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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:34567
Term: benzo[e]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings. It is listed as a Group 3 carcinogen by the IARC.
Chemical ID: MESH:C026487
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1increases activityEXP 6480464CTDbenzo(e)pyrene results in increased activity of CYP1A1 proteinPMID:1316759 PMID:8079350
Cyp1a1increases expressionEXP 6480464CTDbenzo(e)pyrene results in increased expression of CYP1A1 mRNAPMID:1316759 PMID:8079350
Cyp1a1multiple interactionsEXP 6480464CTD[benzo(e)pyrene co-treated with GNMT protein] results in increased expression of CYP1A1 mRNAPMID:9261130
Cyp1a1increases expressionISOCyp1a1 (Mus musculus)6480464CTDbenzo(e)pyrene results in increased expression of CYP1A1 mRNAPMID:12117779
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDbenzo(e)pyrene results in increased expression of CYP1A1 mRNAPMID:27196671
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