolochic acid A  (EXP,ISO)
aristolochic acids  (EXP)
Aroclor 1254  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
aspartame  (EXP)
astaxanthin  (EXP)
atrazine  (EXP,ISO)
auraptene  (ISO)
Aurin  (ISO)
aurofusarin  (ISO)
avobenzone  (ISO)
AZD5153  (EXP)
azoxystrobin  (ISO)
baicalein  (ISO)
baicalin  (ISO)
benidipine  (ISO)
benoxaprofen  (EXP,ISO)
benzalkonium chloride  (ISO)
benzarone  (ISO)
benzbromarone  (ISO)
benzene  (EXP,ISO)
benzene-1,2,4-triol  (ISO)
benzimidazoles  (ISO)
benziodarone  (ISO)
Benzo[a]fluorene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[a]pyrene-7,8-diol  (EXP,ISO)
benzo[a]pyrene-7,8-dione  (ISO)
benzo[b]fluoranthene  (EXP,ISO)
Benzo[b]fluorene  (ISO)
Benzo[c]fluorene  (ISO)
benzo[c]phenanthrene  (ISO)
benzo[e]pyrene  (EXP,ISO)
BENZO[G]CHRYSENE  (EXP,ISO)
Benzo[ghi]perylene  (ISO)
Benzo[j]fluoranthene  (ISO)
Benzo[k]fluoranthene  (EXP,ISO)
benzofurans  (EXP,ISO)
benzyl cinnamate  (ISO)
benzyl isothiocyanate  (EXP)
benzylideneacetone  (EXP)
berberine  (EXP,ISO)
bergomottin  (EXP,ISO)
beta-carboline  (ISO)
beta-myrcene  (ISO)
beta-naphthoflavone  (EXP,ISO)
beta-tocopherol  (EXP)
betulin  (EXP)
bezafibrate  (EXP,ISO)
bicalutamide  (ISO)
bifenthrin  (EXP,ISO)
bilirubin IXalpha  (ISO)
bilobalide  (ISO)
biochanin A  (ISO)
biphenyl  (ISO)
biphenyl-2-ol  (ISO)
biphenyl-4-amine  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
Bisphenol Z  (ISO)
bitertanol  (EXP)
blebbistatin  (ISO)
brequinar  (ISO)
Brilliant Blue  (EXP)
bromobenzene  (EXP)
bromocriptine  (ISO)
bucladesine  (EXP,ISO)
bufexamac  (EXP)
busulfan  (ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (EXP,ISO)
butyric acid  (ISO)
cadmium acetate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calciol  (ISO)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
camphor  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
canthaxanthin  (EXP,ISO)
capsaicin  (ISO)
capsazepine  (ISO)
captan  (ISO)
carbamazepine  (EXP,ISO)
carbaryl  (EXP,ISO)
carbendazim  (EXP,ISO)
carbon monoxide  (EXP)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carvacrol  (ISO)
carvedilol  (ISO)
carvone  (ISO)
celastrol  (ISO)
ceric oxide  (ISO)
cerium trichloride  (ISO)
CGP 52608  (ISO)
chalcone  (EXP)
chelerythrine  (EXP)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
chlordecone  (ISO)
chloroacetaldehyde  (ISO)
chlorohydrocarbon  (EXP)
chlorophyllin  (ISO)
chloroprene  (EXP,ISO)
chlorotoluron  (EXP,ISO)
chlorpromazine  (EXP,ISO)
chlorpyrifos  (EXP,ISO)
chlorzoxazone  (EXP)
cholesterol  (ISO)
choline  (EXP)
chromium atom  (ISO)
chromium trioxide  (ISO)
chromium(6+)  (ISO)
chrysene  (EXP,ISO)
chrysin  (ISO)
chrysin 5,7-dimethyl ether  (ISO)
chrysophanol  (ISO)
cidofovir anhydrous  (ISO)
cimetidine  (ISO)
cinnamyl alcohol  (ISO)
cirsiliol  (ISO)
cisplatin  (ISO)
citral  (ISO)
clenbuterol  (EXP)
clevidipine  (ISO)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
clomiphene  (ISO)
clopidogrel  (ISO)
clotrimazole  (EXP,ISO)
clozapine  (EXP,ISO)
Clozapine N-oxide  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) nitrate  (ISO)
copper(II) sulfate  (ISO)
cortisol  (EXP)
crocidolite asbestos  (ISO)
Cryptotanshinone  (ISO)
curcumin  (EXP,ISO)
Cyclofenil  (ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
cylindrospermopsin  (ISO)
Cynaropicrin  (ISO)
cypermethrin  (EXP,ISO)
cyproconazole  (EXP,ISO)
cyprodinil  (ISO)
cyproheptadine  (ISO)
cyproterone acetate  (ISO)
D-glucose  (ISO)
D-mannopyranose 6-phosphate  (ISO)
D-mannose 6-phosphate  (ISO)
D-penicillamine  (ISO)
dacarbazine  (ISO)
daidzein  (EXP,ISO)
danazol  (ISO)
dantrolene  (EXP,ISO)
dapsone  (ISO)
DDE  (EXP,ISO)
DDT  (EXP,ISO)
decabromodiphenyl ether  (EXP,ISO)
deguelin  (ISO)
dehydroepiandrosterone  (ISO)
delphinidin  (ISO)
delta-tocopherol  (EXP)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dexlansoprazole  (ISO)
dexmedetomidine  (ISO)
dextran sulfate  (ISO)
dextromethorphan  (ISO)
diallyl disulfide  (EXP,ISO)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibenz[a,c]anthracene  (EXP,ISO)
dibenz[a,h]anthracene  (EXP,ISO)
Dibenz[a,j]anthracene  (EXP)
dibenziodolium  (EXP,ISO)
Dibenzo[a,e]pyrene  (EXP)
dibenzo[a,l]pyrene  (EXP,ISO)
dibenzofuran  (EXP)
dibenzofurans  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
dicofol  (EXP)
dicrotophos  (ISO)
dicyclanil  (ISO)
Dicyclohexyl phthalate  (EXP)
dieldrin  (EXP)
diethyl phthalate  (ISO)
diethyl sulfate  (ISO)
diethylstilbestrol  (EXP,ISO)
difenoconazole  (ISO)
diflubenzuron  (EXP)
difluorine  (ISO)
dihydroergotamine  (EXP,ISO)
Dihydrotanshinone I  (ISO)
dihydroxyacetone  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP,ISO)
dimethylarsinous acid  (ISO)
diosmetin  (ISO)
dioxygen  (EXP,ISO)
dipropyl disulfide  (ISO)
dipropyl phthalate  (EXP)
Dipropyl sulfide  (ISO)
diprotium oxide  (ISO)
disulfiram  (ISO)
diuron  (EXP,ISO)
dizocilpine maleate  (EXP)
domperidone  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
drometrizole  (ISO)
dronedarone  (ISO)
ebrotidine  (ISO)
elemental selenium  (EXP)
Elemicin  (ISO)
ellagic acid  (ISO)
ellipticine  (EXP,ISO)
emodin  (ISO)
endosulfan  (EXP,ISO)
enilconazole  (ISO)
enniatin  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP,ISO)
erlotinib hydrochloride  (ISO)
Erucin  (EXP)
erythromycin estolate  (EXP)
erythrosin B  (EXP)
esomeprazole  (ISO)
estragole  (ISO)
estramustine  (ISO)
estriol  (ISO)
estrone  (ISO)
etacrynic acid  (EXP,ISO)
ethanol  (EXP,ISO)
ethoxyquin  (EXP)
ethylbenzene  (EXP,ISO)
ethylenediaminetetraacetic acid  (EXP)
ethylisopropylamiloride  (ISO)
ethylparaben  (EXP)
etofenprox  (EXP)
etoposide  (ISO)
etoricoxib  (ISO)
eugenol  (ISO)
eupatorin  (ISO)
farnesol  (EXP,ISO)
felbamate  (EXP)
felodipine  (ISO)
fenarimol  (ISO)
fenhexamid  (ISO)
fenitrothion  (EXP,ISO)
fenofibrate  (EXP,ISO)
fenpropathrin  (EXP)
fenpyroximate  (ISO)
ferric oxide  (EXP)
ferulic acid  (ISO)
filipin III  (ISO)
fingolimod hydrochloride  (ISO)
Finrozole  (ISO)
fipronil  (ISO)
fisetin  (ISO)
flavanone  (ISO)
flavone  (ISO)
flavonoids  (EXP,ISO)
flavonol  (ISO)
flavonols  (ISO)
fludioxonil  (ISO)
flumequine  (ISO)
fluoranthene  (EXP,ISO)
fluoren-9-one  (EXP)
fluorene  (EXP)
fluorescein 5-isothiocyanate  (ISO)
fluorine atom  (ISO)
flusilazole  (ISO)
flutamide  (EXP,ISO)
fluxapyroxad  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
formononetin  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
fumonisin B1  (EXP)
Furafylline  (EXP,ISO)
furazolidone  (EXP)
gabapentin  (EXP)
galangin  (ISO)
gallocatechin  (EXP)
gamma-hexachlorocyclohexane  (EXP,ISO)
gamma-tocopherol  (EXP)
gedunin  (ISO)
gefitinib  (EXP,ISO)
geldanamycin  (ISO)
genistein  (EXP,ISO)
genistein(1-)  (EXP)
genkwanin  (ISO)
gentamycin  (EXP)
geranial  (ISO)
geraniol  (ISO)
Ginkgolide A  (ISO)
ginkgolide B  (ISO)
Ginkgolide C  (ISO)
Ginkgolide J  (ISO)
glafenine  (ISO)
Glu-P-1  (ISO)
glucoerucin  (EXP)
glucoerucin(1-)  (EXP)
glucoraphanin  (EXP)
glucose  (ISO)
glutathione  (ISO)
glyburide  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypetin  (ISO)
granisetron  (ISO)
GW 3965  (ISO)
halocarban  (ISO)
harmaline  (ISO)
harmalol  (ISO)
harman  (EXP,ISO)
harmine  (ISO)
harmol  (ISO)
hemin  (EXP,ISO)
Heptachlor epoxide  (ISO)
heptanal  (ISO)
herbicide  (ISO)
herbimycin  (EXP,ISO)
hesperetin  (ISO)
Hexachloro-1,3-butadiene  (EXP,ISO)
hexachlorobenzene  (EXP,ISO)
hexanal  (ISO)
hexane  (EXP)
homoeriodictyol  (ISO)
HT-2 toxin  (ISO)
hyaluronic acid  (ISO)
hydralazine  (EXP,ISO)
hydrazine  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxamic acid  (EXP)
hyperforin  (ISO)
hypericin  (ISO)
iberin  (EXP)
ifosfamide  (ISO)
imiquimod  (ISO)
imperatorin  (ISO)
Indeno[1,2,3-cd]pyrene  (EXP,ISO)
indigo carmine  (EXP,ISO)
indirubin  (EXP,ISO)
indirubin-3'-monoxime  (EXP,ISO)
indol-3-ylacetaldehyde  (ISO)
indole-3-acetic acid  (ISO)
indole-3-methanol  (EXP,ISO)
indoles  (ISO)
indometacin  (EXP)
indoxyl sulfate  (EXP,ISO)
ionomycin  (ISO)
iprodione  (ISO)
iron dextran  (ISO)
iron trichloride  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isobutanol  (ISO)
isoeugenol  (ISO)
isoflavones  (EXP,ISO)
isoimperatorin  (EXP)
isoliquiritigenin  (ISO)
isopimpinellin  (EXP,ISO)
isoprenaline  (EXP,ISO)
isoproturon  (ISO)
isorhamnetin  (ISO)
Isosafrole  (EXP)
isosorbide dinitrate  (ISO)
isovitexin  (EXP)
Isradipine  (ISO)
itraconazole  (ISO)
ivermectin  (ISO)
juglone  (ISO)
kaempferol  (ISO)
ketamine  (EXP)
ketoconazole  (EXP,ISO)
KN-93  (EXP,ISO)
kynurenic acid  (ISO)
kynurenine  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
L-cysteine  (ISO)
L-methionine  (EXP,ISO)
L-tryptophan  (ISO)
lactacystin  (ISO)
lamotrigine  (EXP)
lansoprazole  (EXP,ISO)
lapatinib  (ISO)
laquinimod  (EXP,ISO)
Lasiocarpine  (ISO)
lead diacetate  (ISO)
lead nitrate  (EXP,ISO)
lead(0)  (EXP,ISO)
lead(II) chloride  (ISO)
leflunomide  (EXP,ISO)
lentinan  (ISO)
letrozole  (EXP)
Licopyranocoumarin  (ISO)
limonene  (ISO)
linalool  (ISO)
linalyl acetate  (ISO)
linoleic acid  (ISO)
linuron  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
lithocholic acid  (ISO)
losartan  (ISO)
lovastatin  (ISO)
lucanthone  (ISO)
luteolin  (ISO)
lycopene  (ISO)
m-xylene  (EXP)
mancozeb  (EXP,ISO)
maneb  (EXP,ISO)
mangiferin  (ISO)
MDL-28170  (ISO)
mebendazole  (EXP,ISO)
medroxyprogesterone acetate  (ISO)
mefenamic acid  (ISO)
MeIQ  (EXP,ISO)
MeIQx  (ISO)
melanins  (ISO)
melatonin  (EXP,ISO)
melphalan  (EXP,ISO)
menadione  (EXP,ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
mesoporphyrin IX  (ISO)
metformin  (EXP,ISO)
methapyrilene  (EXP)
methoxsalen  (EXP,ISO)
methoxychlor  (EXP,ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
methyltestosterone  (EXP,ISO)
Methysticin  (ISO)
metolachlor  (ISO)
metyrapone  (ISO)
miconazole  (EXP)
midazolam  (ISO)
mifepristone  (EXP,ISO)
milnacipran  (ISO)
mitoxantrone  (ISO)
MK 571  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (EXP)
monocrotophos  (EXP,ISO)
monoethyl phthalate  (ISO)
montelukast  (ISO)
morin  (ISO)
musk xylene  (EXP)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
myricetin  (ISO)
myristicin  (ISO)
N'-(2,4-dimethylphenyl)-N-methylformamidine  (EXP)
N'-Nitrosoanabasine  (ISO)
N'-Nitrosonornicotine  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-[3-(aminomethyl)benzyl]acetamidine  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-desethylamiodarone  (EXP)
N-desmethylclozapine  (ISO)
N-hydroxy-PhIP  (ISO)
N-Nitrosodi-n-butylamine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
n-propyl gallate  (ISO)
NADP zwitterion  (EXP,ISO)
NADP(+)  (EXP,ISO)
naled  (ISO)
naphthalene  (ISO)
naphthalenes  (EXP,ISO)
naphthazarin  (ISO)
naringin  (ISO)
NCX-4040  (ISO)
nefazodone  (EXP,ISO)
nelfinavir  (ISO)
Neoandrographolide  (ISO)
nicardipine  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nifedipine  (ISO)
nitroaniline  (EXP)
nitrofurantoin  (EXP,ISO)
nobiletin  (ISO)
nocodazole  (EXP,ISO)
Nonylphenol  (ISO)
norflurazon  (ISO)
norwogonin  (ISO)
o-anisidine  (EXP,ISO)
O-methyleugenol  (ISO)
o-xylene  (EXP)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
Octachlorostyrene  (ISO)
octamethylcyclotetrasiloxane  (EXP)
octanal  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
Olivacine  (ISO)
olivetol  (ISO)
oltipraz  (EXP,ISO)
omeprazole  (EXP,ISO)
Omeprazole sulfide  (ISO)
orcinol  (ISO)
organoselenium compound  (ISO)
oroxylin A  (ISO)
orphenadrine  (EXP)
ortho-Aminoazotoluene  (ISO)
Ortho-topolin riboside  (ISO)
Oxadiazon  (ISO)
oxanthrene  (ISO)
oxfendazole  (EXP)
oxyphenisatine acetate  (ISO)
ozone  (EXP,ISO)
p-aminodiphenylamine  (ISO)
p-cymene  (ISO)
p-tert-Amylphenol  (ISO)
p-xylene  (EXP)
paclitaxel  (ISO)
palmatine  (ISO)
panobinostat  (ISO)
pantoprazole  (EXP)
papaverine  (ISO)
paracetamol  (EXP,ISO)
Paraoxon-methyl  (ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
parathion-methyl  (ISO)
pazopanib  (ISO)
PCB138  (EXP)
pelargonidin  (ISO)
pentachlorobenzene  (ISO)
pentachlorophenol  (EXP,ISO)
pentanal  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (EXP,ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP,ISO)
perphenazine  (EXP,ISO)
Pf-06840003  (ISO)
phenacetin  (EXP,ISO)
phenanthrene  (EXP,ISO)
phenanthrenes  (ISO)
phenanthrolines  (ISO)
Phenelzine  (ISO)
phenethyl isothiocyanate  (EXP,ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenols  (ISO)
phenytoin  (EXP,ISO)
PhIP  (EXP,ISO)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phthalaldehyde  (ISO)
phthalic anhydride  (ISO)
picene  (EXP,ISO)
picolinic acid  (ISO)
pifithrin-alpha hydrobromide  (ISO)
pinocembrin  (ISO)
piperine  (ISO)
piperonyl butoxide  (EXP,ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
poly(vinylpyrrolidone)  (EXP)
polycyclic arene  (ISO)
polymyxin B2  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
prazosin  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
primaquine  (EXP,ISO)
prochloraz  (EXP,ISO)
profenofos  (ISO)
progesterone  (EXP,ISO)
propachlor  (ISO)
propafenone  (ISO)
propanal  (ISO)
propiconazole  (EXP,ISO)
propranolol  (EXP,ISO)
propylbenzene  (EXP)
propylparaben  (EXP,ISO)
protopine  (ISO)
Pseudohypericin  (ISO)
pterostilbene  (ISO)
puromycin  (ISO)
pyocyanine  (ISO)
pyrene  (EXP,ISO)
pyridin-2-ol  (ISO)
pyridine  (EXP,ISO)
pyridine N-oxide  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP,ISO)
quercetin 3-O-beta-D-glucopyranoside  (EXP,ISO)
quercitrin  (ISO)
quinacrine  (ISO)
quinidine  (ISO)
quinine  (ISO)
quinolone  (ISO)
rabeprazole  (EXP,ISO)
raloxifene  (EXP,ISO)
reactive oxygen species  (EXP,ISO)
reserpine  (ISO)
resminostat  (EXP)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
Retrorsine  (EXP)
Rhein  (ISO)
rifampicin  (EXP,ISO)
Riluzole  (ISO)
riociguat  (ISO)
ritonavir  (ISO)
robinetin  (ISO)
romidepsin  (ISO)
RU 58668  (ISO)
Rutecarpine  (EXP,ISO)
rutin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
sabinene  (ISO)
saccharin  (EXP)
salicylamide  (ISO)
Salinomycin  (ISO)
sanguinarine  (EXP,ISO)
saquinavir  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
SB-202190  (ISO)
scutellarein  (ISO)
selenic acid  (EXP)
selenium atom  (EXP)
senecionine  (ISO)
serpentine asbestos  (ISO)
Sesamex  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simazine  (ISO)
simvastatin  (ISO)
sinensetin  (ISO)
sirtinol  (ISO)
skatole  (ISO)
sodium acetate trihydrate  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium benzoate  (ISO)
sodium chromate  (EXP)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
sodium propionate  (ISO)
sodium selenate  (EXP)
sophoraflavanone B  (ISO)
sorafenib  (ISO)
spathulenol  (ISO)
staurosporine  (EXP,ISO)
StemRegenin 1  (ISO)
sterigmatocystin  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
styrene  (ISO)
styrene oxide  (EXP)
SU6656  (ISO)
succimer  (ISO)
sucrose  (EXP)
Sudan I  (EXP,ISO)
Sudan III  (EXP,ISO)
Sudan IV  (EXP)
sulfasalazine  (EXP)
sulforaphane  (EXP,ISO)
sulfur dioxide  (EXP)
sulindac  (EXP,ISO)
sulindac sulfide  (ISO)
sulpiride  (EXP)
sunitinib  (EXP,ISO)
Sunset Yellow FCF  (EXP,ISO)
superoxide  (ISO)
T-2 toxin  (ISO)
tacrine  (EXP,ISO)
tamoxifen  (EXP,ISO)
tangeretin  (ISO)
Tanshinone I  (ISO)
tartrazine  (EXP)
tasquinimod  (EXP,ISO)
tebuconazole  (EXP,ISO)
telmisartan  (ISO)
terbinafine  (ISO)
tert-butyl ethyl ether  (EXP)
Tesaglitazar  (EXP)
testosterone  (EXP,ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
Tetrahydrogestrinone  (ISO)
tetraphene  (EXP,ISO)
tetrodotoxin  (EXP)
thiabendazole  (EXP,ISO)
thiacloprid  (ISO)
thioacetamide  (EXP)
Thiocoraline  (ISO)
thiophanate-methyl  (EXP)
thiostrepton  (ISO)
thiram  (ISO)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
thymoquinone  (ISO)
titanium dioxide  (ISO)
tolcapone  (EXP,ISO)
toluene  (EXP,ISO)
toluene 2,4-diisocyanate  (ISO)
tolvaptan  (ISO)
toxaphene  (ISO)
tranilast  (ISO)
trans-1,2-dichloroethene  (EXP)
trans-anethole  (ISO)
trans-chalcone  (EXP)
trans-isoeugenol  (ISO)
trans-piceid  (ISO)
tranylcypromine  (EXP)
triacetin  (ISO)
triadimefon  (EXP)
tributyl phosphate  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
tricetin  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triciribine  (ISO)
triclocarban  (EXP,ISO)
triclosan  (EXP,ISO)
triflumuron  (ISO)
trimethylarsine oxide  (EXP,ISO)
triphenyl phosphate  (EXP)
triphenylene  (ISO)
tris(2-butoxyethyl) phosphate  (EXP,ISO)
tris(2-chloroethyl) phosphate  (EXP)
troglitazone  (EXP,ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
usnic acid  (ISO)
Valacyclovir hydrochloride  (ISO)
valdecoxib  (EXP,ISO)
valproic acid  (EXP,ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vanillin  (ISO)
varenicline  (ISO)
verapamil  (ISO)
versicolorin A  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP,ISO)
vitamin E  (EXP)
vorinostat  (EXP,ISO)
vorozole  (ISO)
warfarin  (ISO)
water  (ISO)
wogonin  (ISO)
wortmannin  (EXP,ISO)
xanthohumol  (ISO)
Yangonin  (ISO)
zafirlukast  (ISO)
zearalenone  (ISO)
zerumbone  (ISO)
zileuton  (EXP)
zinc dichloride  (ISO)
zinc molecular entity  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP)
zinc pyrithione  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
9-cis-retinoic acid biosynthetic process  (IDA)
amine metabolic process  (ISO)
camera-type eye development  (IEP)
cellular response to copper ion  (IEP)
coumarin metabolic process  (IDA)
dibenzo-p-dioxin catabolic process  (IDA,IMP)
dibenzo-p-dioxin metabolic process  (IDA)
digestive tract development  (IEP)
estrogen metabolic process  (IBA,IEA,ISO,ISS)
fatty acid metabolic process  (IEA,ISO)
flavonoid metabolic process  (IDA)
hepatocyte differentiation  (IEP)
hydrogen peroxide biosynthetic process  (ISO)
insecticide metabolic process  (IDA)
lipid hydroxylation  (IEA,ISO)
lipid metabolic process  (IEA)
liver development  (IEP)
long-chain fatty acid metabolic process  (IEA,ISO)
maternal process involved in parturition  (IEP)
nitric oxide metabolic process  (IEP)
phenol-containing compound metabolic process  (ISO)
porphyrin-containing compound metabolic process  (IDA)
positive regulation of G1/S transition of mitotic cell cycle  (IDA)
response to 2,3,7,8-tetrachlorodibenzodioxine  (IEP)
response to 3-methylcholanthrene  (IEP)
response to Aroclor 1254  (IEP)
response to arsenic-containing substance  (IEP)
response to bacterium  (IEA)
response to diphenyl ether  (IEP)
response to food  (IEP)
response to genistein  (IEP)
response to herbicide  (IEP)
response to hyperoxia  (IEP)
response to hypoxia  (IEP)
response to immobilization stress  (IEP)
response to iron(III) ion  (IEP)
response to lipopolysaccharide  (IEP)
response to nematode  (IEP)
response to toxic substance  (ISO)
response to vitamin A  (IEP)
response to xenobiotic stimulus  (IEP)
retinol metabolic process  (IEA,ISO,ISS)
steroid biosynthetic process  (IEA)
steroid catabolic process  (IBA)
steroid metabolic process  (IEA,ISO)
tissue remodeling  (IEP)
toxin metabolic process  (IBA,ISO)
vitamin D metabolic process  (IEA,ISO)
xenobiotic catabolic process  (IBA)
xenobiotic metabolic process  (IEA,ISO)

Cellular Component

References

References - curated
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103. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
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105. Suppression of cytochrome P450 1A1 and 4A1 gene expression in renal carcinomas of TSC2 gene mutant (Eker) rats. Okamoto T, etal., Int J Oncol. 2001 Jan;18(1):147-9.
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107. In vivo effects of Urtica urens (dwarf nettle) on the expression of CYP1A in control and 3-methylcholanthrene-exposed rats. Ozkarsli M, etal., Xenobiotica. 2008 Jan;38(1):48-61.
108. Frequency variations in the methylated pattern of p73/p21 genes and chromosomal aberrations correlating with different grades of glioma among south Indian population. Palani M, etal., Med Oncol. 2011 Dec;28 Suppl 1:S445-52. doi: 10.1007/s12032-010-9671-4. Epub 2010 Sep 16.
109. Age-related changes in the mRNA levels of CYP1A1, CYP2B1/2 and CYP3A1 isoforms in rat small intestine. Palasz A, etal., Genes Nutr. 2011 Jul 17.
110. Use of a quantitative real-time reverse transcription-polymerase chain reaction method to study the induction of CYP1A, CYP2B and CYP4A forms in precision-cut rat liver slices. Pan J, etal., Xenobiotica 2002 Sep;32(9):739-47.
111. Association of CYP1A1 Msp1 polymorphism with tobacco-related risk of gallbladder cancer in a north Indian population. Pandey SN, etal., Eur J Cancer Prev. 2008 Apr;17(2):77-81.
112. Variants in hormone-related genes and the risk of biliary tract cancers and stones: a population-based study in China. Park SK, etal., Carcinogenesis. 2009 Apr;30(4):606-14. Epub 2009 Jan 23.
113. Application of the ethoxyresorufin-O-deethylase (EROD) assay to mixtures of halogenated aromatic compounds. Petrulis JR, etal., Environ Toxicol. 2001;16(2):177-84.
114. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
115. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
116. Interaction of polyhalogenated compounds of appropriate configuration with mammalian or bacterial CYP enzymes. Increased bilirubin and uroporphyrinogen oxidation in vitro. Pons N, etal., Biochem Pharmacol. 2003 Aug 1;66(3):405-14.
117. Metabolomic profiling reveals potential markers and bioprocesses altered in bladder cancer progression. Putluri N, etal., Cancer Res. 2011 Dec 15;71(24):7376-86. doi: 10.1158/0008-5472.CAN-11-1154. Epub 2011 Oct 11.
118. Increased vascular contractility in isolated vessels from cigarette smoking rats is mediated by basal endothelin release. Rahman MM, etal., Vascul Pharmacol. 2007 Jan;46(1):35-42. Epub 2006 Jun 16.
119. Effect of bitter melon (Momordica charantia) fruit juice on the hepatic cytochrome P450-dependent monooxygenases and glutathione S-transferases in streptozotocin-induced diabetic rats. Raza H, etal., Biochem Pharmacol. 1996 Nov 22;52(10):1639-42.
120. Modulation of xenobiotic metabolism and oxidative stress in chronic streptozotocin-induced diabetic rats fed with Momordica charantia fruit extract. Raza H, etal., J Biochem Mol Toxicol. 2000;14(3):131-9.
121. Evaluation of 7-benzyloxy-4-trifluoromethylcoumarin, some other 7-hydroxy-4-trifluoromethylcoumarin derivatives and 7-benzyloxyquinoline as fluorescent substrates for rat hepatic cytochrome P450 enzymes. Renwick AB, etal., Xenobiotica. 2001 Dec;31(12):861-78.
122. GOA pipeline RGD automated data pipeline
123. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
124. Allelic variants of drug metabolizing enzymes as risk factors in psoriasis. Richter-Hintz D, etal., J Invest Dermatol. 2003 May;120(5):765-70.
125. CYP1A1 activity in renal cell carcinoma and in adjacent normal renal tissue. Rintala S, etal., Urol Res. 1998;26(2):117-21.
126. Soot nanoparticles promote biotransformation, oxidative stress, and inflammation in murine lungs. Rouse RL, etal., Am J Respir Cell Mol Biol. 2008 Aug;39(2):198-207. Epub 2008 Mar 26.
127. Biodegradation of polychlorinated dibenzo-p-dioxins by recombinant yeast expressing rat CYP1A subfamily. Sakaki T, etal., Arch Biochem Biophys. 2002 May 1;401(1):91-8.
128. Diet-relevant phytochemical intake affects the cardiac AhR and nrf2 transcriptome and reduces heart failure in hypertensive rats. Seymour EM, etal., J Nutr Biochem. 2013 Sep;24(9):1580-6. doi: 10.1016/j.jnutbio.2013.01.008. Epub 2013 Mar 22.
129. Hepatocyte differentiation of mesenchymal stem cells from rat peritoneal adipose tissue in vitro and in vivo. Sgodda M, etal., Exp Cell Res. 2007 Aug 1;313(13):2875-86. Epub 2007 May 26.
130. [Relationship between CYP1A1, GSTM1 genetic polymorphisms and susceptibility to esophageal squamous cell carcinoma]. Shao G, etal., Zhonghua Liu Xing Bing Xue Za Zhi. 2000 Dec;21(6):420-3.
131. Hypermethylation of carcinogen metabolism genes, CYP1A1, CYP2A13 and GSTM1 genes in head and neck cancer. Sharma R, etal., Oral Dis. 2010 Oct;16(7):668-73. doi: 10.1111/j.1601-0825.2010.01676.x.
132. Polymorphism in CYP1A1, GSTMI, GSTT1 genes and organochlorine pesticides in the etiology of hypospadias. Shekharyadav C, etal., Hum Exp Toxicol. 2011 Oct;30(10):1464-74. doi: 10.1177/0960327110392402. Epub 2011 Feb 7.
133. Dietary antioxidants (selenium and N-acetylcysteine) modulate paraoxonase 1 (PON1) in PCB 126-exposed rats. Shen H, etal., Environ Sci Pollut Res Int. 2014 May;21(10):6384-99. doi: 10.1007/s11356-013-1690-1. Epub 2013 May 4.
134. Genetic identification of multiple loci that control breast cancer susceptibility in the rat Shepel LA, etal., Genetics 1998 May;149(1):289-99
135. Cytochrome P450 1A1 (CYP1A1) polymorphisms and breast cancer risk in Korean women. Shin A, etal., Exp Mol Med. 2007 Jun 30;39(3):361-6.
136. Metabolic pathways of dioxin by CYP1A1: species difference between rat and human CYP1A subfamily in the metabolism of dioxins. Shinkyo R, etal., Arch Biochem Biophys 2003 Jan 1;409(1):180-7.
137. Generation of 2,3,7,8-TCDD-metabolizing enzyme by modifying rat CYP1A1 through site-directed mutagenesis. Shinkyo R, etal., Biochem Biophys Res Commun. 2003 Aug 29;308(3):511-7.
138. Genetic polymorphism of drug metabolizing enzymes (GSTM1 and CYP1A1) as risk factors for oral premalignant lesions and oral cancer. Shukla D, etal., Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2012 Sep;156(3):253-9. doi: 10.5507/bp.2012.013. Epub 2012 Jan 30.
139. Association of CYP1A1 gene polymorphism with chronic kidney disease: a case control study. Siddarth M, etal., Environ Toxicol Pharmacol. 2013 Jul;36(1):164-70. doi: 10.1016/j.etap.2013.03.008. Epub 2013 Mar 21.
140. Elevated expression of CYP1A1 and gamma-SYNUCLEIN in human ectopic (ovarian) endometriosis compared with eutopic endometrium. Singh MN, etal., Mol Hum Reprod. 2008 Nov;14(11):655-63. Epub 2008 Oct 10.
141. Nicotine and caffeine-mediated modulation in the expression of toxicant responsive genes and vesicular monoamine transporter-2 in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype in mouse. Singh S, etal., Brain Res. 2008 May 1;1207:193-206. Epub 2008 Feb 21.
142. Attenuation of hyperoxic lung injury by the CYP1A inducer beta-naphthoflavone. Sinha A, etal., Toxicol Sci. 2005 Sep;87(1):204-12. Epub 2005 Jun 15.
143. Distinct organization of methylcholanthrene- and phenobarbital-inducible cytochrome P-450 genes in the rat. Sogawa K, etal., Proc Natl Acad Sci U S A 1984 Aug;81(16):5066-70.
144. Smoking, the xenobiotic pathway, and clubfoot. Sommer A, etal., Birth Defects Res A Clin Mol Teratol. 2011 Jan;91(1):20-8. doi: 10.1002/bdra.20742. Epub 2010 Dec 1.
145. Genetic polymorphisms of cytochrome P450 CYP1A1 (*2A) and microsomal epoxide hydrolase gene, interactions with tobacco-users, and susceptibility to bladder cancer: a study from North India. Srivastava DS, etal., Arch Toxicol. 2008 Sep;82(9):633-9. doi: 10.1007/s00204-007-0276-4. Epub 2008 Jan 16.
146. Cytochrome P450IA1 polymorphisms along with PM(10) exposure contribute to the risk of birth weight reduction. Suh YJ, etal., Reprod Toxicol. 2007 Nov-Dec;24(3-4):281-8. Epub 2007 Jul 7.
147. Effects of perinatal PBDE exposure on hepatic phase I, phase II, phase III, and deiodinase 1 gene expression involved in thyroid hormone metabolism in male rat pups. Szabo DT, etal., Toxicol Sci. 2009 Jan;107(1):27-39. Epub 2008 Oct 31.
148. Genetic association between cytochrome P450IA1 gene and susceptibility to Parkinson's disease. Takakubo F, etal., J Neural Transm. 1996;103(7):843-9.
149. Interaction between cytochrome P450 and other drug-metabolizing enzymes: evidence for an association of CYP1A1 with microsomal epoxide hydrolase and UDP-glucuronosyltransferase. Taura KI, etal., Biochem Biophys Res Commun. 2000 Jul 14;273(3):1048-52.
150. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
151. Characteristic properties of a retinoic acid synthetic cytochrome P-450 purified from liver microsomes of 3-methylcholanthrene-induced rats. Tomita S, etal., Biochim Biophys Acta. 1996 Aug 13;1290(3):273-81.
152. Relation of PON1 and CYP1A1 genetic polymorphisms to clinical findings in a cross-sectional study of a Greek rural population professionally exposed to pesticides. Tsatsakis AM, etal., Toxicol Lett. 2009 Apr 10;186(1):66-72. Epub 2008 Oct 28.
153. [Study of cytochrome P450 1A1 gene 3'-UTR 6235T-C polymorphism and susceptibility to breast cancer with Uighur medicine]. Tuerxun M, etal., Zhonghua Yi Xue Za Zhi. 2011 Jan 11;91(2):86-91.
154. Potential roles of fibroblast growth factor-9 in the benzo(a)pyrene-induced invasion in vitro and the metastasis of human lung adenocarcinoma. Ueng TH, etal., Arch Toxicol. 2010 Aug;84(8):651-60. doi: 10.1007/s00204-010-0547-3. Epub 2010 May 13.
155. Cytochrome P-450 family 1 in rat embryo cell culture immortalized by Rausher leukemia virus. Vaiman AV, etal., Biochemistry (Mosc). 2004 Mar;69(3):306-10.
156. The effect of aspartame on rat brain xenobiotic-metabolizing enzymes. Vences-Mejia A, etal., Hum Exp Toxicol. 2006 Aug;25(8):453-9.
157. CYP1A1, CYP1A2 and CYBA gene polymorphisms associated with oxidative stress in COPD. Vibhuti A, etal., Clin Chim Acta. 2010 Apr 2;411(7-8):474-80. Epub 2010 Jan 18.
158. Polymorphisms of the xenobiotic-metabolizing enzymes CYP1A1 and NAT-2 in systemic sclerosis and lupus erythematosus. von Schmiedeberg S, etal., Adv Exp Med Biol. 1999;455:147-52.
159. The CYP1A1*2a allele is an independent prognostic factor for acute myeloid leukemia. Voso MT, etal., Haematologica. 2005 Jul;90(7):982-4.
160. Relationship of tobacco smoking CYP1A1 GSTM1 gene polymorphism and esophageal cancer in Xi'an. Wang AH, etal., World J Gastroenterol. 2002 Feb;8(1):49-53. doi: 10.3748/wjg.v8.i1.49.
161. Risk factor for clear cell renal cell carcinoma in Chinese population: a case-control study. Wang G, etal., Cancer Epidemiol. 2012 Apr;36(2):177-82. doi: 10.1016/j.canep.2011.09.006. Epub 2011 Oct 14.
162. Growth retardation of fetal rats exposed to nicotine in utero: possible involvement of CYP1A1, CYP2E1, and P-glycoprotein. Wang T, etal., Environ Toxicol. 2009 Feb;24(1):33-42. doi: 10.1002/tox.20391.
163. Effect of CYP1A1 MspI polymorphism on cigarette smoking related coronary artery disease and diabetes. Wang XL, etal., Atherosclerosis. 2002 Jun;162(2):391-7.
164. Stable expression of rat cytochrome P450IA2 cDNA and hydroxylation of 17 beta-estradiol and 2-aminofluorene in V79 Chinese hamster cells. Wolfel C, etal., Mol Carcinog 1991;4(6):489-98.
165. beta-Naphthoflavone protects mice from aristolochic acid-I-induced acute kidney injury in a CYP1A dependent mechanism. Xiao Y, etal., Acta Pharmacol Sin. 2009 Nov;30(11):1559-65. doi: 10.1038/aps.2009.156.
166. Induction of P450 1A by 3-methylcholanthrene protects mice from aristolochic acid-I-induced acute renal injury. Xue X, etal., Nephrol Dial Transplant. 2008 Oct;23(10):3074-81. doi: 10.1093/ndt/gfn262. Epub 2008 May 21.
167. Nucleotide sequence of a full-length cDNA coding for 3-methylcholanthrene-induced rat liver cytochrome P-450MC. Yabusaki Y, etal., Nucleic Acids Res 1984 Mar 26;12(6):2929-38.
168. High risk of 'de novo' acute myeloid leukaemia in individuals with cytochrome P450 A1 (CYP1A1) and NAD(P)H:quinone oxidoreductase 1 (NQO1) gene defects. Yamaguti GG, etal., Eur J Haematol. 2009 Sep;83(3):270-2. doi: 10.1111/j.1600-0609.2009.01272.x. Epub 2009 Apr 27.
169. Alterations of placental cytochrome P450 1A1 and P-glycoprotein in tobacco-induced intrauterine growth retardation in rats. Yan YE, etal., Acta Pharmacol Sin. 2005 Nov;26(11):1387-94.
170. Time-dependent effects of Klebsiella pneumoniae endotoxin (KPLPS) on the pharmacokinetics of theophylline in rats: return of the parameters in 96-hour KPLPS rats to the control levels. Yang KH, etal., Drug Metab Dispos. 2008 May;36(5):811-5. Epub 2008 Feb 28.
171. Manganese superoxide dismutase and cytochrome P450 1A1 genes polymorphisms in rheumatoid arthritis in Taiwan. Yen JH, etal., Hum Immunol. 2003 Mar;64(3):366-73.
172. Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in ankylosing spondylitis. Yen JH, etal., Immunol Lett. 2003 Aug 5;88(2):113-6.
173. Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in reactive arthritis. Yen JH, etal., Immunol Lett. 2003 Dec 15;90(2-3):151-4.
174. Cytochrome P450 and manganese superoxide dismutase genes polymorphisms in systemic lupus erythematosus. Yen JH, etal., Immunol Lett. 2003 Nov 15;90(1):19-24.
175. Cytochrome P450 1A1 and manganese superoxide dismutase gene polymorphisms in Behcet's disease. Yen JH, etal., J Rheumatol. 2004 Apr;31(4):736-40.
176. Cytochrome p450 1Al gene polymorphisms in patients with psoriatic arthritis. Yen JH, etal., Scand J Rheumatol. 2004;33(1):19-23.
177. Indole-3-propionic acid suppresses indoxyl sulfate-induced expression of fibrotic and inflammatory genes in proximal tubular cells. Yisireyili M, etal., Nagoya J Med Sci. 2017 Nov;79(4):477-486. doi: 10.18999/nagjms.79.4.477.
178. Mechanisms of exocrine pancreatic toxicity induced by oral treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Harlan Sprague-Dawley Rats. Yoshizawa K, etal., Toxicol Sci. 2005 May;85(1):594-606. Epub 2005 Feb 16.
179. Correlation of CYP1A1 and GSTM1 gene polymorphisms and environmental factors to familial aggregation of esophageal cancer among the Kazakh ethnic group in Xinjiang. Zeng M, etal., Genet Mol Res. 2015 Dec 29;14(4):19102-9. doi: 10.4238/2015.December.29.19.
180. Zhonghua wai ke za zhi [Chinese journal of surgery] Zhao D and Yang BX, Zhonghua Wai Ke Za Zhi. 2009 Mar 1;47(5):373-6.
181. Cooperation of the inducible nitric oxide synthase and cytochrome P450 1A1 in mediating lung inflammation and mutagenicity induced by diesel exhaust particles. Zhao H, etal., Environ Health Perspect. 2006 Aug;114(8):1253-8.
182. Induction of propranolol metabolism by Ginkgo biloba extract EGb 761 in rats. Zhao LZ, etal., Curr Drug Metab. 2006 Aug;7(6):577-87.
183. Metabolism of arachidonic acid by the cytochrome P450 enzyme in patients with chronic Keshan disease and dilated cardiomyopathy. Zhou B, etal., Biomed Rep. 2016 Feb;4(2):251-255. doi: 10.3892/br.2015.563. Epub 2015 Dec 31.
184. Does cytochrome P450 1A1 MspI polymorphism increase acute lymphoblastic leukemia risk? Evidence from 2013 cases and 2903 controls. Zhuo W, etal., Gene. 2012 Nov 15;510(1):14-21. doi: 10.1016/j.gene.2012.08.042. Epub 2012 Sep 3.
Additional References at PubMed
PMID:2382261   PMID:3041969   PMID:3718958   PMID:3753838   PMID:8274012   PMID:8651689   PMID:10681376   PMID:11555828   PMID:12200118   PMID:12210751   PMID:12865317   PMID:12927582  
PMID:14559847   PMID:14592459   PMID:14642533   PMID:14980704   PMID:15041462   PMID:15542068   PMID:15546903   PMID:16137656   PMID:16377763   PMID:16492979   PMID:16636061   PMID:16678472  
PMID:16758613   PMID:16758626   PMID:17052995   PMID:17166882   PMID:17182795   PMID:17276403   PMID:17431589   PMID:17697118   PMID:17719738   PMID:18493746   PMID:19069647   PMID:19219744  
PMID:19330918   PMID:19702544   PMID:19827888   PMID:20663043   PMID:20683339   PMID:21103392   PMID:21115944   PMID:21505853   PMID:21666223   PMID:22159698   PMID:22167220   PMID:22173777  
PMID:22266391   PMID:22579820   PMID:22785257   PMID:23060473   PMID:23275542   PMID:23626760   PMID:23658888   PMID:23956140   PMID:23984390   PMID:24119481   PMID:24557547   PMID:24557852  
PMID:24727239   PMID:25164943   PMID:25224811   PMID:25300103   PMID:25407269   PMID:25555259   PMID:26403959   PMID:26466350   PMID:27444380   PMID:28780123   PMID:28879796   PMID:31974042  
PMID:33766215   PMID:34800366   PMID:36047110   PMID:37489271   PMID:39059132  


Genomics

Comparative Map Data
Cyp1a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8866,991,940 - 66,998,014 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl866,991,970 - 66,998,012 (+)EnsemblGRCr8
mRatBN7.2858,096,021 - 58,102,130 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl858,096,077 - 58,102,125 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx863,629,083 - 63,635,108 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0861,906,655 - 61,912,680 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0859,771,206 - 59,777,229 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0862,472,087 - 62,478,122 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl862,472,095 - 62,478,147 (+)Ensemblrn6Rnor6.0
Rnor_5.0862,249,046 - 62,255,081 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4861,462,207 - 61,468,237 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera857,561,801 - 57,567,827 (+)NCBICelera
RGSC_v3.1861,481,260 - 61,487,291 (+)NCBI
RH 3.4 Map8671.2RGD
Cytogenetic Map8q24NCBI
CYP1A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381574,719,542 - 74,725,528 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1574,719,542 - 74,725,536 (-)Ensemblhg38GRCh38
GRCh371575,011,883 - 75,017,869 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361572,798,943 - 72,804,930 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341572,798,942 - 72,804,930NCBI
Celera1551,961,906 - 51,967,900 (-)NCBICelera
Cytogenetic Map15q24.1NCBI
HuRef1551,809,772 - 51,815,766 (-)NCBIHuRef
CHM1_11575,130,208 - 75,136,202 (-)NCBICHM1_1
T2T-CHM13v2.01572,589,430 - 72,595,416 (-)NCBIT2T-CHM13v2.0
Cyp1a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39957,595,211 - 57,611,107 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl957,595,211 - 57,611,107 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38957,687,928 - 57,703,824 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl957,687,928 - 57,703,824 (+)Ensemblmm10GRCm38
MGSCv37957,535,735 - 57,551,629 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36957,486,065 - 57,501,958 (+)NCBIMGSCv36mm8
Celera985,889,319 - 85,895,530 (-)NCBICelera
Cytogenetic Map9BNCBI
cM Map931.34NCBI
LOC102010850
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554503,183,750 - 3,189,488 (+)Ensembl
ChiLan1.0NW_0049554503,183,958 - 3,189,488 (+)NCBIChiLan1.0ChiLan1.0
CYP1A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21663,949,165 - 63,957,527 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11568,112,819 - 68,121,152 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01553,664,968 - 53,672,277 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11573,284,566 - 73,290,636 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1573,284,566 - 73,290,636 (-)EnsemblpanPan2panpan1.1
CYP1A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13037,793,277 - 37,799,535 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3037,793,508 - 37,796,866 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3037,726,194 - 37,732,463 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03037,998,587 - 38,004,872 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3037,998,848 - 38,002,205 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13037,951,106 - 37,957,375 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03037,976,995 - 37,983,257 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03038,232,580 - 38,238,845 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101969148
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640115,834,681 - 115,840,894 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647133,682,730 - 33,688,332 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647133,682,730 - 33,688,332 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP1A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl758,802,887 - 58,809,775 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1758,802,887 - 58,809,155 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2763,491,496 - 63,497,751 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7qNCBI
CYP1A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1268,753,236 - 8,759,378 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl268,753,327 - 8,759,384 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048132,870,282 - 132,876,394 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101707509
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046279887 - 1,323 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Cyp1a1
32 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:136
Count of miRNA genes:106
Interacting mature miRNAs:130
Transcripts:ENSRNOT00000026473
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84961020468373388Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)85076395167219641Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat

Markers in Region
D8Mgh7  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8866,992,095 - 66,992,317 (+)Marker Load Pipeline
RGSC_v3.4861,462,321 - 61,462,542RGDRGSC3.4
RGSC_v3.4861,462,322 - 61,462,542UniSTSRGSC3.4
Celera857,561,916 - 57,562,112UniSTS
RGSC_v3.1861,481,375 - 61,481,596RGD
RH 3.4 Map8667.1RGD
RH 2.0 Map8519.0RGD
Cytogenetic Map8q24UniSTS
RH94445  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2858,101,546 - 58,101,735 (+)MAPPERmRatBN7.2
Rnor_6.0862,477,539 - 62,477,727NCBIRnor6.0
Rnor_5.0862,254,498 - 62,254,686UniSTSRnor5.0
RGSC_v3.4861,467,659 - 61,467,847UniSTSRGSC3.4
Celera857,567,249 - 57,567,437UniSTS
RH 3.4 Map8671.2UniSTS
Cytogenetic Map8q24UniSTS
PMC15407P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8866,995,916 - 66,996,542 (+)Marker Load Pipeline
mRatBN7.2858,100,029 - 58,100,655 (+)MAPPERmRatBN7.2
Rnor_6.0862,476,022 - 62,476,647NCBIRnor6.0
Rnor_5.0862,252,981 - 62,253,606UniSTSRnor5.0
RGSC_v3.4861,466,142 - 61,466,767UniSTSRGSC3.4
Celera857,565,712 - 57,566,337UniSTS
Cytogenetic Map8q24UniSTS
Cyp1a1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2858,098,974 - 58,099,270 (+)MAPPERmRatBN7.2
Rnor_6.0862,474,967 - 62,475,262NCBIRnor6.0
Rnor_5.0862,251,926 - 62,252,221UniSTSRnor5.0
RGSC_v3.4861,465,087 - 61,465,382UniSTSRGSC3.4
Celera857,564,657 - 57,564,952UniSTS
Cytogenetic Map8q24UniSTS
D8Mgh7  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8866,992,096 - 66,992,317 (+)Marker Load Pipeline
Rnor_6.0862,472,202 - 62,472,422NCBIRnor6.0
Rnor_5.0862,249,161 - 62,249,381UniSTSRnor5.0
RGSC_v3.4861,462,322 - 61,462,542UniSTSRGSC3.4
Celera857,561,916 - 57,562,112UniSTS
RH 3.4 Map8667.1UniSTS
Cytogenetic Map8q24UniSTS


Related Rat Strains
The following Strains have been annotated to Cyp1a1
F344-Tg(Cyp1a1-Ren2)10Jmul    


Genetic Models
This gene Cyp1a1 is modified in the following models/strains:
SS-Cyp1a1em1Mcwi     SS-Cyp1a1em2Mcwi     SS-Cyp1a1em5Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 10 24 68 77 77 49 24 49 6 214 72 3 50 70 62 28 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000026473   ⟹   ENSRNOP00000026473
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl866,991,970 - 66,998,012 (+)Ensembl
mRatBN7.2 Ensembl858,096,077 - 58,102,125 (+)Ensembl
Rnor_6.0 Ensembl862,472,095 - 62,478,147 (+)Ensembl
RefSeq Acc Id: NM_012540   ⟹   NP_036672
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8866,991,982 - 66,998,012 (+)NCBI
mRatBN7.2858,096,089 - 58,102,125 (+)NCBI
Rnor_6.0862,472,087 - 62,478,117 (+)NCBI
Rnor_5.0862,249,046 - 62,255,081 (+)NCBI
RGSC_v3.4861,462,207 - 61,468,237 (+)RGD
Celera857,561,801 - 57,567,827 (+)RGD
Sequence:
RefSeq Acc Id: XM_006243150   ⟹   XP_006243212
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8866,991,940 - 66,998,014 (+)NCBI
mRatBN7.2858,096,021 - 58,102,130 (+)NCBI
Rnor_6.0862,472,087 - 62,478,122 (+)NCBI
Rnor_5.0862,249,046 - 62,255,081 (+)NCBI
Sequence:
RefSeq Acc Id: NP_036672   ⟸   NM_012540
- UniProtKB: P00185 (UniProtKB/Swiss-Prot),   A6J4X3 (UniProtKB/TrEMBL),   Q80UE2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243212   ⟸   XM_006243150
- Peptide Label: isoform X1
- UniProtKB: P00185 (UniProtKB/Swiss-Prot),   A6J4X3 (UniProtKB/TrEMBL),   Q80UE2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026473   ⟸   ENSRNOT00000026473

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P00185-F1-model_v2 AlphaFold P00185 1-524 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:6849918
Promoter ID:EP17065
Type:single initiation site
Name:RN_CP11
Description:Cytochrome P-450 IA1, methylcholanthrene-inducible,CYP1A1 or CYP1A-1 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 111; Mammalian cytochrome P450 IA1
Experiment Methods:Nuclease protection with homologous sequence ladder; Sequencing of a full-length cDNA; Primer extension
Regulation:liver; (induced by or strongly expressed in) MC
Position:
Rat AssemblyChrPosition (strand)Source
RGSC_v3.4861,462,178 - 61,462,238EPD
RGD ID:13696018
Promoter ID:EPDNEW_R6543
Type:single initiation site
Name:Cyp1a1_1
Description:cytochrome P450, family 1, subfamily a, polypeptide 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0862,472,047 - 62,472,107EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2458 AgrOrtholog
BioCyc Gene G2FUF-30298 BioCyc
Ensembl Genes ENSRNOG00000019500 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026473 ENTREZGENE
  ENSRNOT00000026473.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I_CYP1 UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
KEGG Report rno:24296 UniProtKB/Swiss-Prot
NCBI Gene 24296 ENTREZGENE
PANTHER CYTOCHROME P450 1A UniProtKB/Swiss-Prot
  STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PharmGKB CYP1A1 RGD
PhenoGen Cyp1a1 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot
  EP450ICYP1A UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019500 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
TIGR TC211358
UniProt A6J4X3 ENTREZGENE, UniProtKB/TrEMBL
  CP1A1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q80UE2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Cyp1a1  cytochrome P450, family 1, subfamily a, polypeptide 1    cytochrome P450, 1a1  Name updated 625702 APPROVED
2002-06-10 Cyp1a1  cytochrome P450, 1a1      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_function monooxygenase that degrades xenobiotics by oxidation, releasing radical oxygen species (ROS) as byproducts 70344
gene_process may play a role in pulmonary oxygen toxicity 70344
gene_protein 523 amino acid residues 70345
gene_regulation induced by hyperoxia 70344
gene_regulation mRNA expression can be induced by polycyclic aromatic hydrocarbons (PAH) via the aryl hydrocarbon receptor (AhR) 625582
gene_regulation mRNA level in intestine increases after adminstration of oltipraz, a synthetic derivative of the cruciferous vegetable product 1,2-dithiole-3-thione 625582
gene_transcript first exon untranslated 70345