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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:17263
Term: estrone
Definition: A 17-oxo steroid that is estra-1,3,5(10)-triene substituted by an hydroxy group at position 3 and an oxo group at position 17.
Chemical ID: MESH:D004970
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1affects bindingISOCYP1A1 (Homo sapiens)6480464CTDCYP1A1 protein binds to EstronePMID:27966929
Cyp1a1increases hydroxylationISOCYP1A1 (Homo sapiens)6480464CTDCYP1A1 protein polymorphism results in increased hydroxylation of EstronePMID:15805301
Cyp1a1multiple interactionsISOCyp1a1 (Mus musculus)6480464CTDEstrone promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]PMID:12093619
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