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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:28230
Term: hesperetin
Definition: A trihydroxyflavanone having the three hydroxy gropus located at the 3'-, 5- and 7-positions and an additional methoxy substituent at the 4'-position.
Chemical ID: MESH:C013015
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1decreases activityISOCYP1A1 (Homo sapiens)6480464CTDhesperetin results in decreased activity of CYP1A1 proteinPMID:10781868
Cyp1a1multiple interactionsISOCyp1a1 (Mus musculus)6480464CTDhesperetin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]PMID:26546711
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTD[2-hydroxypropyl-beta-cyclodextrin co-treated with hesperetin] inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]PMID:21720915
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